AhmadWeek5

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(finished second question)
Current revision (01:54, 15 February 2013) (view source)
(added reactome pathway)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
 
==<i>Saccharomyces</i> Genome Database==
==<i>Saccharomyces</i> Genome Database==
#Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
#Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
Line 9: Line 8:
#*GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=gln1 GLN1]
#*GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=gln1 GLN1]
#*GLT1- Expression is "regulated by nitrogen source" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=glt1 GLT1]
#*GLT1- Expression is "regulated by nitrogen source" [http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=glt1 GLT1]
 +
#"L-glutamate". How many pathways does it participate in?
 +
#*It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. [http://pathway.yeastgenome.org/YEAST/new-image?type=COMPOUND&object=GLT L-glutamate]
 +
 +
[[Image:LglutamatePathway.gif]]
 +
[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=3 Pathway Image Source]
 +
 +
==Kegg==
 +
 +
[[Image:KeggPathway.jpg]]
 +
[http://www.kegg.jp/kegg-bin/show_pathway?sce00250 Pathway Image Source]
 +
*Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.
 +
==Reactome==
 +
[[Image:ReactomePathwayAhmad.jpg]]
 +
[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=68322&FOCUS_PATHWAY_ID=2666285&ID=2659868&VID=6541595 Reactome Source]
{{Salman Ahmad}}
{{Salman Ahmad}}

Current revision

Contents

Saccharomyces Genome Database

  1. Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
    • GDH2; the homologs are GLUD1 and GLUD2. "Deficiencies in the human homologs of glutamate dehydrogenase, GLUD1 and GLUD2, have been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders." GDH2
  2. How is the expression of each of these genes regulated?
    • GDH1- Expression is "regulated by nitrogen and carbon sources" GDH1
    • GDH3- Expression is "regulated by nitrogen and carbon sources" GDH3
    • GDH2- Expression is "sensitive to nitrogen catabolite repression and intracellular ammonia levels" GDH2
    • GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" GLN1
    • GLT1- Expression is "regulated by nitrogen source" GLT1
  3. "L-glutamate". How many pathways does it participate in?
    • It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. L-glutamate

Image:LglutamatePathway.gif Pathway Image Source

Kegg

Image:KeggPathway.jpg Pathway Image Source

  • Kegg shows both the full amino acid sequence and full nucleotide sequence when you click on the enzyme name. SGD did not show this.

Reactome

Image:ReactomePathwayAhmad.jpg Reactome Source

Assignments

Useful links

Personal tools