BME494 Project Group2: Difference between revisions
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==ABSTRACT== | ==ABSTRACT== | ||
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[[Image:Mussle_foot.jpg|thumb|frame|left| | [[Image:Mussle_foot.jpg|thumb|frame|left|The foot of a mussel]] | ||
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Revision as of 13:52, 11 March 2012
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ABSTRACTWithin the foot of the mussel there are five mussel proteins that vary by amount. This varying amount is caused by the differing amounts of DOPA present within the proteins. These proteins are what cause the adhesive properties present within a mussel. What we aimed to do is create a controllable configuration of cells so that adhesion to a surface can be easily toggled. By using a combination of the existing natural part Mussel Adhesive Protein Mgfp-1 and the pre-existing part Mefp-5 (that was bio-bricked and used by UC Berkeley) a unique bioadhesive that provides desirable adhesion properties can be created.
BACKGROUNDBioadhesives are natural polymeric materials that many organisms, such as mussels, use for their adhesive properties. Bioadhesives have been seen as an excellent alternative to human-made substances as they are very and durable in conjunction with being eco-friendly. In addition, they exhibit properties that allow them to be used in underwater and medical applications which is the main interest of this project.
PROOF OF CONCEPT DESIGNNew Natural Part
The end of the Mefp-1 protein sequence:TATCCATCACAATATTAA
Key Pre-existing Part
TESTINGMeasurement
We expect to see a quasi-linear relationship between adhesive power and glowing intensity. This is because the GFP is being produced in the same plasmid cycle as the adhesive protein. The adhesive power could be monitored to support these conclusion through high cost equipment such as the AFM cantilever.
HUMAN PRACTICESPETA Problems
OUR TEAM
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