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The Covaris S2 sonicator is a versatile, high power system engineered for pre-analytical sample processing with Covaris’ patented Adaptive Focused Acoustics™. Utilizing a spherical acoustic transducer, specifically designed AFA™ Tubes, and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 25 μl to 10 ml. The main applications are shearing of DNA, RNA, and chromatin but it can also perform tissue homogenization for cell lysis and drug delivery and formulation.

Protocols for optimizing the sonication time for next generation sequencing can be found on the the company's website:
Schedule time on the Covaris

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