AhmadWeek5: Difference between revisions

Latest revision as of 23:54, 14 February 2013

Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
- GDH2; the homologs are GLUD1 and GLUD2. "Deficiencies in the human homologs of glutamate dehydrogenase, GLUD1 and GLUD2, have been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders." GDH2
How is the expression of each of these genes regulated?
- GDH1- Expression is "regulated by nitrogen and carbon sources" GDH1
- GDH3- Expression is "regulated by nitrogen and carbon sources" GDH3
- GDH2- Expression is "sensitive to nitrogen catabolite repression and intracellular ammonia levels" GDH2
- GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" GLN1
- GLT1- Expression is "regulated by nitrogen source" GLT1
"L-glutamate". How many pathways does it participate in?
- It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. L-glutamate

Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.

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 ==<i>Saccharomyces</i> Genome Database==
 #Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
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 #*GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=gln1 GLN1]
 #*GLT1- Expression is "regulated by nitrogen source" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=glt1 GLT1]
+#"L-glutamate". How many pathways does it participate in?
+#*It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. [http://pathway.yeastgenome.org/YEAST/new-image?type=COMPOUND&object=GLT L-glutamate]
+[[Image:LglutamatePathway.gif]]
+[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=3 Pathway Image Source]
+==Kegg==
+[[Image:KeggPathway.jpg]]
+[http://www.kegg.jp/kegg-bin/show_pathway?sce00250 Pathway Image Source]
+*Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.
+==Reactome==
+[[Image:ReactomePathwayAhmad.jpg]]
+[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=68322&FOCUS_PATHWAY_ID=2666285&ID=2659868&VID=6541595 Reactome Source]
 {{Salman Ahmad}}