orf	gene	ratio.hl.normalized.mean	ratio.hl.normalized.sd	ratio.hl.count	ratio.hl.normalized.lower.95	ratio.hl.normalized.upper.95	intensity	intensity.h	intensity.l	desc
YHR174W	ENO2	1.152036	0.3077324	892	1.129004	1.175538	4358020000	2056964000	2301055000	Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YPL231W	FAS2	0.9694054	0.3267094	872	0.9486101	0.9906566	1513950000	648257400	865692700	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
YNR016C	ACC1	0.9460414	0.3448668	846	0.9243096	0.9682842	1461491000	607484800	854006400	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YLR044C	PDC1	1.019045	0.4560827	726	0.985791	1.05342	3796646000	1711789000	2084857000	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YDR385W	EFT2	0.9930973	0.2173274	726	0.9775209	1.008922	1948245000	855620800	1092625000	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YMR186W	HSC82	1.477398	0.2767724	688	1.447157	1.508271	3730060000	1986051000	1744009000	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
YAL005C	SSA1	1.895218	0.2242812	654	1.862919	1.928077	3593294000	2154093000	1439202000	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YKL182W	FAS1	0.9057748	0.2716435	606	0.8863949	0.9255784	1129049000	467250300	661799100	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YCR012W	PGK1	1.142672	0.269175	597	1.118263	1.167613	3302308000	1533355000	1768953000	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YLR249W	YEF3	0.970119	0.2583288	594	0.9501729	0.9904838	2084819000	887424800	1197394000	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP
YOR063W	RPL3	0.905177	0.2785328	519	0.8837437	0.9271302	1773166000	733906100	1039260000	Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YNL209W	SSB2	1.014978	0.2992194	510	0.9889592	1.041682	3045941000	1370710000	1675232000	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
YGR192C	TDH3	1.004193	0.5037433	462	0.959109	1.051397	3443380000	1545840000	1897540000	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall
YER091C	MET6	1.026779	0.3394209	433	0.994471	1.060136	862657800	376689500	485968300	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YBR118W	TEF2	1.033987	0.2586197	408	1.008362	1.060263	3665692000	1588816000	2076876000	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus
YER043C	SAH1	1.02417	0.2041269	402	1.003936	1.044813	1704645000	738613400	966031900	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YKL060C	FBA1	1.06267	0.3100239	390	1.03047	1.095876	1860912000	810404000	1050508000	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YOL086C	ADH1	1.038019	0.2340262	353	1.012984	1.063673	2468466000	1062733000	1405732000	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YLL045C	RPL8B	0.9355542	0.2101141	352	0.9152423	0.9563169	1322423000	552370700	770052000	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YLR259C	HSP60	1.213944	0.2016477	346	1.188422	1.240013	635819100	301774400	334044700	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YBR196C	PGI1	0.9813053	0.2632006	345	0.9544258	1.008942	1091971000	456792300	635178600	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
YPL106C	SSE1	1.366686	0.4615535	335	1.300778	1.435933	645303300	325950200	319353200	ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YAL038W	CDC19	0.983163	0.2705389	332	0.9549637	1.012195	1803194000	786939500	1016254000	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YJR045C	SSC1	1.185538	0.2819679	323	1.149637	1.222561	846923300	409066500	437856800	Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease
YGL253W	HXK2	1.034213	0.2155254	319	1.010039	1.058965	995663900	441615500	554048400	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YOR027W	STI1	1.701538	0.2937628	292	1.645161	1.759848	506246800	287575000	218671800	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YJL130C	URA2	1.004206	0.2757961	292	0.9729367	1.036481	314580300	142105800	172474600	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YGL147C	RPL9A	0.9736538	0.1521125	280	0.9564596	0.9911572	778094200	331294000	446800200	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YGL008C	PMA1	0.928129	0.1978577	276	0.9067147	0.950049	1316761000	547450800	769310300	Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
YNL055C	POR1	0.9703481	0.2271744	275	0.9446406	0.9967551	1277143000	533887000	743255700	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YBL076C	ILS1	0.9223043	0.3720375	272	0.882414	0.9639979	289390500	119715400	169675100	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YGR094W	VAS1	0.9269752	0.2721224	271	0.8974232	0.9575004	334395400	142556300	191839100	Mitochondrial and cytoplasmic valyl-tRNA synthetase
YAL003W	EFB1	1.186979	0.2348002	256	1.153325	1.221616	835611400	395077900	440533500	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YFR053C	HXK1	0.9862492	0.2576309	254	0.955491	1.017998	471639800	200862600	270777300	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR374W	ALD4	1.0295	0.3918253	251	0.9807863	1.080634	553944300	230285900	323658400	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YER165W	PAB1	1.104371	0.3727742	250	1.054499	1.156601	762711400	329246500	433464800	Poly(A) binding protein, part of the 3_prime-end RNA-processing complex, mediates interactions between the 5_prime cap structure and the 3_prime mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
YJL080C	SCP160	1.000057	0.3741491	250	0.9547332	1.047532	334459900	146421300	188038500	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YJL138C	TIF2	1.063456	0.2627366	245	1.029038	1.099025	491329600	216828500	274501000	Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YOR335C	ALA1	1.057536	0.4953479	245	0.9939325	1.125209	348471900	158998500	189473400	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YGL076C	RPL7A	1.020328	0.2176314	240	0.9926169	1.048812	1067697000	466711200	600985300	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YGR155W	CYS4	0.9822276	0.3045101	239	0.94503	1.020889	339061800	147186400	191875400	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria
YLR304C	ACO1	0.9475694	0.2180043	239	0.9217382	0.9741246	394761100	166345000	228416000	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YDL185W	TFP1	1.032821	0.4143983	238	0.9798509	1.088654	338250400	146725400	191525000	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YBR079C	RPG1	0.9996552	0.2761756	238	0.965188	1.035353	225903800	94753720	131150000	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YKL152C	GPM1	1.014102	0.2072598	237	0.9876926	1.041218	1565889000	689127600	876761600	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YNL302C	RPS19B	1.06452	0.1830969	237	1.039992	1.089626	1119113000	485150200	633962700	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YIL078W	THS1	1.035653	0.4784209	237	0.9744534	1.100696	249366500	110611400	138755200	Threonyl-tRNA synthetase, essential cytoplasmic protein
YLL024C	SSA2	1.656439	0.2122828	234	1.611992	1.702112	1029847000	579936800	449910600	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YMR116C	ASC1	1.060203	0.2450377	234	1.027434	1.094018	640965900	287154300	353811600	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YER138C	YER138C	1.094786	0.261744	234	1.058679	1.132124	367674800	167526100	200148700	NA
YER110C	KAP123	0.8718829	0.7074291	231	0.7958623	0.9551651	310099000	132605100	177493900	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YFL018C	LPD1	1.028268	0.2669342	226	0.9930974	1.064684	282522600	122065100	160457500	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
YMR012W	CLU1	0.981367	0.1966136	225	0.956476	1.006906	163409900	71507560	91902360	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YHR020W	YHR020W	1.026249	0.3064451	222	0.9857021	1.068464	234013300	101953600	132059700	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YGL245W	GUS1	1.005423	0.3590852	219	0.9587252	1.054395	327558100	138679600	188878500	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
YOR375C	GDH1	1.021074	0.2235933	218	0.991212	1.051835	365705200	160658200	205047000	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YJL034W	KAR2	1.231591	0.2634405	212	1.188681	1.276051	255717700	121916100	133801700	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
YPL061W	ALD6	1.071276	0.3819944	210	1.017334	1.12808	437618200	193763600	243854700	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YPL160W	CDC60	1.058198	0.3609722	210	1.007775	1.111144	342069700	151483100	190586700	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YHR064C	SSZ1	0.9925522	0.2839007	209	0.9550746	1.0315	391084000	170930200	220153800	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YLR043C	TRX1	1.00452	0.2163296	208	0.9754173	1.034491	576674100	247193100	329480900	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YLR355C	ILV5	1.224774	0.2462066	207	1.184376	1.26655	923846300	421822400	502023900	Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YJR121W	ATP2	1.036866	0.2717033	207	0.9991894	1.075964	717480800	312554800	404926000	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR502C	SAM2	1.033182	0.2291271	205	1.001278	1.066102	501118300	214101700	287016600	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDR447C	RPS17B	0.9689398	0.13799	200	0.9505855	0.9876486	732950100	314293000	418657100	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YJR109C	CPA2	1.045844	0.3168235	198	1.000694	1.093032	186733100	81222620	105510500	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YLR441C	RPS1A	0.9258027	0.2577228	195	0.8929116	0.9599054	542746400	221860400	320886000	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YOR120W	GCY1	1.027289	0.6771027	195	0.9341542	1.129709	268559000	109939000	158620000	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YBR121C	GRS1	1.037236	0.2629165	193	0.9994662	1.076433	293423300	127491800	165931500	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3_prime-end of pre-mRNA to promote 3_prime-end formation
YHR183W	GND1	0.9435784	0.1886145	192	0.9187369	0.9690916	537951000	225548000	312403000	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YGR034W	RPL26B	1.072882	0.1442268	191	1.05116	1.095053	1096633000	496411300	600221200	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YLL018C	DPS1	0.9834928	0.1909511	191	0.9572164	1.01049	232308300	103306400	129002000	Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YKL210W	UBA1	1.023849	0.211109	189	0.9934924	1.055133	145086400	62406800	82679620	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
YKL081W	TEF4	0.9768527	0.2427802	186	0.9433571	1.011538	729289800	312366000	416923900	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
YDR127W	ARO1	1.037454	0.2072072	184	1.006853	1.068985	153114600	66343230	86771380	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
YLR354C	TAL1	0.9830756	0.229562	183	0.9509157	1.016323	467951000	198117500	269833500	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
YBL030C	PET9	0.9718745	0.3409402	182	0.924907	1.021227	824733100	347661500	477071600	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation
YDL083C	RPS16B	0.9752519	0.132116	182	0.956711	0.9941522	887615200	381735800	505879400	Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YPL079W	RPL21B	1.046377	0.1909757	182	1.017744	1.075816	1076529000	482182900	594346400	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YPR074C	TKL1	0.9592124	0.4376666	178	0.899479	1.022913	378903900	161533400	217370500	Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YOR007C	SGT2	1.206543	0.3063892	176	1.153145	1.262414	192648700	92145470	100503300	Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70
YBR011C	IPP1	1.066774	0.3020445	174	1.019956	1.115742	337043100	148290900	188752200	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YEL034W	HYP2	1.118248	0.5963189	174	1.023428	1.221853	636498000	289791000	346707000	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification
YLR340W	RPP0	0.9949585	0.2419422	172	0.9596255	1.031592	838157600	375318800	462838800	Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YIL053W	RHR2	0.9398182	0.1947607	172	0.9128575	0.9675753	473732100	201419800	272312300	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YDR226W	ADK1	1.007175	0.207509	171	0.9763314	1.038993	450064700	196703500	253361300	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
YFL039C	ACT1	1.089945	0.2709841	171	1.046562	1.135126	521281500	227689900	293591600	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YDR023W	SES1	1.006995	0.1823988	171	0.9798383	1.034905	256034800	112704200	143330600	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YPL081W	RPS9A	0.8841132	0.2147369	170	0.8560294	0.9131183	635718200	263972100	371746100	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YGR240C	PFK1	0.9699509	0.1749198	169	0.9447052	0.9958712	237741000	101713300	136027700	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YGL206C	CHC1	0.8772543	0.2478878	168	0.8449792	0.9107622	94331100	38851480	55479620	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YLR432W	IMD3	0.9496017	0.3339378	167	0.9027038	0.9989361	215609500	93915210	121694300	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YDR155C	CPR1	1.181777	0.3330665	166	1.12339	1.243198	449331600	220039800	229291800	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YBL099W	ATP1	1.017206	0.2217943	165	0.9833568	1.05222	515288300	223222100	292066200	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YGL062W	PYC1	1.000743	0.3115287	164	0.9541472	1.049613	179013400	76443010	102570400	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YOR341W	RPA190	0.9757969	0.3073315	164	0.9309609	1.022792	114117700	48501810	65615920	RNA polymerase I largest subunit A190
YGL195W	GCN1	0.9409646	0.6430497	164	0.8527672	1.038284	119242500	51833160	67409320	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YDL126C	CDC48	1.029369	0.422178	163	0.9647695	1.098295	210227700	93807010	116420700	ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YDR341C	YDR341C	1.088526	0.6159795	162	0.9900185	1.196835	147857100	64232440	83624650	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR139C	HOM6	0.9960454	0.1632964	160	0.9711586	1.02157	253980000	110601400	143378500	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YMR229C	RRP5	1.022949	0.3545241	159	0.9681025	1.080902	132786100	73099730	59686340	RNA binding protein with preference for single stranded tracts of U_primes involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YGL026C	TRP5	1.050897	0.1827906	158	1.021367	1.081281	170628500	77934940	92693600	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
YNL096C	RPS7B	1.039942	0.1741262	156	1.01191	1.06875	592222600	265849200	326373400	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YDR450W	RPS18A	0.937902	0.1736284	156	0.9126922	0.9638081	750870200	324850400	426019900	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBL092W	RPL32	0.9278433	0.2239116	156	0.8958074	0.9610249	601834100	253434800	348399300	Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YOR168W	GLN4	1.016655	0.4228783	155	0.9511761	1.086642	101085800	44489690	56596110	Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
YBR181C	RPS6B	0.9594839	0.1692176	154	0.9341799	0.9854733	962608500	414657900	547950600	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YDR298C	ATP5	1.045259	0.1881879	154	1.014648	1.076793	229515900	97936070	131579800	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YDR050C	TPI1	1.013099	0.3431342	153	0.9594857	1.069708	758728900	335940400	422788500	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5_prime non-coding region
YDL055C	PSA1	0.9407808	0.2679084	153	0.9016787	0.9815785	440046700	184844200	255202500	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YJR105W	ADO1	1.008265	0.3188184	153	0.9585935	1.06051	273727100	120065000	153662200	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YJL177W	RPL17B	1.080502	0.1485789	153	1.055361	1.106242	780887400	350764000	430123400	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YGR234W	YHB1	1.353051	0.3901443	153	1.271937	1.439337	240904700	119624200	121280500	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YCL043C	PDI1	1.019445	0.3156917	152	0.9695445	1.071915	273808100	119215600	154592500	Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YGL173C	KEM1	0.9842239	0.4347483	152	0.9184968	1.054654	80904520	36162530	44741990	Evolutionarily-conserved 5_prime-3_prime exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
YJR077C	MIR1	1.062108	0.3365042	150	1.006424	1.120873	316720100	136854400	179865700	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YGL135W	RPL1B	0.9955094	0.3255888	150	0.9449665	1.048756	361699200	154356500	207342700	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YFR031C-A	RPL2A	1.072255	0.5175181	150	0.9870288	1.164841	526406400	242396000	284010400	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YMR145C	NDE1	0.903703	0.1854712	150	0.8772738	0.9309283	182249900	77488440	104761400	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YGR264C	MES1	1.066757	0.3512983	148	1.008057	1.128874	143332900	66444150	76888710	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YDL195W	SEC31	1.028127	0.4590603	147	0.9545916	1.107328	83692440	36389230	47303220	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport
YOR332W	VMA4	1.020709	0.1989894	146	0.9882888	1.054194	199188000	90459440	108728600	Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YBR143C	SUP45	1.068489	0.243208	146	1.027157	1.111484	170981200	72660040	98321180	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin
YNL247W	YNL247W	0.9835072	0.2946581	146	0.9376045	1.031657	81691930	34676290	47015640	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
YLR109W	AHP1	1.26692	0.2190224	145	1.22255	1.312901	645127700	309027600	336100000	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YKL085W	MDH1	1.009975	0.245576	145	0.9704001	1.051163	254081100	108351500	145729700	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YGR061C	ADE6	1.060269	0.3510841	145	1.001378	1.122624	147983600	64949410	83034150	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the _primede novo_prime purine nucleotide biosynthetic pathway
YER177W	BMH1	1.027413	0.3586143	143	0.968764	1.089612	462098300	204259800	257838500	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGR085C	RPL11B	1.075703	0.2135504	142	1.038575	1.114158	789344700	348583100	440761500	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YCR053W	THR4	0.9821027	0.2788417	142	0.9380771	1.028195	272971500	118635500	154336000	Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
YDR037W	KRS1	1.08639	0.252579	142	1.042181	1.132474	140998800	63197720	77801060	Lysyl-tRNA synthetase
YBR031W	RPL4A	0.9740046	0.2848891	140	0.9291071	1.021072	472830000	204242500	268587500	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
YJL191W	RPS14B	1.026895	0.2322854	137	0.9877187	1.067625	461284900	207002600	254282300	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins
YOR198C	BFR1	1.010837	0.2229046	137	0.9738015	1.049281	210466800	96798660	113668100	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YOR204W	DED1	1.029886	0.401048	135	0.9625156	1.101971	195818600	86774580	109044000	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
YOL127W	RPL25	0.9865386	0.2502523	135	0.9457586	1.029077	620788600	267769000	353019600	Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YBR025C	OLA1	1.177435	0.3737607	135	1.10549	1.254062	314522400	142153500	172368900	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide
YHR019C	DED81	0.9401695	0.6229542	134	0.8460536	1.044755	232324700	100642600	131682100	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YMR217W	GUA1	1.014393	0.1638442	134	0.9866382	1.042928	181404000	77768220	103635700	GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5_prime-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YLR448W	RPL6B	0.9861232	0.5971021	133	0.8909619	1.091448	626337200	276618000	349719200	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YGR285C	ZUO1	1.01282	0.3047956	133	0.9616902	1.066668	242329100	103688600	138640500	Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YLR367W	RPS22B	0.9229403	0.166769	133	0.8971486	0.9494734	468026800	195655400	272371400	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YNL064C	YDJ1	1.386475	0.3756094	132	1.300419	1.478225	225368600	114213100	111155500	Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YML008C	ERG6	1.101037	0.4131008	132	1.026114	1.18143	260714700	112904300	147810500	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane
YLR197W	NOP56	0.9971921	0.4010769	131	0.9310012	1.068089	118551700	51693190	66858500	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2_prime-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YLR058C	SHM2	1.011947	0.3404342	130	0.9544255	1.072935	176554800	76680420	99874350	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
YLR359W	ADE13	1.086807	0.3272725	130	1.027352	1.149702	50297100	24410040	25887060	Adenylosuccinate lyase, catalyzes two steps in the _primede novo_prime purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
YIL051C	MMF1	0.887271	0.2648226	129	0.8476353	0.9287601	302880500	125250600	177629900	Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
YFL022C	FRS2	1.041145	0.15946	127	1.012667	1.070424	142857900	62100180	80757720	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YBR048W	RPS11B	0.9339187	0.2706406	126	0.8908113	0.9791121	633925200	276451400	357473900	Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YDR129C	SAC6	0.9344712	0.1910849	125	0.9036862	0.9663049	177024200	78408740	98615430	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YDL100C	GET3	1.048829	0.2184934	125	1.009414	1.089782	104058200	45396440	58661790	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity
YLR150W	STM1	1.048633	0.4174531	124	0.9743448	1.128585	399458300	177020400	222437900	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure
YBR018C	GAL7	0.9956769	0.1950787	124	0.9620692	1.030459	381374200	158033400	223340800	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YOR142W	LSC1	1.033546	0.4689151	124	0.951667	1.122469	138852700	58637380	80215320	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
YKL216W	URA1	0.8668748	0.2217374	124	0.8336935	0.9013767	159215100	64480740	94734340	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YOR317W	FAA1	1.010666	0.4488904	124	0.9338856	1.093758	110958200	45678970	65279230	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles
YKR001C	VPS1	0.9555113	0.4797945	124	0.8781316	1.03971	142339400	72032450	70307000	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YGL148W	ARO2	1.055805	0.1718024	123	1.02423	1.088353	123999700	55247620	68752080	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YBL045C	COR1	0.9840608	0.2610874	123	0.9396866	1.03053	179752600	76979570	102773000	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YJR016C	ILV3	1.110832	0.212832	123	1.069826	1.15341	93755680	43479370	50276300	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YJR007W	SUI2	1.070506	0.4789211	123	0.9836289	1.165057	135236700	54844940	80391760	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YMR318C	ADH6	0.9820605	0.2920531	122	0.9324617	1.034298	201471400	81586690	119884700	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YBR039W	ATP3	1.031276	0.2078309	122	0.9939353	1.070019	197509700	85353840	112155900	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBR106W	PHO88	0.9948565	0.2091794	122	0.9586055	1.032478	213706700	91976120	121730600	Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YBR127C	VMA2	1.003827	0.4686682	121	0.9234041	1.091255	141627000	61146610	80480350	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
YDL075W	RPL31A	1.105671	0.318945	120	1.044341	1.170603	541322800	244085200	297237700	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality
YPR191W	QCR2	1.001302	0.2280769	120	0.9612633	1.043009	183996300	80543160	103453100	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YGL123W	RPS2	0.9264227	0.201003	119	0.8935621	0.9604917	259045900	110346200	148699800	Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p
YPR041W	TIF5	1.027151	0.1728835	118	0.9956051	1.059697	130758200	57336680	73421540	Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
YJL167W	ERG20	0.9776073	0.1610108	118	0.9496148	1.006425	158779200	67832440	90946750	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YKL157W	APE2	0.9927889	0.2439044	118	0.9500454	1.037456	73341130	31047440	42293680	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5_prime exon of APE2/YKL157W
YDR418W	RPL12B	1.080435	0.2145483	117	1.039237	1.123266	868715000	418098200	450616800	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YNL121C	TOM70	0.9984568	0.2099596	116	0.9610266	1.037345	106368200	46938310	59429890	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
YGR209C	TRX2	1.017018	0.2777515	115	0.9666773	1.069979	287991200	125110000	162881200	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YJR104C	SOD1	0.9593869	0.444572	114	0.8842007	1.040967	363022400	158150800	204871600	Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YER178W	PDA1	1.004851	0.3107246	114	0.9491386	1.063834	137751600	58121220	79630410	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YGR124W	ASN2	1.030528	0.2063775	113	0.9920514	1.070498	124438100	55322540	69115540	Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YIL133C	RPL16A	0.8374899	0.2371701	113	0.8016559	0.8749257	232020000	94805380	137214600	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YGL103W	RPL28	0.9081249	0.1375134	112	0.885289	0.9315499	364249700	147945300	216304500	Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YHR203C	RPS4B	0.8406547	0.1505556	112	0.8175383	0.8644248	489087200	201954300	287133000	Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YPR069C	SPE3	1.089167	0.192485	112	1.051024	1.128695	128038500	56687030	71351500	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YKL150W	MCR1	1.055125	0.2404454	112	1.00917	1.103173	111310900	47199900	64111000	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YDR172W	SUP35	1.077214	0.5049684	111	0.980626	1.183315	76513300	34575430	41937870	Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
YML070W	DAK1	1.009747	0.2726171	111	0.9598137	1.062279	84959310	35790290	49169020	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YMR309C	NIP1	0.980765	0.2446094	111	0.9371346	1.026427	54623710	23808480	30815230	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YOR096W	RPS7A	1.033385	0.09810494	110	1.014612	1.052505	700383200	313030700	387352400	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YHL015W	RPS20	1.009387	0.1882726	110	0.9744904	1.045534	847588300	379051900	468536400	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YEL046C	GLY1	1.129111	0.2431369	109	1.078731	1.181843	95735470	43897490	51837980	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YGR118W	RPS23A	0.9259796	0.4345045	108	0.8531234	1.005058	259211600	107924600	151287000	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YLR027C	AAT2	0.9749403	0.1780558	107	0.9425964	1.008394	110829900	47869270	62960620	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YOR323C	PRO2	1.032636	0.3303865	107	0.9699728	1.099347	77337210	35004560	42332660	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YNL135C	FPR1	1.043853	0.1553645	105	1.013289	1.075339	420712700	178093000	242619700	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
YER074W	RPS24A	0.9415173	0.2290335	105	0.9011611	0.9836808	413187700	176693900	236493900	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YER003C	PMI40	1.025372	0.4604195	105	0.9389324	1.11977	49247540	21211380	28036170	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YJL014W	CCT3	1.048008	0.3252702	105	0.9847913	1.115282	81293030	37631550	43661480	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDL082W	RPL13A	0.955046	0.2433135	105	0.9116165	1.000544	178928600	75300240	103628300	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YOL039W	RPP2A	1.045502	0.1907002	104	1.007877	1.084532	543372100	241153300	302218800	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YFR044C	DUG1	1.077505	0.3074595	104	1.015678	1.143096	101938600	45460020	56478580	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YOR361C	PRT1	1.125632	0.4515873	104	1.032056	1.227694	110805800	54482730	56323060	eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YJR064W	CCT5	0.9985371	0.2624395	104	0.9494208	1.050194	87226480	37908510	49317980	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YKL006W	RPL14A	1.025177	0.2146552	102	0.9833478	1.068786	636507500	278863500	357644000	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth
YDL066W	IDP1	1.026342	0.3500803	102	0.9589285	1.098495	156410800	69950230	86460600	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YLR060W	FRS1	0.9962272	0.2055802	102	0.9572634	1.036777	107381000	46397960	60983020	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
YIL125W	KGD1	0.9247293	0.2813715	102	0.8755879	0.9766287	66985170	27936470	39048700	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YMR108W	ILV2	1.104962	0.2738603	101	1.047495	1.165583	82440070	36849210	45590860	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YBL024W	NCL1	1.05434	0.2533587	101	1.003509	1.107746	52314220	23799250	28514970	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YKL035W	UGP1	0.9505067	0.3166005	101	0.8935922	1.011046	79365160	31618620	47746540	UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p
YHR193C	EGD2	1.104361	0.6803121	100	0.9665	1.261887	279836000	119418500	160417500	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YPL028W	ERG10	1.01788	0.2340664	100	0.9722377	1.065665	189257700	81772110	107485600	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YDL084W	SUB2	0.9938305	0.3429796	100	0.9292173	1.062937	163391000	71312590	92078360	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YMR226C	YMR226C	1.000209	0.258277	100	0.9508368	1.052146	88498640	39313420	49185220	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
YGL202W	ARO8	1.005873	0.2420419	100	0.959268	1.054741	68864070	30362070	38502000	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YHR021C	RPS27B	1.042617	0.2563464	99	0.9912755	1.096618	373340300	165880000	207460300	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YNL071W	LAT1	0.9483974	0.1671939	99	0.9176706	0.980153	118582900	48022200	70560690	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
YPL226W	NEW1	1.03322	0.4000968	99	0.9549141	1.117947	82153170	37569940	44583220	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction
UBIQUITIN	UBIQUITIN	1.030347	0.2580983	98	0.9790178	1.084367	343752800	150984400	192768400	NA
YIL041W	GVP36	0.9998612	0.1975594	98	0.9615069	1.039746	139133400	61138150	77995260	BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
YFL045C	SEC53	0.9903412	0.2386234	98	0.9446405	1.038253	234498300	99065620	135432700	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YDL145C	COP1	0.9768508	0.2331141	98	0.9327896	1.022993	66168990	29041770	37127220	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YLR106C	MDN1	1.017217	0.4444232	98	0.9315352	1.110779	85375260	37449560	47925700	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm
YDL136W	RPL35B	0.9295677	0.1738482	97	0.8979573	0.9622909	482946900	204433000	278513900	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YLR216C	CPR6	1.342775	0.2282806	97	1.283138	1.405184	142782900	73163800	69619140	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YMR079W	SEC14	1.026105	0.2156061	97	0.9830091	1.071091	135196700	56509670	78686990	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs
YGR116W	SPT6	0.9522983	0.5420324	97	0.8549215	1.060767	43070560	15051820	28018740	Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YNL138W	SRV2	0.9268281	0.3146204	96	0.8702939	0.9870348	68934900	28408820	40526080	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
YGR185C	TYS1	0.8785646	0.6548471	95	0.7701652	1.002221	189800500	69675050	120125400	Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies
YER036C	ARB1	1.020514	0.4635587	95	0.9296828	1.120219	117046100	54820040	62226060	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YEL031W	SPF1	0.9171609	0.6283541	95	0.8082942	1.040691	46580500	19732140	26848360	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YOR369C	RPS12	1.007315	0.1396462	94	0.9792756	1.036158	758239200	329265100	428974100	Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YER025W	GCD11	0.9973203	0.3487891	94	0.9294205	1.070181	116704000	50398900	66305110	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YBR263W	SHM1	1.019457	0.2933684	94	0.9607537	1.081746	77767780	32490180	45277590	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YGL031C	RPL24A	0.986234	0.2338863	94	0.940688	1.033985	157193500	66482230	90711260	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR353W	TRR1	1.076188	0.4701073	93	0.9781226	1.184086	184403200	82120860	102282300	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YGL105W	ARC1	1.037694	0.5823641	93	0.9218612	1.16808	186829400	84115070	102714300	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YGR180C	RNR4	1.112358	0.1714233	93	1.07427	1.151796	174013100	76266430	97746670	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YLR075W	RPL10	0.9300157	0.3471871	93	0.8666527	0.9980114	192689300	85137530	107551800	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YGR204W	ADE3	1.020302	0.3914362	93	0.9422753	1.10479	73532780	34102360	39430410	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
YPL078C	ATP4	1.00253	0.2797467	92	0.946828	1.061509	153602200	65856610	87745590	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YPR036W	VMA13	0.9114666	0.5154333	92	0.8203484	1.012705	54267820	22543640	31724180	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YOR234C	RPL33B	1.029995	0.2073544	91	0.9870348	1.074825	491890100	230127200	261762900	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YMR235C	RNA1	1.15092	0.2866976	91	1.085082	1.220752	220489800	116269400	104220400	GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
YDR454C	GUK1	0.9793238	0.2075564	90	0.9382165	1.022232	215483200	92667310	122815900	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YKL148C	SDH1	1.124269	0.4916046	90	1.015688	1.244457	85056410	37104880	47951530	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YGL009C	LEU1	1.121925	0.2419343	90	1.067225	1.179428	96977920	42723800	54254130	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YDR212W	TCP1	1.024966	0.2898373	90	0.9653911	1.088216	65784140	29908890	35875250	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
YOR209C	NPT1	1.009014	0.1754271	90	0.973098	1.046255	40566400	17272860	23293540	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
YLR325C	RPL38	1.137673	0.4218694	89	1.042204	1.241888	316439800	142057600	174382300	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YLL026W	HSP104	1.604211	0.4001956	89	1.476224	1.743294	91231570	48771640	42459940	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YNL010W	YNL010W	0.970827	0.2269668	88	0.9258633	1.017974	121338600	51343090	69995520	Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YPL249C-A	RPL36B	0.896462	0.1270462	88	0.8729789	0.9205769	240883300	95213720	145669600	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YOR117W	RPT5	1.180131	0.5982197	88	1.041472	1.33725	54663490	24704690	29958800	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YLR180W	SAM1	1.043046	0.1607067	87	1.008411	1.078871	120344100	52297840	68046260	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YHR010W	RPL27A	0.9379522	0.1184398	87	0.9148963	0.961589	336677100	145008800	191668400	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YNR001C	CIT1	1.067523	0.3185603	87	0.9984016	1.141429	98878190	43668920	55209270	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YBL087C	RPL23A	1.134665	0.1964459	87	1.08878	1.182484	234116700	106514100	127602700	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YMR307W	GAS1	1.022442	0.3402632	87	0.9518888	1.098224	213971200	93533560	120437600	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
YJL111W	CCT7	1.013643	0.2155213	87	0.9687609	1.060605	57647420	25332510	32314910	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL008C	CCT8	1.05438	0.2983437	87	0.9903078	1.122597	64516520	29290650	35225870	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR342C	HXT7	1.12476	0.4409884	86	1.024665	1.234632	204638000	91867090	112770900	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YGL030W	RPL30	1.063479	0.2005434	85	1.019091	1.109799	420839000	184849900	235989100	Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YFP-41-238	YFP-41-238	2.969234	0.5961163	85	2.615812	3.370406	161375600	94799700	66575920	NA
YJR123W	RPS5	0.9789601	0.198067	84	0.9383599	1.021317	404716400	176676500	228039900	Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YBL027W	RPL19B	0.8662386	0.4220153	84	0.791485	0.9480525	497093700	204178300	292915500	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YML106W	URA5	0.9816287	0.3400232	84	0.9127828	1.055667	88975820	37322400	51653420	Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5_prime-phosphate; minor OPRTase encoded by URA10
YOR046C	DBP5	1.049214	0.259046	84	0.9926705	1.108978	579281900	257484100	321797800	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YOR020C	HSP10	1.244361	0.6328636	83	1.085965	1.42586	264191400	126533200	137658200	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YBR286W	APE3	1.109291	0.3230336	83	1.034817	1.189125	109407500	49099100	60308410	Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YIL075C	RPN2	0.9455886	0.3138258	82	0.8834912	1.012051	56417180	23141440	33275740	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
YCL057W	PRD1	1.097748	0.293409	82	1.0302	1.169724	29282590	12847990	16434600	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
YLR061W	RPL22A	0.947819	0.2243269	81	0.9026277	0.9952729	270777300	111445200	159332100	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YHR027C	RPN1	1.102281	0.2664905	81	1.04013	1.168146	63411120	28763980	34647150	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions
YGL106W	MLC1	1.062299	0.2717004	81	1.001266	1.127052	76887880	32984090	43903790	Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
YGR244C	LSC2	0.948659	0.2515922	81	0.8980791	1.002087	50689990	21333940	29356050	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YCL050C	APA1	1.169111	0.1696411	81	1.126707	1.21311	79671720	37237700	42434030	Diadenosine 5_prime,5_prime_prime-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5_prime-nucleosidyl) tetraphosphates; has similarity to Apa2p
YMR242C	RPL20A	1.037375	0.1247164	80	1.009408	1.066118	423008300	189747400	233260900	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein
YMR205C	PFK2	1.012086	0.2540998	80	0.9572711	1.070039	207013100	88646220	118366900	Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YCL040W	GLK1	0.9700483	0.591763	79	0.8513744	1.105264	46353330	18775010	27578320	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YGR054W	YGR054W	1.002367	0.266673	79	0.9451219	1.06308	35303960	14674100	20629860	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YOL097C	WRS1	1.05734	0.2622999	79	0.997917	1.120302	46719570	21109440	25610140	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YJL136C	RPS21B	1.081067	0.1391287	78	1.048197	1.114967	318818200	145697100	173121100	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YLR028C	ADE16	1.029627	0.4210989	78	0.9377645	1.130488	42523180	16108140	26415040	Enzyme of _primede novo_prime purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YPL091W	GLR1	1.009951	0.2321878	78	0.9592281	1.063357	44445430	19002070	25443360	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia
YPL145C	KES1	0.9696156	0.2464024	78	0.9180175	1.024114	43076820	19703020	23373800	Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YDR233C	RTN1	0.9508055	0.2486619	77	0.8994359	1.005109	175675600	73463020	102212600	ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily
YDR158W	HOM2	1.007879	0.2817023	77	0.9464156	1.073334	141466800	61470510	79996250	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YNL239W	LAP3	0.988325	0.3164098	76	0.9204604	1.061193	55467490	23231580	32235920	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YLR029C	RPL15A	0.9305724	0.5934827	76	0.8143325	1.063405	146120900	60117700	86003160	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YPL131W	RPL5	1.017522	0.3763346	75	0.9344453	1.107985	344361000	152319200	192041800	Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YLL050C	COF1	1.033821	0.245992	75	0.9778374	1.093009	260902500	112921200	147981200	Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YPL004C	LSP1	0.9264989	0.2448067	75	0.8765624	0.9792802	86488020	36639400	49848620	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YLR179C	YLR179C	0.9653878	0.2340408	75	0.9155834	1.017901	59043070	25729460	33313610	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
YDL171C	GLT1	0.9785253	0.3906865	75	0.8957183	1.068988	36070310	15059840	21010470	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YGR162W	TIF4631	1.054817	0.4643103	74	0.9489264	1.172523	50606650	22429290	28177360	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit
YGL137W	SEC27	1.045704	0.4150866	74	0.9513389	1.14943	47696800	20168800	27527990	Essential beta_prime-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta_prime-COP
YBR088C	POL30	0.946885	0.2418698	74	0.896115	1.000531	49227800	20081840	29145950	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YDR150W	NUM1	1.051228	0.2443225	74	0.9943072	1.111407	36030120	15319830	20710290	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YCR088W	ABP1	0.9375257	0.2700592	73	0.8812069	0.9974439	80650400	35750590	44899810	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
YDL124W	YDL124W	0.8377135	0.17109	73	0.8054716	0.8712459	37921020	15666450	22254570	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YLR314C	CDC3	0.9663124	0.2320715	73	0.9162139	1.01915	47233770	20038270	27195500	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YPL225W	YPL225W	0.9365505	0.3400592	73	0.8662674	1.012536	41113420	17783040	23330380	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YNL007C	SIS1	1.572662	0.1681122	72	1.512763	1.634933	77240410	43672770	33567640	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins
YNL134C	YNL134C	0.7671581	0.6080067	72	0.6666403	0.8828324	49698170	19536300	30161870	Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YDL081C	RPP1A	1.135192	0.2155134	71	1.079687	1.19355	178897500	81064700	97832840	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
YOR136W	IDH2	0.9603769	0.3729685	71	0.8805704	1.047416	64192870	27436150	36756720	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
YER023W	PRO3	1.017389	0.2779961	71	0.9536819	1.085351	91010910	40472040	50538870	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
YML126C	ERG13	1.061879	0.1449956	71	1.026662	1.098305	92992030	41983630	51008410	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YNL036W	NCE103	2.776643	0.3887403	71	2.536583	3.039422	84207880	57293690	26914190	Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YPR145W	ASN1	1.032502	0.1394465	71	0.9995485	1.066542	72803940	32157320	40646620	Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YLR335W	NUP2	1.091787	0.464233	71	0.9800328	1.216284	68355340	31040920	37314420	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YLR153C	ACS2	1.020483	0.3041285	70	0.9503064	1.095841	75539060	31948460	43590600	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YPR181C	SEC23	0.9862131	0.4430707	70	0.8889816	1.094079	62435810	26810150	35625660	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport
YMR099C	YMR099C	0.9987549	0.2107445	70	0.9506438	1.049301	65724770	28085620	37639160	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YDL040C	NAT1	0.9499881	0.3027244	70	0.8849505	1.019805	29155400	12946710	16208690	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YLR293C	GSP1	1.006399	0.1285804	69	0.9763242	1.037401	332915600	143484000	189431600	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
YLR342W	FKS1	0.9267325	0.3272862	69	0.857859	1.001136	34532060	14153610	20378460	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YML073C	RPL6A	0.974954	0.1134385	68	0.9490179	1.001599	214483700	92600920	121882800	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YGR282C	BGL2	0.9980487	0.5259086	68	0.8807744	1.130938	144779200	66377960	78401200	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YBL002W	HTB2	0.9126246	0.08976643	68	0.893359	0.9323057	152170100	63589400	88580650	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YBR249C	ARO4	1.095452	0.2521145	68	1.031737	1.163103	61585870	26635540	34950330	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YDL125C	HNT1	1.023677	0.2543799	68	0.9636168	1.08748	92071310	40700720	51370590	Adenosine 5_prime-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YML072C	TCB3	0.9710773	0.262988	68	0.9122351	1.033715	31144990	13316890	17828100	Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YKL056C	TMA19	1.098316	0.1819124	67	1.051501	1.147215	466039400	209380700	256658700	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YAL012W	CYS3	1.056497	0.2991279	67	0.9834705	1.134947	125358700	55024730	70333930	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YPL262W	FUM1	0.9697303	0.2687176	67	0.9092981	1.034179	68016000	28677930	39338070	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
