20.109(F09): Omar Abudayyeh and Pablo Crespo Research Proposal

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==References==
==References==
*'''Krag, D., Shukla, G., Shen, G., Pero, S., Ashikaga, T., Fuller, S., Weaver, D., Burdette-Radoux S., & Thomas, C. Selection of tumor-binding ligands in cancer patients with phage display libraries. Cancer Research. 2006; 66: 7724-7733.'''
*'''Krag, D., Shukla, G., Shen, G., Pero, S., Ashikaga, T., Fuller, S., Weaver, D., Burdette-Radoux S., & Thomas, C. Selection of tumor-binding ligands in cancer patients with phage display libraries. Cancer Research. 2006; 66: 7724-7733.'''
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:The human adenovirus E1B gene encodes a protein that deactivates p53, the tumor suppressor protein. The study shows that an adenovirus mutant lacking a functional E1B was able to selectively replicate in and destroy tumor cells that had a defective p53 without affecting normal cells with a normally functioning p53.
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:The researchers used phage display libraries to identify ligands that could be used for targeting cancer, including breast, melanoma, and pancreas. Repeated panning was done by allowing phages to hone in on tumors in patients with stage IV cancer and then excising the tumors and recovering phages that bound. The study identified several motifs on the binding peptide indicating nonrandom specificity for tumors.

Revision as of 20:11, 19 November 2009

Contents

Engineering phages to target tumors

Omar Abudayyeh and Pablo Crespo

Project Overview

Background Information

Research Problem and Goals

Project Methods

Predicted Outcomes

Resources Required

References

  • Krag, D., Shukla, G., Shen, G., Pero, S., Ashikaga, T., Fuller, S., Weaver, D., Burdette-Radoux S., & Thomas, C. Selection of tumor-binding ligands in cancer patients with phage display libraries. Cancer Research. 2006; 66: 7724-7733.
The researchers used phage display libraries to identify ligands that could be used for targeting cancer, including breast, melanoma, and pancreas. Repeated panning was done by allowing phages to hone in on tumors in patients with stage IV cancer and then excising the tumors and recovering phages that bound. The study identified several motifs on the binding peptide indicating nonrandom specificity for tumors.
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