AhmadWeek5

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Revision as of 21:30, 14 February 2013 by Salman Ahmad (talk | contribs) (trouble with reactome)
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Saccharomyces Genome Database

  1. Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
    • GDH2; the homologs are GLUD1 and GLUD2. "Deficiencies in the human homologs of glutamate dehydrogenase, GLUD1 and GLUD2, have been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders." GDH2
  2. How is the expression of each of these genes regulated?
    • GDH1- Expression is "regulated by nitrogen and carbon sources" GDH1
    • GDH3- Expression is "regulated by nitrogen and carbon sources" GDH3
    • GDH2- Expression is "sensitive to nitrogen catabolite repression and intracellular ammonia levels" GDH2
    • GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" GLN1
    • GLT1- Expression is "regulated by nitrogen source" GLT1
  3. "L-glutamate". How many pathways does it participate in?
    • It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. L-glutamate

Pathway Image Source

Kegg

Pathway Image Source

  • Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.

Reactome

I am unable to load the Reactome website. I can use the links at the top, but the search is not working either. Not sure what to do...

Assignments

Useful links

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