BME494 Project Group2: Difference between revisions
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'''New Natural Part''' | '''New Natural Part''' | ||
Mussel Adhesive Protein Mgfp-1 is our Natural Part | |||
*We are using it to test its ability to increase the adhesive properties of a substance to use as a glue in aqueous environments like in dentistry. | *We are using it to test its ability to increase the adhesive properties of a substance to use as a glue in aqueous environments like in dentistry. | ||
*We found this part when searching for adhesive proteins from mussels and first found a trademark Cell-Tak who sold Mgfp-1 but from protein extraction methods. We then found that Idaho National Laboratory (INL) has a patent (number 6987170) and has sequenced the protein such that PCR reactions can mass produce it. Part of the sequence was copied from INL and then located in Genbank. | *We found this part when searching for adhesive proteins from mussels and first found a trademark Cell-Tak who sold Mgfp-1 but from protein extraction methods. We then found that Idaho National Laboratory (INL) has a patent (number 6987170) and has sequenced the protein such that PCR reactions can mass produce it. Part of the sequence was copied from INL and then located in Genbank. |
Revision as of 13:33, 11 March 2012
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ABSTRACTWithin the foot of the mussel there are five mussel proteins that vary by amount. This varying amount is caused by the differing amounts of DOPA present within the proteins. These proteins are what cause the adhesive properties present within a mussel. What we aimed to do is create a controllable configuration of cells so that adhesion to a surface can be easily toggled. By using a combination of the existing natural part Mussel Adhesive Protein Mgfp-1 and the pre-existing part Mefp-5 (that was bio-bricked and used by UC Berkeley) a unique bioadhesive that provides desirable adhesion properties can be created.
BACKGROUNDBioadhesives are natural polymeric materials that many organisms, such as mussels, use for their adhesive properties. Bioadhesives have been seen as an excellent alternative to human-made substances as they are very and durable in conjunction with being eco-friendly. In addition, they exhibit properties that allow them to be used in underwater and medical applications which is the main interest of this project.
PROOF OF CONCEPT DESIGN
Key Pre-existing Part
TESTING
HUMAN PRACTICESPETA Problems
OUR TEAM
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