YMR146C	TIF34	1.078438	0.3350736	67	0.9952908	1.168531	44464010	20504950	23959060	eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation
YOR310C	NOP58	1.021647	0.3499032	67	0.9395362	1.110934	64757350	28140360	36616990	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YER007C-A	TMA20	1.056013	0.3128671	67	0.9797906	1.138165	33998580	14648740	19349830	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YDR071C	PAA1	1.060003	0.1314064	67	1.027169	1.093887	61091220	26459360	34631860	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YMR072W	ABF2	1.015768	0.1456021	67	0.980964	1.051807	80148830	34277720	45871110	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YIL052C	RPL34B	0.9031845	0.1419742	67	0.8729958	0.934417	141396800	55212060	86184760	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YBR248C	HIS7	0.9985835	0.7582813	67	0.8327768	1.197402	30284630	13324090	16960530	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
YKL080W	VMA5	0.893673	0.5370273	66	0.7850733	1.017295	56022860	24482740	31540120	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YCL037C	SRO9	0.9426097	0.3621624	66	0.8637447	1.028676	85075050	34003250	51071810	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YER120W	SCS2	0.9084568	0.1734628	66	0.8712229	0.947282	89870200	37190150	52680040	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YDR188W	CCT6	0.9842455	0.1304241	66	0.9537574	1.015708	53720250	23563860	30156390	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YBL039C	URA7	1.039363	0.2464398	66	0.9793678	1.103033	61918540	26863390	35055140	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YMR083W	ADH3	1.06877	0.2870296	66	0.9972639	1.145404	67299680	29765300	37534380	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YNL178W	RPS3	1.022956	0.246169	65	0.9635327	1.086045	362356300	161986600	200369700	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YEL047C	YEL047C	1.020252	0.1889412	65	0.9744486	1.068208	43390680	18064440	25326240	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YPL093W	NOG1	1.017307	0.3614064	65	0.9317392	1.110732	37034470	16233750	20800720	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YBL047C	EDE1	1.057273	0.3115749	65	0.9801459	1.140468	28281990	13745250	14536740	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
YJL109C	UTP10	0.9101959	0.335107	65	0.8389848	0.9874512	26717820	9642242	17075580	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL069C	RPL16B	0.9506422	0.6391977	64	0.81284	1.111806	185305600	80925000	104380600	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDL014W	NOP1	0.9147166	0.2563866	64	0.8590263	0.9740172	71275710	30316110	40959600	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YPL048W	CAM1	0.9704545	0.3733034	64	0.8856353	1.063397	69314960	29446590	39868370	Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
YHR068W	DYS1	0.9751451	0.1808326	64	0.9328853	1.019319	49909550	21400420	28509130	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YGL234W	ADE5,7	1.111094	0.2949392	64	1.033638	1.194354	40418580	18533620	21884960	Bifunctional enzyme of the _primede novo_prime purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YFL005W	SEC4	0.9215009	0.1732327	63	0.8829126	0.9617757	43690010	18606910	25083100	Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YDR381W	YRA1	0.8518097	0.2573141	63	0.7993691	0.9076905	78644070	31258690	47385380	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3_prime end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
YGL207W	SPT16	0.963945	0.4006181	63	0.8731495	1.064182	23426590	9573298	13853300	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
YDR513W	GRX2	0.9692762	0.2269671	63	0.9164459	1.025152	37884680	16061780	21822900	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress
YDR382W	RPP2B	1.061245	0.4389076	62	0.9514102	1.18376	286785800	130493800	156292000	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YML056C	IMD4	0.9374631	0.3956873	62	0.8495296	1.034498	67510040	27431580	40078460	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YER136W	GDI1	1.011041	0.1428549	62	0.9757209	1.04764	48088980	20662830	27426150	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
KanMX6	KanMX6	1.138303	0.1926544	62	1.085003	1.194221	65844830	31369880	34474950	NA
YBR084W	MIS1	1.013539	0.3555652	62	0.9276887	1.107334	31345830	14008700	17337130	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YER070W	RNR1	0.940099	0.2580802	62	0.8816048	1.002474	31798070	13120860	18677210	One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YOL109W	ZEO1	1.121586	0.4255614	61	1.00798	1.247997	483035400	214241500	268793900	Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YBR109C	CMD1	1.009789	0.3337424	61	0.9286608	1.098005	90324870	38919120	51405740	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
YIL142W	CCT2	1.109971	0.4307932	61	0.9962323	1.236695	39472610	17645660	21826950	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL153C	INO1	1.32831	0.4150378	61	1.196921	1.474121	27832740	13266300	14566450	Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YFR010W	UBP6	1.084545	0.3754285	61	0.9870312	1.191694	19609130	9071551	10537580	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to polyubiquitin elongation activity of Hul5p
YMR303C	ADH2	1.495134	1.243419	60	1.091538	2.04796	74305490	32367710	41937790	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YDL140C	RPO21	1.022432	0.3037093	60	0.9468024	1.104103	41446970	18763160	22683810	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YDR168W	CDC37	0.9743298	0.476303	60	0.8637026	1.099127	27056080	11762490	15293590	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
YDL131W	LYS21	1.045561	0.3501859	59	0.956185	1.14329	45341060	21290020	24051040	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
YGL011C	SCL1	1.154909	0.452992	59	1.02884	1.296427	37933140	18040360	19892780	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
YER006W	NUG1	1.018033	0.3519322	59	0.930596	1.113686	28284940	13072370	15212570	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YPL063W	TIM50	1.10192	0.5704896	59	0.9526407	1.274592	22664670	9590928	13073750	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YDL147W	RPN5	1.065156	0.3922736	59	0.9637003	1.177293	32726330	14511890	18214440	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
YJL026W	RNR2	1.093353	0.3438355	58	1.00076	1.194514	59257570	26178940	33078630	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YKR066C	CCP1	1.050359	0.217894	58	0.9930791	1.110944	57738260	25394310	32343950	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YLR420W	URA4	0.9115264	0.2605515	58	0.8524077	0.9747454	46216990	19216670	27000320	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YHL034C	SBP1	0.9327613	0.4000434	58	0.8415067	1.033912	78109820	32988280	45121540	Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
YAL035W	FUN12	0.9583011	0.1628704	58	0.9189628	0.9993234	37952690	16687760	21264930	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YER090W	TRP2	1.067761	0.6447212	58	0.9045101	1.260477	44867910	19751540	25116360	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YMR230W	RPS10B	1.040358	0.1390568	58	1.003784	1.078264	87374330	39394750	47979580	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YDL137W	ARF2	0.9719276	0.3048416	58	0.8985902	1.05125	89087910	37790650	51297260	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YGR103W	NOP7	0.9132663	0.6511173	58	0.7723637	1.079874	26823170	11162420	15660750	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation
YNL079C	TPM1	1.021613	0.1770702	57	0.9757136	1.069672	174883000	77350850	97532110	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YML092C	PRE8	1.027577	0.1570426	57	0.9865255	1.070336	80236450	34985870	45250580	Alpha 2 subunit of the 20S proteasome
YDL103C	QRI1	0.9993808	0.4839641	57	0.8813852	1.133173	33441980	14531220	18910760	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
YAL060W	BDH1	1.02303	0.311252	57	0.9436167	1.109126	28443690	12585260	15858430	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YMR031C	YMR031C	1.002068	0.2358537	57	0.9425529	1.065342	38454130	16365070	22089070	Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; possible component of the eisosome
YOL040C	RPS15	1.012577	0.1661207	56	0.9694649	1.057607	439659100	195079800	244579300	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YBL072C	RPS8A	0.8272037	0.22159	56	0.7805611	0.8766335	252861700	100655900	152205800	Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YML078W	CPR3	0.9536421	0.1477614	56	0.9174402	0.9912726	97424190	44151380	53272800	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
YDR214W	AHA1	1.472503	0.1843112	56	1.403107	1.54533	45693390	22774350	22919050	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
YLR384C	IKI3	0.991469	0.6331758	56	0.8399554	1.170313	14831100	6255403	8575693	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YGR218W	CRM1	0.8906562	0.3073249	56	0.8217739	0.9653125	20777380	8653521	12123860	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin
YOR298C-A	MBF1	1.628115	0.2153774	56	1.538814	1.722598	59211020	31903700	27307320	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YHR208W	BAT1	1.106798	0.7347241	55	0.9114608	1.343998	40809190	18245160	22564030	Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YDR002W	YRB1	1.148607	0.4853595	55	1.010329	1.30581	45512430	21758330	23754100	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YHR007C	ERG11	0.8511675	0.2831734	55	0.7897923	0.9173121	23935110	9228816	14706290	Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4_prime_prime-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YHR052W	CIC1	1.091526	0.4148444	55	0.9781805	1.218005	39259180	16578770	22680410	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YGR037C	ACB1	1.001168	0.166693	54	0.9576305	1.046685	167724700	71650660	96074000	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion
YNL287W	SEC21	0.923076	0.3467299	54	0.8415379	1.012515	28094740	11414450	16680290	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YIL043C	CBR1	0.9903297	0.2045648	54	0.937743	1.045865	69023820	27180690	41843140	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YDL097C	RPN6	1.134832	0.5531234	54	0.9791741	1.315234	28224680	12168210	16056470	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
YNL044W	YIP3	0.8741351	0.1546223	54	0.8388179	0.9109392	20282390	8297143	11985250	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YGL055W	OLE1	0.8468078	0.3325386	53	0.7742892	0.9261183	27502240	11327460	16174780	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YMR105C	PGM2	0.9212132	0.2672945	53	0.8572492	0.9899499	42207180	17045120	25162060	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YPL237W	SUI3	0.9406324	0.177523	53	0.8967333	0.9866806	38393660	16220440	22173220	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YBR149W	ARA1	0.9682457	0.2269432	53	0.9108577	1.029249	31975100	14032810	17942290	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YPL037C	EGD1	1.068259	0.1693551	53	1.020645	1.118093	41706530	19034120	22672410	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YML085C	TUB1	0.9944778	0.2863579	53	0.9206892	1.07418	61861740	25608670	36253070	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YHR037W	PUT2	0.9867686	0.1586608	53	0.9455056	1.029832	16134870	6755223	9379646	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YDR064W	RPS13	0.8064481	0.2133574	52	0.7610114	0.8545976	88915120	35028840	53886290	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YDR304C	CPR5	0.9827366	0.3591217	52	0.8913442	1.0835	44958800	19878140	25080650	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YDR368W	YPR1	1.018715	0.2570659	52	0.9499656	1.092439	22582580	9300559	13282020	NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases
YNL220W	ADE12	1.035809	0.2008026	52	0.9807913	1.093914	25611230	11343750	14267480	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5_primemonophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YPL117C	IDI1	1.14944	0.5678788	52	0.9850365	1.341282	44011190	21224540	22786640	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YGR090W	UTP22	0.9831012	1.600713	52	0.6362765	1.518975	46598960	19828770	26770200	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YHL033C	RPL8A	0.9862247	0.3453209	51	0.8970479	1.084267	151338100	61290210	90047930	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YOR187W	TUF1	1.00939	0.3228818	51	0.9237905	1.102922	77538140	34933690	42604450	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YOL139C	CDC33	0.963344	0.3978258	51	0.8636998	1.074484	110530900	48415380	62115540	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)
YOR021C	YOR021C	1.087562	0.2520103	51	1.014883	1.165446	27592930	12563760	15029170	Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
YFR009W	GCN20	1.166779	0.5535747	51	1.002318	1.358224	17630750	7798206	9832545	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YDR033W	MRH1	0.9021655	0.2206032	50	0.8486526	0.9590528	81773590	33202230	48571360	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YER057C	HMF1	1.037266	0.1954012	50	0.9825793	1.094996	47420830	20536520	26884310	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YHR047C	AAP1	1.273191	0.7550745	50	1.032755	1.569602	96902120	47817900	49084210	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YAR015W	ADE1	1.058944	0.186482	50	1.005598	1.115121	21054600	9353101	11701500	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for _primede novo_prime purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YLR081W	GAL2	1.112055	0.6700576	49	0.9218185	1.34155	35622990	16487370	19135620	Galactose permease, required for utilization of galactose; also able to transport glucose
YHR008C	SOD2	0.9827142	0.1769529	49	0.9352104	1.032631	112911700	48313140	64598550	Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YFL038C	YPT1	0.9519308	0.2230698	49	0.8942924	1.013284	80370890	32781880	47589010	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YDL160C	DHH1	0.9882496	0.2154328	49	0.9303996	1.049697	41408430	18173510	23234920	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
YGR254W	ENO1	0.7830391	0.8291619	49	0.6208052	0.9876694	67406120	24513320	42892790	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YLR192C	HCR1	1.067624	0.1977834	49	1.010107	1.128417	43256320	19467640	23788680	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YLR196W	PWP1	0.9235968	0.7740369	49	0.7436312	1.147116	26734560	11549780	15184780	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YBL015W	ACH1	1.055349	0.2660397	49	0.9795919	1.136966	20855000	9328685	11526320	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR321W	ASP1	1.051963	0.2707083	49	0.9751732	1.1348	27349590	11998730	15350850	Cytosolic L-asparaginase, involved in asparagine catabolism
YDL168W	SFA1	0.9886297	0.1891048	49	0.9376441	1.042388	25328410	11017700	14310720	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
YPR033C	HTS1	0.9967515	0.243239	49	0.9311259	1.067002	32182190	13461120	18721070	Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YNL175C	NOP13	1.203839	0.5606799	49	1.028936	1.408473	16398000	8650491	7747511	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM)
YJR070C	LIA1	0.9983144	0.4010951	48	0.8912258	1.118271	94017110	40811830	53205280	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YPR163C	TIF3	1.079985	0.3471496	48	0.9789623	1.191432	73340080	32875110	40464980	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YDL143W	CCT4	1.0058	0.1671764	48	0.9593389	1.054512	29084280	12889220	16195050	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YNL301C	RPL18B	0.9043698	0.2509205	48	0.842398	0.9709007	135369900	57611930	77757980	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YML010W	SPT5	0.9803001	0.3799408	48	0.8803969	1.09154	14853980	6349471	8504512	Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p
YNL241C	ZWF1	1.010064	0.3599568	48	0.9122709	1.118341	32702760	14841150	17861610	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YGR193C	PDX1	1.10204	0.6573049	48	0.9150384	1.327259	14984350	6401782	8582567	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
YDL078C	MDH3	0.9674891	0.2773765	48	0.8944723	1.046466	34900970	14969170	19931800	Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YBL022C	PIM1	1.169186	0.5221491	48	1.008628	1.355302	16040370	7008640	9031733	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
YFL014W	HSP12	0.6795768	0.2974306	47	0.6241784	0.7398921	194726000	76101960	118624000	Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YPR110C	RPC40	1.054091	0.2291239	47	0.9872549	1.125451	25841130	11182470	14658670	RNA polymerase subunit AC40, common to RNA polymerase I and III
YGR157W	CHO2	1.06265	0.5062623	47	0.9194569	1.228144	32022830	14506490	17516340	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YGL048C	RPT6	1.07931	0.2653707	47	1.000454	1.164382	25508690	11179600	14329100	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
YDR091C	RLI1	0.9933353	0.1734616	47	0.9452755	1.043839	88890800	37122120	51768680	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YJL123C	MTC1	0.8938796	0.8669672	47	0.6976441	1.145313	33621030	9709945	23911090	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
YOR326W	MYO2	0.884093	0.2385781	47	0.8258011	0.9464997	13039490	5028533	8010956	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
YHR005C-A	TIM10	1.09873	0.3068769	46	1.005487	1.20062	41855620	19095960	22759660	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YDR190C	RVB1	1.061913	0.1867641	46	1.006118	1.120801	31003870	13012230	17991640	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family
YNL281W	HCH1	1.222528	0.1766726	46	1.161677	1.286566	35724690	16997750	18726940	Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus
YER122C	GLO3	0.9961961	0.1940171	46	0.9418781	1.053647	31230450	15049520	16180930	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
YNL132W	KRE33	1.030978	0.2732394	46	0.9527004	1.115687	17229910	7090362	10139550	Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YIL115C	NUP159	1.039274	0.3384608	46	0.9424348	1.146063	20635730	8859539	11776190	Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export
YPR088C	SRP54	1.050031	0.2873065	46	0.9663702	1.140934	11197990	4800882	6397109	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
YOR254C	SEC63	0.8471606	0.2630857	46	0.7851401	0.9140803	18570660	7120539	11450120	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YGR086C	PIL1	1.029976	0.2741772	45	0.9506838	1.115881	87816510	39252180	48564330	Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YLR301W	YLR301W	0.9457669	0.3782156	45	0.8468209	1.056274	44646580	20445380	24201200	Protein of unknown function that interacts with Sec72p
YML022W	APT1	0.9588078	0.1114452	45	0.9280899	0.9905424	59573790	25209760	34364030	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YGL068W	MNP1	0.979829	0.1636016	45	0.9340939	1.027803	27626700	11519300	16107400	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YMR131C	RRB1	1.074969	0.3362053	45	0.9743933	1.185927	24032200	10683450	13348750	Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YFR052W	RPN12	1.02983	0.2718384	45	0.9511988	1.114961	24390440	10441440	13949000	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YOR164C	GET4	0.9750958	0.2302749	45	0.9116482	1.042959	22397010	9681696	12715310	Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p; genetic interactions predict a role in insertion of tail-anchored proteins into the ER membrane
YJL121C	RPE1	1.004242	0.1688502	45	0.9559	1.055028	16192840	6836884	9355952	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YJL041W	NSP1	1.045286	0.2458689	45	0.9728288	1.12314	25988830	11061160	14927670	Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes
YDL236W	PHO13	0.9832141	0.2624016	45	0.9106499	1.061561	14733410	6405340	8328072	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
YNL098C	RAS2	0.9569967	0.1674074	45	0.9113135	1.00497	22530400	9790727	12739670	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
YIL033C	BCY1	1.077698	0.2951175	45	0.9886648	1.174749	20284440	8580572	11703870	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YPL218W	SAR1	0.9066781	0.1410903	44	0.8696562	0.945276	43635620	17648920	25986690	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
YML086C	ALO1	0.8418871	0.6827286	44	0.6880851	1.030067	112791200	67461120	45330030	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
YKL196C	YKT6	1.028878	0.4291479	44	0.9063439	1.167978	35134270	15756160	19378110	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
YKL033W-A	YKL033W-A	1.088043	0.165881	44	1.035999	1.142702	41387070	17728320	23658750	Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YOR356W	YOR356W	1.12737	0.7463172	44	0.904263	1.405524	17952770	8357648	9595126	Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YKL211C	TRP3	0.9802976	0.3418646	44	0.8861105	1.084496	27246480	12131910	15114580	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YBL007C	SLA1	1.044577	0.301605	44	0.9555131	1.141942	20186330	8437767	11748560	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
YER048C	CAJ1	0.9675145	0.8008932	44	0.7636287	1.225837	18953360	7820080	11133280	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YML120C	NDI1	0.8806172	0.2874893	44	0.8089	0.9586928	12340790	4885549	7455239	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YIL155C	GUT2	1.032867	0.3468802	44	0.9322467	1.144348	24857370	10985550	13871820	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YDL058W	USO1	0.9428287	0.6483861	44	0.7784453	1.141925	16421220	6895211	9526009	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
YPL240C	HSP82	2.046669	0.2539165	43	1.897085	2.208047	122329700	74808610	47521070	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YOL123W	HRP1	1.131627	0.19562	43	1.067357	1.199766	28946310	13061370	15884940	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3_prime ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YDL029W	ARP2	0.9770494	0.293376	43	0.8950216	1.066595	29096870	12352340	16744530	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YBL050W	SEC17	0.9931784	0.2722009	43	0.9155731	1.077362	27868110	12495120	15372990	Peripheral membrane protein required for vesicular transport between ER and Golgi, the _primepriming_prime step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
YOR259C	RPT4	1.133229	0.2729381	43	1.04445	1.229554	27409460	12638410	14771050	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle
YOL004W	SIN3	1.026242	0.17574	43	0.9737263	1.081589	11460650	4671458	6789195	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
YKR095W	MLP1	1.179453	0.5359335	43	1.004874	1.384363	46066100	23260550	22805540	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YBR245C	ISW1	1.207992	0.6497743	43	0.9947575	1.466935	19510240	9723335	9786900	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
YGL037C	PNC1	0.9364635	0.3120173	42	0.8521357	1.029137	42268000	17567740	24700260	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YKL117W	SBA1	1.057798	0.1427359	42	1.013106	1.104461	43552430	17191290	26361140	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YDR032C	PST2	0.8783314	0.4764749	42	0.7604585	1.014475	46807450	19110240	27697210	Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR184W	SER1	1.049112	0.218336	42	0.9820747	1.120726	20844600	9016176	11828420	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p
YKL127W	PGM1	0.9117097	0.2297983	42	0.8504985	0.9773263	38350200	15582230	22767970	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YLL040C	VPS13	0.9511603	0.3844585	42	0.846753	1.068441	45914200	17922020	27992190	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
YML028W	TSA1	0.9176873	0.171394	41	0.870783	0.9671179	350974700	147930600	203044200	Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YNL244C	SUI1	1.058273	0.2117352	41	0.9918593	1.129134	46986890	20885200	26101690	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
YEL024W	RIP1	0.8877819	0.469742	41	0.7688822	1.025068	43067420	17696450	25370980	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YMR260C	TIF11	0.8943163	0.1339111	41	0.8583991	0.9317362	65761860	28395240	37366620	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
YOR286W	RDL2	1.020038	0.3480558	41	0.9169516	1.134713	14615930	6027002	8588923	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss
YER062C	HOR2	0.8154088	0.3850739	41	0.7247438	0.9174159	51603580	19411310	32192270	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YFR037C	RSC8	1.06694	0.3696437	41	0.9527969	1.194757	19241390	8426448	10814940	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YKL054C	DEF1	1.225144	0.4142547	41	1.079237	1.390776	40102650	19635110	20467540	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
YOR362C	PRE10	1.049044	0.3404067	41	0.9452373	1.164251	64276540	28239740	36036800	Alpha 7 subunit of the 20S proteasome
YHR170W	NMD3	1.104473	0.4767011	41	0.9545163	1.277987	26132590	12279440	13853150	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YNR043W	MVD1	1.140216	0.5234154	41	0.9714165	1.338347	64354680	28544160	35810520	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
YHR108W	GGA2	1.326752	1.001295	41	0.9765174	1.802602	37689880	17353890	20335990	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YLR429W	CRN1	1.122637	0.4870973	41	0.9671322	1.303146	38930820	16184360	22746460	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
YDR060W	MAK21	0.9784584	0.3803582	41	0.8709202	1.099275	15043970	6453986	8589981	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YLR410W	VIP1	1.044054	0.1566141	41	0.9951831	1.095325	16417800	7059082	9358718	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1
YLR276C	DBP9	0.991069	0.2033538	41	0.931259	1.05472	14479440	5890594	8588849	ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
YBR244W	GPX2	0.9860254	0.1912901	41	0.9299475	1.045485	23817650	10045890	13771770	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YDL065C	PEX19	1.026528	0.3020095	41	0.9358848	1.125951	13272100	5655156	7616942	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
YPL154C	PEP4	1.033403	0.2461885	40	0.9574928	1.115332	76583420	33466460	43116950	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YDR529C	QCR7	0.9980688	0.3871167	40	0.8852353	1.125284	42047530	19497290	22550240	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YMR315W	YMR315W	1.023205	0.7585483	40	0.8088545	1.294361	29703760	14085280	15618480	Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site
YGR167W	CLC1	1.020997	0.2918193	40	0.9327149	1.117636	53835750	25594680	28241070	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
YER086W	ILV1	1.01392	0.3874386	40	0.8992049	1.14327	25038750	10420030	14618720	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YKL142W	MRP8	0.9517831	0.4062965	40	0.8391795	1.079496	31952540	12986220	18966320	Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
YOL027C	MDM38	0.962592	0.4334363	40	0.8416013	1.100977	23230320	10121020	13109290	Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
YPR108W	RPN7	1.032327	0.2141983	40	0.9660252	1.103179	26555390	11496370	15059020	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
YJR125C	ENT3	0.9581917	0.2498991	40	0.8867857	1.035348	13537330	5670973	7866357	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
YDR238C	SEC26	0.9683611	0.3725056	40	0.862784	1.086857	30070140	13105330	16964810	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YIR006C	PAN1	1.069001	0.212022	40	1.001019	1.1416	15848700	6689542	9159158	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YML063W	RPS1B	0.8947588	0.2102608	39	0.8376192	0.9557962	82511500	35497680	47013820	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YOR095C	RKI1	1.157428	0.2999186	39	1.05345	1.271669	32939060	17749000	15190060	Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YOR285W	RDL1	1.029471	0.1843355	39	0.971602	1.090786	46869070	19487560	27381510	Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane
YCL018W	LEU2	1.420409	0.4258028	39	1.242724	1.623498	57839830	25285600	32554220	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YIL094C	LYS12	0.9812899	0.6630508	39	0.7969314	1.208297	25818760	11390820	14427940	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YMR314W	PRE5	1.161062	0.4340538	39	1.013193	1.330511	28486980	13708950	14778030	Alpha 6 subunit of the 20S proteasome
YAL016W	TPD3	1.015395	0.26842	39	0.9333583	1.104642	16381400	7556880	8824517	Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III
YJR144W	MGM101	0.953211	0.2986368	39	0.867928	1.046874	20603840	8681256	11922580	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YDR430C	CYM1	1.006667	0.4207148	39	0.8821467	1.148764	9625657	3945744	5679914	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
YIL076W	SEC28	0.9617909	0.1651583	38	0.9125878	1.013647	24464740	10273620	14191120	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YNL112W	DBP2	1.010902	0.3223474	38	0.9124258	1.120007	29325580	13165490	16160090	Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YOR230W	WTM1	1.132417	0.3071729	38	1.027047	1.248598	28795930	12983030	15812900	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YDR234W	LYS4	0.9748967	0.2126684	38	0.9111547	1.043098	17302340	7700507	9601838	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YBR029C	CDS1	1.053379	0.2844168	38	0.9623003	1.153077	298560700	128301900	170258800	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YLR270W	DCS1	1.063793	0.7692472	38	0.8329809	1.358561	14665850	6423347	8242498	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YPL239W	YAR1	1.109677	0.4484441	37	0.9603765	1.282187	24691620	11225320	13466300	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YOR303W	CPA1	1.142133	0.8408105	37	0.8710725	1.497542	38146710	17558290	20588420	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5_prime-leader
YGR123C	PPT1	1.028904	0.193267	37	0.9667838	1.095016	286571700	124690100	161881600	Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YDR120C	TRM1	1.032473	0.2191284	37	0.9620859	1.108009	17567980	6881019	10686960	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YCR093W	CDC39	0.845128	0.1803447	37	0.7974165	0.8956943	8321398	3174443	5146955	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YMR027W	YMR027W	1.111686	0.4655177	37	0.9568366	1.291594	26883080	12222370	14660710	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
YLR244C	MAP1	1.147802	0.8690078	36	0.864134	1.524588	58038710	26462840	31575870	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
YBR078W	ECM33	0.9527062	0.1315837	36	0.9126227	0.9945502	145867100	61672480	84194620	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YLL041C	SDH2	1.072421	0.2781349	36	0.979279	1.174422	36246100	16089570	20156530	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YKL104C	GFA1	1.040236	0.248675	36	0.9590748	1.128265	34917900	15474900	19443000	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
YPR028W	YOP1	0.8858797	0.1861066	36	0.8336272	0.9414074	51195370	21968170	29227200	Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes
YBR177C	EHT1	0.9535265	0.2018706	36	0.8926753	1.018526	13805610	6045999	7759610	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YPL085W	SEC16	0.9339904	0.1671988	36	0.8843456	0.9864222	14485920	6515677	7970247	COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
YBR017C	KAP104	0.8829776	0.7277536	36	0.6961513	1.119943	38390690	15142600	23248090	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
YGR178C	PBP1	1.12398	0.4402225	36	0.9734296	1.297815	15324960	7310646	8014314	Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation
YLL013C	PUF3	0.9883716	0.2424493	36	0.913112	1.069834	18931880	7673209	11258680	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YOL049W	GSH2	0.9680849	0.607749	36	0.7937658	1.180686	25244020	10010260	15233760	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YOR265W	RBL2	1.097488	0.3623055	36	0.9749891	1.235378	25953200	11404260	14548940	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A
YMR203W	TOM40	1.009238	0.1236981	35	0.9687139	1.051457	37236800	16400800	20836000	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YDL022W	GPD1	0.8495905	0.2904521	35	0.7716473	0.9354067	55329840	23514780	31815060	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YHR039C-A	VMA10	1.121585	0.2885824	35	1.01932	1.23411	65547950	28256290	37291660	Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification
YIR012W	SQT1	1.059247	0.2172881	35	0.9856744	1.138312	20813090	10411430	10401660	Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YLR208W	SEC13	1.086067	0.195802	35	1.017851	1.158854	60806510	26304020	34502490	Component of both the Nup84 nuclear pore sub-complex and the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport and nuclear pore complex organization
YPR062W	FCY1	1.175551	0.354934	35	1.045136	1.322239	29655700	14395880	15259820	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YJR065C	ARP3	0.9792185	0.1958119	35	0.9177107	1.044849	14018810	5887449	8131360	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YKL009W	MRT4	1.077387	1.177365	35	0.7294076	1.591379	45944640	14399300	31545330	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YPR010C	RPA135	1.058821	0.2601956	35	0.9713713	1.154144	17713580	9643911	8069664	RNA polymerase I second largest subunit A135
YNL016W	PUB1	1.060562	0.2315851	35	0.9822346	1.145136	48203200	20671680	27531520	Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly
YNL141W	AAH1	1.236857	0.2985647	35	1.12037	1.365456	18116620	8191286	9925332	Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YEL055C	POL5	0.8994607	0.2009851	35	0.8415192	0.9613916	17895170	8650069	9245100	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YAL036C	RBG1	1.174662	0.6218986	35	0.9559452	1.443421	19063780	9729572	9334208	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
YNR050C	LYS9	1.103162	0.2619817	35	1.011451	1.203189	12495860	5424387	7071473	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
YER021W	RPN3	1.030663	0.2895327	35	0.9363934	1.134424	18643040	7810647	10832390	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YGL043W	DST1	0.972909	0.2511351	34	0.894151	1.058604	23233720	9897727	13336000	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
YIL109C	SEC24	0.9590719	0.2968837	34	0.8679832	1.05972	39132610	17207030	21925580	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
YNL243W	SLA2	0.9917476	0.5370638	34	0.8279406	1.187963	14630230	5956500	8673725	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
YNL052W	COX5A	1.079574	0.2245873	34	1.001075	1.164228	42314440	18159590	24154850	Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YAR002C-A	ERP1	0.9549956	0.4955367	34	0.8084658	1.128083	10091520	4148256	5943265	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YMR296C	LCB1	1.028565	0.5315145	34	0.8602805	1.22977	14147240	7834175	6313063	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YDR516C	EMI2	1.108408	0.3724195	34	0.9779862	1.256221	13790250	6006612	7783641	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YFR004W	RPN11	1.126609	0.285291	34	1.023589	1.239997	11407350	5748886	5658463	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes
YPL235W	RVB2	1.04332	0.2390755	33	0.9615938	1.131991	32549700	14185440	18364260	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family
YGR253C	PUP2	1.021476	0.1815461	33	0.9601234	1.086749	87073090	36831390	50241700	Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YKL195W	MIA40	1.284932	0.7419848	33	0.9975496	1.655107	24028290	11407790	12620500	Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins
YIR037W	HYR1	1.165853	0.5726302	33	0.9589428	1.417408	23422880	11328750	12094130	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
YHR196W	UTP9	0.9156826	0.5518116	33	0.7585404	1.105379	72273770	29585830	42687940	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLR388W	RPS29A	1.269718	0.5948303	33	1.036493	1.555421	63012210	28703450	34308760	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YNL061W	NOP2	1.111814	0.5436043	33	0.9235963	1.338389	15750650	7655031	8095623	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YHR146W	CRP1	0.9861358	0.2139527	33	0.9167136	1.060815	11186830	4651772	6535056	Protein that binds to cruciform DNA structures
YMR241W	YHM2	1.141922	0.5726655	33	0.9392475	1.38833	19639750	8906505	10733250	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
YNL088W	TOP2	0.9948605	0.4612861	33	0.8499821	1.164433	8518392	3405264	5113128	Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
YDR099W	BMH2	1.119288	0.4635929	32	0.9531967	1.31432	113129600	52245250	60884370	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGR159C	NSR1	1.048928	0.109296	32	1.009949	1.089412	67353160	31110880	36242290	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YOL111C	MDY2	0.9926081	0.1114079	32	0.9550226	1.031673	18009870	7530159	10479710	Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with Get4p; has a possible role in insertion of tail-anchored proteins into the ER membrane
YDR101C	ARX1	0.9721343	0.1948453	32	0.9086714	1.04003	32860140	14285530	18574610	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YGR211W	ZPR1	1.241037	0.1799468	32	1.166023	1.320876	29176010	13986180	15189830	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)
YJR117W	STE24	0.9845594	0.2641632	32	0.8984457	1.078927	24633700	7085454	17548250	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
YDL226C	GCS1	1.063853	0.3794584	32	0.9327869	1.213335	20038560	9057826	10980730	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YHR104W	GRE3	0.8383515	0.7242917	32	0.652286	1.077492	37535680	14491470	23044210	Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YMR246W	FAA4	0.9925901	0.2168469	32	0.920746	1.07004	22105190	9286857	12818330	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles
YHR042W	NCP1	0.9892457	0.3808171	32	0.866963	1.128776	17700550	7606122	10094430	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YOR261C	RPN8	1.08695	0.1483037	32	1.032508	1.144263	13384470	5971089	7413384	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
YGR135W	PRE9	1.190546	0.8662444	32	0.8818559	1.607291	29605820	13065960	16539860	Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
YHR141C	RPL42B	0.9582846	0.1352948	32	0.9143995	1.004276	18873390	7906232	10967150	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YMR308C	PSE1	0.8317438	0.2412682	32	0.7650409	0.9042625	23220650	11479020	11741620	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
YML100W	TSL1	0.7670598	0.1638721	32	0.7247205	0.8118727	10199510	3751093	6448415	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5_prime-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YOR206W	NOC2	1.068378	0.5355872	32	0.8874264	1.286227	7952635	3332872	4619763	Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YMR194W	RPL36A	0.8440826	0.1329059	32	0.8060944	0.8838611	3785427	1513561	2271866	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YIL138C	TPM2	1.001788	0.2038884	31	0.9324057	1.076334	39807350	17129550	22677800	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
YHR049W	FSH1	1.048223	0.5072135	31	0.8768173	1.253135	23762470	10818260	12944210	Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
YGR027C	RPS25A	0.8676987	0.1933033	31	0.8106178	0.9287991	70072170	27121670	42950490	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YJR009C	TDH2	0.9329563	0.4269573	31	0.8027618	1.084266	20751660	9122056	11629600	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall
YKR048C	NAP1	0.9856191	0.4613501	31	0.8378696	1.159423	20456430	8900353	11556080	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2
YPL111W	CAR1	1.052632	0.2415975	31	0.9668083	1.146074	18046330	7873962	10172370	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YER156C	YER156C	1.039866	0.2407855	31	0.9553561	1.131851	20315830	9199282	11116550	Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
YDR194C	MSS116	1.01209	0.2576438	31	0.924336	1.108176	10063850	4165123	5898730	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
YPL012W	RRP12	1.002487	0.2806003	31	0.9081965	1.106568	10418260	4542695	5875564	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YDR487C	RIB3	1.045646	0.392119	31	0.9108281	1.20042	10522440	4475863	6046577	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
YKL212W	SAC1	1.024013	0.2517445	31	0.9371694	1.118905	19525320	8343714	11181610	Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance
YBR080C	SEC18	1.056477	0.2299186	31	0.9743378	1.145542	27689930	11519890	16170040	ATPase required for vesicular transport between ER and Golgi, the _primepriming_prime step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
YML001W	YPT7	1.038552	0.4343899	31	0.8912868	1.21015	46250550	19047920	27202630	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YDL130W	RPP1B	1.1036	0.5762383	30	0.8979625	1.356328	127829300	58693660	69135630	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
YDR432W	NPL3	1.09485	0.3832544	30	0.954537	1.255787	53770410	23420560	30349860	RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
YDL007W	RPT2	0.9569386	0.3073235	30	0.8572803	1.068182	16551420	6907652	9643763	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YPR118W	MRI1	1.061674	0.1684468	30	0.9995688	1.127637	19436980	8636605	10800380	5_prime-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YGR128C	UTP8	1.127285	0.3260866	30	1.003128	1.266808	12906830	7037131	5869703	Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YML048W	GSF2	0.9639096	0.1638265	30	0.9090253	1.022108	17101380	7013906	10087480	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YKL172W	EBP2	1.021584	0.3306698	30	0.9075791	1.149909	10357920	4644158	5713764	Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
YCR084C	TUP1	1.067143	0.2496898	30	0.9759294	1.166883	15256210	6670795	8585414	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YGR181W	TIM13	1.098189	0.1031986	30	1.058373	1.139502	15460000	6992181	8467818	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YGR207C	YGR207C	0.9632204	0.325065	30	0.8574469	1.082042	19522300	8328812	11193490	Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR170C	SEC7	1.003218	0.4988548	30	0.8392051	1.199285	7334113	3094884	4239229	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YNR053C	NOG2	1.018222	0.3803162	30	0.8886636	1.166669	18767770	7551294	11216480	Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YAR007C	RFA1	0.965515	0.2018872	30	0.898222	1.037849	8448900	3349120	5099780	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YPL134C	ODC1	0.9727735	0.1745375	30	0.9138751	1.035468	8586208	3534842	5051366	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YDL112W	TRM3	0.8672644	0.2276687	30	0.7994098	0.9408786	4980956	1939559	3041397	2_prime-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YDR174W	HMO1	1.056847	0.2502988	29	0.964824	1.157647	32561560	14839600	17721960	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5_prime-3_prime DNA helicase and Fpr1p, a prolyl isomerase
YPL271W	ATP15	1.077523	0.394872	29	0.9332768	1.244065	53911330	23350720	30560620	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR035W	ARO3	1.027122	0.3213224	29	0.9137588	1.154549	17174810	7497097	9677713	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
YBR082C	UBC4	1.015437	0.240751	29	0.9302463	1.108428	59584890	26548330	33036550	Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YBL091C	MAP2	1.122674	0.6244645	29	0.89443	1.409162	13817040	5879956	7937088	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
YBR052C	RFS1	0.9877819	0.1823523	29	0.9243516	1.055565	15337230	6387358	8949869	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR222C	UTP13	1.067824	0.171088	29	1.003359	1.136431	28316230	13468370	14847860	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR427W	RPN9	0.9732068	0.472366	29	0.8194824	1.155768	20315230	8795151	11520080	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
YKR016W	FCJ1	0.9857773	0.1948696	29	0.9182826	1.058233	8830193	3970655	4859538	Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance
YHR072W-A	NOP10	0.9767501	0.4947152	29	0.8158029	1.16945	6729191	2669566	4059625	Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
YER089C	PTC2	1.080888	0.40441	29	0.9329465	1.252289	13246030	6512573	6733456	Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
YML094W	GIM5	1.002802	0.1618612	29	0.9454318	1.063653	19697400	8510912	11186490	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YER073W	ALD5	1.314391	0.4107071	29	1.131893	1.526313	14933440	8803248	6130189	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOL098C	YOL098C	1.195083	0.8092969	29	0.8901741	1.604432	14980120	6881878	8098243	Putative metalloprotease
YMR074C	YMR074C	1.053202	0.1949931	29	0.9810468	1.130664	18657200	7736525	10920670	Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene
YKL179C	COY1	0.9005707	0.09966392	29	0.8684889	0.9338377	21623320	8192131	13431190	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YMR297W	PRC1	1.012007	0.1888673	29	0.9447783	1.08402	20263430	8517762	11745670	Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YEL042W	GDA1	0.8864454	0.3449721	29	0.7818497	1.005034	14055810	5502696	8553114	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YDR272W	GLO2	1.135951	0.4263328	29	0.9726808	1.326626	16488540	9776817	6711727	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
YBR251W	MRPS5	0.9837061	0.1458148	29	0.9328608	1.037323	76733780	32883110	43850660	Mitochondrial ribosomal protein of the small subunit
