20.109(F12) Pre-Proposal: Engineering Viral Magnetic Nanoparticles for Magnetic Hyperthermic Cancer Therapy: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
Line 16: Line 16:
==Introduction==  
==Introduction==  


The field of magnetic hyperthermia has attracted a lot of attention in the past thirty years as an alternative cancer therapy method.  Magnetic hyperthermia proposes the placement of magnetic nanoparticles (MNP) in tumor cells under an alternating magnetic field. As the direction of the magnetic field alternates, MNPs undergo magnetic hysteresis losses that are dissipated to local surroundings as thermal energy. One of the biggest challenges to this method is the localization of MNPs in targeted tumor cells. Historically, scientists have had issues concentrating MNPs within tumor cells to produce sufficient heat for complete apoptosis. This inevitably leads to higher applied dosage of MNPs in this form of treatment. Our project aims to tackle this problem by introducing viral MNPs into magnetic hyperthermia. Viral MNPs are nothing but MNPs attached to viruses that are mostly found to be non-harmful to humans. Viral MNPs have been worked on for quite some time, but their functions are mostly limited to ''in vivo'' MRI imaging and targeted gene delivery. Using viral MNPs, our approach can potentially concentrate MNPs in targeted tumor cells, thereby achieving the level of heat necessary for effective cell apoptosis yet at the same time, lowering the minimum MNP dosage required for the treatment.
The field of magnetic hyperthermia has attracted a lot of attention in the past thirty years as an alternative cancer therapy method.  Magnetic hyperthermia proposes the placement of magnetic nanoparticles (MNP) in tumor cells under an alternating magnetic field. As the direction of the magnetic field alternates, MNPs undergo magnetic hysteresis losses that are dissipated to local surroundings as thermal energy. Targeted sites usually are heated to temperatures between 42 and 45 C to cause cell damage or death. A main challenge to this method is the localization of MNPs to targeted tumor cells. Historically, scientists have had issues concentrating MNPs within tumor cells to produce sufficient heat for complete apoptosis, inevitably leading to higher applied dosage of MNPs. This project aims to tackle this problem by introducing viral MNPs into magnetic hyperthermia. Viral MNP complexes consist of MNPs attached to viruses with minimal harmful effects to humans. While viral MNPs have been worked on for quite some time, their functions have been mostly limited to ''in vivo'' MRI imaging and targeted gene delivery. Using viral MNPs, our approach can potentially concentrate MNPs in targeted tumor cells, thereby achieving the level of heat necessary for effective cell apoptosis yet at the same time, lowering the minimum MNP dosage required for the treatment.


References: <font color = red> Please correct the references formatting </font>
References: <font color = red> Please correct the references formatting </font>

Revision as of 02:55, 29 November 2012


20.109(F12): Laboratory Fundamentals of Biological Engineering

Home        People        Schedule Fall 2012        Assignments        Lab Basics        OWW Basics       
DNA Engineering        System Engineering        Biomaterials Engineering              

Investigators

  • Coyin Oh
  • Joanna Yeh
  • T/R
  • Green

Title of Proposed Project

20.109(F12) Pre-Proposal: Engineering viral magnetic nanoparticles for magnetic hyperthermic cancer therapy

Project Summary

THREE SENTENCES ONLY.
The robot is summarising the project. Key words: magnetic nanoparticles, virus, hyperthermia.

Introduction

The field of magnetic hyperthermia has attracted a lot of attention in the past thirty years as an alternative cancer therapy method. Magnetic hyperthermia proposes the placement of magnetic nanoparticles (MNP) in tumor cells under an alternating magnetic field. As the direction of the magnetic field alternates, MNPs undergo magnetic hysteresis losses that are dissipated to local surroundings as thermal energy. Targeted sites usually are heated to temperatures between 42 and 45 C to cause cell damage or death. A main challenge to this method is the localization of MNPs to targeted tumor cells. Historically, scientists have had issues concentrating MNPs within tumor cells to produce sufficient heat for complete apoptosis, inevitably leading to higher applied dosage of MNPs. This project aims to tackle this problem by introducing viral MNPs into magnetic hyperthermia. Viral MNP complexes consist of MNPs attached to viruses with minimal harmful effects to humans. While viral MNPs have been worked on for quite some time, their functions have been mostly limited to in vivo MRI imaging and targeted gene delivery. Using viral MNPs, our approach can potentially concentrate MNPs in targeted tumor cells, thereby achieving the level of heat necessary for effective cell apoptosis yet at the same time, lowering the minimum MNP dosage required for the treatment.

References: Please correct the references formatting

  1. A.J. Giustini, A.A. Petryk, S.M. Cassim, J.A. Tate, I. Baker, P.J. Hoopes. Magnetic nanoparticle hyperthermia in cancer treatment. Nano LIFE. 01, 17 (2010). http://www.worldscientific.com/doi/abs/10.1142/S1793984410000067#citedBySection
  2. M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer,

D. Ghosh, Y. Lee, S. Thomas, A. G. Kohli, D. S. Yun, A. M. Belcher, K. A. Kelly, Nat. Nanotechnol. 2012, 7 (10), 677–82.

  1. Add more references as deem appropriate

Your idea

TWO PARAGRAPHS
My idea is to eat dinner!


A sketch

yaadda

Retrieved from "https://openwetware.org/mediawiki/index.php?title=20.109(F12)_Pre-Proposal:_Engineering_Viral_Magnetic_Nanoparticles_for_Magnetic_Hyperthermic_Cancer_Therapy&oldid=660910"