BMCB625:Topo: Difference between revisions
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==(Homework) Questions== | ==(Homework) Questions== | ||
OK, I have read more. I may have mis-spoke in class so I wanted to answer Chayne's question. | |||
The G-quads inhibit tolemerase (active in stem,germ, and cancer cells). The would be a rare structure in the cell too. So the ideas is that drugs that mimic them or bind to them (stabalize the G-quartet) would inhibit tolemerase. --[[User:Jonfay|Jonfay]] 13:11, 12 June 2007 (EDT) | |||
===Mahta=== | ===Mahta=== | ||
Revision as of 10:11, 12 June 2007
Gao et al
Proposed Paper(s) for Jon --Contact Jon for inquiries
Evidence that two smaller subunits of RPA bind weakly and preferentially to telomeric DNA. These telomere capping proteins have functional similarities (OB fold) with ssDNA binding proteins and may be involved in the recruitment of telomere maintenance proteins.
- Gao H, Cervantes RB, Mandell EK, Otero JH, and Lundblad V. RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol. 2007 Mar;14(3):208-14. DOI:10.1038/nsmb1205 |
(Homework) Questions
OK, I have read more. I may have mis-spoke in class so I wanted to answer Chayne's question. The G-quads inhibit tolemerase (active in stem,germ, and cancer cells). The would be a rare structure in the cell too. So the ideas is that drugs that mimic them or bind to them (stabalize the G-quartet) would inhibit tolemerase. --Jonfay 13:11, 12 June 2007 (EDT)