YMR062C	ARG7	1.141256	0.3940875	29	0.9887601	1.317272	12837150	5562577	7274574	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YHR051W	COX6	1.061967	0.2010348	28	0.9857607	1.144064	46324180	19694120	26630070	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
YLR038C	COX12	0.9170933	0.3325078	28	0.8108205	1.037295	33133160	14096910	19036250	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated
YDR189W	SLY1	0.8751653	0.4122007	28	0.7512447	1.019527	9667248	4221538	5445710	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YLR167W	RPS31	1.126221	0.8539641	28	0.8208251	1.545242	110107100	49292800	60814300	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YPL260W	YPL260W	0.9884716	0.1981007	28	0.9185372	1.063731	12016950	4786295	7230659	Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
YDR346C	SVF1	0.9760733	0.1973123	28	0.907281	1.050082	11748350	5077705	6670645	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YPL212C	PUS1	0.815454	1.189917	28	0.5247875	1.267113	9584202	4209145	5375057	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YBR227C	MCX1	1.038931	0.1369789	28	0.9875332	1.093004	442564000	206799900	235764000	Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YPR183W	DPM1	0.9468473	0.2682333	28	0.8572956	1.045753	20960310	8379524	12580790	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YGR078C	PAC10	1.097947	0.7201582	28	0.8408782	1.433605	14943530	6473542	8469986	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YJL001W	PRE3	0.9664837	0.575882	28	0.7808279	1.196283	13446130	5859813	7586315	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
YLR175W	CBF5	0.9228227	0.7614906	28	0.6960191	1.223532	18498740	8334035	10164700	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
YOL145C	CTR9	0.8866048	0.3738723	28	0.7719464	1.018294	9341450	3687222	5654228	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats
YMR189W	GCV2	0.8540803	0.1453026	28	0.8093281	0.9013071	8027332	3125434	4901899	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
YPR148C	YPR148C	1.051091	0.1603315	28	0.9904868	1.115404	14446170	6172785	8273387	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL092W	NUP145	0.9421343	0.4786416	28	0.7890711	1.124888	7152372	2915755	4236617	Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p
YOR061W	CKA2	0.9500759	0.1834618	28	0.8876581	1.016883	15808360	6532824	9275532	Alpha_prime catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YBR159W	IFA38	0.9889171	0.949161	28	0.695782	1.405551	20282360	10625350	9657013	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YOR270C	VPH1	0.8710284	0.2477754	27	0.7933092	0.9563615	23557590	9490982	14066610	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
YMR276W	DSK2	1.090133	0.2345959	27	0.9978117	1.190995	52624470	23260020	29364440	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
YGR130C	YGR130C	1.007887	0.3904924	27	0.8698465	1.167834	9879985	4168905	5711080	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; possible component of the eisosome; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YJR002W	MPP10	1.052117	0.2380682	27	0.9617548	1.150969	9146960	3915854	5231106	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YDR395W	SXM1	0.946165	0.5636766	27	0.7649397	1.170325	7313689	3016653	4297036	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
YJL172W	CPS1	0.9511391	0.1763249	27	0.8899365	1.016551	21477430	9077208	12400220	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YOL057W	YOL057W	0.9186416	0.2148362	27	0.8471344	0.9961848	10805870	4552525	6253348	Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
YDR177W	UBC1	1.016042	0.2122417	27	0.9378706	1.100729	34969600	14630730	20338870	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response
YGR232W	NAS6	1.159875	0.55096	27	0.9422249	1.427801	7158095	3129906	4028189	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
YER081W	SER3	1.022913	0.2555109	27	0.9289269	1.126407	17246220	7287771	9958445	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YHR158C	KEL1	1.121146	0.4940977	27	0.930509	1.350839	7444691	3409873	4034818	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YJL061W	NUP82	1.011393	0.1401192	27	0.9593257	1.066286	8849153	3827364	5021789	Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC
YLR344W	RPL26A	1.124717	0.1890255	27	1.047316	1.207838	55257980	24568680	30689290	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YMR128W	ECM16	1.095563	0.4420453	27	0.9273056	1.29435	11004540	5385180	5619356	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YLR129W	DIP2	0.7075973	1.032279	27	0.4793818	1.044458	43496150	3805788	39690360	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YML103C	NUP188	1.070017	0.487627	27	0.8902445	1.286093	5443096	2249621	3193475	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YDL061C	RPS29B	1.050123	0.3171624	27	0.9317161	1.183577	13710490	5822035	7888452	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
YOR232W	MGE1	1.355589	1.050315	26	0.9052975	2.029855	32609930	14242910	18367020	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YLR447C	VMA6	0.8873707	0.4714923	26	0.7402789	1.063689	28362350	12483150	15879200	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YPL059W	GRX5	0.9220721	0.1012479	26	0.8868758	0.9586652	16702720	6963458	9739264	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
YPR004C	AIM45	1.185613	0.4500506	26	0.9972696	1.409526	13087520	6052581	7034944	Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss
YCL035C	GRX1	0.9342322	0.1008425	26	0.8987118	0.9711565	15790860	6240333	9550532	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YHR197W	RIX1	0.9383042	0.2816931	26	0.8420125	1.045608	7654002	3194194	4459808	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YOL005C	RPB11	0.9630816	0.2215381	26	0.8844639	1.048687	7098147	2950383	4147764	RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YIL022W	TIM44	1.060381	0.3510356	26	0.926533	1.213564	9543542	4660366	4883176	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
YJR060W	CBF1	1.002311	0.1803223	26	0.9351905	1.074249	11063970	4800134	6263836	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA
YHR107C	CDC12	0.958217	0.2838153	26	0.8591806	1.068669	9496129	4827507	4668622	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR128C	ADE2	0.8717166	1.06048	26	0.5798845	1.310416	12504980	5507738	6997246	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the _primede novo_prime purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
YOL077W-A	ATP19	1.238856	0.8121232	26	0.9066652	1.692756	51775490	26780210	24995280	Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YNL084C	END3	1.089246	0.3076453	26	0.9677616	1.22598	9732158	4304124	5428034	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
YGL078C	DBP3	1.143377	0.5161535	26	0.9376141	1.394295	8573487	3736680	4836807	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YGL167C	PMR1	1.292568	1.031637	26	0.8694301	1.921642	31834920	25517350	6317571	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YER087C-B	SBH1	0.8774922	0.2711295	26	0.7906451	0.9738788	17831350	7483319	10348030	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
YOL038W	PRE6	1.101622	0.1527556	26	1.0388	1.168244	9198922	4010342	5188580	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YDR211W	GCD6	1.208448	0.5209201	26	0.9891609	1.476349	15334550	6761112	8573442	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YOR165W	SEY1	1.004044	0.2737283	26	0.9037684	1.115445	9768872	4050637	5718235	GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3
YNL037C	IDH1	1.00417	0.276449	25	0.9010391	1.119105	34704290	14427800	20276500	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YDR148C	KGD2	0.9848123	0.2303379	25	0.8997874	1.077871	27207660	11762780	15444880	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YNL015W	PBI2	0.9262737	0.1571382	25	0.8709386	0.9851244	49322310	20693110	28629190	Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YER080W	AIM9	1.198412	0.3107271	25	1.06098	1.353647	44876560	19091050	25785500	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YIL070C	MAM33	1.024424	0.1351285	25	0.9715724	1.080151	45661810	19444320	26217490	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
YPL243W	SRP68	0.8890258	0.3525511	25	0.7742743	1.020784	10793750	4388136	6405618	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YLR351C	NIT3	1.000408	0.214346	25	0.9197845	1.088098	10111580	4268776	5842808	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YKL145W	RPT1	1.029965	0.1290691	25	0.9791499	1.083417	19001550	8248292	10753260	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
YBR218C	PYC2	1.021616	0.2264047	25	0.9348543	1.116431	8923208	3907914	5015294	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YLR438C-A	LSM3	1.025638	0.2092321	25	0.9448736	1.113306	13474230	5627653	7846578	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YKL040C	NFU1	1.120394	0.3721111	25	0.9683251	1.296344	14353170	5943001	8410170	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YDL178W	DLD2	1.016428	0.2540737	25	0.9200728	1.122874	9668390	4055177	5613213	D-lactate dehydrogenase, located in the mitochondrial matrix
YDR496C	PUF6	1.167288	0.8161309	25	0.8476903	1.607382	27768240	11631670	16136570	Pumilio-homology domain protein that binds the 3_prime UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
YKR081C	RPF2	0.9929269	0.1820157	25	0.9245498	1.066361	4362651	1932829	2429822	Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YOL143C	RIB4	0.6362612	0.2776149	25	0.5706546	0.7094104	38824140	17841730	20982410	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
YFR002W	NIC96	1.049846	0.6164365	25	0.824482	1.33681	9482132	3839778	5642354	Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
YMR092C	AIP1	0.9669679	0.1819448	25	0.9004035	1.038453	5637746	2489317	3148429	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats
YER049W	TPA1	1.138182	0.2419912	25	1.035176	1.251437	8066687	3523572	4543115	Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
YER125W	RSP5	0.9448394	0.2432581	25	0.8589046	1.039372	15847080	6700931	9146144	E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including MVB sorting, heat shock response, transcription, and endocytosis; the human homolog is invovled in Liddle syndrome
YFR006W	YFR006W	1.034592	0.2172371	25	0.9501368	1.126555	5599063	2412893	3186170	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
YOL144W	NOP8	0.9898267	0.2116902	25	0.911004	1.075469	17319060	7468053	9851006	Nucleolar protein required for 60S ribosomal subunit biogenesis
YOR124C	UBP2	0.9821237	0.1393218	25	0.9299242	1.037253	3408199	1476467	1931732	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
YDL225W	SHS1	1.100429	0.3427312	25	0.9620871	1.258664	8632332	3928840	4703492	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
YNL313C	YNL313C	1.111181	0.242529	25	1.010406	1.222007	13624630	5951819	7672809	Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to cytoplasm and nucleus
YER133W	GLC7	0.9934922	0.2232056	24	0.9086185	1.086294	12308290	5379946	6928345	Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits
YPR035W	GLN1	1.072619	0.1925906	24	0.9930748	1.158534	43650270	19441410	24208860	Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YLR056W	ERG3	0.7015281	0.4941478	24	0.575685	0.8548801	24470600	9111963	15358630	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YFR033C	QCR6	0.9145384	0.1392044	24	0.8649971	0.9669172	82556510	34505160	48051350	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YOR239W	ABP140	1.055699	0.3148016	24	0.9307692	1.197397	8858473	3758567	5099906	Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases
YKL192C	ACP1	1.029336	0.08987547	24	0.9929806	1.067022	30551320	13608700	16942620	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YBR101C	FES1	1.659866	0.2958323	24	1.474589	1.868422	5446779	2827848	2618931	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YHR190W	ERG9	0.9128464	0.3024405	24	0.8088117	1.030263	14359260	5904537	8454720	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YER031C	YPT31	0.9358307	0.2107824	24	0.8601477	1.018173	21334380	8845291	12489090	Rab family GTPase, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YIL063C	YRB2	1.130067	0.6265644	24	0.8795003	1.452018	10980890	5214770	5766116	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
YOR272W	YTM1	0.9985045	0.6155731	24	0.7805339	1.277345	12671910	5936440	6735471	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YER063W	THO1	0.9758386	0.1809448	24	0.9076912	1.049102	12016240	5268837	6747403	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YPL217C	BMS1	0.8749132	0.7102801	24	0.6584927	1.162463	8423864	3382328	5041536	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
YCR009C	RVS161	0.9383621	0.1602395	24	0.8800922	1.00049	10264580	4306032	5958548	Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YPL126W	NAN1	1.060795	0.2181038	24	0.9721537	1.157518	43344980	19736460	23608520	U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
YMR125W	STO1	1.083618	0.9819897	24	0.7315629	1.605096	6535713	2587646	3948067	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YDL031W	DBP10	1.180005	0.6317536	24	0.9164616	1.519335	6274241	3027812	3246429	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YOR089C	VPS21	0.9876724	0.2127136	24	0.9070957	1.075407	10393620	4213246	6180371	Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
YEL003W	GIM4	1.006252	0.3159152	24	0.8867787	1.141822	12531240	5625877	6905360	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YPR060C	ARO7	1.047628	0.215663	24	0.9610254	1.142035	9151335	4282962	4868373	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YHR099W	TRA1	0.9207509	0.2451824	24	0.8347199	1.015649	4420519	1798329	2622190	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
YKL014C	URB1	0.901458	0.3663198	24	0.778567	1.043747	7567341	3083940	4483401	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YGL238W	CSE1	0.8756364	0.2571709	24	0.7900223	0.9705284	5650782	2267144	3383638	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YML091C	RPM2	0.9355059	0.2348472	24	0.8516102	1.027666	6818269	2906227	3912042	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YLR309C	IMH1	1.045866	0.2151362	24	0.9596116	1.139874	2749202	1126397	1622805	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
YLR048W	RPS0B	0.9539239	0.1194829	23	0.9084617	1.001661	93722840	41896380	51826460	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGL099W	LSG1	1.026126	0.2630421	23	0.9215376	1.142584	7919777	3399801	4519976	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YHR025W	THR1	1.034685	0.2005987	23	0.9532435	1.123085	13238730	5731602	7507127	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YBR034C	HMT1	1.054003	0.2779051	23	0.9408409	1.180776	21586310	9383911	12202400	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; also methylates ribosomal protein Rps2p
YOL061W	PRS5	0.9848333	0.3340008	23	0.8591729	1.128872	10301580	5173870	5127710	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YLR025W	SNF7	0.9125474	0.2408053	23	0.8270174	1.006923	18562010	7713435	10848580	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YNL248C	RPA49	1.013321	0.1679384	23	0.9461053	1.085312	11713680	4917577	6796099	RNA polymerase I subunit A49
YMR290C	HAS1	1.017263	0.2592501	23	0.9149948	1.130961	26136550	11084680	15051870	ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YKR035W-A	DID2	1.052235	0.3070426	23	0.928144	1.192916	8405228	3703437	4701791	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
YEL071W	DLD3	1.130278	0.1851823	23	1.047893	1.21914	5146349	2373735	2772614	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
YMR033W	ARP9	1.151073	0.3962606	23	0.978972	1.35343	5249301	2528247	2721054	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YDR347W	MRP1	0.9733821	0.3538623	23	0.8423178	1.12484	8631356	3543857	5087499	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
YDR457W	TOM1	1.03426	0.357632	23	0.8936209	1.197033	21843680	12391720	9451962	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones
YNR017W	TIM23	0.9122423	0.2422892	23	0.8262397	1.007197	8114073	3311636	4802437	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YJL200C	ACO2	1.133473	0.8296951	23	0.8075098	1.591017	12486720	6717685	5769036	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YLL048C	YBT1	2.217932	1.824302	23	1.052328	4.674611	9335053	4990025	4345028	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters
YLR248W	RCK2	1.123344	0.463324	23	0.9295591	1.357528	9616774	4116576	5500198	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YDL208W	NHP2	0.9830899	0.2013612	23	0.9054269	1.067414	15252270	6670852	8581414	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YER151C	UBP3	0.9376058	0.4097387	23	0.7930404	1.108524	7625997	3168571	4457426	Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
YDR258C	HSP78	1.990319	0.5010038	23	1.621806	2.442567	6298589	3679605	2618984	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
YJL050W	MTR4	0.9559434	0.2603064	23	0.8594688	1.063247	7991494	3424808	4566686	ATP-dependent 3_prime-5_prime RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity
YMR300C	ADE4	1.22294	0.3995597	23	1.038692	1.439871	10725280	4647309	6077973	Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the _primede novo_prime purine nucleotide biosynthetic pathway
YGL191W	COX13	0.9922132	0.2118482	23	0.9099213	1.081947	5844347	2420833	3423514	Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YBR015C	MNN2	0.8626793	0.3385921	23	0.7511944	0.9907098	8540820	3224365	5316455	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YJL039C	NUP192	0.9887771	0.3989003	23	0.8400346	1.163857	18142150	7176602	10965540	Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YKL024C	URA6	0.928005	0.1698976	22	0.8644051	0.9962845	14025180	6203806	7821372	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5_prime-diphosphate (UDP)
YLR200W	YKE2	1.004383	0.1528956	22	0.9422194	1.070649	26487140	11809920	14677220	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
YEL037C	RAD23	1.055384	0.2356822	22	0.9563988	1.164615	34275750	15332560	18943190	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that recognizes and binds damaged DNA; enhances protein deglycosylation activity of Png1p; homolog of human HR23A and HR23B
YBR154C	RPB5	0.9864176	0.1262325	22	0.9357334	1.039847	9449280	3971953	5477327	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YPR133C	SPN1	1.038447	0.1897505	22	0.9592871	1.12414	9440749	4106997	5333752	Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype
YMR109W	MYO5	0.8106802	0.185885	22	0.7500931	0.8761612	7398144	2735686	4662458	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YLL021W	SPA2	1.265484	0.682596	22	0.9514347	1.683194	7109408	3388449	3720959	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YBL003C	HTA2	0.8499706	0.1574473	22	0.7958484	0.9077734	18388390	7336242	11052140	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YNL154C	YCK2	0.9670421	0.2576785	22	0.8683241	1.076983	17293610	8340728	8952881	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
YMR237W	BCH1	0.9347098	0.1753058	22	0.8686849	1.005753	11531250	4541794	6989460	Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes
YNL189W	SRP1	0.9574814	0.1138778	22	0.9129853	1.004146	15985940	6914555	9071383	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YEL058W	PCM1	1.01704	0.4064	22	0.8581923	1.20529	21534440	8970379	12564060	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YJL158C	CIS3	0.9271885	0.1293946	22	0.8783861	0.9787022	13467950	5569680	7898270	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YLR133W	CKI1	1.0179	0.266899	22	0.9104753	1.137999	5818934	2453782	3365152	Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
YIL021W	RPB3	0.7903778	0.7590198	22	0.5755562	1.08538	5858267	2586255	3272012	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YFL004W	VTC2	1.045939	0.343304	22	0.9061573	1.207284	12286020	7845726	4440297	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
YGR020C	VMA7	1.069897	0.3259179	22	0.9336723	1.225998	14242750	6450642	7792112	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YBL068W	PRS4	1.109211	0.2787416	22	0.9872526	1.246236	5087563	2273148	2814415	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YKR014C	YPT52	0.8785747	0.2563791	22	0.7893162	0.9779269	16525620	6592580	9933038	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YMR015C	ERG5	0.8955443	0.5096904	22	0.7237497	1.108117	5822860	2317094	3505767	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YOR098C	NUP1	1.098962	0.5400866	22	0.8769359	1.377202	8148752	3570662	4578090	Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
YDR299W	BFR2	1.120044	0.409188	22	0.9440075	1.328907	3182245	1368526	1813719	Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
YHR216W	IMD2	0.8145793	0.3025904	22	0.7178261	0.9243736	15574910	5822132	9752778	Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio
YGR173W	RBG2	1.234579	0.3184697	22	1.080744	1.410311	5316146	2446948	2869198	Protein with similarity to mammalian developmentally regulated GTP-binding protein
YHR205W	SCH9	0.8978274	0.9643474	22	0.6000438	1.343392	6338040	2614156	3723885	Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
YEL038W	UTR4	0.9714997	0.4701409	22	0.7982179	1.182399	9440737	5873353	3567384	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
YDR458C	HEH2	0.9240639	0.295756	22	0.8166353	1.045625	7526456	2918231	4608225	Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
YBL017C	PEP1	1.091685	0.8746827	22	0.7574601	1.573384	11162030	4743617	6418415	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YOR122C	PFY1	0.9846958	0.2359725	21	0.8901639	1.089267	22519930	9615465	12904470	Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress
YOR224C	RPB8	0.965289	0.1182472	21	0.9176833	1.015364	29866600	12984810	16881790	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YBR086C	IST2	0.8378045	0.07793927	21	0.8103365	0.8662036	18650330	7411151	11239180	Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
YHR179W	OYE2	0.9073935	0.1959754	21	0.834436	0.9867298	25010570	10570920	14439650	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death
YLR372W	SUR4	0.925598	0.2890849	21	0.8179461	1.047418	21650000	9123846	12526160	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YMR173W	DDR48	1.021457	0.3999292	21	0.8608606	1.212013	10971870	4896649	6075225	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YAL021C	CCR4	1.0418	0.1229748	21	0.9884202	1.098062	21205320	9287206	11918110	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YPL129W	TAF14	0.9523625	0.1981698	21	0.8749678	1.036603	21048150	9182827	11865320	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
YML125C	PGA3	0.9604612	0.1669519	21	0.8942694	1.031552	11004160	4764315	6239842	Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking
YDL132W	CDC53	0.9327719	0.1855835	21	0.861595	1.009829	15232810	6589852	8642956	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YCR083W	TRX3	1.076162	0.1960878	21	0.9895879	1.170311	20247590	8705393	11542200	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
YER052C	HOM3	0.9771574	0.2225762	21	0.888425	1.074752	10185320	4557835	5627487	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YDR372C	VPS74	0.9315218	0.2464438	21	0.8383317	1.035071	5914788	2670660	3244129	Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function
YFL023W	BUD27	0.8705343	0.3817403	21	0.7393964	1.024931	26499370	9063884	17435490	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding
YKR028W	SAP190	1.012829	0.6853213	21	0.7555044	1.357798	23294310	10302510	12991800	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
YBL079W	NUP170	0.8409175	0.2828371	21	0.7451028	0.9490534	4828975	1830037	2998938	Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly
YCL026C-B	HBN1	0.7248887	0.5108355	21	0.5826171	0.9019022	14101680	4969448	9132228	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion
YEL026W	SNU13	0.998887	0.2022172	21	0.9161242	1.089127	14470190	6046075	8424111	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YNL208W	YNL208W	0.8299678	0.2919826	21	0.7325297	0.9403667	17056230	6742989	10313240	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YOR151C	RPB2	1.116335	0.2887263	21	0.9866504	1.263065	7609011	3286805	4322206	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YDR074W	TPS2	0.8498298	0.1723057	21	0.7894525	0.9148247	4352550	1602545	2750005	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YOL022C	TSR4	1.009285	0.1659308	21	0.9401393	1.083517	5373981	2307452	3066529	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
YLR399C	BDF1	0.9726253	0.2049206	21	0.8910075	1.061719	4432367	1734505	2697862	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YHL030W	ECM29	0.9293113	0.2178095	21	0.846648	1.020045	4860636	1874790	2985846	Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YBR081C	SPT7	1.095367	0.2845191	21	0.969862	1.237113	8655601	3638353	5017248	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YMR278W	PGM3	1.048079	0.5316713	21	0.8349019	1.315686	8168833	3183773	4985060	Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
YPR189W	SKI3	0.9882019	0.5314837	21	0.7872672	1.240421	5732144	2564818	3167326	Ski complex component and TPR protein, mediates 3_prime-5_prime RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5_prime-3_prime mRNA decay
YLR069C	MEF1	1.205879	0.6810353	21	0.9011579	1.61364	3945251	1719916	2225335	Mitochondrial elongation factor involved in translational elongation
YNL085W	MKT1	1.076726	0.2493004	21	0.9678264	1.197879	17088930	7911360	9177571	Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability
YBR112C	CYC8	0.9667254	0.1054915	21	0.9240767	1.011343	17050130	7722167	9327967	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]
YOR109W	INP53	0.8441595	0.3093401	21	0.7395446	0.9635732	4018258	1661022	2357236	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
YDR356W	SPC110	1.195794	0.7484292	21	0.8682302	1.646939	3926512	1792098	2134414	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
YKL016C	ATP7	1.015456	0.1387996	20	0.9555255	1.079145	25837860	11366130	14471730	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPL143W	RPL33A	0.9482565	0.07822738	20	0.9162968	0.9813308	149397300	65807290	83590000	N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YKL067W	YNK1	0.9246078	0.3223347	20	0.8027957	1.064903	36671080	15173530	21497550	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YDL051W	LHP1	0.951268	0.3751518	20	0.8070441	1.121266	27370850	11951370	15419480	RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YNL149C	PGA2	0.9054243	0.2699468	20	0.8043981	1.019139	14430280	6378823	8051455	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
YOR153W	PDR5	0.7929902	0.2378721	20	0.7144827	0.8801241	8169706	3264958	4904748	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YNL298W	CLA4	0.9467867	0.2149407	20	0.8616696	1.040312	32538030	13552300	18985730	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
YJL104W	PAM16	1.168252	0.6225253	20	0.8892957	1.534711	10620190	4803002	5817190	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
YBL075C	SSA3	1.110607	0.2467465	20	0.9967708	1.237444	25105050	11153540	13951510	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YFR011C	AIM13	1.010476	0.157715	20	0.9429891	1.082792	10518630	4664852	5853778	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
YMR208W	ERG12	1.143279	0.2110861	20	1.042256	1.254093	8454990	3747322	4707668	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YKL181W	PRS1	0.9340244	0.2864708	20	0.8238193	1.058972	11311620	4553116	6758501	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YMR129W	POM152	0.8727246	0.2114025	20	0.7954984	0.9574479	5035372	2007346	3028026	Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;
YCR004C	YCP4	1.0657	0.3589761	20	0.9105591	1.247273	12939220	5788947	7150274	Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL076W	NET1	1.208988	0.8312025	20	0.8398709	1.740329	9900644	4864011	5036633	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
YIL027C	KRE27	1.018351	0.2078316	20	0.9296923	1.115464	7707919	3348793	4359126	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance
YFL016C	MDJ1	1.260025	0.1940688	20	1.157285	1.371885	5088571	2532391	2556180	Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YMR049C	ERB1	1.130785	0.2478631	20	1.014383	1.260543	30359890	12745460	17614430	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
YGL027C	CWH41	1.028599	0.3410867	20	0.885777	1.19445	4647883	2056253	2591630	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
YKR082W	NUP133	0.9055749	0.3950565	20	0.7616056	1.076759	8264051	3563881	4700170	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YER055C	HIS1	1.058953	0.2103659	20	0.9656867	1.161228	8546874	3663820	4883054	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YJL217W	REE1	1.253436	0.6526174	20	0.9416389	1.668477	6360464	2783336	3577128	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
YLR185W	RPL37A	0.894017	0.1087984	20	0.852388	0.9376791	3370451	1259312	2111139	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YGL129C	RSM23	1.052599	0.5816116	20	0.8157558	1.358206	5827074	2401089	3425985	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
YHR128W	FUR1	0.9913885	0.1367344	19	0.9322707	1.054255	174848400	70202070	104646300	Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YDR429C	TIF35	1.266554	0.5865191	19	0.9729414	1.648772	15348350	6928728	8419625	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation
YJR069C	HAM1	0.9776506	0.08629975	19	0.9404394	1.016334	18311450	7767375	10544080	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YDL219W	DTD1	1.014705	0.180257	19	0.9357046	1.100375	20365950	8210309	12155640	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YAL044C	GCV3	1.057175	0.3264858	19	0.9128297	1.224345	10306320	4437722	5868601	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
YLR347C	KAP95	1.006226	0.1913861	19	0.9232542	1.096655	11054820	4775296	6279528	Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
YDL135C	RDI1	1.290547	0.5910545	19	0.9893528	1.683436	12815850	6911648	5904202	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YGR279C	SCW4	1.068595	0.1493527	19	0.9991876	1.142823	6802959	2901281	3901678	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YPR103W	PRE2	1.139413	0.2096872	19	1.03689	1.252072	16493960	7232097	9261865	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YGL097W	SRM1	1.060192	0.2018094	19	0.9682217	1.160899	12513610	5507639	7005970	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YGR132C	PHB1	1.017096	0.2067154	19	0.9268167	1.116168	4436870	1917820	2519050	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YOR176W	HEM15	0.8951654	0.2655866	19	0.7943993	1.008713	11400720	5138933	6261789	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YJL020C	BBC1	1.034062	0.3691928	19	0.8758899	1.220797	12619500	5250367	7369135	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YML069W	POB3	1.067076	0.2532098	19	0.9522435	1.195757	5691235	2634220	3057015	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
YHR063C	PAN5	0.9520012	0.1631859	19	0.8846472	1.024483	5019447	2014096	3005351	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YGL001C	ERG26	1.043333	0.2627631	19	0.9270642	1.174183	7181004	3074982	4106023	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YHR018C	ARG4	1.079385	0.1364426	19	1.015153	1.147681	15781290	6359105	9422186	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YJL033W	HCA4	1.008108	0.4184572	19	0.8351984	1.216815	5596121	2157590	3438531	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YKL213C	DOA1	1.190976	0.6471101	19	0.8902942	1.593207	8579277	3571596	5007681	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YGR229C	SMI1	1.078245	0.2001448	19	0.9854453	1.179783	9027746	4024965	5002781	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YNL166C	BNI5	0.9018237	0.3593927	19	0.7672528	1.059997	4230433	2243595	1986838	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
YOR243C	PUS7	0.9798596	0.3364249	19	0.8422983	1.139887	6766640	3386721	3379919	Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
YPR129W	SCD6	1.002352	0.2147184	19	0.9101004	1.103954	6734866	3034271	3700595	Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin
YBL064C	PRX1	0.9473413	0.3541928	19	0.807865	1.110898	12688480	5303427	7385048	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated
YDR232W	HEM1	1.284638	0.4925797	19	1.02941	1.603146	8446809	3787600	4659209	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YDR477W	SNF1	1.003349	0.3470796	19	0.8583681	1.172818	13420020	5526516	7893502	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YDR519W	FPR2	1.012245	0.2461533	19	0.9061833	1.13072	9140009	4087577	5052432	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking
YJR068W	RFC2	1.215748	1.128127	19	0.7320491	2.01905	5135931	2198230	2937701	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YLR452C	SST2	0.9708095	0.1986288	19	0.8878615	1.061507	3407450	1388532	2018918	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
YOL010W	RCL1	0.8818801	0.4132516	19	0.7323332	1.061966	4688588	2026127	2662461	Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected
YBR049C	REB1	1.111481	0.447023	19	0.9090888	1.358933	4775223	2017627	2757596	RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YLR389C	STE23	1.13549	0.3703166	19	0.9613176	1.341219	6437003	3231924	3205079	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
YLR181C	VTA1	0.7854793	0.8490092	19	0.5362138	1.150619	5230376	1880908	3349468	Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain
YOR257W	CDC31	0.9595586	0.2413895	19	0.8608596	1.069574	16027910	6182763	9845151	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YPR020W	ATP20	0.8032768	0.4352891	19	0.6604818	0.9769439	10101950	3804673	6297276	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YHR098C	SFB3	0.9359739	0.1677655	19	0.8679646	1.009312	5351666	1969650	3382016	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
YNR051C	BRE5	1.066836	1.227404	19	0.6143377	1.852629	5150417	1957282	3193135	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YDR056C	YDR056C	1.037371	0.2967083	19	0.9078041	1.18543	4284297	1627177	2657120	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein
YFR014C	CMK1	1.112848	0.6651001	19	0.8251886	1.500784	2828255	1202471	1625784	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
YBR221C	PDB1	0.9591672	0.1381356	18	0.8998697	1.022372	74286630	32022970	42263660	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
YDR161W	YDR161W	0.9772068	0.3273488	18	0.840058	1.136747	13174530	5657983	7516551	Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
YML079W	YML079W	0.9813162	0.2394487	18	0.878552	1.096101	9936521	4149270	5787251	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
YGL221C	NIF3	0.9554103	0.2042144	18	0.8693959	1.049935	15125100	6358117	8766983	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR419W	YLR419W	0.9347559	0.4207269	18	0.7696375	1.135299	13853810	5999539	7854268	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
YMR142C	RPL13B	1.158182	0.608991	18	0.8741633	1.534479	41687150	17585970	24101180	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YNL153C	GIM3	1.051896	0.2013763	18	0.9584506	1.154451	5290490	2368918	2921572	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YDL004W	ATP16	1.019548	0.1739363	18	0.9408281	1.104855	17366240	7744511	9621734	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YLL001W	DNM1	1.047764	0.2781992	18	0.9213983	1.191461	6022552	2519808	3502744	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
YJL145W	SFH5	1.084447	0.3621085	18	0.9173965	1.281916	8232447	3629266	4603181	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p
YBL036C	YBL036C	1.123205	0.365988	18	0.9484824	1.330113	12695480	5725804	6969672	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5_prime-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
YOR042W	CUE5	1.060063	0.3145021	18	0.9167102	1.225834	18731340	9053658	9677686	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDL053C	PBP4	0.9981424	0.2004392	18	0.9098664	1.094983	11953640	5056996	6896645	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay
YPR024W	YME1	1.171193	0.7011851	18	0.8471243	1.619235	4717364	2095419	2621945	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YDL205C	HEM3	1.173878	0.2319056	18	1.054617	1.306625	8900210	4382902	4517308	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
YDR081C	PDC2	1.414586	0.3747475	18	1.189714	1.681963	35962770	21320370	14642400	Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
YER083C	GET2	0.8719457	0.164008	18	0.8083211	0.9405784	5674701	2239932	3434769	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
YNL137C	NAM9	1.186951	0.96991	18	0.7582911	1.857931	14875820	6486014	8389806	Mitochondrial ribosomal component of the small subunit
YFL037W	TUB2	0.9322428	0.2279598	18	0.8390592	1.035775	6799590	3226805	3572785	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YML124C	TUB3	1.038286	0.239482	18	0.9295416	1.159752	7735046	3313186	4421860	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YDL092W	SRP14	0.9834956	0.164248	18	0.9116302	1.061026	5994863	2497367	3497496	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YFL048C	EMP47	1.005048	0.1793921	18	0.9251131	1.09189	4568923	1810932	2757991	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YGR275W	RTT102	1.124408	0.2159242	18	1.017659	1.242355	5374041	2513308	2860733	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
YBL041W	PRE7	1.068769	0.1322916	18	1.005407	1.136125	4826472	2064301	2762171	Beta 6 subunit of the 20S proteasome
YDR165W	TRM82	0.9554939	0.3526922	18	0.8118316	1.124579	10784420	4317627	6466793	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YGL020C	GET1	0.9679219	0.3274004	18	0.8320563	1.125973	6404643	2599747	3804896	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YLR380W	CSR1	0.8996316	0.2103329	18	0.8163282	0.9914358	6011523	2663099	3348424	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YNR021W	YNR021W	0.8636219	0.3404033	18	0.7379505	1.010695	8097291	3428861	4668430	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
YJL087C	TRL1	1.133674	0.3330532	18	0.9720006	1.322239	6290147	2820037	3470110	tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope
YJL148W	RPA34	0.9167332	0.9010761	18	0.604584	1.390046	8940837	3284303	5656534	RNA polymerase I subunit A34.5
YKL193C	SDS22	1.117885	0.6131079	18	0.8421455	1.48391	7643102	3191120	4451982	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
YGL083W	SCY1	1.074932	0.4328852	18	0.8800954	1.312903	2556370	1039026	1517344	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YML029W	USA1	0.9382606	0.2100158	18	0.851505	1.033855	21855070	9685064	12170010	Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p
YMR244C-A	YMR244C-A	0.9367267	0.7429128	18	0.6645987	1.320281	5327569	2301124	3026445	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YPL127C	HHO1	0.8267817	0.2481243	18	0.7372397	0.927199	5891545	2255374	3636171	Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
YCR030C	SYP1	1.027274	0.2037981	18	0.9349697	1.128691	4145050	1727882	2417168	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
YLR163C	MAS1	0.9859557	0.2177081	18	0.8916159	1.090277	3983989	1707491	2276498	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YNL001W	DOM34	0.8811022	0.5996175	18	0.6679173	1.162331	2739760	1165867	1573893	Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota
YCR077C	PAT1	0.9651364	0.2017252	18	0.8792569	1.059404	13124450	4928820	8195626	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3_prime-UTRs from trimming; functionally linked to Pab1p
YOL090W	MSH2	1.172258	0.6833296	18	0.8549175	1.607394	13067920	5654716	7413201	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
YLR330W	CHS5	0.8146489	0.265372	18	0.7206558	0.9209012	5460531	2057657	3402874	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
YNL157W	IGO1	1.035045	0.2745956	18	0.9117296	1.175039	3589906	1501917	2087989	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5_prime-3_prime mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
YBR204C	YBR204C	0.9720615	0.1145096	18	0.9219752	1.024869	11751470	4755460	6996014	Serine hydrolase; YBR204C is not an essential gene
YEL051W	VMA8	1.010466	0.2913564	18	0.8832138	1.156053	7678414	3064907	4613507	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YDR324C	UTP4	1.125097	0.3412694	18	0.9609924	1.317226	4376906	1975323	2401583	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YCR028C-A	RIM1	1.025406	0.1526473	17	0.9536337	1.102579	44578080	19847170	24730910	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YEL020W-A	TIM9	0.9472868	0.2407703	17	0.8448397	1.062157	6355018	3038835	3316183	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YOR340C	RPA43	1.019186	0.1164237	17	0.9643127	1.077183	16175710	6653731	9521977	RNA polymerase I subunit A43
YIL162W	SUC2	1.261279	0.1984243	17	1.147747	1.386041	8579114	4167107	4412007	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YBR126C	TPS1	0.8623435	0.2111816	17	0.7799769	0.9534081	6191414	2651600	3539814	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YDL095W	PMT1	0.8286896	0.1468012	17	0.7728313	0.8885851	8566479	3354471	5212008	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; one of seven related proteins involved in O-glycosylation which is essential for cell wall rigidity
YJL068C	YJL068C	0.9767724	0.1904336	17	0.892233	1.069322	5985871	2485179	3500692	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YDL201W	TRM8	0.8295025	0.5450719	17	0.6401582	1.074851	3727366	1533590	2193776	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YBR191W	RPL21A	1.099383	0.1157204	17	1.040539	1.161554	34360670	15727920	18632750	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YOL041C	NOP12	1.234595	0.739568	17	0.8686407	1.754723	11255610	4724722	6530889	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
YGL122C	NAB2	0.9569219	0.2174695	17	0.8629384	1.061141	9646221	3862009	5784212	Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p
YJR143C	PMT4	0.9693805	0.3897389	17	0.8054387	1.166692	8028463	3524983	4503480	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
YBR256C	RIB5	0.9544205	0.1780938	17	0.8769447	1.038741	9416083	3875699	5540384	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YLR186W	EMG1	1.081371	0.6165347	17	0.8066608	1.449635	7170846	2870516	4300330	Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
YPL112C	PEX25	0.9896518	0.151216	17	0.9210088	1.063411	101081000	43570600	57510430	Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YPL207W	TYW1	0.7030212	1.04702	17	0.4273764	1.156448	4539486	1830142	2709344	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3_prime-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YOR056C	NOB1	0.9446777	0.3034949	17	0.8177621	1.09129	5541790	2508058	3033732	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
YCL011C	GBP2	1.01893	0.4338693	17	0.8290331	1.252325	4289243	1908947	2380296	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro
YGR136W	LSB1	0.9206162	0.2402895	17	0.8212412	1.032016	22707740	9432144	13275600	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YEL060C	PRB1	0.9524478	0.2064688	17	0.8634071	1.050671	3838836	1680128	2158708	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p
YJR051W	OSM1	0.842573	0.4599404	17	0.6770997	1.048486	3594680	1442897	2151783	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YOR260W	GCD1	1.00799	0.1261928	17	0.9493006	1.070308	5330777	2253001	3077776	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YGL153W	PEX14	1.026162	0.2802941	17	0.8981504	1.172419	3718862	1584629	2134233	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
YCL030C	HIS4	1.314931	0.4402407	17	1.066633	1.621029	7603499	3372889	4230610	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
YGL107C	RMD9	0.9072194	0.2104888	17	0.8208368	1.002693	3013929	1209330	1804599	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
YKL215C	OXP1	0.8969847	0.6086284	17	0.6716351	1.197944	3931696	1811250	2120446	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YIR003W	AIM21	1.031452	0.1939909	17	0.9405883	1.131094	3419370	1432918	1986452	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton
YIR008C	PRI1	0.9971889	0.18954	17	0.9112695	1.091209	205460300	113094900	92365410	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YIR038C	GTT1	1.186499	1.008324	17	0.7346802	1.916179	4513075	1932995	2580080	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YBR014C	GRX7	0.928514	0.2449722	17	0.8264448	1.043189	8824752	3847464	4977288	Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6
YPR086W	SUA7	1.065484	0.5184628	17	0.8327414	1.363277	3345585	1407288	1938297	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
YDR251W	PAM1	0.9779268	0.4156963	17	0.802575	1.191591	3238116	1449686	1788430	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YLR295C	ATP14	1.01541	0.1651606	16	0.9364715	1.101003	59501280	25680710	33820570	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YCL028W	RNQ1	1.007771	0.2106136	16	0.9089552	1.11733	13479590	5980623	7498965	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
