What Bayes Statistics Imply about This Diagnostic Approach
Calculations 1
Sensitivity to detect disease SNP.
Calculations 2
Specificity to detect disease SNP.
Calculations 3
Sensitivity to predict the disease.
Calculations 4
SPecificity to predict the disease.
Computer-Aided Design
TinkerCAD
Our Design
Feature 1: Consumables Kit
Feature 2: Hardware - PCR Machine & Fluorimeter
The main focus of our designed PCR machine set would be portability, meaning that it can be moved to places where it is needed. To do this, the PCR machine set must be durable so that any accidental drop or hit would not break it. Similar to the system used in the lab, our system would keep the PCR machine and Fluorimiter as separate machines, so that fluorimeter tests and PCR reactions can take place. The two devices would be a complete solid box that can attach to each other, with no parts sticking out of it that would potentially break off during when being boxed up and moved.
Other improvements over the current openPCR machine would be cutting down on the uncessessary space within the device. This would include putting the internal parts together in a way that less open space is between them, bringing the size down, making it more portable. In addition to this, the power supply would be moved outside of the device, cutting down the size of the device even further. The device would also be widened to allow for more test tubes slots, resulting in an increased rate of testing, as the time of reaction could not be increased.
Regarding the fluorimeter, the entire device would be one apparatus, with its own built in camera. While this may bring the overal cost of the device up, it would eliminate any possibility of unintentional user hardware error, such as changing resolutions. The device would be connected to the computer directly via USB, allowing for direct transfer to the computer rather than emailing it to one's self like it was used in the fluorimeter in the lab.
BME 100 Fall 2014
