Biomod/2011/Harvard/HarvarDNAnos

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=DNA Origami Containers=
=DNA Origami Containers=
Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. '''We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo''', with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.
Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. '''We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo''', with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.
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<html><iframe width="560" height="315" src="http://www.youtube.com/embed/NaAE_4AFVlA" frameborder="0" allowfullscreen></iframe></html>
 
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=Presentation=
=Presentation=
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<div class="prezi-player"><style type="text/css" media="screen">.prezi-player { width: 550px; } .prezi-player-links { text-align: center; }</style><object id="prezi_uj6xu0za4jti" name="prezi_uj6xu0za4jti" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" width="550" height="400"><param name="movie" value="http://prezi.com/bin/preziloader.swf"/><param name="allowfullscreen" value="true"/><param name="allowscriptaccess" value="always"/><param name="bgcolor" value="#ffffff"/><param name="flashvars" value="prezi_id=uj6xu0za4jti&amp;lock_to_path=1&amp;color=ffffff&amp;autoplay=no&amp;autohide_ctrls=0"/><embed id="preziEmbed_uj6xu0za4jti" name="preziEmbed_uj6xu0za4jti" src="http://prezi.com/bin/preziloader.swf" type="application/x-shockwave-flash" allowfullscreen="true" allowscriptaccess="always" width="550" height="400" bgcolor="#ffffff" flashvars="prezi_id=uj6xu0za4jti&amp;lock_to_path=1&amp;color=ffffff&amp;autoplay=no&amp;autohide_ctrls=0"></embed></object><div class="prezi-player-links"></div></div>
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</center></html>
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=Video=
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<center>
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<html><iframe width="560" height="315" src="http://www.youtube.com/embed/NaAE_4AFVlA" frameborder="0" allowfullscreen></iframe></html>
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</center>
=Thank you=
=Thank you=

Revision as of 16:22, 8 November 2011


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2011/11/05: We won 3rd Place at The International Bio-molecular Design Competition! Please also check out the websites of all of our incredible competitors. Congrats to everyone!

DNA Origami Containers

Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo, with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.

Presentation

Video

Thank you

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