YML074C	FPR3	0.9670506	1.04139	16	0.5805464	1.610873	17018310	7562076	9456231	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YNL131W	TOM22	1.132449	0.3153363	16	0.9703176	1.321672	15094310	6507105	8587203	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YDR363W-A	SEM1	0.9857419	0.3352972	16	0.8363933	1.161759	12947910	5863011	7084898	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1
YGL012W	ERG4	0.7875239	0.1864174	16	0.7187756	0.8628478	5565554	1918317	3647237	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YBR164C	ARL1	1.059612	0.263829	16	0.9311142	1.205843	11449310	4777186	6672120	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YIL015W	BAR1	1.008585	0.3260237	16	0.8596729	1.183292	10276750	4257511	6019235	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YDR377W	ATP17	0.9573167	0.1493423	16	0.8897642	1.029998	60719010	24650610	36068400	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPL043W	NOP4	1.064992	0.1396814	16	0.9945385	1.140437	13419180	6344760	7074417	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YHL039W	EFM1	1.142619	0.7901587	16	0.7758047	1.682871	5329169	2214052	3115117	Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR097C	MSH6	0.9189199	0.1155162	16	0.868351	0.9724337	7728558	3238176	4490382	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
YOR051C	YOR051C	1.453324	0.7922817	16	0.9857379	2.14271	3592201	1867824	1724377	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YBL004W	UTP20	0.9496822	0.2103722	16	0.8566633	1.052801	4078184	1545731	2532453	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YBR094W	PBY1	0.9915283	0.4333126	16	0.8018522	1.226072	32190950	15757780	16433170	Putative tubulin tyrosine ligase associated with P-bodies
YDR348C	YDR348C	1.209198	2.618593	16	0.3351581	4.3626	9285397	3892017	5393380	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YGL150C	INO80	0.9484728	0.1969031	16	0.8612377	1.044544	14606940	6353624	8253312	ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3_prime to 5_prime DNA helicase activity in vitro; has a role in modulating stress gene transcription
YNL110C	NOP15	0.9236938	0.1035245	16	0.8780062	0.9717588	6435330	2619286	3816044	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YCR057C	PWP2	1.010102	0.2351669	16	0.9001623	1.13347	6551435	2999155	3552280	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YGL232W	TAN1	1.102073	0.2834013	16	0.9591827	1.26625	7334225	3163661	4170564	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
YOR354C	MSC6	1.057472	0.4936066	16	0.8302852	1.346823	3501646	1451623	2050023	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR280W	RRP45	1.127204	0.2726452	16	0.9862393	1.288316	2553959	1115064	1438895	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)
YBR026C	ETR1	1.042226	0.2598455	16	0.9176256	1.183745	6938228	2902929	4035299	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
YPL245W	YPL245W	1.020442	0.1022841	16	0.9705592	1.07289	19817880	8539038	11278840	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YJR072C	NPA3	0.8668344	0.1156996	16	0.8190582	0.9173975	3222548	1374376	1848172	Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
YNL182C	IPI3	1.492251	1.661534	16	0.6610895	3.368399	8212547	5113082	3099465	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YPR091C	YPR091C	0.9438866	0.1754657	16	0.8661238	1.028631	5214572	2105947	3108625	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YBR222C	PCS60	0.9241867	0.306614	16	0.7952633	1.07401	13848440	5825546	8022896	Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YDR320C	SWA2	1.283529	0.7636566	16	0.8828692	1.866015	13772760	6239177	7533585	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
YLL034C	RIX7	1.003341	0.1483644	16	0.9329875	1.078999	8506993	3571983	4935010	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YNL087W	TCB2	1.036968	0.1992716	16	0.9405015	1.143329	3563882	1522299	2041583	Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
YPR160W	GPH1	0.9548719	0.1879538	16	0.8708588	1.04699	4753170	2161123	2592047	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YFR016C	YFR016C	0.7539417	0.7480997	16	0.5225633	1.087769	6586882	3088049	3498833	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YOR251C	TUM1	0.8699695	0.4087772	16	0.7120566	1.062903	4619023	1833995	2785028	Mitochondrial protein, required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs; has similarity to mammalian thiosulfate sulfurtransferase (rhodanese)
YKR008W	RSC4	0.8792191	0.6263882	16	0.6468432	1.195075	8580542	3181157	5399385	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling
YNR038W	DBP6	1.00775	0.280768	16	0.8782217	1.156382	3734935	1504477	2230458	Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YDL237W	AIM6	1.04318	0.2290754	16	0.9324188	1.167098	3961366	1535612	2425754	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
YJL186W	MNN5	0.7712958	0.1826331	16	0.7052708	0.8435019	4753382	1926886	2826496	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YMR093W	UTP15	1.151147	0.7692166	16	0.7896566	1.678122	7995809	3447614	4548195	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLR195C	NMT1	0.9647665	0.2318681	16	0.8611517	1.080848	2515257	1044406	1470851	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YOR217W	RFC1	0.7351414	1.255506	16	0.3973689	1.360028	2877986	1085829	1792157	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YPL139C	UME1	0.8980083	0.4707697	16	0.7130148	1.130999	3187760	1282688	1905072	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
YAR002W	NUP60	1.015428	0.160064	16	0.9388301	1.098276	4792518	1965187	2827331	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YBR142W	MAK5	1.082499	0.4731269	16	0.8585077	1.364932	5654370	2227210	3427160	Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YER105C	NUP157	0.9820755	0.4154113	16	0.8012049	1.203777	2546097	955681	1590416	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly
YKL114C	APN1	0.9764156	0.1232761	16	0.919181	1.037214	3880145	1837283	2042862	Major apurinic/apyrimidinic endonuclease, 3_prime-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3_prime-5_prime exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YGL187C	COX4	0.9820297	0.2300884	15	0.8740878	1.103302	28690800	12487460	16203340	Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation
YKR006C	MRPL13	0.9920425	0.2181981	15	0.8883292	1.107864	11130880	4594748	6536130	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YJR088C	EMC2	0.8968396	0.1269449	15	0.8410357	0.9563463	21054800	7520987	13533820	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response
YKR092C	SRP40	1.070114	0.2224355	15	0.9561859	1.197616	6692484	3103694	3588790	Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNR035C	ARC35	0.9907831	0.2953348	15	0.8532355	1.150504	7853731	3486396	4367335	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
YIL137C	TMA108	0.9905205	0.1212487	15	0.931569	1.053203	4391207	1844362	2546845	Protein that associates with ribosomes; putative metalloprotease
YJR094W-A	RPL43B	1.124735	0.6198728	15	0.8218875	1.539174	85940820	38125800	47815020	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR257W	YLR257W	0.9733007	0.2259779	15	0.8681222	1.091222	7963591	3114577	4849014	Putative protein of unknown function
YNL201C	PSY2	0.9822462	0.1517734	15	0.9096264	1.060663	8266133	3689277	4576856	Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3
YOR045W	TOM6	1.067079	0.2294872	15	0.9500776	1.198489	5954999	2400968	3554031	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YHR163W	SOL3	0.9531336	0.1424523	15	0.8868397	1.024383	6309696	2710713	3598983	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YLR406C	RPL31B	1.090439	0.2321403	15	0.9695737	1.226371	11447270	5021457	6425813	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality
YOL151W	GRE2	0.9413785	0.3104253	15	0.8045221	1.101515	3967659	1532969	2434690	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YBR162C	TOS1	0.9480842	0.2646025	15	0.8292618	1.083932	7550275	3313415	4236860	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YNR003C	RPC34	1.415737	1.20665	15	0.768743	2.607259	8329397	5219810	3109587	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YDR038C	ENA5	1.05225	0.2660346	15	0.9197055	1.203895	12775990	5626189	7149799	Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family
YDR394W	RPT3	1.063202	0.2507959	15	0.9364727	1.207082	7485619	3306225	4179394	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YGR200C	ELP2	0.9528151	0.3157353	15	0.8121108	1.117897	6825804	2789833	4035971	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YHL011C	PRS3	0.8602244	0.4000103	15	0.7025806	1.05324	6718593	2827933	3890660	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YJR048W	CYC1	1.556885	0.7412655	15	1.069889	2.265554	24819950	12771200	12048750	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR272C	SCS7	0.8094376	0.198213	15	0.7321826	0.8948439	6266302	2331877	3934425	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YOL030W	GAS5	1.058772	0.1430126	15	0.9848509	1.138241	5398309	2318450	3079859	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YGR208W	SER2	1.042898	0.2396293	15	0.9237941	1.177357	7185903	3246470	3939433	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YLR449W	FPR4	1.074878	0.1754276	15	0.9835656	1.174669	12789130	5566546	7222585	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YOL058W	ARG1	1.213736	0.7236961	15	0.8415266	1.750574	3550278	1534712	2015566	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YDR449C	UTP6	1.034718	0.1653713	15	0.9516473	1.125039	3816964	1608621	2208343	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLL036C	PRP19	1.064537	0.2930886	15	0.9177928	1.234743	4894180	2109360	2784820	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
YLR401C	DUS3	0.9367587	0.3946635	15	0.7671623	1.143848	4285657	1772874	2512783	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YMR183C	SSO2	0.9449467	0.2156299	15	0.8472576	1.053899	9976353	4304591	5671762	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YDR228C	PCF11	0.9459435	0.1987728	15	0.8554177	1.046049	2066358	854007	1212351	mRNA 3_prime end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3_prime end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YHR009C	YHR009C	1.138062	0.1780515	15	1.039999	1.245371	3865508	1611749	2253759	Putative protein of unknown function; not an essential gene
YHR089C	GAR1	1.069946	1.222294	15	0.5763971	1.986102	22090380	9732438	12357940	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YMR214W	SCJ1	0.9908421	0.2129297	15	0.8896231	1.103577	5181901	2333877	2848024	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
YBL026W	LSM2	0.9676658	0.2331171	15	0.8599836	1.088831	4140468	1656433	2484035	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDL060W	TSR1	0.9725194	0.1859535	15	0.8851743	1.068483	3537306	1392115	2145191	Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles
YGL039W	YGL039W	1.19991	0.2606171	15	1.051646	1.369078	11659280	5267134	6392147	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
YKL073W	LHS1	0.920415	0.202012	15	0.830969	1.019489	4980293	2144305	2835988	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
YBL032W	HEK2	0.9731198	0.1623301	15	0.8963732	1.056437	8179220	3344691	4834529	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
YBR111C	YSA1	0.9801985	0.06935755	15	0.9463905	1.015214	5209525	2305030	2904495	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5_prime-phosphate
YOL051W	GAL11	0.9579964	0.5601712	15	0.7215187	1.27198	10203200	4520914	5682286	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YOR215C	AIM41	1.018221	0.4900415	15	0.7945829	1.304803	3034289	1224232	1810057	Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
YNL307C	MCK1	0.9943454	0.1978577	15	0.8996041	1.099064	3214472	1392515	1821957	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
YHR024C	MAS2	0.9999442	0.3134066	15	0.8532852	1.17181	12689400	5057607	7631790	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YLR287C	YLR287C	0.8411752	0.5526488	15	0.6359507	1.112627	7322131	2902459	4419672	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
YNL192W	CHS1	1.085661	0.4943441	15	0.8453677	1.394257	28841180	12220650	16620530	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor
YDL043C	PRP11	1.048434	0.1231115	15	0.985107	1.115833	2729708	1144842	1584866	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YNL216W	RAP1	1.16581	0.3334606	15	0.9847786	1.38012	5163665	2499931	2663734	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
YGR286C	BIO2	1.169364	0.1707418	15	1.072565	1.274899	3530499	1466365	2064134	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YHR117W	TOM71	0.8862724	0.1783951	15	0.8097649	0.9700084	9224758	3666318	5558440	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
YJR059W	PTK2	0.9005232	0.2210284	15	0.8052237	1.007102	2940268	1397678	1542590	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
YKL057C	NUP120	0.9909935	0.1765285	15	0.9063017	1.0836	2564661	1065961	1498700	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YKL068W	NUP100	1.187332	0.2228535	15	1.060701	1.329082	4746415	2001232	2745183	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YML127W	RSC9	1.113759	0.4759799	15	0.8753443	1.417111	1253691	583479.1	670211.6	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YEL002C	WBP1	0.9839919	0.3061397	15	0.8427662	1.148883	4611337	2232519	2378818	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
YMR220W	ERG8	1.140119	0.6396989	15	0.8248118	1.57596	7801374	3082630	4718744	Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YML017W	PSP2	0.9488579	0.1367318	15	0.885421	1.01684	7011824	2763396	4248428	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
YNL262W	POL2	0.8359421	1.162321	15	0.464213	1.505341	3162551	1192936	1969615	Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
YHR088W	RPF1	1.217386	0.657892	15	0.8726393	1.69833	2790064	1317458	1472606	Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YKL194C	MST1	1.200622	0.3851815	14	0.9812474	1.469042	22385250	10239610	12145640	Mitochondrial threonyl-tRNA synthetase
YNL113W	RPC19	1.216815	0.4922644	14	0.9402337	1.574757	12390420	5821422	6568994	RNA polymerase subunit AC19, common to RNA polymerases I and III
YDR361C	BCP1	0.9639302	0.09878268	14	0.9153196	1.015122	7733161	3307843	4425318	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YPR112C	MRD1	1.045749	0.120653	14	0.9817014	1.113976	4369871	1874359	2495512	Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
YPR169W	JIP5	1.058933	0.3267161	14	0.8923629	1.256596	2809731	1298717	1511014	Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
YLR328W	NMA1	1.050297	0.2190331	14	0.9364461	1.17799	17692340	9892162	7800180	Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YBR155W	CNS1	1.195804	0.2766365	14	1.034489	1.382273	10770350	5066685	5703661	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
YCR002C	CDC10	0.9748587	0.2056607	14	0.8752949	1.085748	5357198	2261972	3095226	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YBL058W	SHP1	1.042382	0.1938094	14	0.9417501	1.153766	7971799	3614667	4357132	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YDL174C	DLD1	1.156958	0.1795395	14	1.053108	1.271049	3896151	1764230	2131921	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YML004C	GLO1	1.651743	1.417036	14	0.7862676	3.46988	9187689	6941137	2246552	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YNL212W	VID27	1.074796	0.402469	14	0.8704935	1.327049	5479118	2293168	3185950	Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
YNL074C	MLF3	1.049048	0.2442397	14	0.9230629	1.192227	5778018	2639681	3138337	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YOR014W	RTS1	0.8501586	0.08088333	14	0.8148904	0.8869532	3786504	1411780	2374724	B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B_prime subunit of PP2A
YBR053C	YBR053C	0.9578232	0.2396797	14	0.8448096	1.085955	5054374	2137000	2917374	Putative protein of unknown function; induced by cell wall perturbation
YDL235C	YPD1	1.068995	0.1162207	14	1.005856	1.136097	16780530	10288870	6491660	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YDR122W	KIN1	1.294995	1.110108	14	0.7239716	2.316406	9047903	4388156	4659747	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YOL021C	DIS3	1.018239	0.1399355	14	0.9462691	1.095682	7598568	3260134	4338434	Exosome core complex catalytic subunit; possesses both endonuclease and 3_prime-5_prime exonuclease activity; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3
YPR105C	COG4	0.9852707	0.2747018	14	0.8532212	1.137757	13426890	5850266	7576622	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YHR082C	KSP1	0.9922326	0.1154971	14	0.9339813	1.054117	8349363	3464743	4884620	Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10
YCL045C	EMC1	0.968184	0.1372613	14	0.9010135	1.040362	4712168	1862803	2849365	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p
YDL067C	COX9	0.9429804	0.7255639	14	0.6448204	1.379007	13039300	6909784	6129512	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YNL315C	ATP11	0.9812027	0.3831855	14	0.8027587	1.199313	4961078	2043031	2918047	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YBL055C	YBL055C	1.139239	0.276357	14	0.9856995	1.316696	3262059	1492700	1769359	3_prime-->5_prime exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YDR178W	SDH4	0.9095688	0.1889513	14	0.8238528	1.004203	5017845	2042092	2975753	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YFL007W	BLM10	1.111644	0.3786601	14	0.9116362	1.355532	28470430	12147760	16322660	Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YGL231C	EMC4	0.9531619	0.1778828	14	0.8683579	1.046248	4359761	1672111	2687650	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis
YGR270W	YTA7	1.003608	0.1466456	14	0.9293998	1.083741	11022820	4293886	6728929	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
YHR076W	PTC7	1.140478	0.43898	14	0.9061917	1.435336	4659508	2080107	2579401	Type 2C protein phosphatase; YHR076W is alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
YKL005C	BYE1	1.160762	0.3185422	14	0.9823713	1.371547	6927683	3037382	3890301	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YDR152W	GIR2	1.041015	0.2013545	14	0.936805	1.156816	2412744	994769	1417975	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein
YGL171W	ROK1	0.7271991	0.6519683	14	0.5168116	1.023233	41003010	15819370	25183640	ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
YHR133C	NSG1	0.9056655	0.2054985	14	0.8132377	1.008598	3613158	1520146	2093012	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YIL128W	MET18	0.9043301	0.2242554	14	0.8040989	1.017055	2193507	792006	1401501	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
YLR409C	UTP21	1.13488	0.195156	14	1.024595	1.257035	4292927	1847625	2445302	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
YPR135W	CTF4	1.011741	0.1416132	14	0.9394043	1.089647	4341558	1893863	2447695	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
YER174C	GRX4	0.940208	0.1559091	14	0.866473	1.020218	5580720	2307108	3273612	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
YLR199C	PBA1	0.9926283	0.3472509	14	0.8275381	1.190653	7894275	3350908	4543367	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YNL041C	COG6	0.9705182	0.171806	14	0.8869891	1.061913	7278224	2808977	4469247	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YPL266W	DIM1	0.9497169	0.3083715	14	0.8080542	1.116215	3278234	1409881	1868353	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3_prime-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YDR001C	NTH1	0.8694627	0.2786141	14	0.7513927	1.006086	3041039	1214941	1826098	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YNL045W	LAP2	1.723373	0.9534374	14	1.045863	2.839774	3548564	2413057	1135507	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR195W	SLK19	0.9841506	0.3257687	14	0.8297553	1.167275	3089049	1415786	1673263	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
YBR260C	RGD1	0.6928826	0.6542182	14	0.4918433	0.9760961	8410809	3372091	5038718	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
YER004W	FMP52	1.051221	0.2552811	14	0.919641	1.201627	2556800	1259029	1297771	Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER172C	BRR2	0.9231903	0.1324659	14	0.8613022	0.9895252	1545668	609442	936226	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
YGL223C	COG1	1.14346	0.3308058	14	0.9615315	1.359811	2162716	858894.5	1303821	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YKL204W	EAP1	1.078394	0.1954404	14	0.9734536	1.194647	2691732	1042815	1648917	eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
YGR087C	PDC6	1.059691	0.09970307	13	1.003785	1.11871	61536530	28114450	33422080	Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YBR009C	HHF1	0.8559553	0.3374408	13	0.7125024	1.028291	11487590	4536613	6950974	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YHL001W	RPL14B	1.063304	0.1229995	13	0.9945326	1.136831	42904380	19029640	23874740	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YJR025C	BNA1	1.259294	0.2286503	13	1.112106	1.425962	8535976	3735289	4800687	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YGL040C	HEM2	0.914131	0.1819879	13	0.8280257	1.00919	6968026	2738891	4229135	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
YLR421C	RPN13	0.990226	0.1472264	13	0.9140635	1.072735	9209358	4097723	5111635	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability
YDR388W	RVS167	1.063791	0.2403025	13	0.9335215	1.212238	10081170	4263476	5817693	Actin-associated protein, interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
YGL054C	ERV14	1.046946	0.2162032	13	0.9308544	1.177515	8834494	3980986	4853508	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YJR014W	TMA22	1.152282	0.3825493	13	0.9359327	1.418643	13833860	5830253	8003603	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1
YDR044W	HEM13	1.023771	0.1803872	13	0.9281458	1.129249	6752272	2695858	4056414	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDR335W	MSN5	0.9233095	0.2838731	13	0.791278	1.077372	11974290	6998458	4975828	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
YKL094W	YJU3	0.946492	0.08789024	13	0.9023341	0.9928109	6125826	2848217	3277609	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
YOL076W	MDM20	0.9656067	0.2099059	13	0.8614788	1.082321	6892401	4001139	2891262	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
YPL105C	SYH1	0.997087	0.2604571	13	0.865452	1.148744	3019619	1293547	1726072	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR160W	CDC28	1.143083	0.3952508	13	0.9220722	1.417068	21294060	9024726	12269340	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
YMR261C	TPS3	0.9432383	0.09049474	13	0.89796	0.9907998	4500130	1798712	2701418	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YDR141C	DOP1	0.807453	0.1715209	13	0.7355694	0.8863613	2489239	919122	1570117	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
YOR099W	KTR1	1.084639	0.5348869	13	0.810973	1.450655	4265984	1848528	2417456	Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YER042W	MXR1	1.106539	0.4417095	13	0.8703334	1.40685	4234135	1967477	2266658	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
YER127W	LCP5	1.627211	0.9643185	13	0.9633466	2.74856	11388350	5045654	6342698	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YKR018C	YKR018C	0.9102542	0.2468258	13	0.7959592	1.040961	2046459	768311	1278148	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YLR430W	SEN1	0.8674814	0.1699058	13	0.790948	0.9514203	3033372	1213122	1820250	Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis
YOL006C	TOP1	0.9825118	0.1718783	13	0.8948699	1.078737	11884910	5446757	6438153	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YDL005C	MED2	0.9684605	0.2907483	13	0.8268763	1.134288	6054813	3057910	2996903	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YFR051C	RET2	1.103135	0.3841402	13	0.8952385	1.359309	3810789	1627010	2183779	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YKL007W	CAP1	1.146017	0.2300639	13	1.011292	1.298691	4023945	1725036	2298909	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YKR074W	AIM29	1.069177	0.2511289	13	0.9327422	1.225567	4935148	2172412	2762736	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
YKR077W	MSA2	0.9132775	0.2670088	13	0.7898888	1.055941	13593350	6296839	7296512	Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
YLR438W	CAR2	1.496658	1.112123	13	0.8176488	2.739545	1612185	825724	786460.7	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YMR024W	MRPL3	0.9934749	0.4126572	13	0.7938431	1.243309	2879229	1093408	1785821	Mitochondrial ribosomal protein of the large subunit
YCL054W	SPB1	0.7883879	0.6497184	13	0.5537976	1.122351	9835378	4051771	5783607	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDR293C	SSD1	1.019529	0.4829862	13	0.7841038	1.325639	4234487	1845567	2388920	Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
YPL082C	MOT1	1.530161	1.378897	13	0.7231028	3.237981	2565475	1144804	1420671	Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
YPL273W	SAM4	1.052058	0.1871298	13	0.9503009	1.164711	9220503	4180080	5040423	S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YEL013W	VAC8	0.9669013	0.3112449	13	0.8163979	1.14515	6193628	2671071	3522557	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YKL135C	APL2	0.9216376	0.08251344	13	0.8812111	0.9639186	2745657	1053200	1692457	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
YLR305C	STT4	0.7750071	0.6477557	13	0.5449795	1.102126	14701000	7864989	6836013	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
YLR319C	BUD6	1.374495	0.9126651	13	0.8369056	2.257407	3445252	1341451	2103801	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
YOL070C	NBA1	1.129921	0.6767033	13	0.7821472	1.632329	2049129	862982	1186147	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
YCL019W	YCL019W	3.885347	1.79997	13	1.460439	10.33656	3011390	1847142	1164248	NA
YDR328C	SKP1	1.059841	0.07513838	13	1.017424	1.104028	5102662	2115844	2986818	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
YKR071C	DRE2	1.110692	0.5987305	13	0.8021256	1.53796	2774552	1066037	1708515	Protein that may prevent apoptosis by forming a complex with Tah18p in the absence of stress; required for iron-sulfur cluster assembly and sister chromatid cohesion; homolog of human anti-apoptotic protein Ciapin1
YOL126C	MDH2	0.8253837	0.9128394	13	0.5025139	1.3557	4863625	2065974	2797651	Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YOR076C	SKI7	1.132637	0.8413577	13	0.7169001	1.789463	12143150	5581533	6561616	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3_prime-5_prime RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
YKL201C	MNN4	0.5580129	0.5354068	13	0.4171024	0.7465275	3938452	1377646	2560806	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YGL226C-A	OST5	1.073886	0.925292	13	0.6493973	1.775849	4080857	1518945	2561912	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YKL032C	IXR1	0.9898774	0.145764	13	0.9144684	1.071505	2776796	1177817	1598979	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YKL079W	SMY1	1.740604	1.482761	13	0.7773954	3.897247	10691640	5633666	5057973	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
YDL122W	UBP1	0.9351687	0.2091239	13	0.8346779	1.047758	3016760	1969675	1047085	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
YDR009W	GAL3	1.305114	0.355561	13	1.075737	1.583402	2789971	1211432	1578539	Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YGR196C	FYV8	1.022597	0.1150804	13	0.960585	1.088613	4058431	1611915	2446516	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YJL207C	LAA1	0.8617147	0.4488507	13	0.6751442	1.099842	1978211	878144	1100067	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
YML049C	RSE1	0.852843	0.4903467	13	0.6532892	1.113353	5047159	1632821	3414338	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
YML075C	HMG1	1.165547	0.199228	13	1.045912	1.298867	3183545	1383486	1800059	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YNL290W	RFC3	0.9538375	0.1912423	13	0.8596565	1.058337	3513831	1738793	1775038	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YMR259C	YMR259C	1.029722	0.3533646	13	0.849759	1.247797	3198336	1337726	1860610	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene
YML128C	MSC1	0.9103683	0.2705702	13	0.7858498	1.054617	1840568	748094	1092474	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YBR085C-A	YBR085C-A	1.034808	0.3033715	12	0.8715931	1.228587	14125200	6681870	7443330	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YLR300W	EXG1	0.9463415	0.2738711	12	0.810496	1.104956	3421863	1379964	2041899	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YBR171W	SEC66	0.9175287	0.3510629	12	0.7522369	1.119141	3707872	1501067	2206805	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YOR157C	PUP1	1.097257	0.1992956	12	0.980249	1.228232	13666200	6798060	6868140	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YGR186W	TFG1	1.191001	0.3480701	12	0.9780987	1.450247	3534721	1730219	1804502	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
YGR187C	HGH1	1.016229	0.2148396	12	0.8999117	1.14758	5492071	2418463	3073608	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YAL042W	ERV46	0.88507	0.8843344	12	0.5366292	1.459758	13917610	6990432	6927179	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YFR049W	YMR31	1.070558	0.1913515	12	0.960706	1.192972	14155450	5861694	8293758	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YHR143W-A	RPC10	1.019224	0.1641962	12	0.9288003	1.11845	11401430	5153294	6248135	RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III
YLR262C-A	TMA7	1.169136	0.440761	12	0.9110853	1.500276	14170830	5721672	8449159	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YML055W	SPC2	1.036548	0.3293604	12	0.8603149	1.248883	3945605	1751297	2194308	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
YNL308C	KRI1	0.9065945	0.2343765	12	0.7940006	1.035155	4599479	2019752	2579727	Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p
YGL203C	KEX1	1.040783	0.2736106	12	0.8915123	1.215048	8882602	4026164	4856438	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
YER112W	LSM4	1.109893	0.1804055	12	1.002192	1.229168	10273550	4477592	5795960	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGR231C	PHB2	1.284703	0.6390002	12	0.8949203	1.844256	13406200	6188349	7217851	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YHR074W	QNS1	0.9344658	0.3045501	12	0.7865526	1.110194	3636917	1621827	2015090	Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YIL038C	NOT3	1.002302	0.1453777	12	0.9231567	1.088232	2853902	1250229	1603673	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YPR165W	RHO1	0.8977536	0.2248688	12	0.7904988	1.019561	16083620	6374604	9709017	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YBR166C	TYR1	1.069613	0.08108435	12	1.02165	1.119827	4648561	1904872	2743689	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
YLR397C	AFG2	1.048061	0.1504343	12	0.9625453	1.141175	4064819	1643601	2421218	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs
YNL231C	PDR16	1.001236	0.2098355	12	0.8891495	1.127453	10089210	3784630	6304580	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YOR197W	MCA1	0.7988911	0.9256625	12	0.4731828	1.348796	2965942	1097188	1868754	Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progression
YHR114W	BZZ1	1.041812	0.1825251	12	0.9395895	1.155155	2606725	1115940	1490785	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
YMR067C	UBX4	0.9657111	0.282361	12	0.8231216	1.133001	5069794	2045459	3024335	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YMR076C	PDS5	0.8205803	0.1900563	12	0.7369185	0.9137401	2386118	848364.5	1537754	Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis
YNL111C	CYB5	1.080276	0.2087709	12	0.9599186	1.215724	9559928	3687137	5872791	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YOR207C	RET1	0.9909922	0.2092103	12	0.8803634	1.115523	3665708	1409813	2255895	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YDL202W	MRPL11	0.9212509	0.2637547	12	0.7935362	1.069521	5409291	2296788	3112503	Mitochondrial ribosomal protein of the large subunit
YDR145W	TAF12	1.111743	0.3147902	12	0.930363	1.328484	3926900	1575644	2351256	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YGL016W	KAP122	0.8765086	0.1612741	12	0.8000683	0.9602522	3836158	1497979	2338179	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
YHL007C	STE20	1.392399	0.5287981	12	1.032345	1.878031	6595773	3356058	3239715	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
YJL055W	YJL055W	0.9405992	0.2062077	12	0.8370168	1.057	8557058	3567165	4989893	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
YJR131W	MNS1	0.8550428	0.1960011	12	0.765289	0.9553231	1108099	415049	693050	Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane
YKL184W	SPE1	1.215313	0.2382755	12	1.062032	1.390716	3805926	1709590	2096336	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
YML110C	COQ5	0.9816086	0.4122592	12	0.7773845	1.239484	3725928	1599215	2126713	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YDR201W	SPC19	0.959775	0.2553851	12	0.8306439	1.108981	3066953	1389137	1677816	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YDR407C	TRS120	0.9598029	0.1774863	12	0.8680989	1.061194	4952259	2098075	2854184	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YJL178C	ATG27	1.063878	0.2365127	12	0.9306252	1.216212	3345627	1389231	1956396	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site
YBR046C	ZTA1	0.8270857	0.8062324	12	0.5241298	1.305155	2361501	1134822	1226679	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
YDR333C	YDR333C	1.192029	0.7781658	12	0.7674883	1.851406	12554100	5260928	7293174	Putative protein of unknown function
YFR024C-A	LSB3	0.8558915	0.1313516	12	0.7945885	0.921924	4038793	1700983	2337810	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YNL123W	NMA111	1.056539	0.3157875	12	0.8836669	1.26323	4592961	2094327	2498634	Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YNL168C	FMP41	0.9911039	0.1368999	12	0.9172325	1.070925	969032.8	428150.8	540882	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR091W	TMA46	0.9944607	0.2074846	12	0.8843077	1.118335	4972424	2081186	2891238	Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
YOR116C	RPO31	0.9344181	0.06770665	12	0.8992988	0.9709089	16246820	6651294	9595528	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YBR140C	IRA1	0.8902447	0.2669812	12	0.7654298	1.035413	1185605	430975	754630	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
YBR281C	DUG2	0.8188537	0.5195708	12	0.6102877	1.098697	2282718	884713	1398005	Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YER008C	SEC3	1.12828	0.5690162	12	0.8177021	1.55682	1825441	808739	1016702	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
YLR221C	RSA3	1.255008	0.6600788	12	0.8638703	1.823243	6468627	3013394	3455233	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YBR056W	YBR056W	0.9387961	0.1505154	12	0.862156	1.022249	4455191	1787778	2667413	Putative cytoplasmic protein of unknown function
YDR195W	REF2	1.049735	0.2688675	12	0.9015967	1.222214	3672722	1768048	1904674	RNA-binding protein involved in the cleavage step of mRNA 3_prime-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3_prime-ends of snoRNA- and mRNA-encoding genes
YJR032W	CPR7	1.008684	0.121763	12	0.9415316	1.080626	5334685	2085842	3248843	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YOL071W	EMI5	1.21972	0.6621047	12	0.838618	1.774009	4615871	1788498	2827373	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
YDR216W	ADR1	0.7808515	0.1916777	12	0.7005973	0.8702991	1570196	614405.5	955790	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YEL022W	GEA2	0.9043332	0.4469147	12	0.7022799	1.164519	1754825	669137	1085688	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
YLR454W	FMP27	1.069383	0.2625007	12	0.9217858	1.240612	3081825	1269429	1812396	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR297C	TIM18	1.134448	0.5099239	12	0.8501264	1.51386	5109206	2130032	2979174	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
YPR097W	YPR097W	0.851078	0.1118323	12	0.7988943	0.9066703	1448550	646122	802428	Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL143C	SSL2	1.281048	0.7483669	12	0.8388278	1.956402	1917663	764794	1152869	Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3
YJL179W	PFD1	1.061793	0.8659687	12	0.6505035	1.733127	8471731	3878217	4593514	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YNL181W	YNL181W	1.1939	1.222109	12	0.5979499	2.383805	6791057	3325132	3465925	Putative oxidoreductase; required for cell viability
YMR304W	UBP15	1.207572	1.091053	12	0.651349	2.238784	4000884	1875558	2125326	Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YER146W	LSM5	0.9715662	0.1472935	11	0.8905725	1.059926	10887220	4612839	6274379	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YHR013C	ARD1	1.585369	1.153548	11	0.8018078	3.134659	14172810	9193947	4978859	Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells
YGR214W	RPS0A	1.043699	0.1543464	11	0.952713	1.143375	58867760	25283540	33584220	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGR148C	RPL24B	0.9254253	0.07974699	11	0.8828241	0.9700823	35104150	15535130	19569010	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YNL252C	MRPL17	1.224744	0.7096906	11	0.8051972	1.862897	4595533	2409800	2185733	Mitochondrial ribosomal protein of the large subunit
YMR305C	SCW10	0.9775623	0.1794855	11	0.8791829	1.08695	3565464	1558604	2006860	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YOR196C	LIP5	0.9945333	0.1058907	11	0.9342052	1.058757	6509252	2699680	3809572	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YOL064C	MET22	0.9429058	0.1485939	11	0.8636374	1.02945	2236496	982467	1254029	Bisphosphate-3_prime-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3_prime-phosphoadenosine-5_prime-phosphate and 3_prime-phosphoadenosine-5_prime-phosphosulfate, intermediates of the sulfate assimilation pathway
YBR035C	PDX3	1.106162	0.2366032	11	0.9618206	1.272164	9271712	3982841	5288871	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YGL244W	RTF1	0.8930598	0.3716366	11	0.7169674	1.112402	6117081	2137203	3979878	Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
YMR039C	SUB1	0.9764506	0.2848923	11	0.8251486	1.155496	4212844	1896942	2315902	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes
YKL143W	LTV1	1.279185	0.4779101	11	0.9644437	1.69664	5494841	2522104	2972737	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YNL232W	CSL4	1.078612	0.1021616	11	1.015419	1.145738	4558797	2020106	2538691	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
YFR050C	PRE4	1.081478	0.1564924	11	0.9859473	1.186265	5356129	2711600	2644529	Beta 7 subunit of the 20S proteasome
YDR483W	KRE2	0.8829836	0.1514867	11	0.8073713	0.9656771	5439999	2058189	3381810	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation
YBR069C	TAT1	1.076088	0.5412394	11	0.7815161	1.481692	4748875	1881294	2867581	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YDR117C	TMA64	0.9273558	0.1704944	11	0.8384723	1.025661	2976590	1142399	1834191	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain
YDR508C	GNP1	0.8827343	0.2553242	11	0.7591029	1.026501	2869394	1219417	1649977	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YFL013C	IES1	1.016027	0.251993	11	0.8754488	1.179179	10205480	4569184	5636299	Subunit of the INO80 chromatin remodeling complex
YHR043C	DOG2	0.9275866	0.08137224	11	0.8840364	0.9732822	14209160	5877425	8331731	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YLR250W	SSP120	1.114414	0.2006263	11	0.9898187	1.254694	2767291	1211292	1555999	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR178W	YMR178W	1.096745	0.3872888	11	0.8723835	1.378809	14314880	6247649	8067229	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene
YMR298W	LIP1	1.006667	0.6484676	11	0.6862074	1.47678	5546351	2660649	2885702	Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
YOR241W	MET7	0.9433617	0.2551194	11	0.8113373	1.09687	2741177	1433447	1307730	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
YPR114W	YPR114W	0.8474923	0.1922274	11	0.7564849	0.9494481	5058154	2029041	3029113	Putative protein of unknown function
YDL190C	UFD2	0.902215	0.1381714	11	0.831473	0.9789759	2261583	986787	1274796	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
YDR017C	KCS1	1.036969	0.2880511	11	0.8746557	1.229404	12543610	5566186	6977425	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YLR003C	CMS1	1.148491	0.9579024	11	0.6520492	2.022902	2167308	905151.3	1262157	Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable
YLR286C	CTS1	1.140125	0.5099306	11	0.8434862	1.541087	6432980	2857474	3575506	Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
YDR507C	GIN4	1.009604	0.2039248	11	0.8949803	1.138908	6966165	3153554	3812611	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YEL032W	MCM3	1.049434	0.2000929	11	0.932397	1.181161	14348500	5913769	8434735	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YPL263C	KEL3	1.129256	0.4578554	11	0.8615551	1.480136	7810832	3372561	4438271	Cytoplasmic protein of unknown function
YBR205W	KTR3	0.8764103	0.1213558	11	0.8157579	0.9415722	1909231	719142	1190089	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YFL047W	RGD2	0.9854351	0.1816889	11	0.8851101	1.097132	1791350	679461	1111889	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p
YGR083C	GCD2	1.078465	0.3197723	11	0.8927623	1.302795	8905489	3165691	5739798	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YKR067W	GPT2	1.403436	1.312893	11	0.6460061	3.048939	3719840	2264875	1454965	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YLR357W	RSC2	1.538457	0.6928134	11	1.021583	2.316845	31946310	14430480	17515830	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YOL121C	RPS19A	1.142209	0.1146814	11	1.067363	1.222302	3134613	1438713	1695900	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YOR065W	CYT1	0.9556393	0.2651483	11	0.8170399	1.11775	2913708	1111572	1802135	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YCL017C	NFS1	0.9449559	0.1927154	11	0.8432392	1.058942	7409029	3080346	4328683	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YDR398W	UTP5	1.354556	0.7572611	11	0.8658542	2.11909	1379402	658797	720605	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YGR261C	APL6	0.809199	0.2190168	11	0.7109586	0.9210143	1497392	579120.4	918272	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
YJL010C	NOP9	1.00139	0.922978	11	0.5803895	1.727775	2509737	1093139	1416598	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
YKR003W	OSH6	1.10025	0.6402446	11	0.7536529	1.606242	5410576	2323484	3087093	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YMR086W	YMR086W	1.130783	0.3479748	11	0.9205998	1.388953	2842243	1184397	1657846	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; possible component of the eisosome; expression is repressed by cAMP
YNL173C	MDG1	1.153675	0.2334474	11	1.005007	1.324336	2809946	1390682	1419264	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YNL271C	BNI1	0.7984676	0.6141346	11	0.5554419	1.147826	1229235	519068.8	710166	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YER166W	DNF1	0.9027547	0.2026419	11	0.8008688	1.017602	3389309	1409973	1979336	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YGR026W	YGR026W	0.9295042	0.3735408	11	0.7453865	1.159101	6303942	2280725	4023217	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR156W	PTI1	1.243021	0.7182359	11	0.8130966	1.900268	2106120	879463.2	1226657	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3_prime end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YHR169W	DBP8	1.13502	0.4011095	11	0.8954844	1.438629	2853267	1414439	1438828	ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esp2p
YKR002W	PAP1	0.8889526	0.1151619	11	0.8304665	0.9515576	3356518	1310456	2046062	Poly(A) polymerase, one of three factors required for mRNA 3_prime-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs
YKR046C	PET10	1.964915	1.646394	11	0.7426669	5.198683	6063400	4144696	1918704	Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YML035C	AMD1	1.06297	0.121818	11	0.9891363	1.142315	4295378	1838394	2456984	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YPL050C	MNN9	1.07751	0.2471461	11	0.9310886	1.246958	2374825	1147906	1226919	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation
YAL019W	FUN30	2.302321	1.906346	11	0.7462752	7.102853	4169567	2869289	1300278	Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER139C	RTR1	1.219791	0.8045909	11	0.7582037	1.962389	15682060	10078950	5603105	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm
YHR081W	LRP1	1.124624	0.1647743	11	1.020276	1.239644	3157873	1344056	1813817	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YJL168C	SET2	0.9319412	0.1832104	11	0.83631	1.038508	1821145	774009	1047136	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YML130C	ERO1	1.182075	0.2107078	11	1.043678	1.338824	6907710	2533086	4374624	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YMR266W	RSN1	1.328589	0.8749491	11	0.7921974	2.228167	4739894	2235004	2504890	Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane
YGL050W	TYW3	1.051591	0.231008	11	0.9173994	1.205412	1965799	893607	1072192	tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3_prime-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YOR336W	KRE5	0.9340097	0.2188338	11	0.8207055	1.062956	1485890	564632	921258	Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YIL039W	TED1	0.9181099	0.1362192	11	0.8470982	0.9950744	1818633	657677.6	1160955	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YOR252W	TMA16	0.9369161	0.2036508	11	0.8306793	1.05674	2558765	1082445	1476320	Protein of unknown function that associates with ribosomes
