基礎ゼミチーム/basic seminar team: Difference between revisions

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BIOMOD2012 Tohoku Team B
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<h1 id="wiki-mode1"><strong><font color="#3070B4">BIOMOD2012 Tohoku Team B</font></strong></h1>
 
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  <li>index</li>
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<h2>Abstract</h2>
<div class="text">
<p>
<font size="5">R</font>ecently, many nano scale robots have been build, and they store molecules inside. To develop further, we propose and design a robot which can select and store a DNA molecule after creation.<br>
<br>
<font size="5">A</font>nd this robot can catch various molecules if its structure is changed.<br>
<br>
<font size="5">O</font>ur robot has "Selector". "Selector" is single-stranded DNA which has complementary sequences to the target DNA here and there. We have three "Selectors", and the inner "Selector" attaches to the target more strongly. "Selector" can catch and draw DNA close to the robot, and take DNA to the center of the robot, even if there's little target DNA.<br>
<br>
<font size="5">O</font>n this project, our target is DNA. But we think our robot would catch not only DNA, but also various nano scale molecules like proteins.<br>
<br>
<font size="5">N</font>ow we are working on our robot's parts and body. After that, we will combine them and complete the robot.<br>
</p>
<!-- 目的




<h2>目的</h2>
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<p>　ナノスケールの世界において分子を捕獲するためにはそのための機構を様々な方法で作らなくてはならず、非常に困難である。<br>
 
そこで私たちは、DNAの自発的に多様な構造体を形成する性質を用いて、少しの設計変更で様々な分子を捕獲できる分子ロボットを製作する。<br>
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We're making a molecular robot that can capture an object DNA and put it inside the robot.<br>
Our robot has the function we named "Selector".<br>
<br>
<br>
　第一目標として、比較的捕獲が簡単と思われるRNAをターゲットとした。RNAはアルツハイマーの原因となる異常配列RNAに決定した。<br>
"Selector" is single-stranded DNA which has complementary sequences to the "Target DNA" here and there, and consecutive adenine sequences in other portion. We have three "Selectors", and the inner "Selector" attaches to the target more strongly. When "Selector 1" catches the "Target DNA", the left sequences (which are not complementary and do not attach to the object) make loops. Then the structure shrinks and becomes shorter.<br>
<br>
<br>
　私たちのロボットの構造は筒状のDNAorigami本体にターゲットを捕まえるループと、ターゲットを奥まで運ぶトーナメントの2種類のDNAを内側に付加したものである。<br>
Thanks to "Selector 1", the robot can select and draw the target DNA close to the robot. Next, "Selector 2" receives the target DNA from "Selector 1". And "Selector 3" receives the target from "Selector 2". Thanks to "Selector 2" and "Selector 3", the robot can deliver only the object inside certainly.<br>
ループはターゲットのRNAとハイブリダイゼーション(?) すると、相補にならなかった部分がループ構造をいくつも作ることで全体の長さが縮み、RNAを内部へ引きいれる。<br>
トーナメントは複数のstapleからなり、奥に行くほどRNAと相補になる配列が増えて安定性が増すようになっている。この安定性の差を利用してRNAを奥へと運ぶとともに、捕獲したRNAの配列を確認していくことが出来る。<br>
　さらにロボット内部の奥にはRNAseというRNA分解酵素を付加し、異常配列のRNAを破壊する。<br>
<br>
<br>
　現在はRNAを捕獲する機構を完成させることを第一段階の目標としており、最終的にはRNAを含む様々な物質を捕獲し、ロボット内部で処理を施せる機構を持たせる。<br>
Then, we will explain the body structure containing these functions.<br>
</p>
We design the robot like a tube of hexagonal base. In case it is too difficult to form and observe, we also design a triangle prism body. As for the latter shape, we made the same kind of structure last year. We've acquired some know-how of it.<br>
 
<br>
-->
We think the robot should have a lid so that nothing would come in from the back. So we arrange "Selectors" symmetrically. <br>
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Yeah!
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<h2>連絡先</h2>
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<li id="FOOTER01"><a href="#PAGETOP">TOP</a></li>
<li id="FOOTER02"><address><a href="biomod.teamsendai.2012@gmail.com">mail</a></address></li>
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Revision as of 04:03, 6 September 2012

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<div id="head-1"> BIOMOD2012 Tohoku Team B </div>

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<div id="yohaku"></div> <div id="kiji-line1"></div> <div id="kiji"> We're making a molecular robot that can capture an object DNA and put it inside the robot.<br> Our robot has the function we named "Selector".<br> <br> "Selector" is single-stranded DNA which has complementary sequences to the "Target DNA" here and there, and consecutive adenine sequences in other portion. We have three "Selectors", and the inner "Selector" attaches to the target more strongly. When "Selector 1" catches the "Target DNA", the left sequences (which are not complementary and do not attach to the object) make loops. Then the structure shrinks and becomes shorter.<br> <br> Thanks to "Selector 1", the robot can select and draw the target DNA close to the robot. Next, "Selector 2" receives the target DNA from "Selector 1". And "Selector 3" receives the target from "Selector 2". Thanks to "Selector 2" and "Selector 3", the robot can deliver only the object inside certainly.<br> <br> Then, we will explain the body structure containing these functions.<br> We design the robot like a tube of hexagonal base. In case it is too difficult to form and observe, we also design a triangle prism body. As for the latter shape, we made the same kind of structure last year. We've acquired some know-how of it.<br> <br> We think the robot should have a lid so that nothing would come in from the back. So we arrange "Selectors" symmetrically. <br>

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<div id="yohaku"></div> <div id="kiji-line1"></div> <div id="kiji"> Yeah! </div>


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