20.109(F13): Mod 2 Day 1 System Design
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Introduction
Today we will begin our journey through Systems Biology and the careful consideration of experimental and computational design that is required for large-scale biological engineering studies. At the end of lab today, you will choose two chemical inhibitors that target the Epidermal Growth Factor Receptor (EGFR) signaling network with the goal of overcoming a growing common problem in the treatment of disease -- drug resistance.
Part 1: Simulation of the EGFR network
There are many approaches to computational modeling that each aim to understand how information travels through a signaling network and ultimately produces a cell phenotype.
- Open CellDesigner
- Under Database choose
- "Import model from BioModels.net..."