YPR127W	YPR127W	0.7751183	0.5341294	11	0.565305	1.062804	4062554	1262389	2800165	Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YFL010C	WWM1	1.034366	0.298553	11	0.8670622	1.233953	4775725	1215514	3560211	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YKR027W	BCH2	0.8446519	0.7629069	11	0.5381167	1.325803	944864	425116	519748	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YPL067C	YPL067C	0.636721	0.6517264	10	0.4251268	0.9536301	6369868	2552470	3817399	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YDL121C	YDL121C	0.9832843	0.2265777	10	0.8544551	1.131538	12323400	5102490	7220905	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YIL034C	CAP2	1.084841	0.2804553	10	0.9117456	1.290799	3219131	1422156	1796975	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YGL115W	SNF4	1.020828	0.1255718	10	0.9443897	1.103453	6850035	2768201	4081834	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YLR100W	ERG27	0.9388634	0.2053565	10	0.8266561	1.066301	6542793	2844019	3698774	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YLR148W	PEP3	1.198741	0.5962558	10	0.8283736	1.734701	4095626	1789016	2306611	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
YLR268W	SEC22	1.023639	0.3582894	10	0.8197904	1.278175	4078506	1870386	2208120	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YPR063C	YPR063C	0.8780441	0.2656677	10	0.7447394	1.03521	4550646	2179696	2370950	ER-localized protein of unknown function
YPR143W	RRP15	1.436981	1.415037	10	0.5977968	3.454209	7419277	4654711	2764566	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YER155C	BEM2	0.8989376	0.1790294	10	0.8045233	1.004432	1512474	567969	944505	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
YJL173C	RFA3	1.100318	0.2228248	10	0.9583819	1.263275	5344171	2524034	2820137	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YJR135W-A	TIM8	1.275452	0.3708406	10	1.013542	1.605042	5087985	2383538	2704447	Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
YBR283C	SSH1	1.138877	0.798667	10	0.694213	1.868361	4512396	1704077	2808319	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YER148W	SPT15	0.8306467	0.4101206	10	0.6442	1.071056	3578783	1671900	1906883	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YFR025C	HIS2	1.185703	0.267503	10	1.004546	1.39953	2977054	1307393	1669661	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YJR041C	URB2	1.137265	0.3226886	10	0.9311098	1.389065	11900320	5381191	6519130	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
YLR334C	YLR334C	0.9869692	0.11523	10	0.9189379	1.060037	23974230	10416610	13557620	NA
YML105C	SEC65	1.035073	0.2031988	10	0.9125867	1.173999	6253094	2711754	3541340	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
YOR158W	PET123	1.109651	0.4129623	10	0.8590645	1.433332	3739321	1574629	2164692	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
YPR156C	TPO3	0.9854907	0.1757403	10	0.8837858	1.0989	3063487	1270079	1793408	Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR292C	SRP101	1.160993	0.3392024	10	0.9408566	1.432635	1094172	456019	638153	Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with Srp102p
YDR300C	PRO1	1.07883	0.1909011	10	0.9584434	1.214337	3914732	1740819	2173913	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
YIL126W	STH1	1.038872	0.1676745	10	0.936327	1.152647	2712032	1088844	1623188	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YLR277C	YSH1	1.080384	0.132085	10	0.9954593	1.172553	2093389	958478	1134911	Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3_prime processing, splicing, and transcriptional termination of mRNAs and snoRNAs
YNL183C	NPR1	1.155337	0.3873466	10	0.9087474	1.468838	10635450	4694760	5940693	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YOR171C	LCB4	1.236918	0.2486601	10	1.060247	1.443028	2679479	1949837	729642	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
YDR086C	SSS1	0.8119649	0.1586015	10	0.7359446	0.8958378	6215241	2451979	3763262	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YDR354W	TRP4	1.035122	0.05597947	10	0.9998227	1.071667	2228074	946026	1282048	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YEL056W	HAT2	1.023185	0.266017	10	0.8676573	1.206592	8321126	3266671	5054455	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YGL125W	MET13	1.15032	0.1082411	10	1.075679	1.230141	2158580	921260	1237320	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YGR284C	ERV29	1.030944	0.1505072	10	0.9391218	1.131745	3695804	1606760	2089044	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
YBR279W	PAF1	1.245112	0.4527638	10	0.940447	1.648477	4956503	2171253	2785250	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1
YLL008W	DRS1	0.9356578	0.3071163	10	0.7734779	1.131843	2414141	912432	1501709	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YER072W	VTC1	1.472228	0.8534184	10	0.8674672	2.498601	16260480	6992475	9268009	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
YML057W	CMP2	0.9440841	0.5254164	10	0.6816789	1.307499	2651045	1227060	1423985	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YPL032C	SVL3	1.046242	0.1733649	10	0.9396502	1.164926	11173460	5351103	5822358	Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
YAL007C	ERP2	0.8261582	0.1376357	10	0.7586031	0.8997291	28255890	11876380	16379510	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YCL014W	BUD3	0.8824748	0.7085959	10	0.5688051	1.369119	3499916	1578048	1921868	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YCR016W	YCR016W	0.9372176	0.2412544	10	0.8070491	1.088381	3909033	1633988	2275045	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis
YDL019C	OSH2	0.9876781	0.1334917	10	0.9092479	1.072873	1906637	808506	1098131	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YGL196W	DSD1	0.9836715	0.120334	10	0.9129747	1.059843	2208760	915377	1293383	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5_prime-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
YHR077C	NMD2	0.8968946	0.2944028	10	0.7472991	1.076436	3034280	1181987	1852293	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
YIL127C	RRT14	1.699651	2.083116	10	0.4673368	6.181442	5693241	4936222	757019	Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YNL297C	MON2	0.745003	0.4952517	10	0.5480837	1.012673	1498020	549074	948946	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
YBR151W	APD1	1.146887	0.2893785	10	0.9585754	1.372193	2674248	1066830	1607418	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
YDL215C	GDH2	1.686197	0.2569145	10	1.437978	1.977261	4847834	2312711	2535123	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDR376W	ARH1	1.05344	0.1800205	10	0.9422195	1.177789	2164764	868029	1296735	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YGL120C	PRP43	1.297413	0.5068417	10	0.9476484	1.77627	3004794	1282636	1722158	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YGL151W	NUT1	0.9429523	0.1477168	10	0.8604538	1.033361	10046820	4524672	5522145	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
YHR039C	MSC7	0.8734262	0.2582503	10	0.7442362	1.025042	4659147	1725477	2933670	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YIR026C	YVH1	1.398225	0.7684609	10	0.8684085	2.251284	3452209	1538205	1914003	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
YJR134C	SGM1	0.7957541	0.661763	10	0.5280153	1.199254	2296884	584077	1712807	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
YJR148W	BAT2	1.061771	0.1713135	10	0.9548102	1.180714	7194431	2897170	4297261	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YLR002C	NOC3	0.8895931	0.1161525	10	0.8278004	0.9559984	1991698	787844.6	1203853	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YOR086C	TCB1	1.218557	1.094936	10	0.6181769	2.402035	4683644	1861314	2822330	Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YBR172C	SMY2	1.064445	0.1472994	10	0.9715685	1.1662	3143513	1311541	1831972	Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2
YDR028C	REG1	1.225247	0.6530235	10	0.8174171	1.836553	3856680	1683776	2172904	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YHR073W	OSH3	0.9892513	0.1341677	10	0.9103147	1.075033	2310549	937784	1372765	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YJL074C	SMC3	0.9358952	0.1218452	10	0.8678189	1.009312	6335569	1458323	4877246	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YKL027W	YKL027W	1.06077	0.2661736	10	0.8994419	1.251035	1560323	748200	812123	Protein of unknown function, localized to the mitochondrial outer membrane
YKL164C	PIR1	1.071163	0.1855923	10	0.9547686	1.201747	5426306	2231214	3195092	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YKL205W	LOS1	0.8876093	0.2850148	10	0.7438784	1.059112	6281223	4174110	2107113	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
YML131W	YML131W	0.9132802	0.1702643	10	0.8218122	1.014929	4827330	1955903	2871427	Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm
YMR110C	HFD1	0.8724028	0.09025818	10	0.8249383	0.9225982	2431475	968724	1462751	Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YPR154W	PIN3	0.9633935	0.2194356	10	0.8408845	1.103751	2769903	1250739	1519164	Protein that induces appearance of [PIN+] prion when overproduced
YBL035C	POL12	0.9361856	0.1946699	10	0.8297763	1.056241	4127202	1676096	2451106	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
YBR058C	UBP14	1.00504	0.145723	10	0.9182434	1.100041	2002827	906943	1095884	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
YER107C	GLE2	1.029901	0.5290771	10	0.7419579	1.42959	1577179	733755.9	843423	Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p
YGL014W	PUF4	0.9670265	0.9946859	10	0.5220238	1.791375	1420169	658795	761374	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
YGL145W	TIP20	0.9216843	0.4217541	10	0.7096677	1.197042	4156111	1704264	2451847	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
YIL169C	YIL169C	0.6730106	0.1637283	10	0.6080647	0.7448932	4281880	1610326	2671554	Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR074C	BUD20	1.325019	0.7686694	10	0.8228351	2.13369	2275753	1304378	971375	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR124W	YMR124W	0.9299234	0.2619489	10	0.7905624	1.093851	15797500	6448518	9348982	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
YNL130C	CPT1	1.17762	0.7875986	10	0.7227709	1.918712	2175683	790964	1384719	Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YAL026C	DRS2	0.951428	0.2663471	10	0.8066424	1.122202	2064614	908612	1156002	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YBL101C	ECM21	1.068141	0.07078828	10	1.02229	1.11605	3849052	1719411	2129641	Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements
YER069W	ARG5,6	0.895428	0.153717	10	0.8140543	0.984936	1696080	688739.7	1007340	Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YJL183W	MNN11	0.8525797	0.1805778	10	0.7623024	0.9535482	1620973	639248	981725	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
YKL065C	YET1	0.9524415	0.3326146	10	0.7750069	1.170499	4172086	1530855	2641231	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YMR061W	RNA14	1.109517	0.5121135	10	0.8077635	1.523997	1987489	813821.7	1173667	Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3_prime ends; bridges interaction between Rna15p and Hrp1p in the CF I complex
YNL139C	THO2	0.9163779	0.1922494	10	0.8134394	1.032343	1286258	511271.9	774986	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
YOR069W	VPS5	1.188432	0.2120403	10	1.042072	1.355349	4095086	1622476	2472610	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p
YOR211C	MGM1	0.884253	0.1692991	10	0.7961683	0.9820831	1715984	715653.3	1000331	Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YOR288C	MPD1	0.6994536	0.5625765	10	0.4935434	0.991271	1239671	457136.4	782535	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
YDL148C	NOP14	1.014281	0.3066686	10	0.8387057	1.226611	7158914	2421913	4737001	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YLR258W	GSY2	1.004942	0.237334	10	0.8674731	1.164197	1848065	665592	1182473	Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YKR054C	DYN1	0.850559	0.1291605	10	0.7851221	0.9214498	1053959	389216.3	664743	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
YPR051W	MAK3	1.058345	0.1614136	10	0.9575866	1.169705	2627476	1109947	1517529	Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YJL002C	OST1	0.912443	0.1778629	9	0.8123423	1.024879	3121418	1402908	1718510	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YDR156W	RPA14	1.135966	0.0819701	9	1.076731	1.19846	6004232	2712194	3292038	RNA polymerase I subunit A14
YPL169C	MEX67	0.9571857	0.1432681	9	0.8716567	1.051107	10287420	4256372	6031048	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
Q0250	COX2	0.7911271	0.1584966	9	0.7133039	0.877441	9322208	3482694	5839514	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits
YDR330W	UBX5	0.9207722	0.2855858	9	0.7640475	1.109645	3026582	1306583	1719999	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YMR149W	SWP1	1.009749	0.3676395	9	0.7941449	1.283888	4377980	1779172	2598808	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YOR108W	LEU9	1.101788	0.209765	9	0.9606815	1.26362	5897113	2599981	3297132	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YDR166C	SEC5	0.9359005	0.149209	9	0.8489718	1.03173	5849920	2451201	3398719	Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YLR229C	CDC42	0.8086483	0.1493387	9	0.733477	0.8915237	2422450	944368	1478082	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YER082C	UTP7	0.9872383	0.1091662	9	0.9192789	1.060222	7993033	3438216	4554817	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR005C	TFG2	0.7526245	1.251334	9	0.3322967	1.704632	4211657	1668635	2543022	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
YLR435W	TSR2	1.379416	0.8973273	9	0.7675177	2.479145	3609348	1542152	2067196	Protein with a potential role in pre-rRNA processing
YBR234C	ARC40	1.095658	0.1810704	9	0.9734155	1.233252	8308344	4188882	4119462	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YLR262C	YPT6	1.059429	0.5896403	9	0.7207221	1.557313	1944634	758818.5	1185815	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YOL077C	BRX1	1.083508	0.249596	9	0.9204754	1.275418	2102094	976055	1126039	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YOR112W	CEX1	0.8598113	0.183149	9	0.7628455	0.9691023	48367510	20855110	27512400	Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
YMR216C	SKY1	0.9968875	0.1198658	9	0.9217976	1.078094	1737863	671014	1066849	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YPR137W	RRP9	1.065682	0.2168687	9	0.9248969	1.227896	1702620	731926	970694	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YBR200W	BEM1	1.03479	0.2051829	9	0.9049694	1.183234	2943097	1242927	1700170	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
YDL072C	YET3	0.7767009	0.1413535	9	0.7081843	0.8518464	4297293	1711532	2585761	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YDR087C	RRP1	0.9541531	0.09698164	9	0.8955722	1.016566	3402421	1410622	1991799	Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YBL034C	STU1	0.9987319	0.1739502	9	0.8914407	1.118936	35752730	16359330	19393400	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
YDR176W	NGG1	1.171335	0.2103822	9	1.02091	1.343925	2139403	910606	1228797	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YIL062C	ARC15	1.060769	0.4673723	9	0.7816438	1.439569	3551298	1620697	1930601	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YIL149C	MLP2	1.152689	0.1366511	9	1.054238	1.260333	1788885	1032360	756525	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YJR042W	NUP85	0.8820743	0.1996147	9	0.7742241	1.004948	1474631	606574	868057	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
YLL011W	SOF1	1.539019	0.5929775	9	1.044703	2.267226	26410570	12744280	13666290	Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YMR170C	ALD2	0.8082371	0.07061383	9	0.7717966	0.8463981	1828593	642656	1185937	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YPR002W	PDH1	1.286276	0.6661272	9	0.8323918	1.987652	1243753	693740.7	550012	Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YGR175C	ERG1	1.027329	0.8819592	9	0.5773819	1.827914	2680391	1284118	1396273	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YIL064W	SEE1	1.090886	0.103547	9	1.019528	1.167239	6546940	2860029	3686911	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport
YIL145C	PAN6	1.026529	0.1377847	9	0.9381585	1.123223	7891312	3272546	4618766	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YMR038C	CCS1	0.9368137	0.3173977	9	0.7613688	1.152687	16661870	7365209	9296665	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
YCR086W	CSM1	2.253284	1.531034	9	0.8287083	6.12675	1744616	962360	782255.5	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
YFL008W	SMC1	1.219391	0.6978019	9	0.7729464	1.923697	1133448	530114	603334	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YJL197W	UBP12	1.056258	0.3057394	9	0.8650073	1.289794	1474442	611481.8	862960	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
YKR026C	GCN3	1.042381	0.437528	9	0.7832183	1.3873	6718765	2931401	3787364	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YML059C	NTE1	0.9735596	0.1849259	9	0.8627637	1.098584	7889385	3715431	4173954	Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
YPL210C	SRP72	0.9655268	0.2235308	9	0.834334	1.117349	2330763	956779	1373984	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YHR023W	MYO1	0.866623	0.2152683	9	0.7529223	0.9974938	2842799	1255679	1587120	Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YHR070W	TRM5	0.8382676	0.3144586	9	0.6825878	1.029454	2780165	1220579	1559586	tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
YIL009W	FAA3	1.424628	1.061547	9	0.7120312	2.850386	5310705	2223233	3087472	Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YLR395C	COX8	1.136651	1.430951	9	0.4462831	2.894969	7743376	2785829	4957547	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YNL127W	FAR11	0.9473237	0.1761229	9	0.8443557	1.062848	3061091	1401377	1659714	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
YNL207W	RIO2	1.27018	0.4114934	9	0.9707527	1.661966	18568430	7805711	10762720	Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YOR141C	ARP8	1.130226	0.3207446	9	0.9165531	1.393712	1858574	802352	1056222	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YOR175C	ALE1	0.8458164	0.3027837	9	0.6940081	1.030831	3572822	1400511	2172311	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YPL084W	BRO1	1.189273	0.3281179	9	0.959802	1.473606	1608213	652098	956115	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YBR073W	RDH54	0.7366221	0.5766662	9	0.5053846	1.073662	6997485	2565424	4432061	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference
YDR047W	HEM12	1.013402	0.1888013	9	0.8958007	1.146442	2770658	1125524	1645134	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
YER164W	CHD1	0.9005169	0.09765739	9	0.844856	0.959845	1759560	968391	791169	Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
YGL086W	MAD1	1.021339	0.1038018	9	0.954371	1.093006	1309070	549131	759939	Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
YJL180C	ATP12	1.639081	0.9133662	9	0.9024909	2.976858	3392697	1403886	1988811	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YKL021C	MAK11	1.137566	0.3097311	9	0.9291671	1.392706	3007831	1370466	1637365	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YKL126W	YPK1	0.9624973	0.8890845	9	0.5384328	1.720551	3515389	1475593	2039796	Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK
YKL173W	SNU114	0.8894434	0.1703991	9	0.7957368	0.994185	1413488	505860	907628	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
YKL214C	YRA2	1.227767	0.75281	9	0.7507827	2.007786	3195950	1406231	1789719	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
YML025C	YML6	1.050093	0.2210519	9	0.9088802	1.213246	5106293	2137607	2968686	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YPR034W	ARP7	1.079152	0.4819872	9	0.787633	1.478567	3622368	1508629	2113739	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YPR128C	ANT1	0.907859	0.1501926	9	0.8230058	1.001461	11056370	4957493	6098878	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
YGR001C	YGR001C	1.402618	0.2941565	9	1.157379	1.69982	4546951	2288483	2258468	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YJL060W	BNA3	1.188083	0.528811	9	0.8410128	1.678384	4175789	2053042	2122747	Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
YLR083C	EMP70	0.9119943	0.2727574	9	0.763133	1.089894	1833129	586283	1246846	Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YNL292W	PUS4	1.102954	0.3638821	9	0.8695805	1.398959	15302610	6213564	9089047	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YOR281C	PLP2	1.288403	0.4940796	9	0.9329582	1.779269	2450955	1191554	1259401	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP
YOR370C	MRS6	0.9758565	0.1942495	9	0.8595473	1.107904	863774.4	343479.4	520295	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene
YPR115W	RGC1	0.9351021	0.2116899	9	0.8143185	1.073801	701794.2	265984.2	435810	Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBL051C	PIN4	0.9049459	0.4391819	9	0.6792186	1.20569	1702960	668168.9	1034791	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
YEL066W	HPA3	1.100268	0.2340873	9	0.9442325	1.28209	1523378	724082	799296	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YJL069C	UTP18	1.11012	0.2527355	9	0.9411504	1.309426	4215804	1973496	2242308	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR118C	YLR118C	0.8144088	0.4768076	9	0.5964218	1.112068	13247660	5364714	7882944	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
YLR166C	SEC10	0.9879666	0.3673803	9	0.7771451	1.255979	1515742	590011	925731	Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YOR160W	MTR10	1.024738	0.3202529	9	0.8312748	1.263226	2019912	875780	1144132	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs
YOR299W	BUD7	0.9924011	0.1239329	9	0.915214	1.076098	3353346	1379734	1973612	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YCR042C	TAF2	1.276678	0.8561329	9	0.7297316	2.233571	13992820	5581813	8411005	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
YFL017C	GNA1	1.133378	0.3546385	9	0.8989797	1.428892	7562486	4135633	3426853	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YGR287C	IMA1	0.9889797	0.2591519	9	0.8349411	1.171437	1440888	625960	814928	Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family
YLR045C	STU2	1.146779	0.7924935	9	0.6833111	1.924603	1458149	706982	751167	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
YLR292C	SEC72	1.114828	1.445765	9	0.4334988	2.867002	6550964	2896819	3654146	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YNL160W	YGP1	0.6975424	0.4159168	9	0.5315679	0.91534	1274826	388142	886684	Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YPR161C	SGV1	1.10884	0.3936977	9	0.8573566	1.43409	3091456	1352212	1739244	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p
YBL105C	PKC1	0.9525596	0.1705451	9	0.8521222	1.064835	4275038	1654398	2620640	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YBL106C	SRO77	1.078378	0.1129345	9	1.001675	1.160953	951094	389136	561958	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p
YDR049W	YDR049W	1.293201	0.4365102	9	0.9723241	1.719971	2997674	1434296	1563378	Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines
YDR245W	MNN10	0.8677889	0.1116182	9	0.8067587	0.933436	1415948	662290.3	753658	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
YGL233W	SEC15	0.9357178	0.1540922	9	0.8461023	1.034825	2017748	785132	1232616	Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
YLR203C	MSS51	0.8085682	0.1528728	9	0.7317128	0.893496	3617307	1427687	2189620	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase
YJL005W	CYR1	1.011238	0.4368689	9	0.7601449	1.345272	2491840	946317	1545523	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YNR030W	ALG12	0.8478212	0.1855989	9	0.7510046	0.9571189	3898512	1317334	2581178	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YCR036W	RBK1	0.9886926	0.5109937	9	0.7080639	1.380544	2488039	927476	1560563	Putative ribokinase
YNL067W	RPL9B	0.9212223	0.2559914	8	0.7714782	1.100032	6998678	3101344	3897334	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins
Q0045	COX1	0.8272276	0.2191124	8	0.7106945	0.9628687	8256479	3351388	4905091	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits
YDL181W	INH1	1.031959	0.1605255	8	0.9233198	1.153381	19344430	8758208	10586220	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YJL115W	ASF1	0.9406816	0.09051947	8	0.8834882	1.001577	4196988	1722767	2474221	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YOL088C	MPD2	0.9524082	0.3130706	8	0.7666627	1.183156	5923928	2405531	3518397	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
YJL084C	ALY2	2.092917	2.447566	8	0.3838444	11.41166	4131951	1806203	2325748	Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase
YOR360C	PDE2	0.942345	0.2280332	8	0.8046058	1.103664	3333816	1599325	1734491	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
YAL049C	AIM2	1.122423	0.2725709	8	0.9292364	1.355773	4987799	2149573	2838226	Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
YDR311W	TFB1	0.6554967	0.9465726	8	0.3401722	1.263113	3396096	1226225	2169871	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YDR511W	ACN9	1.145727	0.2375272	8	0.9718452	1.350719	2551734	1079026	1472708	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YDL150W	RPC53	1.023202	0.1356674	8	0.9313917	1.124063	2877712	1249212	1628500	RNA polymerase III subunit C53
YHL004W	MRP4	1.205895	0.721436	8	0.731464	1.988045	4796232	2677235	2118997	Mitochondrial ribosomal protein of the small subunit
YHR087W	RTC3	0.9843572	0.4345939	8	0.7283856	1.330283	8461175	5143982	3317193	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YJL011C	RPC17	1.042088	0.1044532	8	0.969324	1.120313	5389676	2276535	3113141	RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YLR413W	YLR413W	1.145288	0.1982551	8	0.9982736	1.313952	1860153	860415	999738	Putative protein of unknown function; YLR413W is not an essential gene
YNL274C	GOR1	1.061058	0.435351	8	0.7847291	1.43469	2843133	1232685	1610448	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR101W	RAS1	1.073858	0.3999077	8	0.813944	1.416771	8765482	3592524	5172958	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YDR533C	HSP31	0.7583209	0.3778568	8	0.5836288	0.9853019	1720635	608454	1112181	Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson_primes disease; exists as a dimer and contains a putative metal-binding site
YHR121W	LSM12	0.9854764	0.06656609	8	0.9410509	1.031999	1416881	587784	829097	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
YKR043C	YKR043C	1.043934	0.2651579	8	0.8687078	1.254506	5846195	2693646	3152549	Metal-independent fructose 1,6-bisphosphatase, may play a role in gluconeogenesis under metal-limiting conditions; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YLR209C	PNP1	0.9872956	0.1454757	8	0.8926192	1.092014	2238668	1048699	1189969	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
YMR120C	ADE17	1.478593	0.2028305	8	1.284715	1.70173	985571	477979	507592	Enzyme of _primede novo_prime purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
YMR215W	GAS3	0.862912	0.2106137	8	0.7457309	0.9985064	2915170	648223	2266947	Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YOR138C	RUP1	0.9080059	0.2579689	8	0.7593688	1.085737	1002211	384944	617267	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain
YDR021W	FAL1	1.004822	0.156562	8	0.9015128	1.119971	3165409	1345869	1819540	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YDR084C	TVP23	0.8847316	0.2562623	8	0.74078	1.056657	1041016	380526.4	660490	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR096W	GIS1	0.9619543	0.1194326	8	0.885546	1.044955	826470	348019	478451	JmjC domain-containing histone demethylase; transcription factor involved in expression of genes during nutrient limitation and in negative regulation of DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis
YGR048W	UFD1	0.9279356	0.3696745	8	0.7182308	1.198869	2225679	917133	1308546	Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
YJL066C	MPM1	0.9660453	0.2195666	8	0.8296956	1.124802	6309557	2739751	3569806	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YKR020W	VPS51	1.029233	0.1242962	8	0.9442928	1.121814	1087581	465851	621730	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
YLR206W	ENT2	1.328081	1.088545	8	0.6246347	2.82373	3358485	1433118	1925367	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YDR011W	SNQ2	0.8043799	0.2683258	8	0.6678953	0.9687552	1351869	556122.4	795747	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
YDR322W	MRPL35	0.8824056	0.09293208	8	0.827371	0.941101	11751690	4659709	7091980	Mitochondrial ribosomal protein of the large subunit
YMR219W	ESC1	1.083921	0.2064656	8	0.9394239	1.250644	4415583	1951302	2464281	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
YNL048W	ALG11	0.9924165	0.1988895	8	0.8646454	1.139069	6485152	2806413	3678739	Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
YNL264C	PDR17	0.9010984	0.07242651	8	0.8569894	0.9474778	1160850	435599	725251	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
YOR367W	SCP1	1.055352	0.1883222	8	0.9262362	1.202467	4199627	1836667	2362960	Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
YPR125W	YLH47	0.9377575	0.2482966	8	0.7895243	1.113821	7081947	3216041	3865906	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
YCL044C	MGR1	1.086561	0.4461351	8	0.797608	1.480195	1532307	691678	840629	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
YCR072C	RSA4	1.110166	0.5633915	8	0.7513372	1.640367	3027803	1218279	1809524	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YDR297W	SUR2	1.031114	0.3157983	8	0.828451	1.283353	2690162	952797	1737365	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YGR163W	GTR2	1.268307	0.5594209	8	0.8607289	1.868885	2328203	1041642	1286561	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
YIR004W	DJP1	1.078568	0.201763	8	0.937836	1.240419	1633914	699873	934041	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
YLR440C	SEC39	1.11445	0.2126779	8	0.9617338	1.291416	1783810	820116	963694	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
YMR089C	YTA12	1.052762	0.1547258	8	0.9457263	1.171912	12255500	4868458	7387037	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YOR256C	TRE2	0.9050449	0.8234246	8	0.5115168	1.601328	8512688	3666103	4846585	Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31
YBR246W	RRT2	1.501501	0.8524716	8	0.8317134	2.710676	1073135	562725	510410	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype
YDR007W	TRP1	1.027072	0.3172539	8	0.8243718	1.279613	3813866	1666138	2147728	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YEL052W	AFG1	0.7646141	0.7450295	8	0.4562734	1.281325	1548712	580904.7	967807	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YHR029C	YHI9	1.037346	0.3375187	8	0.8210075	1.31069	1654936	761439	893497	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
YHR062C	RPP1	0.9088963	0.09835751	8	0.8490115	0.9730051	29094680	11822560	17272120	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5_prime ends
YHR137W	ARO9	1.263083	0.7885563	8	0.731333	2.181466	1846891	753307	1093584	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YIL030C	SSM4	1.518824	1.068522	8	0.7243275	3.184785	3923983	1912771	2011212	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YKL137W	CMC1	0.9488272	0.459244	8	0.6902038	1.304358	831272.5	346115.5	485157	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
YNR026C	SEC12	1.145269	0.3269458	8	0.9130886	1.436488	1137220	506582	630638	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
YOR057W	SGT1	1.146581	0.2749557	8	0.9476687	1.387244	1055948	467492.1	588456	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes
YBR247C	ENP1	1.21905	0.3061015	8	0.9860524	1.507103	12365210	5111611	7253602	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YCR008W	SAT4	0.9132909	0.4097099	8	0.6875538	1.213142	4227063	1580526	2646537	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YDR163W	CWC15	1.07204	0.3809404	8	0.8233159	1.395902	19960170	9185358	10774810	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
YDR465C	RMT2	1.078727	0.2026901	8	0.9373714	1.241398	1180668	503623	677045	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67
YDR527W	RBA50	1.322541	0.6501488	8	0.8428427	2.075258	1063834	464884	598950	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YER075C	PTP3	1.007166	0.1090405	8	0.9338675	1.086218	3656192	1489475	2166717	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YFL044C	OTU1	1.105409	0.04563444	8	1.071	1.140924	2249666	992190	1257476	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family
YFR015C	GSY1	0.8437383	0.1710055	8	0.7494515	0.9498871	873428	332397	541031	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YGL004C	RPN14	0.9549025	1.459592	8	0.3472912	2.625575	4423721	1934172	2489549	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
YGR283C	YGR283C	0.9726905	0.2533089	8	0.8160959	1.159333	1756022	661276	1094746	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
YHR113W	YHR113W	1.048929	0.1224234	8	0.9636135	1.141799	1250982	540066	710916	Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes
YIL136W	OM45	0.872865	0.2171684	8	0.7509138	1.014622	1724437	681517	1042920	Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YMR247C	RKR1	1.024138	0.5240094	8	0.7122908	1.472514	2043567	897481	1146086	Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YPL031C	PHO85	0.862331	0.103193	8	0.8028196	0.9262538	835003	362357	472646	Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
YPR179C	HDA3	1.187349	0.2317445	8	1.011195	1.394191	3413432	1523721	1889711	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
YBR102C	EXO84	1.39915	0.6026746	8	0.9214862	2.124416	3041151	1400601	1640550	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
YBR169C	SSE2	1.020654	0.06967914	8	0.9725426	1.071146	7655843	2870660	4785183	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YCL059C	KRR1	0.6681458	0.9074832	8	0.3562571	1.253081	1815112	568683	1246429	Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YCR034W	FEN1	0.753909	0.3075402	8	0.6092064	0.9329822	3009220	1204766	1804454	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YDR109C	YDR109C	0.9874298	0.664563	8	0.623025	1.564973	742059.4	361443.4	380616	Putative kinase
YDR301W	CFT1	1.179495	0.2517268	8	0.9906924	1.40428	608335	260515	347820	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YDR500C	RPL37B	0.8321556	0.03197725	8	0.8139185	0.8508012	1069810	408810.5	660999	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YER015W	FAA2	0.9109209	0.2586218	8	0.761462	1.089715	846074	314205	531869	Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
YGR183C	QCR9	0.7441521	0.1758994	8	0.6587561	0.8406181	2813271	939205	1874066	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YGR233C	PHO81	1.185876	0.5664162	8	0.8008956	1.755911	1033110	418146	614964.5	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YJR067C	YAE1	1.030231	0.09749384	8	0.9629283	1.102239	1739221	589122	1150099	Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions
YKL088W	CAB3	1.18759	0.2354651	8	1.008796	1.398073	1562583	597737.6	964845	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
YKL112W	ABF1	1.033291	0.1401315	8	0.9376698	1.138663	5574540	2343401	3231139	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YKR038C	KAE1	0.9273406	0.3298876	8	0.7378351	1.165519	1714582	680931	1033651	Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YKR042W	UTH1	0.9918811	0.3328194	8	0.7875849	1.249171	891057	320846	570211	Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death
YNR015W	SMM1	1.092025	0.1890012	8	0.9579716	1.244838	8698765	3796660	4902105	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YOR038C	HIR2	0.987803	0.142389	8	0.8949902	1.090241	1083044	462427	620617	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
YOR275C	RIM20	1.228887	0.3711324	8	0.9502097	1.589295	1212588	491939.5	720648	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
YPL138C	SPP1	1.226344	0.2721583	8	1.015561	1.480875	9628413	4586795	5041618	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
YPL183C	RTT10	0.9504609	0.1884028	8	0.8341311	1.083014	2058089	859486	1198603	Cytoplasmic protein with a role in regulation of Ty1 transposition
YDR088C	SLU7	1.111727	0.1535153	8	0.9995341	1.236513	10865040	5064249	5800787	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YGR271W	SLH1	1.170492	0.2289729	8	0.9987544	1.371759	3668318	1538478	2129840	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
YHL003C	LAG1	0.8172513	0.1219746	8	0.7510127	0.8893321	778938.2	289585.2	489353	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YIR034C	LYS1	1.151671	0.3886294	8	0.8797722	1.507603	5005853	2322624	2683229	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YJR113C	RSM7	0.9472821	0.1929504	8	0.8287256	1.082799	1642085	644967	997118	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YOL052C	SPE2	1.139568	0.9174757	8	0.6034276	2.152064	1263396	666519	596877	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YOR222W	ODC2	0.9277736	0.2765778	8	0.7659594	1.123772	5129245	1864042	3265203	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YPR172W	YPR172W	0.9056442	0.1326981	8	0.8260799	0.9928719	1379984	562760	817224	Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YBR055C	PRP6	0.9403047	0.1657079	8	0.8382985	1.054723	716647	308072	408575	Splicing factor, component of the U4/U6-U5 snRNP complex
YDR221W	GTB1	1.832164	1.720883	8	0.5559854	6.037611	1861739	805874	1055865	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
YGR276C	RNH70	1.385496	0.9679006	8	0.7084595	2.709542	1840324	845942	994382.5	3_prime-5_prime exoribonuclease; required for maturation of 3_prime ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts
YLR290C	YLR290C	0.7785689	0.6780037	8	0.4866888	1.245497	1189134	474059	715075	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
YNL256W	FOL1	1.055742	0.06738031	8	1.00758	1.106205	2094796	890240	1204556	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YPL094C	SEC62	0.6883938	0.4377692	8	0.5082648	0.9323606	1858987	710555	1148432	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YPR113W	PIS1	0.8628751	0.1246618	8	0.7914634	0.94073	2490733	1005912	1484821	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YDL198C	GGC1	0.7286504	0.1654325	8	0.6497289	0.8171584	2994031	1010380	1983651	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
YDR061W	YDR061W	1.36079	1.229674	8	0.5803897	3.190528	3826262	1880628	1945634	Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YGL236C	MTO1	1.051643	0.2983422	8	0.8552287	1.293168	1661917	672200	989717	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YGR165W	MRPS35	0.9039718	0.3091443	8	0.7296552	1.119933	3233026	1211841	2021185	Mitochondrial ribosomal protein of the small subunit
YJL042W	MHP1	0.9321396	0.1532201	8	0.8382417	1.036556	1201461	492452	709009	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YJR003C	YJR003C	1.415051	1.124671	8	0.6490851	3.084912	932983	460007	472976	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
YML046W	PRP39	0.9178363	0.1697045	8	0.8160044	1.032376	1076192	417389	658803	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
YNL267W	PIK1	0.8719626	0.4567835	8	0.6353727	1.19665	1787182	743263	1043919	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton
YNR067C	DSE4	0.9449867	0.1305844	8	0.8632294	1.034487	896576	355135	541441	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YOR320C	GNT1	0.9171981	0.1760275	8	0.811872	1.036188	883875	339108	544767	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YPL228W	CET1	0.9749071	0.1513697	8	0.877826	1.082725	587402.5	228566.5	358836	Beta (RNA 5_prime-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5_prime cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YPR144C	NOC4	0.8530789	0.2316698	8	0.7265542	1.001637	879924.1	324771.1	555153	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YBR282W	MRPL27	0.9558094	0.1798744	8	0.843797	1.082691	4203347	1641524	2561823	Mitochondrial ribosomal protein of the large subunit
YHR034C	PIH1	1.030475	0.190099	8	0.9032895	1.175568	4709664	1955167	2754497	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
YDR510W	SMT3	0.97523	0.08705061	7	0.9143243	1.040193	17536060	7241474	10294590	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
YPR133W-A	TOM5	1.025884	0.03970425	7	0.9961487	1.056507	11457010	4826380	6630634	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
YDL212W	SHR3	0.8903188	0.2488347	7	0.7404368	1.07054	11773950	4953176	6820774	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YKL141W	SDH3	0.902364	0.09013618	7	0.8440774	0.9646755	8404274	3279261	5125013	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YKR056W	TRM2	1.273427	0.1148669	7	1.169547	1.386532	2304803	1132812	1171991	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YER012W	PRE1	1.024719	0.1187717	7	0.9384098	1.118967	4458947	2028501	2430446	Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YGL041W-A	YGL041W-A	1.019443	0.1258574	7	0.9286904	1.119064	2416367	1036314	1380053	Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry
YIL044C	AGE2	0.9601896	0.1058773	7	0.887755	1.038534	5602645	2432700	3169945	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
YJL140W	RPB4	0.8014273	0.3683922	7	0.6100162	1.0529	1447590	644903	802687	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3_prime-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YDL213C	NOP6	0.8595556	0.1528302	7	0.7675452	0.9625959	8852006	3782388	5069618	Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YJR080C	AIM24	0.8950526	0.2165223	7	0.762407	1.050776	3881733	1611642	2270091	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
YKL069W	YKL069W	0.9376083	0.1497511	7	0.8391547	1.047613	2666636	1130144	1536492	Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress
YNL009W	IDP3	1.028819	0.111365	7	0.9473477	1.117296	19541800	8392283	11149520	Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids
YCR087C-A	YCR087C-A	0.938964	0.1213224	7	0.8582541	1.027264	4010212	1814454	2195758	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YHL021C	AIM17	0.8866739	0.3763765	7	0.6709225	1.171805	2600592	1039050	1561542	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
YJR076C	CDC11	2.383012	1.5848	7	0.7366291	7.709097	13818620	6355800	7462820	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR294W	RRS1	1.221351	0.4078963	7	0.9028344	1.652239	3928166	1798631	2129535	Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington_primes disease model mice
YPL246C	RBD2	0.908613	0.2546114	7	0.7524244	1.097223	4038725	1488134	2550591	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YDR289C	RTT103	1.107905	0.4682526	7	0.7831622	1.567305	3769714	1590261	2179453	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
YOR327C	SNC2	0.9576063	0.2935293	7	0.7704596	1.190212	3632855	1700534	1932321	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YDL052C	SLC1	0.6811168	0.3561999	7	0.5231442	0.8867919	5141557	1729962	3411595	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
YDR098C	GRX3	1.113358	0.1331098	7	1.00881	1.228741	15835820	7212865	8622959	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YJR039W	YJR039W	0.91072	0.1709438	7	0.802393	1.033672	5995891	2411581	3584310	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR084C	HBS1	0.9505814	0.1140673	7	0.8735554	1.034399	1507252	658648	848604	GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components
YLR089C	ALT1	1.078445	0.2797503	7	0.8765849	1.32679	3338123	1582643	1755480	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML015C	TAF11	1.085148	0.1687	7	0.9576641	1.229603	4013171	1688788	2324383	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YNL059C	ARP5	0.7081857	0.9728834	7	0.3444622	1.455971	1674718	543190	1131528	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YNL206C	RTT106	1.191758	0.2149893	7	1.016295	1.397515	4033914	2113430	1920484	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
YDR068W	DOS2	1.205053	0.2075187	7	1.033335	1.405306	1694888	775951	918937	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR399W	HPT1	1.02308	0.3260279	7	0.8035572	1.302575	2914790	1273743	1641047	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YER103W	SSA4	2.818741	1.297969	7	1.077605	7.373108	10805580	9951033	854552	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YGR169C-A	YGR169C-A	1.430673	0.6640031	7	0.8748037	2.339752	3745452	1720158	2025294	Putative protein of unknown function
YBR269C	FMP21	0.9887353	0.1510824	7	0.8840409	1.105828	6275667	2711387	3564280	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL099W	BUG1	0.8911236	0.2541004	7	0.7382208	1.075696	1640122	706071	934051	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YDL141W	BPL1	1.024424	0.04954034	7	0.987509	1.062719	5307115	2153280	3153835	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YDR491C	YDR491C	0.8561173	0.5360966	7	0.5755128	1.273537	9096990	3976382	5120608	NA
YFL036W	RPO41	0.8519319	0.1978246	7	0.7357984	0.9863953	3564521	1495173	2069348	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YIL005W	EPS1	0.9564566	0.1412528	7	0.86143	1.061966	4825245	1976716	2848529	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
YIL108W	YIL108W	0.9663205	0.09132474	7	0.9031072	1.033958	8858124	3324682	5533442	Putative metalloprotease
YKL010C	UFD4	1.081918	0.5658983	7	0.7114231	1.645359	4214567	1898143	2316424	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YML039W	YML039W	1.124973	0.2403925	7	0.9414572	1.344261	10698670	5114093	5584580	NA
YNL005C	MRP7	1.007183	0.08969453	7	0.942434	1.07638	3789064	1582389	2206675	Mitochondrial ribosomal protein of the large subunit
