BME103:T930 Group 11 l2 - Revision history

Samantha Boccasini: /* Research and Development */

2012-11-29T20:33:16Z

Research and Development

←Older revision		Revision as of 20:33, 29 November 2012
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	<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>		<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>

-	<math> P(A\|B) </math> represents the probability that cancer will produce a positive outcome in the test (when the primer ~~bind~~ to the mutated gene).	+	<math> P(A\|B) </math> represents the probability that cancer will produce a positive outcome in the test (when the primer binds to the mutated gene).

	<math> P(B\|A) </math> represents the probability a person will yield a positive result for the cancer test.		<math> P(B\|A) </math> represents the probability a person will yield a positive result for the cancer test.

Samantha Boccasini: /* Research and Development */

2012-11-29T20:32:24Z

Research and Development

←Older revision		Revision as of 20:32, 29 November 2012
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	Prostate Cancer: androgen receptor		Prostate Cancer: androgen receptor

-	"Prostate Cancer is cancer that starts in the prostate gland. The prostate is a small walnut-sized structure that makes up part of a man's reproductive system. It wraps around the urethra, the tube that carries urine out of the body."[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/] Prostate Cancer is the most common cause of death from cancer in men over age 75. It's very rare to find it in men younger than 40. ~~The~~ most common problem in almost all men as they grow older is an enlarged prostate. More information can be found regarding Prostate cancer is here.[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/]	+	"Prostate Cancer is cancer that starts in the prostate gland. The prostate is a small walnut-sized structure that makes up part of a man's reproductive system. It wraps around the urethra, the tube that carries urine out of the body."[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/] Prostate Cancer is the most common cause of death from cancer in men over age 75. It's very rare to find it in men younger than 40. In fact, the most common problem in almost all men as they grow older is an enlarged prostate. More information can be found regarding Prostate cancer is here.[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/]

	An image of a normal prostate and cancer prostate[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/figure/A000380.B18038/?report=objectonly]		An image of a normal prostate and cancer prostate[http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/figure/A000380.B18038/?report=objectonly]

Samantha Boccasini: /* Thermal Cycler Engineering */

2012-11-29T20:29:23Z

Thermal Cycler Engineering

←Older revision		Revision as of 20:29, 29 November 2012
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	'''Instructions'''<br>		'''Instructions'''<br>
-	The same type of instructions to setting up the PCR ~~is the same~~ however running the ~~cycle~~ will be quite different. There will no longer be a USB drive or cord to ~~connect it the~~ laptop. ~~So now~~ the actual readings and programs will all be on the touch-screen. So now you will be able to set up the machine very similarly as before except everything will be on the screen. The idea for the new PCR machine is to be more mobile and accessible to users. Setting up the cycling will all be the same with the same options as well, so there will not be any huge differences other than it will be less worry about connection to the laptop.	+	The same type of instructions to setting up the original PCR machine apply to this one; however, running the cycles will be quite different. There will no longer be a USB drive or cord that connect to a laptop. Now the actual readings and programs will all be on the touch-screen. So now you will be able to set up the machine very similarly as before except everything will be on the screen. The idea for the new PCR machine is to be more mobile and accessible to users. Setting up the cycling will all be the same with the same options as well, so there will not be any huge differences other than it will be less worry about connection to the laptop, which in turn equally reduces worry about portability.

	<!--- From Week 4 exercise --->		<!--- From Week 4 exercise --->

Samantha Boccasini: /* Research and Development */

2012-11-29T20:26:39Z

Research and Development

←Older revision		Revision as of 20:26, 29 November 2012
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	'''Illustration'''		'''Illustration'''

-	~~This is~~ the primers for the Retinoblastoma sample binding.	+	These are the primers for the Retinoblastoma sample binding:

	[[Image:Retinoblastoma.jpg]]		[[Image:Retinoblastoma.jpg]]

-	~~This is~~ the primers for the Prostate Cancer sample binding.	+	These are the primers for the Prostate Cancer sample binding:

	[[Image:Prostate Cancer.jpg]]		[[Image:Prostate Cancer.jpg]]

-	This is the process of DNA amplification.	+	This is the process of DNA amplification:

	http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif		http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif

