20.902(S09):Advanced topics in synthetic biology: Difference between revisions
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'''DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways.'''<br> Shao Z, Zhao H, Zhao H. Nucleic Acids Res. 2008 Dec 12<br>[[PMID: 19074487]]<br> '''Article 2:''' <br> '''Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides.'''<br>Stemmer WP, Crameri A, Ha KD, Brennan TM, Heyneker HL. Gene. 1995 Oct 16;164(1):49-53.<br> [[PMID: 7590320]] | |||
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Revision as of 12:04, 23 December 2008
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Home | Lecture and Studio schedule |
20.902 Reading Schedule | |
Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 | |||
Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 |
Expectations | Guidelines: 3 Ideas Presentation | Guidelines: Tech Spec Review | Guidelines: Final Presentations |
Team Building Resources | Teacher Resources |
20.902: Advanced Topics in Synthetic Biology
Assignments
Part 1: Readings
Instructions for these assignment are here |
Part 2: Team Mentoring
Instructions for these assignments are here |
Reading Schedule
Discussions will be 1 hour long during Wednesday 2-5 studio block
26-152
TOPIC | DATE | Discussion leader(s) | Discussion paper(s) | Related paper(s) to enjoy |
A Voyage To Lilliput: How a small number of AA substitution change activity of a protein |
Wed Feb 4 | Natalie Kuldell |
Turning lambda Cro into a transcriptional activator.Bushman FD, Ptashne M.Cell. 1988 Jul 15;54(2):191-7. |
Genetic Switch: Phage Lambda and Higher Organisms Mark Ptashnepreviewed here or Sci Am summary (request from NK) |
Slide rule optional: Computational design of novel protein activities |
Wed Feb 11 | |||
Nature heart Legos™: Proteins are modular too |
Wed Feb 18 | |||
Better odds in Vegas: DNA elements are modular too, allowing for circuits, but circuits don't always work |
Wed Feb 25 | |||
Darwin is alive and well: Directed evolution at the device level |
Wed Mar 4 | |||
I demand the cone of silence: nature's constraints on genetic circuit design |
Thursday Mar 12 | |||
Intelligent Design: Functional composition at the device level |
Wed Mar 18 | |||
Spring Break Mar 24-28 | No class all week | |||
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Writing in genetic code: DNA construction and editing technologies |
Wed Apr 1 | article 1: article 2: |
Article 1: DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. |
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We're only human: What is the state of the art? |
Thursday Apr 9 | article 1: article 2: |
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Little Red Corvette: Once you've got the DNA, where do you put it? Introducing... THE CHASSIS |
Wed Apr 15 | article 1: article 2: |
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(R)evolution: Can we understand it? Can we program it? |
Wed Apr 22 | article 1: article 2: |
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On your mark, get set, go: System dynamics | Thur Apr 30 | article 1: article 2: |
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Rough consensus and running code: building patterns and memories | article 1: article 2: |
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mine mine mine: property rights in synthetic biology | Tue May 12 | article 1: |
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2020: Empire of Reason | article 2: |
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drop it like it's hot: safety! | article 3: |