YNR008W	LRO1	0.9263998	0.08402298	7	0.8704939	0.9858961	2055364	912242.1	1143122	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
YPL086C	ELP3	1.284434	0.8083666	7	0.705726	2.337693	2022153	841822	1180331	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YPL208W	RKM1	0.9676582	0.3046636	7	0.7721517	1.212666	3750328	1943323	1807005	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)
YPR173C	VPS4	0.9829338	0.2235061	7	0.8329438	1.159933	3126887	1357964	1768923	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
YBR264C	YPT10	1.378829	0.9818073	7	0.6662444	2.85356	2229038	983247	1245791	Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
YCL057C-A	YCL057C-A	0.7051267	0.1412347	7	0.635079	0.7829005	1206357	403512	802845	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR397C	NCB2	0.8527375	0.3866422	7	0.6403553	1.135559	1594811	588484	1006327	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YER157W	COG3	0.9308883	0.117428	7	0.8533309	1.015495	1410169	540173	869996	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGL190C	CDC55	1.114143	0.1745173	7	0.9790242	1.26791	1848811	790021	1058790	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip
YHL020C	OPI1	1.274605	0.3679156	7	0.9705236	1.673959	1377582	508385	869197	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YKL018W	SWD2	1.302151	0.4190929	7	0.9546114	1.776217	10150480	4017463	6133013	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
YKR025W	RPC37	1.036827	0.06799363	7	0.9858949	1.09039	1618372	702402	915970	RNA polymerase III subunit C37
YML080W	DUS1	0.7893321	0.7314322	7	0.4591306	1.357011	4627329	1848913	2778416	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YNL258C	DSL1	0.8937969	0.04699665	7	0.8632143	0.9254631	2222520	877087	1345433	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p
YPL190C	NAB3	1.037473	0.1455819	7	0.9314057	1.15562	827813	368441	459372	Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p
YAL043C	PTA1	1.321925	0.788008	7	0.7373628	2.369914	10322480	1330851	8991624	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3_prime ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
YBR092C	PHO3	1.113826	0.3638763	7	0.8506432	1.458435	2974490	1203145	1771345	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YBR261C	TAE1	1.104031	0.1419281	7	0.9938454	1.226433	8190742	4247702	3943040	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
YCL031C	RRP7	1.077378	0.2942557	7	0.866358	1.339797	2349289	930889	1418400	Essential protein involved in rRNA processing and ribosome biogenesis
YDR036C	EHD3	0.9616281	0.104178	7	0.8902049	1.038782	2093091	850803	1242288	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YDR144C	MKC7	0.7128035	0.6755205	7	0.4321502	1.175723	941569.4	342610.4	598959	GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YDR153C	ENT5	0.9961263	0.1510022	7	0.8907022	1.114029	1331750	516067	815683	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YER134C	YER134C	1.217423	0.58839	7	0.7872973	1.882539	7432980	3606940	3826040	Putative protein of unknown function; non-essential gene
YFL059W	SNZ3	0.9026095	0.1932555	7	0.7822109	1.04154	3402412	2040338	1362074	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YIL065C	FIS1	0.7862952	0.2062817	7	0.6748677	0.9161205	2356017	849351.4	1506666	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
YIL074C	SER33	0.9500126	0.4561795	7	0.6775835	1.331974	1306667	564348	742319	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YKL113C	RAD27	0.9672525	0.3432673	7	0.7500678	1.247324	1443835	599832	844003	5_prime to 3_prime exonuclease, 5_prime flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YKL175W	ZRT3	0.9136952	0.214126	7	0.7796696	1.07076	1960329	747795	1212534	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
YLR110C	CCW12	1.415049	0.896113	7	0.7285598	2.748386	3176556	1628496	1548060	Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR450W	HMG2	0.7833905	0.2382567	7	0.6566349	0.9346146	1975209	733026	1242183	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
YML097C	VPS9	1.051013	0.1348781	7	0.9510729	1.161455	2830002	1122215	1707787	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YNL073W	MSK1	1.047459	0.2068051	7	0.8986733	1.220879	11011030	5215240	5795786	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
YNL186W	UBP10	1.248426	0.5757786	7	0.8149253	1.912529	1494875	621515	873360.1	Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YOL045W	PSK2	0.9576834	0.217571	7	0.8151225	1.125178	1254654	629922	624732	One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
YOL094C	RFC4	1.013349	0.2178171	7	0.8623441	1.190795	868949.9	363327.9	505622	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YPL270W	MDL2	0.9778109	0.1875054	7	0.8509985	1.12352	9931010	4016336	5914674	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
YAL024C	LTE1	0.6864825	0.4549663	7	0.4900645	0.9616249	1943005	678274	1264731	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
YAL039C	CYC3	1.20879	0.2672003	7	0.9917093	1.473388	2222551	1001331	1221220	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YCR033W	SNT1	1.466145	1.171506	7	0.6155574	3.492091	738407	382755	355652	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
YGR271C-A	EFG1	0.8861332	0.1584952	7	0.787964	0.996533	1257881	563985	693896	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YJL095W	BCK1	0.9923054	0.2211901	7	0.8423293	1.168985	4771176	2067654	2703521	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
YLR033W	RSC58	1.068208	0.3166407	7	0.8448568	1.350606	2217196	974478	1242718	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YLR226W	BUR2	1.097405	0.3970761	7	0.817741	1.472713	2497175	1048066	1449109	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
YLR418C	CDC73	0.5366507	0.9909614	7	0.2575549	1.118185	4199913	680588	3519325	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance
YNL102W	POL1	0.9242351	0.1210378	7	0.8449694	1.010937	1615116	709995	905121	Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
YNL278W	CAF120	1.175504	0.237521	7	0.9858403	1.401657	5066509	2409837	2656672	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YOL055C	THI20	0.9486113	0.1527877	7	0.8470947	1.062294	1898604	725682	1172922	Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p
YOR304W	ISW2	1.205676	0.5475489	7	0.8036515	1.808812	2760773	1136579	1624194	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
YPR056W	TFB4	0.9883554	0.1547384	7	0.8813109	1.108402	2011927	720944	1290983	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
YDR159W	SAC3	1.025301	0.09178076	7	0.9579059	1.097438	2819240	1208049	1611191	Nuclear pore-associated protein, required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
YDR164C	SEC1	0.8218114	0.1241002	7	0.7496274	0.9009463	4666737	2057593	2609144	Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
YDR295C	HDA2	1.075601	0.251722	7	0.8926164	1.296098	2387859	968409	1419450	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
YGL025C	PGD1	1.037559	0.1220584	7	0.9478571	1.135749	905259	376939	528320	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YGL067W	NPY1	1.273351	0.7916029	7	0.7083792	2.288919	1260516	539634.8	720880.7	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YIL124W	AYR1	1.671039	0.9530762	7	0.8248092	3.385475	5165391	3887258	1278133	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
YJL012C	VTC4	1.004923	0.2170218	7	0.8556779	1.180199	3245320	2150192	1095128	Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion
YJR073C	OPI3	0.9786051	0.1236314	7	0.892959	1.072466	1770852	742924	1027928	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
YJR142W	YJR142W	0.8927939	0.2289804	7	0.7534967	1.057843	2729411	1150125	1579286	Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition
YLR285W	NNT1	1.033031	0.2476489	7	0.8598791	1.24105	2112998	923593	1189405	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YML013W	UBX2	0.88732	0.1525756	7	0.792487	0.9935013	2349172	936955.7	1412216	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
YML071C	COG8	1.137455	0.22816	7	0.9605683	1.346914	774414	343119	431295	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL197C	WHI3	1.138969	0.1869824	7	0.9916397	1.308186	4325180	2064580	2260600	RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start
YBL057C	PTH2	0.8654365	0.1023955	7	0.8022163	0.9336387	3443447	1366008	2077439	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
YBL069W	AST1	1.089383	0.290191	7	0.8786532	1.350653	2509984	990055	1519929	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YDR494W	RSM28	0.8659053	0.6254086	7	0.544826	1.376205	542512.2	212066.2	330446	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
YDR518W	EUG1	0.9216598	0.1813947	7	0.805769	1.054219	1435112	594221	840891	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
YGL130W	CEG1	1.074349	0.1506568	7	0.9608917	1.201202	445993	184475	261518	Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5_prime-triphophatase) involved in adding the 5_prime cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YGL213C	SKI8	1.084953	0.1440491	7	0.9751382	1.207135	2019595	856586	1163009	Ski complex component and WD-repeat protein, mediates 3_prime-5_prime RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype
YGR002C	SWC4	1.100803	0.4439884	7	0.7922557	1.529516	1097985	439455	658530	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
YGR205W	YGR205W	0.9683881	0.1089192	7	0.8933196	1.049765	4446841	1773064	2673777	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases
YIL144W	TID3	1.028893	0.1652512	7	0.9103403	1.162884	1614507	681576	932931	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YJL117W	PHO86	0.9275701	0.188671	7	0.8065767	1.066714	616480	268581	347899	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
YKL207W	AIM27	0.8650056	0.1611696	7	0.7676546	0.9747023	1741045	643064	1097981	Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response
YMR302C	YME2	1.034909	0.321735	7	0.8154368	1.313451	3115990	1322922	1793068	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
YOR048C	RAT1	1.133159	0.1638591	7	1.003627	1.279409	1819573	796516	1023057	Nuclear 5_prime to 3_prime single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YPL195W	APL5	0.8874347	0.1094075	7	0.8183456	0.9623567	2064786	757349	1307437	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
YBR208C	DUR1,2	2.061229	1.700663	7	0.5847526	7.265744	635671.3	405091.3	230580	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YBR275C	RIF1	0.8423004	0.1068798	7	0.7781809	0.9117031	5033261	2516865	2516396	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YCL034W	LSB5	0.7708107	0.3012725	7	0.6166225	0.9635541	510926.6	175131.6	335795	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
YDL156W	YDL156W	1.213508	0.3547423	7	0.9330641	1.578243	1317452	578664	738788	Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR135C	YCF1	0.8635423	0.1850119	7	0.752939	0.9903928	1207549	480876	726673	Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YGL082W	YGL082W	0.9227216	0.1313497	7	0.837166	1.017021	2326927	937398	1389529	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
YGR223C	HSV2	1.143848	0.3546188	7	0.8795832	1.48751	628901	268991	359910	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
YJL112W	MDV1	0.9467977	0.1087108	7	0.8735378	1.026202	2007540	822970	1184570	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YKL059C	MPE1	0.9638467	0.06944033	7	0.9155181	1.014726	6135651	2870713	3264938	Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3_prime end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YML108W	YML108W	1.009553	0.5574481	7	0.6680076	1.525727	767647	332044	435603	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YOR145C	PNO1	0.8634707	0.1300774	7	0.7841476	0.950818	3587677	1420343	2167334	Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YBR123C	TFC1	0.9737951	0.09417463	7	0.9081734	1.044158	823226	335693	487533	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63
YMR115W	MGR3	0.9145363	0.2094029	7	0.7831227	1.068002	957231	419163	538068	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
YCR081W	SRB8	0.896807	0.188082	7	0.7801666	1.030886	1072898	465855	607043	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
YLR378C	SEC61	0.890085	0.1967444	6	0.7604335	1.041842	565239	224942	340297	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YPL199C	YPL199C	1.086206	0.1920844	6	0.931454	1.266669	2544447	1068563	1475884	Putative protein of unknown function, predicted to be palmitoylated
YFL034C-A	RPL22B	0.8478348	0.1939738	6	0.7259451	0.9901903	3586438	1584608	2001830	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
YPL204W	HRR25	0.9919335	0.2103504	6	0.8382704	1.173765	3795986	1582512	2213474	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YBR252W	DUT1	1.040073	0.3449428	6	0.7892117	1.370674	3877156	1537155	2340001	dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YDL047W	SIT4	1.15915	0.1648658	6	1.015892	1.32261	8875287	4344927	4530360	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDR266C	YDR266C	1.120521	0.1775894	6	0.9720892	1.291617	3175052	1365914	1809138	Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
YBR257W	POP4	0.8960951	0.1935862	6	0.7675053	1.046229	3310383	1302217	2008166	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5_prime ends; binds to the RPR1 RNA subunit in RNase P
YJL125C	GCD14	0.9936395	0.1045822	6	0.9138727	1.080369	2281098	920140	1360958	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YLR022C	SDO1	0.8903466	0.2462165	6	0.7311338	1.08423	1300691	508100	792591	Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
YOR103C	OST2	0.8946619	0.3810096	6	0.6595612	1.213564	2125251	887678	1237573	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YCR073W-A	SOL2	0.8941712	0.1398976	6	0.7994755	1.000083	3834406	1541199	2293207	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YDR138W	HPR1	1.09805	0.08692558	6	1.024271	1.177144	1215037	510087	704950	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
YLR055C	SPT8	1.024011	0.09277331	6	0.9507471	1.10292	1666131	708223	957908	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YPR187W	RPO26	1.087987	0.1244778	6	0.9848423	1.201934	5091209	2067108	3024101	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YDL116W	NUP84	0.9494066	0.1189344	6	0.8632202	1.044198	2909494	1135864	1773630	Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
YDR027C	VPS54	0.9613308	0.1162001	6	0.8759764	1.055002	7798659	3208939	4589720	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
YPR010C-A	YPR010C-A	0.9713624	0.2387201	6	0.8024614	1.175813	3572228	1522835	2049393	Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YDL113C	ATG20	1.03166	0.1351862	6	0.9258879	1.149516	2168044	874308	1293736	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YER002W	NOP16	1.018358	0.1263118	6	0.9204629	1.126665	2109440	875031	1234409	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YFL002C	SPB4	0.9250564	0.09721462	6	0.8558257	0.9998873	1767279	797066	970213	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YAL017W	PSK1	1.291058	0.7528099	6	0.7068681	2.358051	1594402	632112	962289.8	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YBR022W	POA1	1.025818	0.1757375	6	0.8912511	1.180702	4400923	1847531	2553392	Phosphatase that is highly specific for ADP-ribose 1_prime_prime-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YDL086W	YDL086W	0.835619	0.5111638	6	0.5551045	1.257887	940111	343649	596462	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
YDL153C	SAS10	1.052825	0.2239141	6	0.8801246	1.259413	1378987	580623	798364	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced
YFL034C-B	MOB2	0.9666088	0.149411	6	0.8576878	1.089362	570350	234198	336152	Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
YGL049C	TIF4632	1.152228	0.3430392	6	0.8756481	1.516168	9327821	4404926	4922895	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p
YNL108C	YNL108C	0.7504757	0.674616	6	0.4374236	1.287571	574646.7	239171.7	335475	Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus
YOR274W	MOD5	1.038986	0.1166292	6	0.946412	1.140616	2877964	1278075	1599889	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YOR283W	YOR283W	0.9582227	0.1228737	6	0.8684941	1.057222	2485283	1040502	1444781	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
YAL059W	ECM1	2.184892	1.757127	6	0.5355676	8.913446	447145.9	205361	241784.9	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
YDL101C	DUN1	0.8916302	0.2016367	6	0.7587775	1.047744	26819870	12209020	14610850	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YDR515W	SLF1	0.9700774	0.1750128	6	0.8433115	1.115899	1638423	959728.2	678695	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
YGR097W	ASK10	1.043252	0.03709869	6	1.012738	1.074685	714482	290972	423510	Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p
YHR069C	RRP4	0.9321238	0.1277804	6	0.8415286	1.032472	1308713	604217	704496	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
YJR132W	NMD5	0.9414165	0.2157831	6	0.7921282	1.11884	2035440	805397	1230043	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
YMR264W	CUE1	0.870756	0.1388123	6	0.7792164	0.9730493	1072976	424969	648007	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination
YNR023W	SNF12	1.099642	0.1355586	6	0.9866053	1.225629	1692779	825863	866916	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive
YOL059W	GPD2	1.428103	0.8480968	6	0.7245015	2.815011	2411920	1248300	1163620	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YPL053C	KTR6	0.9910006	0.1221783	6	0.8987026	1.092778	1537395	612121	925274	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family
YPL116W	HOS3	0.9064207	0.06452034	6	0.8608124	0.9544455	1038585	402796	635789	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
YCR090C	YCR090C	0.9770742	0.1768727	6	0.8481309	1.125621	2778062	1097945	1680117	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YDL203C	ACK1	0.9932068	0.09534431	6	0.920252	1.071945	623780	249339	374441	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
YDR326C	YSP2	0.9491909	0.1921058	6	0.8139454	1.106909	970206.8	398286.8	571920	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YDR468C	TLG1	0.8478155	2.937151	6	0.08083846	8.891699	9170568	2707390	6463178	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
YDR505C	PSP1	0.9585626	0.0972615	6	0.8867912	1.036143	1686596	697790	988806	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YGL220W	FRA2	1.26436	0.3180819	6	0.9802454	1.630823	1527891	672072	855819	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
YGL228W	SHE10	1.033774	0.3119719	6	0.8054026	1.326901	2907597	1133773	1773824	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YGR056W	RSC1	1.038593	0.09749989	6	0.9606461	1.122865	518060	224502	293558	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YHR186C	KOG1	0.9979888	0.2148256	6	0.8403729	1.185166	2552834	926071	1626763	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
YIR036C	IRC24	1.143992	0.2800455	6	0.9143343	1.431334	2785946	1171866	1614080	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci
YJL176C	SWI3	1.059746	0.2367148	6	0.8768827	1.280743	1478789	690445	788344	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YKL103C	LAP4	0.9183907	0.4181264	6	0.6572419	1.283305	2246253	495922	1750331	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YLR005W	SSL1	1.050556	0.2480609	6	0.8614222	1.281216	1168075	461035	707040	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YNR032C-A	HUB1	1.175297	0.1880864	6	1.011081	1.366183	1016550	400611	615939	Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
YPL013C	MRPS16	0.9413274	0.1014416	6	0.8679384	1.020922	6280992	2462147	3818845	Mitochondrial ribosomal protein of the small subunit
YPR072W	NOT5	1.118315	0.1294082	6	1.00831	1.240323	1012526	455955	556571	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YDL077C	VAM6	0.8172673	0.07384313	6	0.7703765	0.8670122	856591	332220	524371	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
YDL111C	RRP42	1.051456	0.1413202	6	0.9390337	1.177338	1839176	914167.3	925009	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
YDR231C	COX20	1.204257	0.4406797	6	0.8464071	1.7134	1501977	993211	508766	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YGL246C	RAI1	1.132745	0.2339374	6	0.9393709	1.365927	5166961	2429607	2737354	Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YGR040W	KSS1	1.118215	0.344826	6	0.8485851	1.473516	1067969	418394	649575	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YGR111W	YGR111W	0.902828	0.06847131	6	0.854694	0.9536727	4492831	1998558	2494273	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR140W	CBF2	1.775527	1.243772	6	0.6563065	4.803388	646437.2	291104	355333.2	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YIL118W	RHO3	0.8708891	0.1731522	6	0.7582128	1.00031	2129093	765568	1363525	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YJL047C	RTT101	1.489766	1.175994	6	0.5813672	3.817556	1489100	744006	745093.7	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
YJL154C	VPS35	0.8173103	0.07865722	6	0.7674551	0.8704042	1349267	564729	784538	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
YJR034W	PET191	1.001305	0.04848681	6	0.9632006	1.040916	10924970	4745238	6179728	Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif
YKL028W	TFA1	0.9217721	0.1931561	6	0.7897693	1.075838	2345275	951882.4	1393393	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YKL154W	SRP102	0.9703727	0.1218981	6	0.8801932	1.069791	7241295	2960520	4280775	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YML093W	UTP14	1.188203	0.2725068	6	0.9554154	1.477709	4831098	2131191	2699907	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YNL253W	TEX1	1.028433	0.1217068	6	0.933001	1.133627	1533452	734364	799088	Protein involved in mRNA export, component of the transcription export (TREX) complex
YNR022C	MRPL50	0.8873578	0.1351124	6	0.7964273	0.9886701	692761	285977	406784	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YOL053W	AIM39	0.8920482	0.05343534	6	0.8547107	0.9310168	785592.3	317835.3	467757	Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
YOL140W	ARG8	0.9733525	0.1083919	6	0.8924895	1.061542	796735	332507	464228	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
YOR052C	YOR052C	1.216485	0.2984374	6	0.9580702	1.5446	13900730	6080033	7820701	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YOR291W	YPK9	0.9770299	0.3012453	6	0.7677551	1.243349	1080677	453637.8	627039	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor?Rakeb syndrome
YOR347C	PYK2	0.9604514	0.1413915	6	0.8577105	1.075499	879546.7	379754.7	499792	Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YBR057C	MUM2	1.077794	0.1343252	6	0.9679585	1.200093	1261288	562870	698418	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
YDR206W	EBS1	0.9613336	0.09137495	6	0.8935536	1.034255	4494370	1926463	2567907	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YDR244W	PEX5	1.196035	0.3635484	6	0.894145	1.599852	1336342	690227	646115	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
YDR310C	SUM1	1.011947	0.117351	6	0.9212495	1.111573	4774468	1884583	2889885	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
YDR334W	SWR1	0.8862031	0.1273233	6	0.8003637	0.9812487	1697515	690985	1006530	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YDR497C	ITR1	0.8629196	0.2014543	6	0.734452	1.013858	2666859	1211557	1455302	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YGL197W	MDS3	1.038568	0.1105729	6	0.9506262	1.134644	703286.4	312395.4	390891	Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
YHR005C	GPA1	0.8904653	0.1402745	6	0.7959219	0.9962389	701688	277313	424375	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YHR072W	ERG7	1.177337	0.3504509	6	0.8894391	1.558422	3058463	1333733	1724730	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YJL045W	YJL045W	0.8772621	0.1597335	6	0.772006	0.9968689	4262307	1790139	2472168	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YJR010C-A	SPC1	0.8865505	0.3740518	6	0.6572302	1.195885	747900	316422	431478	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
YLR039C	RIC1	0.6979999	0.7325299	6	0.3884145	1.25434	647913.6	186502.6	461411	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YLR078C	BOS1	1.118287	0.3730851	6	0.8296659	1.507313	2547202	1191460	1355742	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YPR025C	CCL1	0.9125506	0.05138544	6	0.8757903	0.9508539	377633	151624	226009	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YBL023C	MCM2	0.9131718	0.1884576	6	0.7853477	1.061801	663134	260846	402288	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBL025W	RRN10	1.155669	0.4540011	6	0.8036456	1.661891	971018	443251	527767	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YBR216C	YBP1	0.9363107	0.195255	6	0.8008798	1.094643	1058601	379430	679171	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
YDR383C	NKP1	1.141783	0.151087	6	1.011765	1.288509	1963140	1200830	762310	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YHR154W	RTT107	0.9838067	0.4069237	6	0.7103961	1.362445	995052	389339	605713	Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YJL155C	FBP26	1.006178	0.2106773	6	0.8500856	1.190931	2429069	1052513	1376556	Fructose-2,6-bisphosphatase, required for glucose metabolism
YJL203W	PRP21	1.09851	0.09895033	6	1.014887	1.189022	1024233	445674	578559	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YJL204C	RCY1	0.8002293	0.1517436	6	0.7087325	0.9035382	596462.4	211257.4	385205	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
YJR017C	ESS1	1.091126	0.3051036	6	0.8547695	1.392839	3108775	1340870	1767905	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
YKL129C	MYO3	0.8424537	0.1572178	6	0.7428679	0.9553895	912102	392898	519204	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YMR059W	SEN15	0.9767985	0.2879486	6	0.7757835	1.229899	2819221	1191099	1628122	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YMR240C	CUS1	1.274896	0.2865593	6	1.013662	1.603454	580107	258115	321992	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
YNL076W	MKS1	0.7818566	1.108577	6	0.3220237	1.898307	783904.1	320563.1	463341	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
YNL163C	RIA1	1.09931	0.3537708	6	0.8282894	1.459011	870394	366092	504302	Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
YNL242W	ATG2	0.894633	0.09949026	6	0.8261735	0.9687653	1240756	498216	742540	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria
YNL272C	SEC2	1.867225	0.880923	6	0.9227178	3.778543	1270268	826055	444213	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transportand for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
YNR006W	VPS27	1.029563	0.1374516	6	0.9223324	1.149261	3398520	1453934	1944586	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
YOL016C	CMK2	0.8649451	0.1763611	6	0.7511067	0.9960369	695217.3	273926.3	421291	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YPL161C	BEM4	1.21977	0.4745167	6	0.8344099	1.783102	1183021	472421	710600	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
YPL206C	PGC1	0.5529402	0.904811	6	0.2680706	1.140531	1796011	251214.4	1544797	Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
Q0140	VAR1	0.9846731	0.2393497	6	0.8130479	1.192526	455666	189731	265935	Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane
YBL066C	SEF1	1.014515	0.2430705	6	0.8351982	1.232331	1340579	597988	742591	Putative transcription factor, has homolog in Kluyveromyces lactis
YBR236C	ABD1	1.339743	0.9219768	6	0.6406593	2.801662	1593434	642423	951011.3	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YDL108W	KIN28	1.43772	0.3798708	6	1.06088	1.94842	1774320	842784	931536	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YDL157C	YDL157C	1.14833	0.9641704	6	0.5308963	2.483839	1991721	1266059	725662	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR365C	ESF1	0.9182012	0.2223187	6	0.7685646	1.096972	1872076	697795.7	1174280	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YGR021W	YGR021W	1.106192	0.2530004	6	0.9034642	1.35441	1136726	597500.9	539225	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR219W	MSC3	1.116407	0.1740426	6	0.9712732	1.283228	1408759	526640	882119	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate
YMR231W	PEP5	1.128549	0.5448226	6	0.7297771	1.745222	1188762	480090	708672	Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p
YNL035C	YNL035C	0.8478881	0.4875462	6	0.5740006	1.252462	1229196	439698	789498	Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YPR095C	SYT1	1.025064	0.05309293	6	0.9824276	1.06955	1214101	503785	710316	Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family
YBL085W	BOI1	0.9688638	0.1394598	6	0.8665614	1.083244	3288343	1334622	1953721	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YGL066W	SGF73	4.732266	2.109659	6	0.8748748	25.59719	811576.8	528216	283360.8	Subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis
YGL094C	PAN2	0.4087589	1.141483	6	0.1639807	1.018924	2983458	337138	2646320	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YHR147C	MRPL6	1.187253	0.3107742	6	0.9258632	1.522439	1375793	576362	799431	Mitochondrial ribosomal protein of the large subunit
YIL026C	IRR1	0.717267	0.4610557	6	0.4959756	1.037293	744793	288227	456566	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YPL040C	ISM1	0.7765605	0.4286687	6	0.5510735	1.094312	2661994	1292972	1369022	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YPL259C	APM1	1.376269	1.559535	6	0.3951413	4.793516	3767765	1740006	2027759	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YKL185W	ASH1	1.287895	0.3343587	6	0.9855717	1.682956	1503511	574718	928793	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YML096W	YML096W	0.9903654	0.1867791	6	0.8528806	1.150013	633984	247309	386675	Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
YLL009C	COX17	0.9438748	0.1345187	5	0.8388926	1.061995	3254397	1467762	1786635	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
YNR046W	TRM112	1.184516	0.2520384	5	0.9497205	1.477358	4361367	1934841	2426526	Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin
YIL002W-A	YIL002W-A	1.016478	0.1100212	5	0.9230298	1.119388	6462644	2886269	3576375	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YLR008C	PAM18	1.008082	0.1180991	5	0.9089465	1.11803	5091343	2215911	2875432	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
YGL019W	CKB1	0.9525021	0.1147414	5	0.8613639	1.053283	2190134	918231	1271903	Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
YFR038W	IRC5	1.021855	0.1059505	5	0.9312288	1.1213	7256155	3375472	3880683	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
YLR291C	GCD7	0.6458447	0.7387367	5	0.3379939	1.234091	8128704	3219198	4909506	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YAR027W	UIP3	0.9559136	0.2699799	5	0.7544732	1.211138	882857	361302	521555	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YNR054C	ESF2	1.050167	0.1075903	5	0.9556555	1.154026	1458801	599580	859221	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YGR012W	YGR012W	0.9520217	0.07924954	5	0.8881339	1.020505	11980030	6230709	5749317	Putative cysteine synthase, localized to the mitochondrial outer membrane
YIR035C	YIR035C	0.9717349	0.218453	5	0.8023946	1.176813	1467567	617587	849980	Putative cytoplasmic protein of unknown function
YML036W	CGI121	0.8555055	0.1611007	5	0.7428406	0.9852579	632605	233935	398670	Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
YFR032C-A	RPL29	3.47261	1.709175	5	0.7762729	15.53451	3081468	1533127	1548341	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YGR082W	TOM20	0.8143714	0.2618095	5	0.647378	1.024441	1789057	888172	900885	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
YIL088C	AVT7	1.056858	0.304554	5	0.8092451	1.380234	1831309	854026	977283	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YOR253W	NAT5	1.125662	0.1385223	5	0.9969562	1.270984	1620917	728022	892895	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YBR179C	FZO1	0.957455	0.07447867	5	0.8969456	1.022046	5850722	2635941	3214781	Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system
YDR239C	YDR239C	0.9502611	0.1742783	5	0.8156417	1.107099	309208.4	124292.4	184916	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YGL111W	NSA1	0.9725221	0.1394225	5	0.8606463	1.098941	2598834	1133091	1465743	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YHR120W	MSH1	1.106316	0.1792855	5	0.94543	1.294579	2572338	1230972	1341366	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YKR024C	DBP7	1.197272	0.8249285	5	0.5809815	2.467306	1155802	421336.7	734465	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
YLR398C	SKI2	0.9322106	0.06612411	5	0.8797154	0.9878384	3068103	1344703	1723400	Ski complex component and putative RNA helicase, mediates 3_prime-5_prime RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5_prime-3_prime mRNA decay
YOL069W	NUF2	0.9777896	0.1348151	5	0.8688095	1.10044	381953	149049	232904	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YPL249C	GYP5	0.9502436	0.1196492	5	0.8556327	1.055316	818357	298524	519833	GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p
YBR058C-A	TSC3	0.9018043	0.546803	5	0.5584156	1.456354	673288	303923	369365	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YBR231C	SWC5	0.952381	0.3243883	5	0.7166777	1.265603	106067100	48045830	58021320	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YDL064W	UBC9	0.7327001	0.47548	5	0.4829726	1.111553	2379260	1030946	1348314	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
YGL035C	MIG1	1.615061	1.141836	5	0.5936346	4.393984	2587208	1184423	1402785	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YGR266W	YGR266W	1.120792	0.3751341	5	0.8067159	1.557147	1038203	431988	606215	Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YHR058C	MED6	0.9974892	0.1055135	5	0.9093723	1.094144	949067	309949	639118	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YJL085W	EXO70	0.9398401	0.07198439	5	0.8823711	1.001052	545023	219525	325498	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding
YKL047W	YKL047W	1.117327	0.2228167	5	0.9190928	1.358317	691782	279499	412283	Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOL149W	DCP1	0.9927367	0.07269631	5	0.9314517	1.058054	709111	283135	425976	Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5_prime cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p
YBR041W	FAT1	4.313383	2.535064	5	0.4674986	39.7975	1676886	800908	875978.3	Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids
YDL173W	PAR32	1.070768	0.04500587	5	1.029349	1.113854	1149263	512519	636744	Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
YHR148W	IMP3	0.9774888	0.1339489	5	0.8692019	1.099266	1847174	817724	1029450	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YKL106W	AAT1	0.9948568	0.1030283	5	0.9089504	1.088882	1075510	486716	588794	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YKR089C	TGL4	0.9096876	0.1079104	5	0.8275865	0.9999336	350210	131499	218711	Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p
YLR071C	RGR1	0.9895275	0.09553003	5	0.9100429	1.075954	797263	278978	518285	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
YLR337C	VRP1	1.001391	0.03739163	5	0.969102	1.034755	437815	175101	262714	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YMR135C	GID8	1.488224	0.9496144	5	0.6474005	3.421083	1280678	856288	424390	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNL004W	HRB1	1.217654	0.2893287	5	0.944895	1.56915	1526063	710419	815644	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p
YPR045C	YPR045C	0.9442341	0.08087784	5	0.8796126	1.013603	728166	304822	423344	Protein of unknown function; involvement in splicing based on pre-mRNA accumulation defect for many intron-containing genes; contains a SAC3 domain; physically interacts with Csn12p; YRP045C is not an essential gene
R0020C	REP1	0.8996224	0.1205213	5	0.8094326	0.9998615	1965979	738648.6	1227330	Master regulator that acts in concert with Rep2p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; autoregulates levels of its own transcript
YAL046C	AIM1	1.072562	0.2772281	5	0.8411787	1.367591	1508496	634447	874049	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
YBR137W	YBR137W	0.9384493	0.3280882	5	0.7039074	1.251141	2580977	1025843	1555134	Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YCR052W	RSC6	1.351154	0.5110938	5	0.8632641	2.114783	968109	423008	545101	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YDR257C	RKM4	0.9524344	0.1046847	5	0.8689287	1.043965	967812	383463	584349	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
YFL030W	AGX1	1.022225	0.8119372	5	0.5017201	2.082722	1300674	358036	942638	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGL157W	ARI1	0.9877905	0.2553801	5	0.7896739	1.235611	1530153	621838	908315	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
YGL169W	SUA5	1.329744	0.5522093	5	0.8195118	2.157649	2535045	1097807	1437238	Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
YHR065C	RRP3	1.103261	0.430674	5	0.7563641	1.609257	543749	219290	324459	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YJL157C	FAR1	0.7854687	0.449949	5	0.5294734	1.165235	976748	409954	566794	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YJR112W	NNF1	0.9441742	0.4775016	5	0.6212677	1.434913	4013206	1466981	2546225	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YKL140W	TGL1	0.8368575	0.1717571	5	0.7198927	0.9728263	1000252	376776	623476	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YLR066W	SPC3	0.9300805	0.2031537	5	0.7783678	1.111364	638212	255931	382281	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YLR174W	IDP2	3.307338	0.1297112	5	2.951893	3.705582	327962.4	225370	102592.4	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YMR011W	HXT2	1.093676	0.3274403	5	0.8208052	1.457261	1747574	803900	943674	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL049C	SFB2	1.029032	0.2916035	5	0.7969344	1.328726	22993510	8782010	14211500	Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p
YNL330C	RPD3	1.316987	0.7043539	5	0.7103151	2.441812	496465	209619	286846	Histone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transposition
YOR090C	PTC5	1.006406	0.07101111	5	0.9456733	1.07104	1254764	524259	730505	Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
YOR220W	RCN2	0.9086218	0.2478593	5	0.731188	1.129112	1668934	664455.7	1004478	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor
YPL030W	TRM44	1.007015	0.02664614	5	0.9837677	1.030812	835226	351730	483496	tRNA(Ser) Um(44) 2_prime-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YAL054C	ACS1	2.007942	0.9120155	5	0.9027528	4.466152	1545032	685622	859410.2	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YBR059C	AKL1	0.984334	0.1208087	5	0.8854285	1.094288	732726	301534	431192	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
YCL016C	DCC1	0.9558281	0.07328322	5	0.8963603	1.019241	986220	284333	701887	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YDL015C	TSC13	0.9467859	0.4177784	5	0.6564681	1.365494	1790062	675897	1114165	Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
YDL166C	FAP7	0.9951362	0.05797488	5	0.9458296	1.047013	5391119	2283453	3107666	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YDL167C	NRP1	1.186938	0.2903819	5	0.9202094	1.53098	2757914	820466	1937448	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
YDR083W	RRP8	2.218574	1.744422	5	0.4808554	10.23607	1149133	772498	376635	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YDR283C	GCN2	1.148211	0.5024251	5	0.7391974	1.783539	340312	156707	183605	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
YEL020C	YEL020C	0.8284877	0.3842112	5	0.5915972	1.160235	5245788	2040560	3205228	Hypothetical protein with low sequence identity to Pdc1p
YGL095C	VPS45	1.110186	0.1784324	5	0.9494471	1.298137	2230327	925027	1305300	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
YGR076C	MRPL25	0.9892676	0.08076332	5	0.9216566	1.061838	1704979	727423	977556	Mitochondrial ribosomal protein of the large subunit
YGR106C	VOA1	1.029365	0.1590897	5	0.8953813	1.183399	1265790	546061	719729	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
YGR203W	YCH1	0.9654428	0.1108868	5	0.8760212	1.063992	470875	187240	283635	Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YHL002W	HSE1	1.153073	0.1427034	5	1.017497	1.306714	1573139	645400	927739	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YIL114C	POR2	0.7634022	0.5140582	5	0.4864787	1.197962	7031590	2927029	4104561	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YKR060W	UTP30	0.8674121	0.1906703	5	0.7339085	1.025201	678750	269375	409375	Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YKR072C	SIS2	0.7429003	0.9378055	5	0.3265356	1.69017	1295582	486510	809072	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
YLR086W	SMC4	0.9305808	0.2312713	5	0.759827	1.139708	908406	252987	655419	Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
YLR256W	HAP1	1.187676	0.4542823	5	0.7975602	1.76861	340690.7	178046.7	162644	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YMR202W	ERG2	0.9901414	0.3153901	5	0.7509929	1.305445	6449522	2660045	3789477	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YMR255W	GFD1	1.14433	0.8647517	5	0.5362422	2.441975	891349	405121	486228	Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YNL118C	DCP2	0.9618423	0.146508	5	0.8459249	1.093644	551345	218674	332671	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5_prime cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YNL119W	NCS2	1.004684	0.1377707	5	0.8903962	1.13364	1966268	885137	1081131	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
YOL002C	IZH2	0.7740287	0.1224877	5	0.6952307	0.8617577	8411520	1718717	6692803	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
YOL081W	IRA2	0.8828547	0.1048181	5	0.8053553	0.9678119	1287187	618887	668300	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YPL009C	YPL009C	0.9053531	0.08620142	5	0.8394661	0.9764113	989356	406952	582404	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL009C is not an essential gene
YPL019C	VTC3	1.13761	0.5632105	5	0.6943729	1.863778	1040847	424145	616702	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
YPL274W	SAM3	0.9067321	0.1199599	5	0.8162311	1.007268	282988	107221	175767	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YPR101W	SNT309	2.539522	1.857792	5	0.4983507	12.94103	1169049	661171	507878	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YAL029C	MYO4	0.9214829	0.2083646	5	0.7676582	1.106131	382139	142139	240000	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YBR120C	CBP6	1.437303	0.9306779	5	0.6357139	3.249638	727866.4	301027	426839.4	Mitochondrial translational activator of the COB mRNA; phosphorylated
YBR176W	ECM31	1.659475	1.208359	5	0.5754101	4.785903	1937308	792052	1145256	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
YDL207W	GLE1	0.9601834	0.08438251	5	0.8917268	1.033895	5690311	2591385	3098926	Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal
YDR041W	RSM10	1.052645	0.07679047	5	0.9841236	1.125937	619104	239595	379509	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YDR213W	UPC2	1.199208	0.3301261	5	0.8978906	1.601642	903055	341273	561782	Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
YDR264C	AKR1	0.9961071	0.04862557	5	0.9545429	1.039481	1445625	574882	870743	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
YDR389W	SAC7	0.7886675	0.3722781	5	0.5690844	1.092978	1602320	562215	1040105	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YDR472W	TRS31	1.216627	1.097054	5	0.4650883	3.182582	518532.9	213547	304985.9	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YER001W	MNN1	0.8578338	0.1983715	5	0.7209214	1.020748	1463407	586044	877363	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YER056C	FCY2	1.065017	0.2284903	5	0.8717178	1.30118	608467	304776	303691	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
YFR007W	YFH7	1.030356	0.1638495	5	0.8925117	1.189491	1084196	463143	621053	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
YGR081C	SLX9	1.07199	0.102325	5	0.9800267	1.172582	739940	279732	460208	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YHR172W	SPC97	0.8670563	0.1953464	5	0.7306067	1.028989	462701	174324	288377	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YJL122W	ALB1	0.9273317	0.07161406	5	0.8709102	0.9874085	7338245	2994725	4343520	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YJL131C	AIM23	0.9410532	0.07260287	5	0.8830311	1.002888	545917	224140	321777	Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
YJL159W	HSP150	0.9881623	0.2117432	5	0.8207724	1.18969	364438.6	139015.6	225423	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YJR075W	HOC1	0.850296	0.06343916	5	0.8043043	0.8989177	1008385	357795	650590	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
YJR091C	JSN1	1.121338	0.1470932	5	0.9856928	1.275649	1507532	598696	908836	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
YKL025C	PAN3	0.9069339	0.1478528	5	0.7966941	1.032428	910192	362293	547899	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YLR114C	AVL9	0.773742	0.4488656	5	0.5220641	1.146749	930887	328199	602688	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms
YLR172C	DPH5	1.026101	0.1288285	5	0.9165332	1.148767	1619399	667252	952147	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
YLR362W	STE11	1.012466	0.1784449	5	0.8658659	1.183886	7961661	3586158	4375503	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p
