Batada:Training: Difference between revisions
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We are seeking an experienced Research Associate to develop novel molecular biology methods for measuring transcriptomes (abundance, differentially spliced isoforms and noncoding RNAs) and epigenomes (DNA methylation and histone modifications) to identify the molecular basis for stem cell pluripotency and phenotypic variation among tissue types in human and mouse model systems. | We are seeking an experienced Research Associate to develop novel molecular biology methods for measuring transcriptomes (abundance, differentially spliced isoforms and noncoding RNAs) and epigenomes (DNA methylation and histone modifications) to identify the molecular basis for stem cell pluripotency and phenotypic variation among tissue types in human and mouse model systems. | ||
The successful applicant will have extensive knowledge of advanced molecular biology techniques (nucleic acid manipulation methods, chromatin immunoprecipitation (ChIP), DNA methylation analysis by bisulphite modification, | The successful applicant will have extensive knowledge of advanced molecular biology techniques (nucleic acid manipulation methods, chromatin immunoprecipitation (ChIP), DNA methylation analysis by bisulphite modification, and RNA flourescence in situ hybridisation (RNA-FISH), tissue culture), experience working with RNAs (noncoding and rare transcripts) and must be interested in expanding their expertise of molecular biology by developing genome-wide methods for DNA and RNA extraction, capturing and library construction from single or few cells. | ||
The successful candidate will enjoy access to cutting-edge technologies such as Solexa and SOLID sequencers, well-funded and intellectually stimulating environment of OICR's genomic platform, opportunity to drive projects and publish in scientific journals and attend scientific meetings. | The successful candidate will enjoy access to cutting-edge technologies such as Solexa and SOLID sequencers, well-funded and intellectually stimulating environment of OICR's genomic platform, opportunity to drive projects and publish in scientific journals and attend scientific meetings. | ||
Revision as of 12:21, 25 August 2008
Openings:
Research Associate:
Description: We are seeking an experienced Research Associate to develop novel molecular biology methods for measuring transcriptomes (abundance, differentially spliced isoforms and noncoding RNAs) and epigenomes (DNA methylation and histone modifications) to identify the molecular basis for stem cell pluripotency and phenotypic variation among tissue types in human and mouse model systems.
The successful applicant will have extensive knowledge of advanced molecular biology techniques (nucleic acid manipulation methods, chromatin immunoprecipitation (ChIP), DNA methylation analysis by bisulphite modification, and RNA flourescence in situ hybridisation (RNA-FISH), tissue culture), experience working with RNAs (noncoding and rare transcripts) and must be interested in expanding their expertise of molecular biology by developing genome-wide methods for DNA and RNA extraction, capturing and library construction from single or few cells.
The successful candidate will enjoy access to cutting-edge technologies such as Solexa and SOLID sequencers, well-funded and intellectually stimulating environment of OICR's genomic platform, opportunity to drive projects and publish in scientific journals and attend scientific meetings.
Qualifications: Ph.D.in a molecular biology or related field
Application details: Send CV and a half page description of the type of research questions you are interested in and your career goals to nizar.batada "at" oicr.on.ca. Two references will be requested from short-listed applicants.
Postdoctoral Fellow in Computational Epigenetics
Description: We have an opening for a Postdoctoral fellow in Computational Epigenetics. Our lab is part of the OICR's Genomics Platform which has ten next generation sequencers. We are in midst of generating massive amounts of sequencing data on DNA methylation, histone modification, transcript abundance, splice isoforms and noncoding RNAs in stem cells and cancer tissues and are in need of bioinformatic analysis of this data. Questions of interest include the following: Analysis of human and mouse epigenomes; identification of epigenetically labile genes; relating epigenetic modification patterns to gene expression; understanding the genomic basis of stem cell pluripotency; identification of aberrant epigenetic modification in cancer.
Qualifications: Applicants must have a PhD in computational biology/bioinformatics with interests in genome analysis and epigenetics and have a working knowledge of bioinformatics, statistical methods and basic programming (python or perl, matlab or R etc). I am happy to train you in programming/statistics if you have a very strong knowledge of epigenetics and strongly motivated to move in to Bioinformatics.
Application details: Send CV and a half page description of the type of research questions you are interested in and your career goals to nizar.batada "at" oicr.on.ca. Two references will be requested from short-listed applicants.
