# BIOL398-03/S13

(Difference between revisions)
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## Revision as of 20:10, 14 January 2013

BIOL398-03: Biomathematical Modeling

MATH 388-01: Survey of Biomathematics

Loyola Marymount University

## Schedule

Updates to the schedule will be posted here. Readings need to be completed in preparation for class.

 Week Date Reading Topic Assignment 1 Tues Jan 15 Syllabus walkthrough Pairwise interviews (report back after each sub-bullet) Basic acquaintance information Like a cell/not like a cell Thurs Jan 17 Berg, Tymoczko, Stryer (2002) Biochemistry, 5th ed., Sections 8.1-8.4 Introduction to population growth, nutrients, and the chemostat Discuss the Week 1 assignment (accounts should be ready to wiki at this point) Quick wiki overview User wiki page setup Introduction to the readings Jan 18: last day to add or drop a class without a grade of W Week 1 Assignment Due midnight 1/23 2 Tues Jan 22 Matlab tutorial Introduction to Matlab and simulating the chemostat Thurs Jan 24 Chem Kinetics Background Enzyme kinetics/nitrogen metabolism Week 2 Assignment Due midnight 1/25 3 Tues Jan 29 ter Schure et al. (1995) J. Bacteriology Enzyme kinetics/nitrogen metabolism Thurs Jan 31 Journal Club 1 Week 3 Assignment Due midnight 1/31 4 Tues Feb 5 Metabolic pathway modeling project Thurs Feb 7 Chemostat Metabolic pathway modeling project Week 4 Assignment Due midnight 2/8 5 Tues Feb 12 Metabolic pathway modeling project Thurs Feb 14 Metabolic pathway modeling project Week 5 Assignment Due midnight 2/15 6 Tues Feb 19 Lander (2010) BMC Biology Metabolic pathway modeling project Thurs Feb 21 ter Schure et al. (1995) Microbiology Metabolic pathway modeling project Week 6 Assignment Due midnight 2/22 7 Tues Feb 26 Metabolic Pathway Modeling Project Thurs Feb 28 Research Presentation 1: Metabolic Pathways NO Week 7 Assignment Have a Happy Spring Break! Mar 5, 7 Spring Break 8 Tues Mar 12 Alberts et al. (2002) Molecular Biology of the Cell Ch. 6: From DNA to RNA and Ch. 6: From RNA to Protein Introduction to the Central Dogma of Molecular Biology and Gene Expression Thurs Mar 14 Alberts et al. (2002) Ch. 8: Microarrays, Campbell & Heyer Ch. 4 on MyLMUConnect, DeRisi et al. (1997), Microarray animation Central Dogma (continued) Introduction to DNA microarrays Week 8 Assignment Due midnight 3/15 9 Tues Mar 19 Microarrays ("low level analysis") Slides on MyLMUConnect Thurs Mar 21 Introduction to probability and statistics Mar 22: Last day to withdraw or change to credit/no-credit status Week 9 Assignment Due midnight 3/22 10 Tues Mar 26 Statistics continued (T test) Thurs Mar 28 Easter break No Week 10 Assignment 11 Tues Apr 2 Schade et al. (2004) Molecular Biology of the Cell 15: 5492–5502. Journal Club 2 Thurs Apr 4 Alberts et al. (2002) Ch. 7: An Overview of Gene Control, Ch. 7: DNA-Binding Motifs, and [http://www.ncbi.nlm.nih.gov/books/NBK26872 Review of Week 8 Assignment Regulatory Transcription Factors Start Week 11 Assignment in class Week 11 Assignment Due midnight 4/5 12 Tues Apr 9 Ernst & Bar-Joseph (2006) BMC Bioinformatics Clustering Finding candidate transcription factors Thurs Apr 11 Oltvai & Barabasi (2002) Science, Lee et al. (2002) Science, Harbison et al. (2004) Nature, and MacIsaac et al. (2006) BMC Bioinformatics Gene regulatory networks Week 12 Assignment Due midnight 4/12 13 Tues Apr 16 Sontag et al (2004) Bioinformatics, Kim et al. (2007) Comp Bio Chem, and Vu and Vohradsky (2007) Nucleic Acid Res Gene regulatory network modeling project: estimating parameters Thurs Apr 18 TBA Gene regulatory network modeling project: estimating parameters Week 13 Assignment Due midnight 4/19 14 Tues Apr 23 TBA Gene regulatory network modeling project: estimating parameters Thurs Apr 25 Week 14 Assignment Due midnight 4/26 15 Tues Apr 30 TBA Gene regulatory network modeling project: forward simulation Thurs May 2 TBA Gene regulatory network modeling project: forward simulation Finals Thurs May 9 Final Research Presentation: Gene Regulatory Networks 8:00AM Final Report due 5:00 PM, Friday, May 10

