BME103:T130 Group 10 l2: Difference between revisions
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<!--- A description of the diseases and their associated SNP's (include the database reference number and web link) ---> | <!--- A description of the diseases and their associated SNP's (include the database reference number and web link) ---> | ||
The disease that we chose was Sickle Cell Anemia. Sickle Cell is a inherited disease that comes from both parents. If only one parent has the Sickle Cell trait, then the child will be a carrier. If both parents have the trait, then the child will have Sickle Cell. This disease causes the red blood cells to change into a crescent shape instead of being disk shape resulting in the loss of efficient oxygen delivery. It can also result in clotting because the blood cells can not make it through small blood vessels very well. The SNP for this disease is 78478128 and the reference SNP is rs78478128 | The disease that we chose was Sickle Cell Anemia. Sickle Cell is a inherited disease that comes from both parents. If only one parent has the Sickle Cell trait, then the child will be a carrier. If both parents have the trait, then the child will have Sickle Cell. This disease causes the red blood cells to change into a crescent shape instead of being disk shape resulting in the loss of efficient oxygen delivery. It can also result in clotting because the blood cells can not make it through small blood vessels very well. The SNP for this disease is 78478128 and the reference SNP is rs78478128 | ||
The link to the page with more info on Sickle cell is http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001554/ | The link to the page with more info on Sickle cell is http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001554/ | ||
The link to the page with the genetic information and SNP is http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=78478128#locus | The link to the page with the genetic information and SNP is http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=78478128#locus | ||
Revision as of 09:29, 29 November 2012
BME 103 Fall 2012 | Home People Lab Write-Up 1 Lab Write-Up 2 Lab Write-Up 3 Course Logistics For Instructors Photos Wiki Editing Help | ||||||||||||||||||||||||||||||||||||||||
OUR TEAMLAB 2 WRITE-UPThermal Cycler EngineeringOur re-design is based upon the Open PCR system originally designed by Josh Perfetto and Tito Jankowski.
Key Features There are two specific features that will be upgraded in the OpenPCR machine - the case and the power source. The case will be changed from a thin wood to a more durable plastic, so that the device can be taken out into the field. The device will also have solar panels, which will provide for the power. This shift allows the device to be used where electricity is not always available, such as rural and undeveloped regions. When combined, these two features open the device up to a larger market. Instructions The instructions would remain the same, as the solar panel array would come attached to the plastic on the device's top side.
ProtocolsMaterials
Also included: Access code for smart phone app download.
PCR Protocol
Research and DevelopmentBackground on Disease Markers The disease that we chose was Sickle Cell Anemia. Sickle Cell is a inherited disease that comes from both parents. If only one parent has the Sickle Cell trait, then the child will be a carrier. If both parents have the trait, then the child will have Sickle Cell. This disease causes the red blood cells to change into a crescent shape instead of being disk shape resulting in the loss of efficient oxygen delivery. It can also result in clotting because the blood cells can not make it through small blood vessels very well. The SNP for this disease is 78478128 and the reference SNP is rs78478128 The link to the page with more info on Sickle cell is http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001554/ The link to the page with the genetic information and SNP is http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=78478128#locus
Primer Design
Illustration
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