3D printing in the life sciences: Difference between revisions
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* 2004 - Forgacs & colleagues develop cell droplet printing (bioink) | * 2004 - Forgacs & colleagues develop cell droplet printing (bioink) | ||
: Nozzles much wider than those of an inkjet allow for 3D deposition (circles & tubes) of clusters of cells with support of a gel. This technology is the basis of the company Organovo. | : Nozzles much wider than those of an inkjet allow for 3D deposition (circles & tubes) of clusters of cells with support of a gel. This technology is the basis of the company Organovo. | ||
* 2006 - Atala & colleagues present a ground-breaking trial of bladder repair using 3D prints | |||
: In 7 patients with bladder problems, cells are taken, grown in culture, put on a bladder-shaped collagen and polyglycolic acid scaffold, and re-implanted into the patients reducing bladder leakage during the mean 4 year follow up ([http://www.ncbi.nlm.nih.gov/pubmed/16631879 Atala06]). | |||
* 2012 - sugar scaffold for cell structuring | * 2012 - sugar scaffold for cell structuring | ||
Revision as of 07:55, 15 April 2016
With technical improvements and increased affordability, 3D printing is fast gaining importance in the life science. For a graphical overview of the history of 3D printing see the timeline.
3D printing molecules & cells
- 2000 - first pilot experiments with modified inkjet printers
- Boland & colleagues attempt to deposit proteins & cells in 2D patterns
- 2002 - artificial kidney (not functional) by Wake Forest University School of Medicine
- It is occasionally claimed (for example in the timeline above) that a working kidney was 3D printed in 2002. Cells were indeed 3D printed but the organ was not functional since it lacked working blood supply and urine drainage.
- 2004 - Forgacs & colleagues develop cell droplet printing (bioink)
- Nozzles much wider than those of an inkjet allow for 3D deposition (circles & tubes) of clusters of cells with support of a gel. This technology is the basis of the company Organovo.
- 2006 - Atala & colleagues present a ground-breaking trial of bladder repair using 3D prints
- In 7 patients with bladder problems, cells are taken, grown in culture, put on a bladder-shaped collagen and polyglycolic acid scaffold, and re-implanted into the patients reducing bladder leakage during the mean 4 year follow up (Atala06).
- 2012 - sugar scaffold for cell structuring
- Jordan Miller & colleagues develop a method to use 3D printed to scaffold cells (Miller12)
- 2014 - 3D printed slices of liver tissue for testing
- Organovo delivers the first 3D printed slices of liver tissue for preclinical testing to pharmaceutical companies
