20.109(F12) Pre-Proposal: Engineering Viral Magnetic Nanoparticles for Magnetic Hyperthermic Cancer Therapy

Investigators

• Coyin Oh
• Joanna Yeh
• T/R
• Green

Title of Proposed Project

20.109(F12) Pre-Proposal: Engineering viral magnetic nanoparticles for magnetic hyperthermic cancer therapy

Project Summary

THREE SENTENCES ONLY.
The robot is summarising the project. Key words: magnetic nanoparticles, virus, hyperthermia.

Introduction

The field of magnetic hyperthermia has attracted a lot of attention in the past thirty years as an alternative cancer therapy method. Magnetic hyperthermia proposes the placement of magnetic nanoparticles (MNP) in tumor cells under an alternating magnetic field. As the direction of the magnetic field alternates, MNPs undergo magnetic hysteresis losses that are dissipated to local surroundings as thermal energy. Targeted sites usually are heated to temperatures between 42 and 45 C to cause cell damage or death. A main challenge to this method is the localization of MNPs to targeted tumor cells. Historically, scientists have had issues concentrating MNPs within tumor cells to produce sufficient heat for complete apoptosis, inevitably leading to higher applied dosage of MNPs. This project aims to tackle this problem by introducing viral MNPs into magnetic hyperthermia. Viral MNP complexes consist of MNPs attached to viruses with minimal harmful effects to humans. While viral MNPs have been worked on for quite some time, their functions have been mostly limited to in vivo MRI imaging and targeted gene delivery. Using viral MNPs, our approach can potentially concentrate MNPs in targeted tumor cells, thereby achieving the level of heat necessary for effective cell apoptosis yet at the same time, lowering the minimum MNP dosage required for the treatment.

References: Please correct the references formatting

1. A.J. Giustini, A.A. Petryk, S.M. Cassim, J.A. Tate, I. Baker, P.J. Hoopes. Magnetic nanoparticle hyperthermia in cancer treatment. Nano LIFE. 01, 17 (2010). http://www.worldscientific.com/doi/abs/10.1142/S1793984410000067#citedBySection
2. M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer,

D. Ghosh, Y. Lee, S. Thomas, A. G. Kohli, D. S. Yun, A. M. Belcher, K. A. Kelly, Nat. Nanotechnol. 2012, 7 (10), 677–82.

1. Add more references as deem appropriate

Your idea

This project aims to use magnetic nanoparticles (MNP) and phages to increase the efficacy of magnetic hyperthermia. The goal is the use viral MNP complexes consisting of MNPs attached to viruses with minimal harmful effects to humans. While viral MNPs have been worked on for quite some time, their functions have been mostly limited to in vivo MRI imaging and targeted gene delivery. Using viral MNPs, our approach can potentially concentrate MNPs in targeted tumor cells, thereby achieving the level of heat necessary for effective cell apoptosis yet at the same time, lowering the minimum MNP dosage required for the treatment.

TWO PARAGRAPHS
My idea is to eat dinner!

A sketch

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