YMR152W	YIM1	0.8186439	0.326413	5	0.6149466	1.089814	676815	322210	354605	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL126W	SPC98	1.017388	1.624545	5	0.2449409	4.225829	615451.9	223448	392003.9	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YNL284C	MRPL10	0.4923965	1.390987	5	0.1454788	1.666596	2545068	879677.8	1665390	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YNR027W	BUD17	1.040586	0.08147871	5	0.96886	1.117622	651736	246839	404897	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
YOL129W	VPS68	0.8597126	0.09757688	5	0.7892383	0.9364799	888715	317154	571561	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
YOR143C	THI80	1.08488	0.284096	5	0.8457332	1.391651	929348	332250	597098	Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YOR266W	PNT1	2.130218	1.3864	5	0.6319097	7.181134	621490.7	293749	327741.7	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
YBL098W	BNA4	0.8890183	0.09565402	5	0.8175184	0.9667716	391048	143086	247962	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
YBR272C	HSM3	1.217056	0.6387578	5	0.6952659	2.130445	1003317	461287	542030	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b
YDL102W	POL3	0.9541668	0.2594498	5	0.7600778	1.197817	1106136	433030	673106	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YDR267C	CIA1	1.10611	0.209612	5	0.9204583	1.329207	4244247	1873118	2371129	WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene
YDR287W	INM2	1.182251	0.1535915	5	1.033335	1.352628	1523502	720078	803424	Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YDR337W	MRPS28	1.434551	2.026581	5	0.2427981	8.475913	3971901	2086122	1885779	Mitochondrial ribosomal protein of the small subunit
YDR358W	GGA1	0.9827198	0.06065126	5	0.9318398	1.036378	1166924	463585	703339	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YDR443C	SSN2	0.9442431	0.08963951	5	0.8728914	1.021427	6297301	2670998	3626303	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
YGR013W	SNU71	1.160657	0.1802582	5	0.9910237	1.359327	923001	357016	565985	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
YHR045W	YHR045W	1.247561	0.8252743	5	0.6052013	2.571722	1217764	652196	565568	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YHR135C	YCK1	0.8886441	0.5400369	5	0.5535398	1.426615	1131861	503337	628524	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
YIL083C	CAB2	1.021126	0.1078504	5	0.9290158	1.122368	2698399	1138578	1559821	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
YIL093C	RSM25	0.9404615	0.1808278	5	0.8026094	1.10199	588325	354101	234224	Mitochondrial ribosomal protein of the small subunit
YIR001C	SGN1	1.099405	0.200387	5	0.9223065	1.31051	2459392	1091874	1367518	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
YJL029C	VPS53	0.9215982	0.1194168	5	0.8300085	1.023295	654148	255650	398498	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YJL054W	TIM54	0.8342282	0.1010147	5	0.7635386	0.9114623	681157	255020	426137	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
YJL174W	KRE9	0.9800162	0.04944872	5	0.9384461	1.023428	1962426	772872	1189554	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
YJR062C	NTA1	1.117143	0.3512793	5	0.8210793	1.51996	571876	244787	327089	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
YJR137C	MET5	1.538529	0.3430505	5	1.138976	2.078245	599520	260596	338924	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YKL074C	MUD2	1.062749	0.05465984	5	1.013031	1.114906	1935978	819826	1116152	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
YKL155C	RSM22	1.238377	0.6378577	5	0.7080043	2.166058	838048	395245	442803	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
YKL191W	DPH2	1.16085	0.1580708	5	1.010654	1.333368	4703804	1894166	2809638	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YLR015W	BRE2	1.580729	1.532566	5	0.4125213	6.057152	3606968	1758244	1848724	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
YLR247C	IRC20	0.9090692	0.7462489	5	0.4726264	1.748541	668507	202451	466056	Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YMR078C	CTF18	0.8309537	0.08898294	5	0.7686049	0.8983601	455347.1	172961.1	282386	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
YMR113W	FOL3	1.132982	0.2324047	5	0.9241706	1.388973	2822159	1137769	1684390	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YOR001W	RRP6	0.9028322	0.1743078	5	0.7749118	1.051869	1752579	665395	1087184	Nuclear exosome exonuclease component; has 3_prime-5_prime exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)
YOR094W	ARF3	1.012557	0.4215535	5	0.699752	1.465192	1143570	454201	689369	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity
YOR301W	RAX1	0.8905966	0.1201601	5	0.8015654	0.9895166	2415080	992374	1422706	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YPL198W	RPL7B	1.09814	0.04860363	5	1.052338	1.145935	307829	134133	173696	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YPR029C	APL4	0.7881094	0.0521072	5	0.752923	0.8249402	3833869	1346905	2486964	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YPR104C	FHL1	1.228488	0.5350005	5	0.7686154	1.963508	14507370	6405357	8102017	Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants
YPR162C	ORC4	0.9883146	0.361563	5	0.7198746	1.356855	2491939	1380247	1111692	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YCL033C	MXR2	1.079567	0.1444522	5	0.9511744	1.225291	661429	270890	390539	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
YDR208W	MSS4	0.9031972	0.23771	5	0.7333176	1.112431	941108	420896	520212	Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YER022W	SRB4	1.023306	0.08985455	5	0.9458012	1.107161	443859	185605	258254	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YER071C	YER071C	1.224834	0.4000494	5	0.8625578	1.739268	1371696	648428	723267.8	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGR191W	HIP1	0.8333272	0.3834339	5	0.5954585	1.166218	574477.7	224034.7	350443	High-affinity histidine permease, also involved in the transport of manganese ions
YGR274C	TAF1	1.166923	0.2805771	5	0.9125008	1.492283	1241419	606295	635124	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
YKR009C	FOX2	1.425179	0.2753211	5	1.119596	1.814167	1850623	838738	1011885	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YKR029C	SET3	1.126764	0.203243	5	0.9428947	1.346488	3239161	1461388	1777773	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains
YKR036C	CAF4	1.065019	0.1543196	5	0.9302758	1.21928	797419	328722	468697	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YLR405W	DUS4	1.000338	0.06374948	5	0.9459729	1.057827	755123	320376	434747	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
YOR085W	OST3	1.31354	0.8151318	5	0.6428982	2.683764	887644	495045	392599	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
YPR184W	GDB1	0.8828712	0.1704007	5	0.7603787	1.025097	699785.3	342865.3	356920	Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YBL063W	KIP1	1.669453	1.064835	5	0.6564731	4.245523	1374527	875975.7	498551	Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
YBR044C	TCM62	0.9550306	0.09756146	5	0.8767544	1.040295	3317412	1462856	1854556	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YFR031C	SMC2	1.008447	0.07345315	5	0.9455647	1.075511	5897376	2529168	3368208	Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
YGL013C	PDR1	1.461458	1.207368	5	0.5071898	4.211166	989389.3	419549	569840.3	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
YJL046W	AIM22	0.9905984	0.4371334	5	0.6752918	1.453128	613390	237452	375938	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
YJL082W	IML2	0.8876387	0.1122582	5	0.8044559	0.9794229	2099806	1305809	793997	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL023C	POM33	0.9050343	0.1358114	5	0.8034612	1.019448	930849	412591	518258	Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p
YLR108C	YLR108C	1.249413	0.3339315	5	0.9323659	1.674271	396176	193933	202243	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YOR016C	ERP4	1.134438	0.2555853	5	0.9067463	1.419306	468651	187591	281060	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YER056C-A	RPL34A	0.9497074	0.1184119	4	0.845654	1.066564	16701780	7751498	8950280	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YOR276W	CAF20	0.9390431	0.06373576	4	0.8821838	0.9995673	6405370	2755560	3649810	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YJL198W	PHO90	0.7709217	0.3697184	4	0.5366053	1.107556	8037022	3476467	4560555	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDR378C	LSM6	1.21632	0.246988	4	0.9548333	1.549416	2784647	1276192	1508455	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YAL023C	PMT2	1.040295	0.5414934	4	0.6119169	1.768565	2436542	1049001	1387541	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YNL259C	ATX1	0.9053063	0.2446916	4	0.7122832	1.150637	1319404	557153	762251	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
YPL010W	RET3	1.068944	0.3766624	4	0.7389996	1.5462	908568	388240	520328	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YBR188C	NTC20	1.049444	0.0795091	4	0.9707772	1.134486	1687787	698251	989536	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YGR158C	MTR3	1.075419	0.04426041	4	1.029769	1.123092	2139494	895550	1243944	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
YGL100W	SEH1	0.9301442	0.1815836	4	0.7785145	1.111306	1564952	660228	904724	Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
YGR145W	ENP2	1.097063	0.04091532	4	1.053945	1.141946	1602293	668604	933689	Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YKL203C	TOR2	0.9249702	0.2618568	4	0.7156146	1.195573	508883	189289	319594	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
YBR002C	RER2	0.9161088	0.07608902	4	0.8502819	0.9870319	3099320	1158385	1940935	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YDR080W	VPS41	1.052641	0.07038368	4	0.9824816	1.127811	2491053	1059840	1431213	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YEL015W	EDC3	1.091037	0.2213392	4	0.8782852	1.355325	1078479	495319	583160	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
YFL028C	CAF16	1.117718	0.3142241	4	0.8214776	1.520788	2748888	1223285	1525603	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
YGR277C	CAB4	0.9811792	0.08439319	4	0.9032956	1.065778	4198584	1700854	2497730	Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
YPL221W	FLC1	0.9733539	0.2098246	4	0.7924423	1.195567	542820	273380	269440	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YPR098C	YPR098C	0.8125927	0.2057555	4	0.6642042	0.9941323	2121371	858031	1263340	Protein of unknown function, localized to the mitochondrial outer membrane
YCL061C	MRC1	1.025736	0.0414447	4	0.9849096	1.068255	2921981	1395615	1526366	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
YDL229W	SSB1	0.9677373	0.1144838	4	0.8650321	1.082637	12128320	6056480	6071840	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YDR288W	NSE3	1.082374	0.0795669	4	1.001182	1.170151	3489415	1449806	2039609	Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth
YDR428C	BNA7	0.9097932	0.0627794	4	0.8555063	0.9675249	677069	271705	405364	Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
YDR460W	TFB3	1.915792	1.196347	4	0.5931616	6.187623	9865358	4151128	5714230	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
YEL007W	YEL007W	0.9328235	0.1014543	4	0.844539	1.030337	1035770	420141	615629	Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YGR055W	MUP1	0.8749839	0.3012225	4	0.6513242	1.175447	488760	166723	322037	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YMR041C	ARA2	1.271099	0.1839064	4	1.061469	1.522129	2355625	839218	1516407	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
YNL310C	ZIM17	0.9693317	0.3382281	4	0.6958564	1.350284	1439767	679825	759942	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
YOR352W	YOR352W	0.981368	0.09792987	4	0.8915631	1.080219	1256264	519624	736640	Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YAL053W	FLC2	0.773929	0.2563695	4	0.6019883	0.9949795	1151458	470300	681158	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YDL002C	NHP10	0.8484466	0.1122798	4	0.7600414	0.9471347	411814	177479	234335	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
YDL115C	IWR1	1.064828	0.05573194	4	1.00823	1.124604	768073	337220	430853	Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin
YDR054C	CDC34	0.922999	0.2142627	4	0.7481854	1.138658	1292508	554151	738357	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
YDR375C	BCS1	0.887911	0.2144432	4	0.7196156	1.095565	1323264	469196	854068	Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases
YER171W	RAD3	0.9554436	0.1254574	4	0.8449078	1.08044	336535	127081	209454	5_prime to 3_prime DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein
YGL124C	MON1	1.122906	0.06912182	4	1.04936	1.201606	2672459	1235968	1436491	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
YGR028W	MSP1	4.007176	1.275299	4	1.148313	13.98353	2614534	1339578	1274956	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YGR267C	FOL2	0.9639716	0.04043413	4	0.9265207	1.002936	1800864	754536	1046328	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YHR012W	VPS29	1.141824	0.3571442	4	0.8046284	1.620327	3234885	1279337	1955548	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
YJL098W	SAP185	1.060956	0.1693793	4	0.8986863	1.252526	1088594	433710	654884	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YKL029C	MAE1	1.08175	0.1143034	4	0.9671153	1.209972	687410	280844	406566	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YLR225C	YLR225C	0.946272	0.1285748	4	0.8342447	1.073343	1192715	621216	571499	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
YLR272C	YCS4	0.9270382	0.1211294	4	0.8232731	1.043882	1829316	807632	1021684	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus
YPR131C	NAT3	0.9222409	0.05425207	4	0.8744888	0.9726006	1217840	477001	740839	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
YBR028C	YBR028C	0.916853	0.1020361	4	0.8296068	1.013275	1263748	494168	769580	Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YCR051W	YCR051W	0.8491019	0.3551248	4	0.5995366	1.202552	1205205	480743	724462	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YDL128W	VCX1	1.178437	0.3766989	4	0.8146671	1.70464	1086622	469319	617303	Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YDR089W	YDR089W	0.9085348	0.2116511	4	0.7383479	1.117949	455503	166945	288558	Protein of unknown function; deletion confers resistance to Nickel
YDR390C	UBA2	0.953742	0.07733882	4	0.8841274	1.028838	1339338	529288	810050	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YER017C	AFG3	1.017548	0.1019835	4	0.9207675	1.124502	1375685	574628	801057	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YER159C	BUR6	0.8043453	0.2253509	4	0.6449577	1.003122	578303	217405	360898	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YER176W	ECM32	0.9433502	0.02737482	4	0.9183791	0.9690003	2388020	967043	1420977	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
YFR030W	MET10	1.024164	0.07025624	4	0.9560222	1.097163	2685441	1217715	1467726	Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
YIL104C	SHQ1	0.9273204	0.07698234	4	0.8599347	0.9999866	489825	186289	303536	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
YKL033W	TTI1	0.905765	0.08845547	4	0.8305545	0.9877861	6379978	2889991	3489987	Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
YKL165C	MCD4	0.8632138	0.1088092	4	0.7759044	0.9603477	915180	323489	591691	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YLR018C	POM34	0.8146774	0.212705	4	0.6613884	1.003494	3048064	1184284	1863780	Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
YMR104C	YPK2	1.02213	0.04440604	4	0.9786027	1.067593	413058	177753	235305	Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YNL075W	IMP4	0.7952644	0.398043	4	0.538395	1.174687	1660677	513441	1147236	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YOR173W	DCS2	0.8535898	0.08776788	4	0.7832393	0.9302592	442393	177645	264748	Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YOR250C	CLP1	0.9453172	0.2154966	4	0.7653505	1.167602	754279.6	313918.6	440361	Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3_prime-end maturation
YAL030W	SNC1	0.8598741	0.1161369	4	0.7673721	0.9635266	2137501	944076	1193425	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YAL041W	CDC24	1.111813	0.1132527	4	0.995017	1.242319	1275847	520230	755617	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
YDL012C	YDL012C	1.006047	0.07946043	4	0.9306775	1.08752	621085	272509	348576	Plasma membrane protein of unknown function; may contribute to Non-homologous end-joining (NHEJ) based on double deletion with htz1; YDL012C is not an essential gene
YDL046W	NPC2	1.378036	0.2262694	4	1.103973	1.720136	633499	314043	319456	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
YDL230W	PTP1	1.059732	0.1248167	4	0.9377194	1.19762	1052560	421306	631254	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria
YDR424C	DYN2	0.9088789	0.2693057	4	0.6980511	1.183382	3446562	1348476	2098086	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
YER094C	PUP3	1.046645	0.07043043	4	0.9768404	1.121438	1069773	448654	621119	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YFR013W	IOC3	1.922622	1.764249	4	0.341204	10.83362	1166377	561755	604622	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YGL159W	YGL159W	1.006644	0.2070163	4	0.8218037	1.233059	836610	327491	509119	Putative protein of unknown function; deletion mutant has no detectable phenotype
YGR251W	YGR251W	0.9684601	0.07003831	4	0.9042173	1.037267	11195180	5316960	5878225	Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus
YHR165C	PRP8	0.8524463	0.06496959	4	0.7998627	0.9084869	555958	200413	355545	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa
YIL010W	DOT5	0.9870403	0.07344689	4	0.9184918	1.060705	2359064	949339	1409725	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
YIL091C	UTP25	0.9777216	0.2517203	4	0.7639781	1.251266	1360572	603214	757358	Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; proposed to function as an RNA helicase based on structure prediction and remote homology searches
YJR046W	TAH11	1.285509	0.07536343	4	1.193987	1.384046	1101298	566410	534888	DNA replication licensing factor, required for pre-replication complex assembly
YLR063W	YLR063W	1.005769	0.05886245	4	0.9493928	1.065493	2512739	1080738	1432001	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YLR104W	YLR104W	0.9212627	0.04094334	4	0.8850293	0.9589795	1063499	415047	648452	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
YMR047C	NUP116	1.003877	0.1165525	4	0.8955185	1.125346	603898	282551	321347	Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
YMR289W	ABZ2	0.919237	0.2199499	4	0.7409944	1.140355	704521	264827	439694	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
YNL219C	ALG9	0.8926671	0.1919909	4	0.7395653	1.077463	359055	141203	217852	Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YNL240C	NAR1	0.9828697	0.1173103	4	0.8761282	1.102616	662961	299309	363652	Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
YNR047W	FPK1	1.023462	0.1914209	4	0.8484018	1.234646	1275682	748235	527447	Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane
YOL147C	PEX11	0.5758061	0.3862238	4	0.3943629	0.8407297	1507858	597860	909998	Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
YOR185C	GSP2	0.9327101	0.2084634	4	0.7603663	1.144117	1370982	517345	853637	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
YBL103C	RTG3	0.9392132	0.3108084	4	0.6925984	1.273641	403629	158515	245114	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YBR202W	MCM7	0.98969	0.0642168	4	0.9293257	1.053975	8707262	3404632	5302630	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YCR054C	CTR86	0.9812817	0.068626	4	0.9174573	1.049546	7680865	3548011	4132854	Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis
YDL106C	PHO2	1.018265	0.07297865	4	0.9479831	1.093758	2266923	1029992	1236931	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
YDL240W	LRG1	0.9289067	0.2135415	4	0.7535065	1.145136	596550	241314	355236	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YDR294C	DPL1	1.34241	1.314971	4	0.3700175	4.870212	1260801	555282	705519	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
YDR316W	OMS1	1.193805	0.6991795	4	0.6016676	2.368701	1389772	711708	678064	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
YDR441C	APT2	1.209037	0.07320941	4	1.125333	1.298967	346526	155543	190983	Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YER041W	YEN1	0.9415316	0.08438127	4	0.8668052	1.0227	2270054	1065402	1204652	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
YER065C	ICL1	2.292254	0.5992322	4	1.274161	4.123834	1276704	593086	683618	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YGL180W	ATG1	0.4927452	2.071844	4	0.06468858	3.753333	2669797	945095	1724702	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
YGR095C	RRP46	1.627454	1.047323	4	0.5831215	4.542118	3725692	1639150	2086542	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
YGR119C	NUP57	1.182425	0.2170664	4	0.9558467	1.462712	465900	212330	253570	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
YGR179C	OKP1	0.9957649	0.2458992	4	0.7825282	1.267108	2355356	1145031	1210325	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YGR202C	PCT1	1.08112	0.1797142	4	0.9065382	1.289324	3784515	1683455	2101060	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
YHR201C	PPX1	1.190735	0.2909911	4	0.8952962	1.583665	399271	161937	237334	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YIL090W	ICE2	0.8508441	0.08810516	4	0.7804619	0.9275735	590457	221943	368514	Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
YIL116W	HIS5	0.8607372	1.77835	4	0.1506571	4.91758	576113	306848	269265	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YJL030W	MAD2	0.9480397	0.08431421	4	0.8728542	1.029702	4734854	1842206	2892648	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
YJL081C	ARP4	2.256221	1.399831	4	0.5722707	8.895328	8730718	8040084	690634	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YJR130C	STR2	1.071858	0.158511	4	0.9176426	1.25199	1663278	623392	1039886	Cystathionine gamma-synthase, converts cysteine into cystathionine
YJR133W	XPT1	1.059253	0.6226915	4	0.5754092	1.949946	1161716	432193	729523	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YKL019W	RAM2	0.8842813	0.3840021	4	0.6069541	1.288324	312745	136951	175794	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
YKL041W	VPS24	1.06029	0.03950303	4	1.020027	1.102142	1150503	547723	602780	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
YLR093C	NYV1	0.9924119	0.2274791	4	0.7940995	1.240249	2688082	1434773	1253309	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
YLR215C	CDC123	1.092632	0.1834871	4	0.9128101	1.30788	4672773	2065333	2607440	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YLR382C	NAM2	0.7992462	0.07108241	4	0.7454651	0.8569074	334906	133952	200954	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
YML014W	TRM9	1.11017	0.176123	4	0.9341786	1.319316	1571089	771304	799785	tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin
YNL020C	ARK1	1.042812	0.1070449	4	0.9389596	1.158152	1251862	600697	651165	Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis
YNL193W	YNL193W	1.466855	0.9078389	4	0.602564	3.570847	11202600	5490457	5712148	Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
YNR013C	PHO91	1.137013	0.5170729	4	0.6850064	1.887278	3470080	1691727	1778353	Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOL073C	YOL073C	0.933611	0.1733727	4	0.7877294	1.106509	1972864	876041	1096823	Putative protein of unknown function
YOL087C	YOL087C	0.8943102	0.4288689	4	0.5874324	1.361503	1168213	449819	718394	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
YOR081C	TGL5	0.8348519	0.8482641	4	0.3635641	1.91707	1751609	767110	984499	Bifunction enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
YOR093C	YOR093C	0.9248233	0.08014716	4	0.8549633	1.000392	516085	240178	275907	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
YOR118W	RTC5	1.04241	0.1619595	4	0.8894204	1.221715	946663	402108	544555	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
YOR227W	HER1	1.075507	0.153863	4	0.9249707	1.250543	221117	101265	119852	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments
YPL181W	CTI6	1.002877	0.1100944	4	0.9003071	1.117133	357516	139337	218179	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YPR180W	AOS1	0.8326444	0.2269401	4	0.6666102	1.040033	923900	341575	582325	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YAL048C	GEM1	0.8885594	0.1271423	4	0.7844651	1.006466	614528	235243	379285	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YBL037W	APL3	1.141219	0.3853227	4	0.7822983	1.664814	527684	217054	310630	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YBR215W	HPC2	0.9355885	0.08516201	4	0.860675	1.017022	2305943	927225	1378718	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
YDL056W	MBP1	0.9389316	0.0310564	4	0.9107855	0.9679476	471107	174390	296717	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
YDL234C	GYP7	1.052399	0.05670086	4	0.9955154	1.112533	1478844	550131	928713	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YDR012W	RPL4B	0.8736873	0.05860199	4	0.8249251	0.9253319	897392	336550	560842	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YDR063W	AIM7	1.180081	0.1396411	4	1.029152	1.353145	559265	261401	297864	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays elevated frequency of mitochondrial genome loss
YDR067C	OCA6	1.191445	1.628718	4	0.2414781	5.878548	336980.5	224934.5	112046	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
YDR486C	VPS60	1.031815	0.08649377	4	0.9479586	1.12309	1858679	826704.3	1031975	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
YDR495C	VPS3	0.9311831	0.06782923	4	0.8712973	0.9951849	316364.1	120892.1	195472	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
YDR531W	CAB1	1.131567	0.3521147	4	0.8013405	1.597876	267021	118623	148398	Pantothenate kinase (ATP:D-pantothenate 4_prime-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)
YGR198W	YPP1	0.7648768	0.2647808	4	0.5900631	0.9914812	391531.8	135390.8	256141	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YGR245C	SDA1	0.9713975	0.06485509	4	0.9115785	1.035142	840475	357951	482524	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YHR028C	DAP2	0.8390477	0.1994721	4	0.6900644	1.020196	560718	219277	341441	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
YHR192W	YHR192W	1.190342	0.4451164	4	0.7695317	1.841269	898643.9	339731.9	558912	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YHR206W	SKN7	1.13178	0.1404577	4	0.9862387	1.298799	2175310	976581	1198729	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YIL153W	RRD1	0.6030672	0.9692412	4	0.2332643	1.559133	583930.2	177223.2	406707	Peptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
YKL091C	YKL091C	0.820513	0.04937593	4	0.7817549	0.8611926	802121	292803	509318	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YKR055W	RHO4	0.7819199	0.1659991	4	0.6645254	0.9200532	1021826	397193.3	624633	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YKR063C	LAS1	0.9279264	0.1407998	4	0.8083285	1.06522	646150	247907	398243	Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability
YLL032C	YLL032C	0.8629313	0.09929566	4	0.7829159	0.9511244	1690800	654209	1036591	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
YLR143W	YLR143W	1.111285	0.2632214	4	0.8586108	1.438318	2572381	1087926	1484455	Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
YLR144C	ACF2	0.9469362	0.4894211	4	0.5861637	1.529757	663765	304890	358875	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
YML031W	NDC1	0.9193314	0.2764922	4	0.7011237	1.205451	483684	170179	313505	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YML050W	AIM32	1.775555	2.801574	4	0.1140145	27.65084	643978.7	227670.6	416308	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
YMR157C	AIM36	0.9801348	0.2967219	4	0.7328219	1.310911	378516.5	127775.5	250741	Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YMR224C	MRE11	1.09027	0.08553378	4	1.002605	1.185599	381889	168706	213183	Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved
YNL185C	MRPL19	1.152882	0.2668472	4	0.88759	1.497467	1850292	905442	944850	Mitochondrial ribosomal protein of the large subunit
YOR039W	CKB2	0.9606555	0.08564109	4	0.8833201	1.044762	686049	283133	402916	Beta_prime regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YOR174W	MED4	1.070015	0.07411881	4	0.9950481	1.150629	515514	226110	289404	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YPL002C	SNF8	1.071572	0.1555791	4	0.9200377	1.248065	655752	277216	378536	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
YPR021C	AGC1	1.321272	0.8374	4	0.5815508	3.001905	510097	297713	212384	Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
YBR104W	YMC2	0.9027549	0.1105875	4	0.8100333	1.00609	2062819	795106	1267713	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YBR130C	SHE3	0.9945337	0.156716	4	0.8529427	1.159629	751586	326542	425044	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YBR131W	CCZ1	1.046984	0.3051079	4	0.7763962	1.411876	1077808	469945	607863	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
YDR227W	SIR4	0.8553261	0.3519002	4	0.6058428	1.207546	507232	239466	267766	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
YER099C	PRS2	1.010816	0.1679172	4	0.8574431	1.191624	487178	202393	284785	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YGR112W	SHY1	2.283194	2.064451	4	0.3019219	17.26598	788314.8	656977	131337.8	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
YGR296W	YRF1-3	1.071874	0.2554205	4	0.8345156	1.376743	137126	57134	79992	Helicase encoded by the Y_prime element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YHL014C	YLF2	4.550467	2.428934	4	0.4209988	49.18482	295602.6	186734	108868.6	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR056C	RSC30	1.138429	0.4167433	4	0.7567222	1.712677	2685064	1117750	1567313	Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive
YHR181W	SVP26	1.218226	0.8298032	4	0.5402024	2.747257	4246718	1556035	2690683	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YIL035C	CKA1	1.111426	0.4107454	4	0.7431282	1.662253	4008132	1633748	2374384	Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YKL042W	SPC42	1.034787	0.05463162	4	0.9808421	1.091698	1062732	466942	595790	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YLR173W	YLR173W	0.9399123	0.1024868	4	0.8500962	1.039218	685837	272634	413203	Putative protein of unknown function
YLR299W	ECM38	1.12135	0.2862133	4	0.8470835	1.484417	343295	150196	193099	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YML054C	CYB2	1.346832	0.2344798	4	1.070328	1.694768	699451	322250	377201	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YMR212C	EFR3	0.9317342	0.09648313	4	0.8476723	1.024132	256735	101997	154738	Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene
YMR213W	CEF1	1.565554	1.105298	4	0.529961	4.624793	230841.9	94565.9	136276	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YOL042W	NGL1	9.158547	2.709238	4	0.6438007	130.2872	1541482	1345493	195989	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR166C	SWT1	0.9738876	0.1153597	4	0.8697826	1.090453	549998	172237	377761	RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
YOR231W	MKK1	0.9902492	0.07695711	4	0.9183134	1.06782	1182884	504302	678582	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YPL125W	KAP120	1.027219	0.2164282	4	0.8309008	1.269921	774254	306315	467939	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
YPL265W	DIP5	1.389599	0.09603457	4	1.264784	1.526732	292645	143185	149460	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YPR032W	SRO7	0.9162289	0.1372836	4	0.8008937	1.048173	1420862	561028	859834	Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor
YDR171W	HSP42	1.600726	0.2877588	4	1.207381	2.122216	1414858	779721	635137	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YHR084W	STE12	0.9944518	0.09308539	4	0.907749	1.089436	734759	308925	425834	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
YJL031C	BET4	0.8953099	0.2176665	4	0.7233236	1.10819	1995040	851392	1143648	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YKL022C	CDC16	1.148848	0.1904959	4	0.9532045	1.384648	374360	166534	207826	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
YLR146C	SPE4	1.681089	0.8530661	4	0.728649	3.878492	800557	485511	315046	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YML051W	GAL80	0.8452718	0.2244256	4	0.6783892	1.053207	625064	278290	346774	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YMR162C	DNF3	0.9698778	0.1841179	4	0.8097573	1.16166	255895.1	106693.1	149202	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
YMR284W	YKU70	1.357332	0.2296131	4	1.083829	1.699853	2169587	1079085	1090502	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YPR188C	MLC2	0.9745633	0.2774681	4	0.7425355	1.279095	499860.6	229659.6	270201	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
YPR016C	TIF6	0.9786568	0.1563607	3	0.819949	1.168084	6869272	2920342	3948930	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YMR311C	GLC8	0.9469426	0.3575466	3	0.6318401	1.419189	3719584	1819636	1899948	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YLR113W	HOG1	0.9078049	0.08364867	3	0.8258161	0.9979337	3310796	1441900	1868896	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YBR268W	MRPL37	0.8457326	0.1688458	3	0.6986404	1.023794	135132	54557	80575	Mitochondrial ribosomal protein of the large subunit
YDR296W	MHR1	0.9940962	0.2051825	3	0.7881182	1.253907	971172	427891	543281	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
YBR267W	REI1	1.048189	0.4386734	3	0.638048	1.721971	875926	434655	441271	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YER067W	RGI1	0.8305599	0.2386852	3	0.6339704	1.08811	2334479	931022	1403457	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene; protein abundance is increased upon intracellular iron depletion
YPL023C	MET12	0.9476766	0.07545733	3	0.8701149	1.032152	1397952	415645	982307	Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
YGL017W	ATE1	1.052227	0.1518528	3	0.886097	1.249503	785486	337568	447918	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
YJL184W	GON7	1.008041	0.07034615	3	0.9309076	1.091566	1364818	552958	811860	Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p
YLR017W	MEU1	1.392147	0.2431833	3	1.057238	1.833149	1769229	685033	1084196	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YMR301C	ATM1	0.873973	0.06232431	3	0.814458	0.9378369	13028410	5681186	7347224	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YBR085W	AAC3	0.9327775	0.1610538	3	0.7773706	1.119252	1390075	671004	719071	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YDR351W	SBE2	1.488509	0.6446264	3	0.717711	3.08712	1463006	867708	595298	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
YER020W	GPA2	0.9252973	0.2756266	3	0.6773677	1.263974	409249	169357	239892	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR177C	ATF2	0.9490593	0.1280724	3	0.8210169	1.097071	356166.6	150657.6	205509	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
YIL049W	DFG10	1.05423	0.2521732	3	0.7925097	1.40238	2664190	1257898	1406292	Protein of unknown function, involved in filamentous growth
YLR139C	SLS1	0.9710419	0.0266461	3	0.9421992	1.000768	1027838	421114	606724	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
YNR033W	ABZ1	0.9785745	0.09716728	3	0.8766798	1.092312	528165	234390	293775	Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis
YHR200W	RPN10	0.992155	0.01437708	3	0.976144	1.008429	5110544	2237925	2872619	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
YJL036W	SNX4	1.298649	0.3747465	3	0.849811	1.984546	385515	174433	211082	Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p
YLL038C	ENT4	1.007054	0.09219087	3	0.9072887	1.117789	772501	309532	462969	Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
YPL247C	YPL247C	0.8667602	0.1561294	3	0.7263887	1.034258	1782495	630161	1152334	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
YBR016W	YBR016W	1.077359	0.09373148	3	0.9689381	1.197912	1814159	845421	968738	Plasma membrane protein of unknown function, predicted to be palmitoylated; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions
YDR412W	RRP17	0.5899578	0.5553314	3	0.3147046	1.105958	3312160	1319323	1992837	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions
YER126C	NSA2	0.9407853	0.01280878	3	0.9272475	0.9545209	184848	72373	112475	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YIL008W	URM1	0.8916131	0.1948238	3	0.7152044	1.111534	1519237	632848	886389	Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YIL031W	ULP2	1.311696	0.2814221	3	0.9539557	1.803592	3518017	1611438	1906579	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
YOR296W	YOR296W	0.8935598	0.05158358	3	0.8428938	0.9472713	2304833	933134	1371699	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
YCL055W	KAR4	1.109661	0.3331126	3	0.7611709	1.617703	14546240	7488103	7058142	Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
YDL087C	LUC7	1.104278	0.3116223	3	0.7761247	1.571178	1279717	579505	700212	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5_prime splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
YDR146C	SWI5	1.122268	0.7047174	3	0.5055485	2.491324	3969968	1970971	1998997	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YER019C-A	SBH2	1.105723	0.1985667	3	0.8832032	1.384306	1465126	697112	768014	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YER092W	IES5	1.142139	0.2513127	3	0.8594314	1.517843	290949	125016	165933	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YER114C	BOI2	1.14413	0.1672356	3	0.9468633	1.382494	980703	416237	564466	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YER169W	RPH1	1.133892	0.1896289	3	0.9149105	1.405287	1079149	435618	643531	JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YFL001W	DEG1	0.9169432	0.06115833	3	0.8556302	0.9826497	3678416	1727952	1950464	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
YFL026W	STE2	1.046894	0.1978232	3	0.8369168	1.309553	455398	178528	276870	Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YGL211W	NCS6	1.067231	0.04485575	3	1.014411	1.122801	869940	373869	496071	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
YGR093W	YGR093W	0.9629665	0.05567409	3	0.9041701	1.025586	469764	192824	276940	Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGR280C	PXR1	0.9357916	0.1717947	3	0.7704608	1.1366	2519775	1196143	1323632	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YHL031C	GOS1	1.131943	0.3939245	3	0.7248197	1.767742	974195	403076	571119	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YJL096W	MRPL49	1.004665	0.04672848	3	0.9529204	1.05922	1179779	484189	695590	Mitochondrial ribosomal protein of the large subunit
YKL013C	ARC19	1.053155	0.09355237	3	0.9473618	1.170762	1432951	598689	834262	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YKL116C	PRR1	1.071829	0.05307727	3	1.009347	1.138178	907959	388141	519818	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YKR090W	PXL1	0.9510083	0.1634325	3	0.7904335	1.144203	504224	201253	302971	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YLR312W-A	MRPL15	0.9027702	0.159548	3	0.7536458	1.081402	5265584	1887549	3378035	Mitochondrial ribosomal protein of the large subunit
YNL169C	PSD1	0.9170871	0.1497009	3	0.7741765	1.086378	1060783	355538	705245	Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YOL102C	TPT1	1.047694	0.1383979	3	0.8958161	1.225322	4134290	1760770	2373520	tRNA 2_prime-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2_prime-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1_prime_prime-2_prime_primecyclic phosphate and nicotinamide
YPL176C	TRE1	0.9512759	0.06791577	3	0.8809054	1.027268	1579224	813696	765528	Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors
YBR170C	NPL4	1.007386	0.1462596	3	0.8537221	1.188708	2336150	1228380	1107770	Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation
YDR062W	LCB2	0.9132643	0.1250788	3	0.7927321	1.052123	446151	154455	291696	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YER005W	YND1	0.987525	0.03626086	3	0.947824	1.028889	359835	141529	218306	Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p
YER068W	MOT2	1.373343	0.1926551	3	1.10433	1.707889	731846	348641	383205	Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p
YGL077C	HNM1	0.9526338	0.07905575	3	0.871112	1.041785	411987	174150	237837	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YGR049W	SCM4	1.152902	0.04444774	3	1.096348	1.212373	1040094	464011	576083	Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YGR117C	YGR117C	0.9567848	0.03898449	3	0.9154936	0.9999383	231486	98051	133435	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR184C	UBR1	1.018967	0.1803812	3	0.8308291	1.249708	842715.5	415276.5	427439	E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
YIL020C	HIS6	1.129467	0.300514	3	0.8038702	1.586943	914647	374259	540388	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YJL128C	PBS2	0.9943984	0.2500966	3	0.7492907	1.319686	1023593	434626	588967	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition
YKR080W	MTD1	0.8480616	0.119511	3	0.7407875	0.9708701	3977394	1333965	2643429	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YLR422W	YLR422W	0.8589919	0.09222672	3	0.7738632	0.9534851	259666	90333	169333	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
YMR197C	VTI1	0.9624864	0.062452	3	0.8968144	1.032968	890161	367734	522427	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YNL236W	SIN4	0.7653098	0.1185492	3	0.6692313	0.8751819	379328	140591	238737	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
YOR123C	LEO1	0.782746	0.345055	3	0.5297164	1.15664	2701659	1143842	1557817	Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition
YAL047C	SPC72	0.9590457	0.1114078	3	0.8454499	1.087904	121591.5	49569.5	72022	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
YBL033C	RIB1	1.077647	0.1249948	3	0.9355082	1.241381	480392	196537	283855	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YBR225W	YBR225W	0.4168867	1.372115	3	0.08824531	1.969448	592186	86818	505368	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
YBR235W	YBR235W	0.9008246	0.1328133	3	0.7751202	1.046915	251629	94438	157191	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YBR242W	YBR242W	1.088981	0.1110131	3	0.9604238	1.234746	587735	250498	337237	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YBR271W	YBR271W	0.3817986	1.489676	3	0.07075098	2.060328	140781.8	42339.8	98442	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
YDL030W	PRP9	1.059124	0.2278885	3	0.8183725	1.370701	638705	271764	366941	Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YDL117W	CYK3	0.9913581	0.188815	3	0.8006401	1.227507	770235	307010	463225	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YDR303C	RSC3	1.313515	1.255725	3	0.3171817	5.439536	788559	608222	180337	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YEL011W	GLC3	1.046255	0.1279915	3	0.9051822	1.209314	1101096	437241	663855	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER123W	YCK3	0.989281	0.2461268	3	0.7487909	1.30701	330140	125748	204392	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
YER152C	YER152C	0.9182354	0.06330769	3	0.8547546	0.9864308	461733	179420	282313	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
YGL073W	HSF1	1.093199	0.09527654	3	0.9814665	1.217651	462905	245991	216914	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YGL101W	YGL101W	1.017935	0.09866655	3	0.910396	1.138177	3605528	1564482	2041046	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YGL140C	YGL140C	1.220851	0.3279635	3	0.8423349	1.769459	1478581	627660	850921	Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YGR134W	CAF130	0.8840274	0.0733017	3	0.8136574	0.9604834	673120.9	266880.9	406240	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YHR026W	PPA1	1.432759	0.2510559	3	1.078429	1.903507	719422	301234	418188	Subunit c_prime_prime of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YHR171W	ATG7	1.107242	0.1710411	3	0.9123978	1.343695	243963	84976	158987	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
YIL085C	KTR7	1.565891	0.990627	3	0.510408	4.804029	1074998	583964	491034	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YJL097W	PHS1	1.119263	0.2071755	3	0.8853512	1.414974	2553927	865091	1688836	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
YJL099W	CHS6	0.7964165	0.3067151	3	0.562866	1.126874	664507	127286	537221	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YJL208C	NUC1	0.9155117	0.2990756	3	0.6526541	1.284236	464948	202817	262131	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YJR019C	TES1	0.9191811	0.1728073	3	0.7559183	1.117705	654782	257084	397698	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YKL002W	DID4	0.9530284	0.18069	3	0.7767936	1.169246	483293	206106	277187	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YKL075C	YKL075C	1.057662	0.1974619	3	0.8458714	1.322482	293523	132329	161194	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
YKL122C	SRP21	1.12206	0.2222338	3	0.8725681	1.44289	626379	303004	323375	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YKR070W	YKR070W	0.9150244	0.03586366	3	0.8786329	0.9529232	698845	266908	431937	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR086W	PRP16	1.598547	0.5267271	3	0.8807754	2.901254	257259	118958	138301	RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity
YLR084C	RAX2	1.169998	0.2117323	3	0.9207236	1.486761	237246	117626	119620	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
YLR117C	CLF1	0.8747999	0.1971568	3	0.6998676	1.093457	412632	170837	241795	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