## Course Information

### Prerequisites/Recommended Background

MATH 123 (Calculus for Life Sciences II) or MATH 132 (Calculus II); BIOL 201 (Cell Function); CHEM 220 (Organic Chemistry I), or consent of instructor

### Class Meetings and Attendance

TR 9:25 – 10:40 AM, Seaver 120

This is a hands-on, participatory course, thus attendance at all class meetings is required. An unexcused absence from class will result in a 5% deduction from the overall course grade. The instructors should be notified as soon as possible, electronically or by phone, of the reasons for all absences.

### Mutual Responsibilities

This course is designed to foster your development as a scientist and mathematician and to give you an authentic research experience. We will be engaged together in discovering, examining, and practicing the personal qualities, technical skills, and community standards of the scientific community. While you are ultimately responsible for your own learning, you are not alone. Our class constitutes a team where we will be learning from each other. The role of the instructors is to provide the expert coaching to support and assist you on your journey. All of the exercises, readings, assignments, and policies detailed below have been designed with this purpose in mind.

### Classroom Conduct

As an LMU Lion, by the Lion’s Code, you are pledged to join the discourse of the academy with honesty of voice and integrity of scholarship and to show respect for staff, professors, and other students. Refer to LMU’s Community Standards for the Student Conduct Code or to the Lion’s Code. Disruptive behavior which is persistent or significantly interferes with classroom activities may be subject to disciplinary action. A student may be referred to the Office of Student Judicial Affairs if his or her behavior constitutes a violation of the conduct code. Specifically for this course, the following rules apply:

1. You are responsible for your own learning and for being a good class citizen.
2. We will act with honesty and integrity at all times.
3. We will always treat individuals with respect.
4. Class will start promptly on time.
5. You are expected to come to class having done the assigned reading and preparatory work.
6. You are expected to bring the required materials to each class session.
7. Cell phones, pagers, and other communication or music devices must be turned off and put out of sight during class sessions.

### Course Web Site

This is the course web site and wiki, hosted by OpenWetWare.org. You will need to register with OpenWetware.org to be able to edit the wiki and complete coursework. Updates to the course schedule and electronic copies of all handouts, assignments, and readings will be posted to this site. You will also use the site to keep an electronic lab notebook/journal for the course. In addition, students have been automatically enrolled in BIOL 398-03 on MyLMUConnect. The MyLMUConnect site may be used for materials that cannot be made public on the OpenWetware.org wiki.

### Required Materials

#### Texts

There is no required text to purchase for the course; materials will be put on reserve at Hannon Library or will be available online on the OpenWetware wiki or MyLMUConnect site. Specific reading assignments are given on the course schedule and should be completed before coming to class.

#### Materials (must be brought to each class meeting)

• 3-ring binder with all course handouts
• Pen, pencil, extra paper
• USB flash drive to store data

### Course Description

Introduction to mathematical and statistical concepts closely related to research problems in biology. Biological topics include the structure, function, and regulation of the three major types of cellular pathways: metabolic, signaling, and gene regulatory pathways. Mathematical topics include statistical analysis of biological measurements, dynamic modeling of biological systems, and fitting models to observed data. Students will critically evaluate the primary literature and carry out three major modeling projects throughout the semester.

#### Course Objectives and Learning Outcomes

• You understand the structure, function, and regulation of the three major types of cellular pathways: metabolic, signaling, and gene regulatory pathways
• You understand and apply quantitative tools for studying cellular pathways, including the construction and analysis of dynamic models, the comparison of models to observed data, and the refinement and validation of models
• You show discipline and proficiency in day-to-day scientific and mathematical best practices, such as maintaining journals and notebooks, managing your files and code, and critically evaluating scientific and technical information
• You recognize and care about how the biological, mathematical, and statistical issues presented in this course relate to and affect society, our daily lives, and ourselves
• You have some skills and tools for “leaving your comfort zone,” flourishing outside of it, and learning more about biology and mathematics on your own
• You learn how to communicate and work effectively with colleagues from different disciplines

