20.109(F11): Light based therapeutics: Difference between revisions
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=<center> | =<center>Light Based Therapeutics</center>= | ||
==Team== | ==Team== | ||
| Line 5: | Line 5: | ||
* [[User: Michael Hwang| Michael Hwang]] | * [[User: Michael Hwang| Michael Hwang]] | ||
==Introduction== | == Introduction == | ||
In an effort to combine the three Modules pursued in 20.109, we wish to explore light-based therapeutics as a method to address significant unmet medical needs. We propose a model where a novel circuit, which senses light and subsequently responds by released a product (ie. apoptosis protein, is inserted into gold nanoparticles that home to a specific cell type (ie. tumor). For example, gold nanoparticles infused with a novel circuit could be introduced into the human body, whereby it will become incorporated and localized to the patient's tumor. Upon delivery of the gold nanoparticles' cargo, herein the novel circuit, we could light activate the circuit by shining light, thus producing highly localized cytotoxicity to the tumor. Such a process could be engineered to combat other medical needs, such as aging, tissue regeneration, neurodegenerative diseases, etc. | In an effort to combine the three Modules pursued in 20.109, we wish to explore light-based therapeutics as a method to address significant unmet medical needs. We propose a model where a novel circuit, which senses light and subsequently responds by released a product (ie. apoptosis protein, is inserted into gold nanoparticles that home to a specific cell type (ie. tumor). For example, gold nanoparticles infused with a novel circuit could be introduced into the human body, whereby it will become incorporated and localized to the patient's tumor. Upon delivery of the gold nanoparticles' cargo, herein the novel circuit, we could light activate the circuit by shining light, thus producing highly localized cytotoxicity to the tumor. Such a process could be engineered to combat other medical needs, such as aging, tissue regeneration, neurodegenerative diseases, etc. | ||
==References== | == Research Goal == | ||
== References == | |||
*Chow, B. Y., & Boyden, E. S. (2011). Synthetic Physiology. Science, 332(6037), 1508-1509. http://www.sciencemag.org/content/332/6037/1508.summary* | |||
*Kleinlogel, S., Feldbauer, K., Dempski, R. E., Fotis, H., Wood, P. G., Bamann, C., & Bamberg, E. (2011). Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh. Nature neuroscience, 14(4), 513-8. http://www.nature.com/neuro/journal/v14/n4/full/nn.2776.html. | |||
*Ye, H., Daoud-El Baba, M., Peng, R.-W., & Fussenegger, M. (2011). A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science, 332(6037), 1565-8. http://www.ncbi.nlm.nih.gov/pubmed/21700876. | |||
Revision as of 21:25, 28 November 2011
Light Based Therapeutics
Team
Introduction
In an effort to combine the three Modules pursued in 20.109, we wish to explore light-based therapeutics as a method to address significant unmet medical needs. We propose a model where a novel circuit, which senses light and subsequently responds by released a product (ie. apoptosis protein, is inserted into gold nanoparticles that home to a specific cell type (ie. tumor). For example, gold nanoparticles infused with a novel circuit could be introduced into the human body, whereby it will become incorporated and localized to the patient's tumor. Upon delivery of the gold nanoparticles' cargo, herein the novel circuit, we could light activate the circuit by shining light, thus producing highly localized cytotoxicity to the tumor. Such a process could be engineered to combat other medical needs, such as aging, tissue regeneration, neurodegenerative diseases, etc.
Research Goal
References
- Chow, B. Y., & Boyden, E. S. (2011). Synthetic Physiology. Science, 332(6037), 1508-1509. http://www.sciencemag.org/content/332/6037/1508.summary*
- Kleinlogel, S., Feldbauer, K., Dempski, R. E., Fotis, H., Wood, P. G., Bamann, C., & Bamberg, E. (2011). Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh. Nature neuroscience, 14(4), 513-8. http://www.nature.com/neuro/journal/v14/n4/full/nn.2776.html.
- Ye, H., Daoud-El Baba, M., Peng, R.-W., & Fussenegger, M. (2011). A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science, 332(6037), 1565-8. http://www.ncbi.nlm.nih.gov/pubmed/21700876.
