BME494 Sp2014 Dhatt: Difference between revisions
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<!-- Incorporate information from Presentation 1. Must be reasonable and clearly relevant to an important health challenge. --> | <!-- Incorporate information from Presentation 1. Must be reasonable and clearly relevant to an important health challenge. --> | ||
Diabetes mellitus, or diabetes, is a group of metabolic diseases in which an individual has high blood sugar. Diabetes occurs due to the either the pancreas not producing enough insulin or because cells of the body do not respond to the insulin being produced. There are three types of diabetes: Type I, Type II, and gestational diabetes. Serious long-term complications of diabetes include heart disease, kidney failure, and damage to the eyes. Diabetes is a chronic disease and there is no known preventative measure for type I diabetes. Having awareness of the disease and treating it at early stages can prevent and lower the risk of complications in patients with diabetes. Patients with diabetes must maintain keeping both short-term and long-term blood glucose levels within acceptable ranges. | |||
Globally, 227-285 million individuals have diabetes and about 90% of these individuals have Type II diabetes. In 2011, 1.4 million deaths occurred worldwide due to the result of diabetes making it the 8th leading cause of death. This number is estimated to double in the next 15 years, therefore, there is a need for a rapid diagnostic test. | |||
Revision as of 13:12, 8 May 2014
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Background & Proposed ApplicationBACKGROUND
The synthetic system modeled in the “Construction of a genetic toggle switch In Escherichia coli” uses two different states, an “on” state” and an “off” state (Gardner et all 2000). The classical system uses two repressor and two promoter pairs in which both repressors are inhibited by a different inducer, aTc and IPTG. The promoters were placed next to the repressor gene of the opposite pair. This system represents a bistable gene-regulatory network where only one promoter can be expressed at one time because the expression of one promoter repressed expression of the other promoter. The on-state of the cell was represented by placing a green fluorescent protein (GFP) transcription gene downstream of the on-state promoter.
Globally, 227-285 million individuals have diabetes and about 90% of these individuals have Type II diabetes. In 2011, 1.4 million deaths occurred worldwide due to the result of diabetes making it the 8th leading cause of death. This number is estimated to double in the next 15 years, therefore, there is a need for a rapid diagnostic test.
Design of a New Device
Building the New DeviceSYNTHETIC DNA LAYOUT
Testing the New DeviceLAC OPERON MODEL SIMULATION
Similarities:
Differences:
Human Practices
About the Designer
References[1] Full reference. [2] Full reference. [3] Full reference.
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