Ryelle Avylaine Pattuinan: /* Research and Development */

2012-11-29T08:17:53Z

Research and Development

←Older revision		Revision as of 08:17, 29 November 2012
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	[[Image:bayes.jpg]]		[[Image:bayes.jpg]]
		+
	<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>		<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>
		+
		+	<math> P(A\|B) </math> represents the probability that cancer will produce a positive outcome in the test (when the primer bind to the mutated gene).
		+
		+	<math> P(B\|A) </math> represents the probability a person will yield a positive result for the cancer test.
		+
		+	<math> P(A) </math> represents the probability of carrying the mutated gene.
		+
		+	<math> P(B) </math>represents the probability of people who would yield a positive result in the test without really having cancer.
		+
	<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->		<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->
-	\|}

Tony Nguyen: /* Research and Development */

2012-11-29T08:12:30Z

Research and Development

←Older revision		Revision as of 08:12, 29 November 2012
Line 163:		Line 163:

	<!--- Bonus: explain how Bayesian statistics can be used to assess the reliability of your team's method. Just write the equation using variables that are relevant to your team's new test. You do not need actual numbers --->		<!--- Bonus: explain how Bayesian statistics can be used to assess the reliability of your team's method. Just write the equation using variables that are relevant to your team's new test. You do not need actual numbers --->
-	~~[[Image:bayes.jpg]]~~	+

	'''Background on Disease Markers'''		'''Background on Disease Markers'''
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	<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->		<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->

-		+	[[Image:bayes.jpg]]
		+	<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>
	<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->		<!-- ##### DO NOT edit below this line unless you know what you are doing. ##### -->
	\|}		\|}

Tony Nguyen: /* Research and Development */

2012-11-29T08:08:19Z

Research and Development

←Older revision		Revision as of 08:08, 29 November 2012
Line 163:		Line 163:

	<!--- Bonus: explain how Bayesian statistics can be used to assess the reliability of your team's method. Just write the equation using variables that are relevant to your team's new test. You do not need actual numbers --->		<!--- Bonus: explain how Bayesian statistics can be used to assess the reliability of your team's method. Just write the equation using variables that are relevant to your team's new test. You do not need actual numbers --->
-		+	[[Image:bayes.jpg]]

	'''Background on Disease Markers'''		'''Background on Disease Markers'''

Ryelle Avylaine Pattuinan: /* Research and Development */

2012-11-29T08:07:35Z

Research and Development

←Older revision		Revision as of 08:07, 29 November 2012
Line 213:		Line 213:
	'''Illustration'''		'''Illustration'''

-	~~http://www2~~.~~le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif~~	+	This is the primers for the Retinoblastoma sample binding.
-	~~[http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif]~~	+

	[[Image:Retinoblastoma.jpg]]		[[Image:Retinoblastoma.jpg]]
		+
		+	This is the primers for the Prostate Cancer sample binding.
		+
	[[Image:Prostate Cancer.jpg]]		[[Image:Prostate Cancer.jpg]]
		+
		+	This is the process of DNA amplification.
		+
		+	http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif
		+	[http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif]
		+
		+

	<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->		<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->

Ryelle Avylaine Pattuinan: /* Research and Development */

2012-11-29T08:05:44Z

Research and Development

←Older revision		Revision as of 08:05, 29 November 2012
Line 217:		Line 217:

	[[Image:Retinoblastoma.jpg]]		[[Image:Retinoblastoma.jpg]]
		+	[[Image:Prostate Cancer.jpg]]

	<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->		<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->

Ryelle Avylaine Pattuinan: /* Research and Development */

2012-11-29T08:03:57Z

Research and Development

←Older revision		Revision as of 08:03, 29 November 2012
Line 215:		Line 215:
	http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif		http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif
	[http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif]		[http://www2.le.ac.uk/departments/emfpu/genetics/explained/images/PCR-process.gif]
		+
		+	[[Image:Retinoblastoma.jpg]]

	<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->		<!--- Include an illustration that shows how your system's primers allow specific amplification of the disease-related SNP --->

←Older revision		Revision as of 20:33, 29 November 2012
Line 234:		Line 234:
	<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>		<math>P(A\|B) = \frac{P(B \| A)\, P(A)}{P(B)}. \,</math><br>

-	<math> P(A\|B) </math> represents the probability that cancer will produce a positive outcome in the test (when the primer ~~bind~~ to the mutated gene).	+	<math> P(A\|B) </math> represents the probability that cancer will produce a positive outcome in the test (when the primer binds to the mutated gene).

	<math> P(B\|A) </math> represents the probability a person will yield a positive result for the cancer test.		<math> P(B\|A) </math> represents the probability a person will yield a positive result for the cancer test.