Your work in this course will be assessed in three areas:

```Weekly electronic lab notebook/journal assignments (10 points each)     110 points
Journal club presentations (20 points each)                              40 points
Research presentations (20 points each)                                  40 points
Final Written Report                                                     80 points
Total                                                                   270 points
```

```94.0-100.0%		A
90.0- 93.9%		A-
86.0- 89.9%		B+
82.0- 85.9%		B
78.0- 81.9%		B-
74.0- 77.9%		C+
70.0- 73.9%		C
67.0- 69.9%		C-
60.0- 66.9%		D
≤  59.9%		F
```

#### Electronic Laboratory Notebook

One of the most important skills you can develop as a scientist is keeping an excellent laboratory notebook. For computational research, the equivalent of the biology paper-based lab notebook is documentation of your “workflow”. For this course you will practice documentation skills by keeping an electronic lab notebook or journal. The technology we will use is a public MediaWiki site hosted by OpenWetware.org, that we will create and edit during the semester. You will create an individual user page and make weekly entries that the instructors will read and grade. You will use the OpenWetware site to complete the assignments as well. The following guidelines apply:

• Your weekly journal entry is due every midnight on Friday PST (Thursday night/Friday morning). Note that the OpenWetware server records the time as Eastern Standard Time (EST). Therefore, midnight will register as 03:00 on the server.
• You will earn 10 points per weekly submission. Late journal entries will be accepted up to one week later for up to half credit.
• The instructors will read and comment on how to improve your journal entries.
• Depending on the type of assignment for that week, you may be given the opportunity to make improvements to previous journal entries as the semester progresses.
• Generally, your journal entries will consist of:
• Workflow and other documentation for hands-on exercises and projects
• Answers to any specific questions posed in the exercise

#### Journal Club Presentations

Each modeling project will begin with a “Journal Club” where students will present and lead discussion of research articles from the primary literature. Because that day’s class content is dependent upon each student being ready to present and lead discussion, late journal club presentations will not be accepted.

#### Research Presentations

The final step in the scientific method is communication of the results to the scientific community. This communication takes place in the form of peer-reviewed papers, presentations and posters at conferences, and through web sites. To build your scientific communication skills, you will give a research presentation (oral lab report) for each of the modeling projects assigned in the course. Because that day’s class content is dependent upon each student being ready to give his or her presentation, late research presentations will not be accepted.

#### Final Written Report

In addition to the research presentation, the culmination of your third modeling project will be the preparation of a written laboratory report in the style of a manuscript that could be submitted to a peer-reviewed journal. Specific instructions will be posted on the OpenWetware site. The Final Written Report cannot be accepted any later than Friday, May 10 at 5:00 PM.

#### Extra Credit

Students may accumulate up to 2.5% of their final grade in extra credit by attending Biology or Mathematics Department seminars and completing the seminar sheets. Each seminar attended is worth 0.5% with up to 5 seminars (2.5%) total. You must attend the entire seminar from start to finish and personally turn in your seminar sheet to a faculty member at the end of the seminar.

Certain, non-Biology/Mathematics Department seminars may be approved in advance for extra credit at the instructors’ discretion. To receive credit for these seminars, you must turn in a one-page summary of the seminar within one week of the date of the seminar or they will not count as extra credit.

### University Policy on Academic Honesty

Loyola Marymount University expects high standards of honesty and integrity from all members of its community. All students are expected to follow the LMU honor code. As stated in the LMU Undergraduate Bulletin, “Examples of academic dishonesty include, but are not limited to, the following: all acts of cheating on assignments or examinations, or facilitating other students’ cheating; plagiarism; fabrication of data, including the use of false citations; improper use of non-print media; unauthorized access to computer accounts or files or other privileged information and improper use of Internet sites and resources.” Click here for an online version of the LMU Honor Code and Process.

You are required to sign the Honor Code Agreement for this course.

### Americans with Disabilities Act

Students with special needs as addressed by the Americans with Disabilities Act who need reasonable modifications, special assistance, or accommodations in this course should promptly direct their request to the Disability Support Services Office. Any student who currently has a documented disability (physical, learning, or psychological) needing academic accommodations should contact the Disability Services Office (Daum Hall Room 224, 310-338-4535) as early in the semester as possible. All discussions will remain confidential. Please visit http://www.lmu.edu/dss for additional information.

### Course Assessment

We ask that students in this class participate in the Research on the Integrated Science Curriculum (RISC) Survey administered by Dr. David Lopatto at Grinnell College, which will allow the instructors to evaluate the effectiveness of this course. Students are asked to complete the student pre-course and post-course surveys.

### Revision Notice

If necessary, this syllabus and its contents are subject to revision; students are responsible for any changes or modifications announced in class. The most current version of this information resides on this page, the course web site at http://www.openwetware.org/wiki/BIOL398-03/S13.