AU Biomaterials Design Lab:Reading/CHEM571Fall2012LitSurvey

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Adenosine Deaminase

Activity Assays

Development of a rapid, microplate-based kinetic assay for measuring adenosine deaminase activity in bodily fluids

• The conversion of adenosine to inosine by adenosine deaminase was spectroscopically analyzed at 265 nm for a period of 15 minutes. The number of assays that could be conducted at one time was increased by carrying out analysis in 96-well microplates. This assay also varies from the standard procedure in that the reaction time was decreased from 60 minutes.
• Melissa Novy 20:19, 21 September 2012 (EDT):

Bovine Serum Albumin

Interaction with other nobel metals

[http://ac.els-cdn.com/S0927776509004792/1-s2.0-S0927776509004792-main.pdf?_tid=c0731a32-0519-11e2-a341-00000aab0f6b&acdnat=1348362073_915b73dd95a60d862a5cd8bdc9e60359%7C Studies on interaction of colloidal Ag nanoparticles with Bovine Serum Albumin (BSA)

• Tests the biofunctionalization of silver nano-particles and as a result investigates the interaction between AgNPs and BSA at different concentrations as observed by a UV-Vis.
• Discovered that AgNPs coated in BSA were observed under UV-Vis to be quite different than the uncoated particles. The BSA adsorption on the surface prevented the Ag nanoparticles from aggregating in solutions of pH greater than 5 which may prevent the uptake of the NPs in live cells.
  • • ""Puja Mody 21:08, 22 September 2012 (EDT)""

Lysozyme

Structure, Function (General Info)

• information about lysozyme -- "Lysozyme is a globular protein with a molecular weight of approximately 14.7 kDa. Lysozyme has been used as a model protein for this study, since its biophysical properties are well understood and the specific contribution of the sugar to its stability over a range of solution conditions can easily be compared with that of the native protein. Lysozyme is a widely studied protein due to its rich phase behavior(17, 18) including crystallization,(19) liquid–liquid phase separation,(20-22) and the formation of equilibrium clusters(23-25) and gels.(24) The solution behavior of lysozyme is also well understood in terms of its interaction with salt ions.(26-28)" from James and McManus J. Phys. Chem. B, 2012, 116 (34), pp 10182–10188

Stability

Thermal and Solution Stability of Lysozyme in the Presence of Sucrose, Glucose, and Trehalose

• James and McManus J. Phys. Chem. B, 2012, 116 (34), pp 10182–10188
• xxxx
  • Abigail E. Miller 12:53, 5 September 2012 (EDT):

Other Syntheses of Gold Nanoparticles

Preparation of Gold Nanoparticles Using Tea: A Green Chemistry Experiment

• R. K. Sharma, Shikha Gulati, and Shilpa Mehta, Journal of Chemical Education Article ASAP
• how to synthesis AuNPs using biomaterials that are not mammalian proteins
  • Abigail E. Miller 21:11, 28 August 2012 (EDT):

New, fast and green procedure for the synthesis of gold nanoparticles based on sonocatalysis

• AuNPs are synthesized using sonic vibration, with sodium citrate dihydrate as a stabilizing and reducing agent. Compared to previous protocols, this method takes an extremely short amount of time to prepare AuNPs and does not require the solutions to be heated.
• Melissa Novy 14:07, 5 September 2012 (EDT)

Green synthesis of gold nanoparticles with Zingiber officinale extract: Characterization and blood compatibility

• Extract from Zingiber officinale, a type of ginger, is used as a stabilizing and reducing agent to synthesize AuNPs. According to the literature, ginger extract is more efficient than aspirin in decreasing blood platelet aggregation, so this method of AuNP synthesis is promising for use in medical treatments.
• Melissa Novy 14:15, 5 September 2012 (EDT)

Biological synthesis of silver and gold nanoparticles using apiin as reducing agent

• Apiin, a compound found in parsley, celery, and henna, is used as a stabilizing and reducing agent to synthesize AuNPs. The interaction between apiin and AuNPs was analyzed using FT-IR.
• Melissa Novy 14:19, 5 September 2012 (EDT)

[http://search.proquest.com.proxyau.wrlc.org/docview/847123129/fulltextPDF?accountid=8285%7C An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells

• Explored the possibility of coating Gold nano-particles in cinnamon to aid in cancer detection procedures. The alcoholic components of cinnamon reduce NaAuCl₄ to produce gold- nanoparticles. the Cin-AuNPs are biocompatible and can serve as excellent CT/ photoacoustic contrast-enhancement agents to detect tumors.
  • ""Puja Mody 20:48, 22 September 2012 (EDT)""

Analysis of Gold Nanoparticles

Determination of Size and Concentration of Gold Nanoparticles from UV−Vis Spectra

• W. Haiss, N. T. K. Thanh, J. Aveyard and D. G. Fernig Analytical Chemistry 2007 79 (11), 4215-4221
• demonstrates how to calculate the size and concentration of the AuNPs from the position of the gold nanoparticle plasmon absorbance peak around 550 nm.
  • Abigail E. Miller 13:54, 4 September 2012 (EDT):

Determination of the Concentration and the Average Number of Gold Atoms in a Gold Nanoparticle by Osmotic Pressure

• Y. Lu, L. Wang, D. Chen, and G. Wang Langmuir 2012 28 (25), 9282-9287
• xx
  • Abigail E. Miller 13:55, 5 September 2012 (EDT):

Fluorescence Dynamics in BSA-Protected Au25 Nanoclusters

• Xiaoming Wen, Pyng Yu, Yon-Rui Toh, An-Chia Hsu, Yu-Chieh Lee, and Jau Tang The Journal of Physical Chemistry C 2012 116 (35), 19032-19038
• fast energy transfer between the singlet and triplet states of a gold cluster.....
  • Abigail E. Miller 15:20, 11 September 2012 (EDT):

[http://ac.els-cdn.com/S0021979712006480/1-s2.0-S0021979712006480-main.pdf?_tid=b569df84-051b-11e2-ae62-00000aab0f01&acdnat=1348362914_63c7484b0014b928f582a79a1e760458%7C Preparation of controlled gold nanoparticle aggregates using a dendronization strategy

• A Dendronization strategy was used to control the interparticle spacing and optical properties of gold nanoparticle aggregates in aqueous solution. Tests how disulfide concentration, temperature, time and nature of the ligand (dendritic vs nondendritic), determine the control exerted over the size and stability of the NP aggregates.
  • ""Puja Mody 20:48, 22 September 2012 (EDT)""