YLR142W	PUT1	35.28842	0.897232	3	12.7846	97.4041	142518.3	130645	11873.32	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YLR182W	SWI6	1.093509	0.2863253	3	0.7908744	1.511948	257103	110112	146991	Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
YLR369W	SSQ1	0.9799633	0.05340676	3	0.9224929	1.041014	598619	254508	344111	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich_primes ataxia
YLR393W	ATP10	0.9981082	0.08584472	3	0.9057101	1.099933	2446114	1153454	1292660	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YLR436C	ECM30	1.334426	0.8209101	3	0.5270573	3.378556	1272822	582511	690311	Non-essential protein of unknown function
YML016C	PPZ1	0.819125	0.2008967	3	0.6525584	1.028208	256447	104968	151479	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YMR037C	MSN2	0.9757232	0.1701751	3	0.8048112	1.182931	248177	109925	138252	Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YMR112C	MED11	0.9428772	0.1650863	3	0.78221	1.136546	339768	134741	205027	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YMR285C	NGL2	0.7856188	0.3647631	3	0.5199347	1.187066	411443	164970	246473	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3_prime-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
YNL021W	HDA1	1.013282	0.05745364	3	0.9494994	1.081349	974630	388922	585708	Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
YNL104C	LEU4	0.901931	0.1484731	3	0.7624408	1.066941	894139	406729	487410	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YNL106C	INP52	0.9938111	0.1194276	3	0.8681826	1.137618	338942	130347	208595	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
YNR049C	MSO1	0.9947749	0.0278251	3	0.9639404	1.026596	716797	285619	431178	Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation
YOR020W-A	YOR020W-A	0.8545793	0.04333107	3	0.8136869	0.8975269	1014376	408691	605685	Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR226C	ISU2	1.133025	0.05118942	3	1.069258	1.200595	2738164	1193287	1544877	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YOR267C	HRK1	1.274582	0.07895469	3	1.165642	1.393702	255879	120165	135714	Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YPL075W	GCR1	1.616642	0.5738077	3	0.8445314	3.094653	9435876	6015878	3419998	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YPL153C	RAD53	1.225776	0.2240612	3	0.9512532	1.579524	229065	110372	118693	Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
YPL227C	ALG5	0.8215953	0.07276339	3	0.7566558	0.8921082	393890	140391	253499	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
R0040C	REP2	1.084957	0.2749213	3	0.7948816	1.48089	1869029	776228	1092801	Master regulator that acts in concert with Rep1p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; also autoregulates levels of its own transcript
YBL008W	HIR1	0.9974268	0.08450923	3	0.9064606	1.097522	582099	246555	335544	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
YBL011W	SCT1	0.8684891	0.05482302	3	0.8162469	0.9240749	2255184	957549	1297635	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YBR023C	CHS3	0.9140064	0.1668274	3	0.7567664	1.103918	411266	114071	297195	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YBR037C	SCO1	0.8907101	0.1637221	3	0.7400739	1.072007	340568	120248	220320	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YBR146W	MRPS9	0.8280395	0.1512496	3	0.6977814	0.9826136	122769	48077	74692	Mitochondrial ribosomal protein of the small subunit
YBR233W-A	DAD3	0.9131006	0.03684954	3	0.875808	0.9519811	828740	323781	504959	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YCR032W	BPH1	0.9400705	0.1576655	3	0.7864582	1.123687	1123657	455627	668030	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YDL107W	MSS2	1.122228	0.3529991	3	0.7526613	1.673257	1101745	448950	652795	Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
YDL110C	TMA17	0.9214913	0.04285169	3	0.8778731	0.9672766	643406	257661	385745	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
YDL120W	YFH1	0.9357137	0.06467109	3	0.8696817	1.006759	911723	391293	520430	Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich_primes ataxia
YDR069C	DOA4	0.8618992	0.1254255	3	0.7478527	0.9933376	155471	62459	93012	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
YDR183W	PLP1	1.426653	0.1487422	3	1.205644	1.688177	286316	174118	112198	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
YDR359C	EAF1	1.090055	0.119223	3	0.9524811	1.247501	173131	73744	99387	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
YEL017W	GTT3	0.8196162	0.02309425	3	0.7984741	0.841318	393623	147029	246594	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YEL043W	YEL043W	0.9364215	0.01035565	3	0.9255121	0.9474595	1829850	738994	1090856	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
YER168C	CCA1	0.780411	0.3675522	3	0.5148606	1.182925	312541	129174	183367	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YGL061C	DUO1	4.044822	2.73424	3	0.1832973	89.2571	704965.8	277813	427152.8	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YGR046W	TAM41	0.7001184	0.04418925	3	0.66597	0.7360178	149767	51664	98103	Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YGR250C	YGR250C	1.331385	0.1237236	3	1.157443	1.531467	470523	175880	294643	Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid
YIL123W	SIM1	1.400036	0.5479874	3	0.7530617	2.602843	338757	178264	160493	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YIR021W	MRS1	1.309475	0.4099199	3	0.8234586	2.082344	320173	134769	185404	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YJL073W	JEM1	1.057623	0.1358829	3	0.9068824	1.233419	233834	75653	158181	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
YJL094C	KHA1	0.8828038	0.01759149	3	0.8654039	0.9005535	503733	177460	326273	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
YJL201W	ECM25	0.8981013	0.0559803	3	0.8429733	0.9568346	1043913	412891	631022	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YJR024C	MDE1	1.835644	0.853138	3	0.6990583	4.820183	762969	549101	213868	5_prime-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
YJR089W	BIR1	1.038335	0.02083515	3	1.01414	1.063107	375496	154822	220674	Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension
YKL045W	PRI2	1.05407	0.08995203	3	0.9520564	1.167015	213875	88751	125124	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YKL096W	CWP1	0.8496455	0.1260915	3	0.736665	0.9799535	218809	82065	136744	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
YKL105C	YKL105C	1.301741	0.2535279	3	0.9770759	1.734288	229514	107953	121561	Putative protein of unknown function
YKL189W	HYM1	0.8993934	0.1161968	3	0.7885781	1.025781	460893	160455	300438	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YKR049C	FMP46	4.182532	2.373301	3	0.2851539	61.34783	440338.4	278227	162111.4	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR068C	BET3	0.9674616	0.01968251	3	0.9461516	0.9892514	1075162	441741	633421	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
YKR085C	MRPL20	0.471858	0.7562932	3	0.2005075	1.110432	724826	174397	550429	Mitochondrial ribosomal protein of the large subunit
YLL002W	RTT109	0.8358548	0.1839507	3	0.6787786	1.02928	175531	66968	108563	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
YLR026C	SED5	0.7782944	0.1950691	3	0.6241329	0.9705338	1437225	560761	876464	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YLR336C	SGD1	0.7541059	0.1063333	3	0.668613	0.8505305	146183	54533	91650	Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YMR016C	SOK2	1.274491	0.2245552	3	0.9885057	1.643216	2484169	1083360	1400809	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YMR021C	MAC1	0.9355822	0.06333964	3	0.8708706	1.005102	425083	218808	206275	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YMR139W	RIM11	0.9186301	0.1116622	3	0.8095883	1.042359	792197	299458	492739	Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
YMR192W	GYL1	0.9165836	0.1057621	3	0.813196	1.033116	296115	110349	185766	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p
YMR223W	UBP8	1.004106	0.05626505	3	0.9421671	1.070116	209498	88289	121209	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
YMR228W	MTF1	0.9045052	0.2047973	3	0.7174033	1.140404	340866.8	115318.1	225548.7	Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
YMR233W	TRI1	2.139732	1.289795	3	0.4971515	9.209369	1776784	734733	1042051	Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus
YMR312W	ELP6	1.092297	0.1787558	3	0.892259	1.337181	2267526	910913.9	1356612	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YNL083W	SAL1	0.1891988	1.344669	3	0.04131238	0.8664761	755187	108052	647135	ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
YNL103W	MET4	1.825015	1.073558	3	0.5415839	6.149885	701188	553610	147578	Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YOR132W	VPS17	1.158729	0.218746	3	0.9046466	1.484173	399402	182280	217122	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation
YOR216C	RUD3	1.549255	1.214208	3	0.3921028	6.121328	1068390	497732	570658	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
YOR236W	DFR1	1.094953	0.1306663	3	0.944451	1.269438	456098	184797	271301	Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YOR246C	YOR246C	0.77638	0.03307897	3	0.7478554	0.8059925	168602	62493	106109	Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
YOR279C	RFM1	1.355068	0.5634309	3	0.7162466	2.563653	181760	91915	89845	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YPL074W	YTA6	1.370798	0.2712058	3	1.008531	1.863193	596408	289617	306791	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
YPL113C	YPL113C	1.033003	0.07838661	3	0.9453195	1.12882	390324	163195	227129	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
YPR073C	LTP1	0.8602987	0.1812638	3	0.7007564	1.056164	921415	363597	557818	Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
YBR007C	DSF2	1.010919	0.2461536	3	0.7651453	1.335637	1857020	607689	1249331	Deletion suppressor of mpt5 mutation
YBR038W	CHS2	0.8093195	0.1091089	3	0.7153167	0.9156755	363239.7	133445.7	229794	Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis
YBR229C	ROT2	0.8688103	0.07597792	3	0.7972335	0.9468133	276838.5	104214.5	172624	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
YCL039W	GID7	0.9372734	0.06818355	3	0.8676758	1.012454	384449.9	187172.9	197277	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
YCR024C	SLM5	0.9010585	0.2004117	3	0.7182251	1.130434	6329330	3026790	3302540	Mitochondrial asparaginyl-tRNA synthetase
YDL074C	BRE1	1.033581	0.01541486	3	1.015708	1.051768	776265	428176	348089	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
YDR142C	PEX7	0.9966539	0.1267583	3	0.8634734	1.150376	253324	104188	149136	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
YDR247W	VHS1	0.9301428	0.102756	3	0.8280378	1.044838	1119661	438345	681316	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YDR268W	MSW1	0.8814593	0.3051677	3	0.6240616	1.245022	789472	312872	476600	Mitochondrial tryptophanyl-tRNA synthetase
YDR291W	HRQ1	0.8847539	0.09599102	3	0.793684	0.9862734	242005	101203	140802	Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
YDR305C	HNT2	1.096287	0.1142661	3	0.9633146	1.247615	522946	232289	290657	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
YDR339C	FCF1	0.8451163	0.1414776	3	0.7200908	0.9918494	331697	120801	210896	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
YER032W	FIR1	1.096678	0.1112621	3	0.9669398	1.243824	584010	276670	307340	Protein involved in 3_prime mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YER087W	AIM10	0.8554413	0.06336242	3	0.7962523	0.91903	285787.9	104788.9	180999	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
YER088C	DOT6	0.8388644	0.1978099	3	0.6706223	1.049314	406377	151666	254711	Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation
YFR039C	YFR039C	0.998474	0.3536036	3	0.6692034	1.489757	308410	121677	186733	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
YGR042W	YGR042W	1.083302	0.1155011	3	0.9505751	1.234561	427297	191999	235298	Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR089W	NNF2	0.9384119	0.09012808	3	0.8474225	1.039171	970181	394014	576167	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
YGR169C	PUS6	0.6180859	0.6547999	3	0.2946097	1.296733	1245576	373487	872089	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
YHR103W	SBE22	1.628072	0.3576401	3	1.086204	2.44026	377574	189434	188140	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YIL047C	SYG1	0.8489465	0.2716607	3	0.6242701	1.154485	610410	214691	395719	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YIL129C	TAO3	1.425224	0.9285823	3	0.498346	4.076011	1229303	720892	508411	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
YIL159W	BNR1	0.9777556	0.1010024	3	0.8721529	1.096145	791824	336921	454903	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YJL063C	MRPL8	0.9967914	0.04160825	3	0.9509461	1.044847	1363176	579786	783390	Mitochondrial ribosomal protein of the large subunit
YJR031C	GEA1	0.9146843	0.2988835	3	0.652206	1.282796	263851	102386	161465	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p
YKL001C	MET14	0.9815742	0.252705	3	0.7374476	1.306517	297457	108971	188486	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YKR099W	BAS1	2.245484	1.000737	3	0.7235978	6.968234	413144	298614	114530	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YLR052W	IES3	1.075654	0.08595842	3	0.9759515	1.185542	381595	160523	221072	Subunit of the INO80 chromatin remodeling complex
YLR119W	SRN2	0.9696224	0.1244508	3	0.8422505	1.116257	2382460	1048760	1333700	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
YLR284C	ECI1	1.019951	0.08939234	3	0.9218227	1.128525	208754	101496	107258	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
YLR310C	CDC25	1.0744	0.09503081	3	0.9648574	1.19638	385362	162350	223012	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
YLR373C	VID22	1.047136	0.301171	3	0.7447189	1.472359	639620	216740	422880	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
YML034W	SRC1	0.8398921	0.08674898	3	0.761361	0.9265232	653149	248564	404585	Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; possible role in chromatid segregation
YMR091C	NPL6	1.506588	0.5248662	3	0.8318573	2.728603	4307666	1946340	2361326	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length
YMR140W	SIP5	1.07359	0.1154383	3	0.9421197	1.223406	428349	178363	249986	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
YMR153W	NUP53	1.060885	0.2804894	3	0.7723635	1.457186	1715728	679438	1036290	Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
YMR161W	HLJ1	0.9108002	0.2176781	3	0.7119428	1.165202	332554	146973	185581	Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
YMR184W	ADD37	0.9519135	0.06239963	3	0.8870154	1.02156	1083311	427414	655897	Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YNL054W	VAC7	1.262407	0.1449019	3	1.071488	1.487345	268529	110962	157567	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
YNL124W	NAF1	1.022196	0.110337	3	0.9022126	1.158135	829767	342657	487110	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YNL152W	INN1	1.025953	0.01925396	3	1.003842	1.048552	339091	141413	197678	Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function
YOL018C	TLG2	0.8396599	0.1511742	3	0.7076341	0.9963182	364940	134939	230001	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
YOL034W	SMC5	1.001861	0.1737753	3	0.8230108	1.219578	287201	121320	165881	Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YOR156C	NFI1	0.9487308	1.258296	3	0.2284299	3.940333	567318	335131	232187	SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length
YPL115C	BEM3	0.6848334	0.5105806	3	0.3842907	1.220422	143522	42277	101245	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
YBR265W	TSC10	0.5066656	0.9480508	3	0.1733011	1.481295	828639	92793	735846	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
YCR035C	RRP43	1.068304	0.2693802	3	0.7876039	1.449045	524319	226060	298259	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)
YCR048W	ARE1	0.5564089	0.2578643	3	0.4155914	0.7449405	551220	210412	340808	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen
YDL217C	TIM22	1.285574	0.299548	3	0.9159761	1.804306	1903669	1038679	864990	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
YER051W	JHD1	0.8422097	0.1073473	3	0.7458721	0.9509905	1692317	823123.8	869193	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
YFL024C	EPL1	1.03576	0.249904	3	0.7806271	1.374278	609872	256390	353482	Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YGL005C	COG7	1.094538	0.1256477	3	0.9494702	1.261771	244985	105734	139251	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGR019W	UGA1	1.148184	0.4605817	3	0.6818023	1.933591	263222	94828	168394	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YHR038W	RRF1	1.023488	0.07339582	3	0.9419168	1.112124	1341963	537042	804921	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YIL119C	RPI1	0.9445537	0.234707	3	0.7242354	1.231895	8250282	3492515	4757767	Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YJL053W	PEP8	1.033447	0.1432765	3	0.8787694	1.21535	241509	99993	141516	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport
YKR079C	TRZ1	1.165721	0.2055842	3	0.9237625	1.471056	254908	108741	146167	tRNA 3_prime-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
YLR390W-A	CCW14	1.001196	0.3177344	3	0.6988246	1.434398	327311	132897	194414	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YML030W	AIM31	0.9195223	0.3251965	3	0.6364207	1.328557	622877	307650	315227	Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss
YMR100W	MUB1	1.011548	0.1812399	3	0.8239786	1.241815	383429	131314	252115	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene
YMR168C	CEP3	0.8371762	0.1060973	3	0.7424638	0.9439705	246707	96867	149840	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
YMR176W	ECM5	0.8802484	0.03483725	3	0.8462223	0.9156427	228825	77162	151663	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks
YMR267W	PPA2	1.230584	0.2148895	3	0.9649477	1.569347	1810387	841698	968689	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YNL047C	SLM2	1.153968	0.1283973	3	0.9979131	1.334426	386441	178133	208308	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex
YOL096C	COQ3	1.392376	0.3465098	3	0.9407282	2.060863	443947	197815	246132	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
YOL138C	RTC1	1.053925	0.1359206	3	0.9036734	1.229159	642570	264678	377892	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity
YOR126C	IAH1	1.049728	0.05440064	3	0.9870558	1.11638	3510473	1599968	1910505	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
YOR372C	NDD1	1.252384	0.340019	3	0.8523833	1.840094	352805	156677	196128	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
YPR037C	ERV2	0.7386628	0.1953818	3	0.5921418	0.9214392	189538	63527	126011	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YHR132C	ECM14	1.023375	0.3832248	2	0.6016877	1.740597	1790016	774369	1015647	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
YKL190W	CNB1	0.8351473	0.167434	2	0.6621926	1.053275	702685	298118	404567	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YJR074W	MOG1	0.8855981	0.2128955	2	0.6593175	1.189539	2630949	1227681	1403268	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
YGL112C	TAF6	0.9213022	0.09653639	2	0.8059289	1.053192	517714	183350	334364	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YNL312W	RFA2	0.9336241	0.06829338	2	0.8493099	1.026309	4313708	1976916	2336792	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YHR050W	SMF2	0.8922098	0.01766439	2	0.8706323	0.9143221	1060809	413159	647650	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YKR062W	TFA2	0.9766905	0.195555	2	0.7448214	1.280742	2469400	1141744	1327656	TFIIE small subunit, involved in RNA polymerase II transcription initiation
YDR121W	DPB4	0.8982268	0.06273148	2	0.8234322	0.9798152	716022	294712	421310	Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YJL166W	QCR8	0.7848084	0.06518276	2	0.717018	0.8590081	724695	261303	463392	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YLR439W	MRPL4	0.9735349	0.02120171	2	0.9453447	1.002566	2019770	757150	1262620	Mitochondrial ribosomal protein of the large subunit
YPL170W	DAP1	1.312903	0.2549835	2	0.9220566	1.869422	930121	370399	559722	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YGR260W	TNA1	0.8186396	0.0465324	2	0.7675114	0.8731738	5888254	2451586	3436668	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YDR079W	PET100	0.8875506	0.2378953	2	0.6382688	1.234192	440194	170580	269614	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
YJL092W	SRS2	1.015279	0.08815259	2	0.8985169	1.147214	13419090	6249123	7169963	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
YLR375W	STP3	1.116388	0.1784292	2	0.8718029	1.429591	516360	190039	326321	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YMR193W	MRPL24	0.9075737	0.01488836	2	0.8890385	0.9264953	843822	240873	602949	Mitochondrial ribosomal protein of the large subunit
YNL200C	YNL200C	0.9126047	0.01135732	2	0.8983524	0.9270832	175195	72200	102995	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL189C	RPS26A	1.290639	0.1257879	2	1.084159	1.536444	731801	325093	406708	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YGR008C	STF2	0.8796698	0.008303537	2	0.8696045	0.8898517	1681645	693065	988580	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YGR092W	DBF2	1.000428	0.07806546	2	0.8978387	1.11474	644592	226642	417950	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
YGR125W	YGR125W	0.7639758	0.05120095	2	0.7116421	0.820158	725516	258550	466966	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR246C	BRF1	1.067669	0.135774	2	0.8845329	1.288721	646902	286950	359952	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
YKL023C-A	YKL023C-A	1.107656	0.1166475	2	0.942312	1.302013	5304670	2647300	2657370	Putative protein of unknown function
YKR037C	SPC34	1.036358	0.06681524	2	0.944699	1.136909	1034726	420318	614408	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YLR455W	YLR455W	0.8894789	0.1525405	2	0.7199815	1.098879	120698	42992	77706	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YMR004W	MVP1	1.01519	0.07733111	2	0.9120145	1.130038	187970	77484	110486	Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
YNL286W	CUS2	1.133645	0.2072031	2	0.8506705	1.510752	149360	62138	87222	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
YNR074C	AIF1	1.024939	0.02146602	2	0.994896	1.05589	134016	56802	77214	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YOR131C	YOR131C	0.9948608	0.05550382	2	0.9212012	1.07441	577092	249385	327707	Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest
YPR164W	MMS1	0.8660849	0.1677144	2	0.6864564	1.092718	783534	231613	551921	Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay
YBR091C	TIM12	1.032948	0.05346017	2	0.959181	1.112387	457994	201294	256700	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YDL073W	YDL073W	0.8485558	0.1337847	2	0.7049449	1.021423	3552270	1325057	2227213	Putative protein of unknown function; YDL073W is not an essential gene
YDL088C	ASM4	0.8772472	0.1012098	2	0.7624365	1.009347	699008	217038	481970	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
YDR246W	TRS23	0.9079089	0.1105662	2	0.7789191	1.05826	3027265	1410044	1617221	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
YEL030W	ECM10	1.002384	0.4133541	2	0.5652435	1.777594	848244	379164	469080	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YER007W	PAC2	0.8235479	0.2981186	2	0.5448172	1.244878	1070917	456259	614658	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YER100W	UBC6	0.9188484	0.07500794	2	0.8281261	1.019509	204912	79735	125177	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway
YGL156W	AMS1	1.272724	0.02556623	2	1.228417	1.318628	412374	206005	206369	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YGR080W	TWF1	1.429749	0.4538174	2	0.762266	2.681719	417847	181980	235867	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
YGR100W	MDR1	0.8948657	0.06591031	2	0.8167447	0.9804588	1537729	604127	933602	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
YGR120C	COG2	0.9766447	0.1737917	2	0.7675932	1.242631	12253910	5336867	6917040	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YHR001W	OSH7	0.9640119	0.03217155	2	0.9219732	1.007967	1262933	373932	889001	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YIL079C	AIR1	1.213948	0.192415	2	0.9297907	1.584947	332117	139741	192376	Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p
YIL105C	SLM1	0.8952013	0.1252341	2	0.7525617	1.064877	1031170	383720	647450	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex
YIR022W	SEC11	0.9120362	0.05061439	2	0.8502511	0.978311	430478	176687	253791	18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
YJL165C	HAL5	0.9955174	0.1234124	2	0.8390092	1.181221	234483	95709	138774	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
YJL171C	YJL171C	0.8116541	0.1187778	2	0.6884596	0.9568933	189565.5	69173.5	120392	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
YJR033C	RAV1	1.005108	0.6222392	2	0.4243128	2.380891	74345	30852	43493	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YJR040W	GEF1	0.9485784	0.05974572	2	0.8731969	1.030467	538974	241084	297890	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels
YKL128C	PMU1	1.083733	0.05656193	2	1.002022	1.172106	675700	287081	388619	Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YLR096W	KIN2	0.970215	0.01975747	2	0.9440085	0.9971489	905968	493626	412342	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
YLR190W	MMR1	0.8955364	0.2127191	2	0.6668794	1.202594	280845	115768	165077	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YML007W	YAP1	1.380281	0.3562967	2	0.8423877	2.261638	224117	128420	95697	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YMR075W	RCO1	1.091302	0.1262468	2	0.9161297	1.29997	520790	226066	294724	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
YMR277W	FCP1	0.9498957	0.06016417	2	0.8739026	1.032497	557040	227060	329980	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YNL032W	SIW14	0.8808412	0.008719828	2	0.8702602	0.8915508	100554	38682	61872	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
YNL250W	RAD50	1.166349	0.05606719	2	1.07915	1.260595	212043	100480	111563	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YNL306W	MRPS18	0.9878549	0.08867474	2	0.8736143	1.117035	1962347	941640	1020707	Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
YOL080C	REX4	1.107337	0.10827	2	0.953042	1.286613	2988247	1197854	1790393	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YOR140W	SFL1	1.020036	0.0582769	2	0.9408894	1.10584	231968	91746	140222	Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YOR271C	FSF1	1.018661	0.1321024	2	0.8482363	1.223326	544884	223901	320983	Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YOR337W	TEA1	0.9706211	0.07176646	2	0.8787258	1.072127	4042838	2001857	2040981	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
YBR087W	RFC5	1.113414	0.2370009	2	0.8016882	1.54635	3197190	1373660	1823530	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YBR201W	DER1	1.042847	0.1334417	2	0.8667663	1.254699	3655250	1727220	1928030	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YBR220C	YBR220C	1.06558	0.04149566	2	1.006027	1.128658	945930	410630	535300	Putative protein of unknown function; YBR220C is not an essential gene
YCR011C	ADP1	0.9005363	0.05023101	2	0.8399764	0.9654623	159061	62377	96684	Putative ATP-dependent permease of the ABC transporter family of proteins
YDL017W	CDC7	0.972828	0.1016038	2	0.8450464	1.119932	259505	103912	155593	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
YDR202C	RAV2	0.9155613	0.106074	2	0.7903897	1.060556	1082959	443620	639339	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
YDR434W	GPI17	0.8745228	0.1438347	2	0.7164681	1.067445	171901	59360	112541	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YDR476C	YDR476C	0.9313302	0.07760408	2	0.8363609	1.037083	259198.6	104883.6	154315	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YEL053C	MAK10	1.009393	0.03817379	2	0.9573783	1.064234	165564	62743	102821	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YER058W	PET117	1.264326	0.1865462	2	0.9762849	1.63735	762650	380350	382300	Protein required for assembly of cytochrome c oxidase
YER180C-A	SLO1	1.047798	0.03086365	2	1.003923	1.093589	351106	143087	208019	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
YFL041W	FET5	1.112231	0.1153332	2	0.9479292	1.305012	411173	174412	236761	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
YGR032W	GSC2	0.9325703	0.0609122	2	0.8570742	1.014717	227413	98291	129122	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YGR047C	TFC4	0.8186941	0.05700662	2	0.7565006	0.8860006	283449	100933	182516	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
YGR084C	MRP13	0.9362831	0.1640262	2	0.7458983	1.175262	322610	109841	212769	Mitochondrial ribosomal protein of the small subunit
YGR215W	RSM27	0.887928	0.498261	2	0.4451166	1.771258	298547	160358	138189	Mitochondrial ribosomal protein of the small subunit
YHR115C	DMA1	0.9768844	0.05106381	2	0.9101391	1.048524	299202	124095	175107	Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.
YHR199C	AIM46	1.01786	0.04804033	2	0.9522975	1.087937	554765	213696	341069	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YJR043C	POL32	1.023609	0.1636694	2	0.8158707	1.284243	719820	304880	414940	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YJR101W	RSM26	1.005296	0.3380097	2	0.6292819	1.605988	1428291	535245	893046	Mitochondrial ribosomal protein of the small subunit
YKL109W	HAP4	1.059844	0.05387046	2	0.9835968	1.142001	208301	93448	114853	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YLR051C	FCF2	0.9739924	0.04246677	2	0.9183215	1.033038	1418074	490685	927389	Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YLR115W	CFT2	0.8506862	0.4753019	2	0.4402349	1.64382	1534978	703443	831535	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
YLR245C	CDD1	0.8908195	0.02588763	2	0.8594248	0.9233609	262768	107052	155716	Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm
YLR414C	PUN1	0.7444932	0.003579762	2	0.7408086	0.748196	276126	93474	182652	Putative protein of unknown function; localizes to bud and cytoplasm; co-localizes with Sur7p in punctate patches in the plasma membrane; null mutant displays decreased thermotolerance; transcription induced on cell wall damage
YLR427W	MAG2	0.8269189	0.09692913	2	0.7229714	0.9458117	1170954	641214	529740	Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
YML021C	UNG1	0.9262046	0.06455324	2	0.8469392	1.012888	172531	64854	107677	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
YML121W	GTR1	1.407498	0.4826483	2	0.7210099	2.747607	251135	114651	136484	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YMR071C	TVP18	0.9137721	0.1183628	2	0.7755238	1.076665	199737	81598	118139	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
YMR196W	YMR196W	0.7987282	0.08111484	2	0.7137989	0.8937625	127164	42718	84446	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YMR269W	TMA23	0.9296704	0.04916184	2	0.8684372	0.9952212	1418776	686436	732340	Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YNL070W	TOM7	1.510073	1.114384	2	0.3222914	7.075342	485298.8	165559.8	319739	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YNL072W	RNH201	1.079074	0.05473304	2	1.000247	1.164112	565973	218436	347537	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome
YNL215W	IES2	1.080191	0.1354304	2	0.8953338	1.303216	308547	128437	180110	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions
YNL227C	JJJ1	0.8629772	0.152806	2	0.6982729	1.066531	276225	109891	166334	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
YNL245C	CWC25	1.043681	0.00320289	2	1.039058	1.048324	103919	46178	57741	Heat-stable protein required for the first step of pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf25p
YOR205C	GEP3	1.415054	0.07919568	2	1.267959	1.579214	7054682	3550221	3504461	Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YPL015C	HST2	1.121446	0.1193844	2	0.9504314	1.323232	194227	85880	108347	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YPL029W	SUV3	0.9652124	0.05889708	2	0.8895547	1.047305	243307	101000	142307	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
YPL215W	CBP3	0.9825597	0.1371557	2	0.8124651	1.188265	1081000	419480	661520	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p
YPR190C	RPC82	0.9858643	0.006761954	2	0.9766683	0.9951468	385757	162444	223313	RNA polymerase III subunit C82
YAL008W	FUN14	0.8342747	0.0958478	2	0.7304965	0.9527961	297670	105584	192086	Mitochondrial protein of unknown function
YBL059C-A	CMC2	1.319829	0.3808175	2	0.7785798	2.237342	326336	148557	177779	Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold
YBR133C	HSL7	1.151147	0.01750835	2	1.123551	1.179422	564592	209850	354742	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YBR198C	TAF5	1.014216	0.1218451	2	0.8566269	1.200796	302688	128111	174577	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YCR071C	IMG2	1.030903	0.0739093	2	0.930533	1.1421	289463	191660	97803	Mitochondrial ribosomal protein of the large subunit
YDL003W	MCD1	0.869298	0.1787052	2	0.6785874	1.113606	572835	215675	357160	Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YDL070W	BDF2	0.8313585	0.02152674	2	0.8069217	0.8565354	408755	176293	232462	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p
YDR040C	ENA1	2.7245	1.51577	2	0.3333826	22.26541	2233410	972310	1261100	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR143C	SAN1	1.076784	0.1894255	2	0.8281576	1.400051	982636	405515	577121	Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins
YDR169C	STB3	1.082721	0.02471229	2	1.046266	1.120446	255803	108553	147250	Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p
YDR192C	NUP42	0.8692673	0.4189356	2	0.4864021	1.5535	413462	203302	210160	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p
YDR207C	UME6	0.983202	0.04692628	2	0.9212929	1.049271	587738	303950	283788	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YDR370C	YDR370C	1.120698	0.01757616	2	1.093728	1.148333	12673120	5434323	7238801	Putative protein of unknown function
YDR371W	CTS2	1.261937	0.3866543	2	0.738431	2.156579	126473	54026	72447	Protein similar to Ashbya gossypii sporulation-specific chitinase
YDR384C	ATO3	1.09165	0.001551545	2	1.089305	1.094	236367	110213	126154	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YDR419W	RAD30	0.7628921	0.2024097	2	0.5762785	1.009936	113735.6	41589.6	72146	DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV
YEL029C	BUD16	1.034075	0.1842312	2	0.8010564	1.334877	79364	31554	47810	Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5_prime-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)
YER034W	YER034W	0.9516533	0.01339092	2	0.9341545	0.9694798	656672	282429	374243	Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YFR040W	SAP155	0.9661361	0.1479487	2	0.7870237	1.186011	158872	57524	101348	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
YGL006W	PMC1	0.7823017	0.008076251	2	0.7735942	0.7911073	159238	52690	106548	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
YGL091C	NBP35	1.0822	0.1229859	2	0.9126035	1.283314	116880	49500	67380	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YGR033C	TIM21	5.24931	2.327271	2	0.2086	132.0961	184024.3	86006	98018.3	Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
YGR105W	VMA21	1.200363	0.2833598	2	0.8105091	1.777736	309205	127741	181464	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YHR011W	DIA4	1.16232	0.03652871	2	1.104941	1.222679	360069	153996	206073	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
YIL017C	VID28	0.8598198	0.173026	2	0.6764923	1.092828	183478	66385	117093	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YIL130W	ASG1	3.596396	1.984315	2	0.2298821	56.2639	157571.5	77028	80543.49	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
YIR030C	DCG1	0.9275485	0.06209149	2	0.8510669	1.010903	618030	261536	356494	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YIR033W	MGA2	0.8618366	0.1788117	2	0.6726635	1.104211	214684	89148	125536	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YJL052W	TDH1	1.023333	0.08998149	2	0.9033519	1.15925	3891394	1621131	2270263	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall
YJL127C	SPT10	0.990035	0.057662	2	0.9139948	1.072401	94558	39405	55153	Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
YJR093C	FIP1	1.099997	0.1519338	2	0.8911324	1.357815	250615	108281	142334	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity
YLR006C	SSK1	1.070039	0.1179055	2	0.9087244	1.25999	180352	74414	105938	Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YLR067C	PET309	1.022781	0.3637385	2	0.6177999	1.693235	128081	53066	75015	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
YLR099C	ICT1	0.8843346	0.04590363	2	0.8298263	0.9424235	282752	130875	151877	Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress
YLR424W	SPP382	0.9109416	0.03980216	2	0.8620522	0.9626037	115165	48792	66373	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
YMR014W	BUD22	0.8844197	0.05689416	2	0.8173607	0.9569805	458444	178438	280006	Protein that cosediments with pre-ribosomal particles, required for biogenesis of the small ribosomal subunit; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR044W	IOC4	1.00573	0.05001955	2	0.9383706	1.077924	736150	305550	430600	Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
YMR169C	ALD3	1.153431	1.246537	2	0.2049741	6.490592	209938	129453	80485	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YMR250W	GAD1	0.7283556	0.1030169	2	0.6314478	0.8401358	173173	72645	100528	Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YMR282C	AEP2	0.8851272	0.04680724	2	0.8295305	0.9444501	579280	223994	355286	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5_prime-untranslated leader
YMR286W	MRPL33	1.536748	0.8900192	2	0.447609	5.27602	357766	125065	232701	Mitochondrial ribosomal protein of the large subunit
YMR291W	YMR291W	0.8680955	0.003253329	2	0.8641902	0.8720185	113527	43912	69615	Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene
YNL050C	YNL050C	0.9528984	0.1647621	2	0.758361	1.197339	733242	296605	436637	Putative protein of unknown function; YNL050c is not an essential gene
YNL068C	FKH2	0.9305249	0.5453324	2	0.4370103	1.981364	717726	222196	495530	Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YNL261W	ORC5	1.523068	0.6660161	2	0.6051225	3.833499	669768	263071	406697	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YOL142W	RRP40	0.992153	0.08202928	2	0.8855338	1.111609	184753	79507	105246	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3)
YOR006C	TSR3	1.946449	0.9818924	2	0.499161	7.590066	177598	115974	61624	Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR035C	SHE4	0.9116252	0.1326351	2	0.7585479	1.095594	172731	66477	106254	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
YOR150W	MRPL23	0.933372	0.08456079	2	0.8301518	1.049427	382071	149021	233050	Mitochondrial ribosomal protein of the large subunit
YOR350C	MNE1	0.9269675	0.1618609	2	0.7406964	1.160082	743067	328709	414358	Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase
YPL001W	HAT1	1.062196	0.05311933	2	0.9868067	1.143345	244590	95849	148741	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
YPL049C	DIG1	1.074158	0.2843598	2	0.7242883	1.593032	884931	441599	443332	Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YPL118W	MRP51	0.9743519	0.1255447	2	0.8187481	1.159528	149051	59315	89736	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5_prime-untranslated leader sequences
YPL193W	RSA1	1.087413	0.03825666	2	1.031259	1.146625	360426	135882	224544	Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
YPR011C	YPR011C	0.9479621	0.004558103	2	0.9419925	0.9539695	533140	207252	325888	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR018W	RLF2	0.7822856	0.46479	2	0.4107784	1.489783	221208	89627	131581	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
YPR089W	YPR089W	0.8537544	0.07512476	2	0.7693346	0.9474377	141025	47778	93247	Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
YPR139C	VPS66	1.087025	0.3943485	2	0.6293329	1.877579	385804	144815	240989	Cytoplasmic protein of unknown function involved in vacuolar protein sorting.
YPR198W	SGE1	1.104669	0.1966528	2	0.8411364	1.450767	70271	25962	44309	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YAL001C	TFC3	0.9124605	0.2063468	2	0.6855097	1.214548	485148	194269	290879	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YAL014C	SYN8	0.9005607	0.2575198	2	0.630248	1.28681	373198	131244	241954	Endosomal SNARE related to mammalian syntaxin 8
YAL015C	NTG1	0.8732167	0.03006791	2	0.8375758	0.9103742	166711	64372	102339	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress
YAL058W	CNE1	1.213507	0.5650523	2	0.5545444	2.65551	808014	268604	539410	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YBL006C	LDB7	1.088932	0.03456147	2	1.038002	1.142361	189255	86130	103125	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YBL097W	BRN1	1.272117	0.7619574	2	0.4424904	3.657214	338404	159102	179302	Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
YBL104C	YBL104C	1.036838	0.05229139	2	0.9643546	1.11477	541154	236000	305154	Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YBR077C	SLM4	0.8795189	0.2476655	2	0.6239861	1.239697	428577	179024	249553	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YBR122C	MRPL36	0.9570652	0.1469984	2	0.7806618	1.17333	314233	157591	156642	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region
YCL010C	SGF29	1.057059	0.01439571	2	1.036178	1.078361	263042	117174	145868	Probable subunit of SAGA histone acetyltransferase complex
YCL052C	PBN1	0.7688903	0.166041	2	0.6108352	0.9678426	390943	133393	257550	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
YDL182W	LYS20	0.9502815	0.3055388	2	0.6222258	1.451298	173214	69006	104208	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YDR320C-A	DAD4	1.273827	0.4516388	2	0.6811901	2.382058	217332	93928	123404	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR325W	YCG1	0.8357711	0.06840873	2	0.7601723	0.9188881	381327	137003	244324	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus
YDR379W	RGA2	1.236535	0.2472756	2	0.8777502	1.741976	626332	288371	337961	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
YDR530C	APA2	1.318743	0.2292732	2	0.9597546	1.812008	748095	336293	411802	Diadenosine 5_prime,5_prime_prime-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5_prime-nucleosidyl) tetraphosphates; has similarity to Apa1p
YDR532C	YDR532C	1.467443	0.5878856	2	0.6496986	3.314441	89405	38058	51347	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
YER019W	ISC1	1.145939	0.4922949	2	0.5792268	2.267121	283769	99504	184265	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
YER095W	RAD51	1.294587	0.04675225	2	1.213364	1.381248	289485	137061	152424	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YER101C	AST2	0.3366304	0.6817247	2	0.1308646	0.8659333	843324	86414	756910	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YFL009W	CDC4	1.039318	0.4425208	2	0.5628524	1.919121	289176	138239	150937	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
YGL036W	YGL036W	0.8997867	0.02513037	2	0.8689876	0.9316774	175708	63424	112284	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YGL143C	MRF1	0.9630865	0.04262446	2	0.9078405	1.021694	219461	91845	127616	Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YGL200C	EMP24	1.072507	0.2252685	2	0.7848932	1.465512	1315270	653030	662240	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YGL224C	SDT1	0.8983591	0.1380714	2	0.7418987	1.087816	105963	40672	65291	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YGL241W	KAP114	1.12398	0.4883082	2	0.5712752	2.211425	127869	43451	84418	Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
YGR006W	PRP18	1.196082	0.1198105	2	1.013088	1.412132	122369	57402	64967	Splicing factor involved in the positioning of the 3_prime splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
YGR043C	NQM1	0.9354822	0.02950013	2	0.8980063	0.9745221	87961	36323	51638	Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
YGR189C	CRH1	1.057031	0.08816249	2	0.9354543	1.194408	1215501	527211	688290	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
YGR194C	XKS1	0.969352	0.05509506	2	0.8980897	1.046269	91346	38093	53253	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YHR003C	YHR003C	1.291346	0.4501219	2	0.692012	2.409748	829920	467100	362820	Protein of unknown function, localized to the mitochondrial outer membrane
YHR030C	SLT2	1.007865	0.07508709	2	0.9082542	1.118401	225501	92123	133378	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YIL161W	YIL161W	1.10603	0.260106	2	0.7712742	1.58608	2066826	740792	1326034	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
YJL006C	CTK2	0.9427741	0.001333284	2	0.9410336	0.9445178	283986	115400	168586	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3_prime end processing, and ribosomal protein Rps2p to increase translational fidelity
YJL101C	GSH1	1.048283	0.02085054	2	1.018423	1.079017	366074	155709	210365	Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YJR001W	AVT1	0.8433451	0.02570063	2	0.8138345	0.8739258	132061	45217	86844	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YJR138W	IML1	0.8812172	0.00461104	2	0.8756037	0.8868668	121018	44897	76121	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YKL017C	HCS1	0.943702	0.01281195	2	0.9270931	0.9606085	229950	91596	138354	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
YKL062W	MSN4	0.9700544	0.08818799	2	0.8584512	1.096167	159416	63763	95653	Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YKL092C	BUD2	0.8129022	0.418681	2	0.4550233	1.452255	504943	210923	294020	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
YKL134C	1-Oct	0.7944917	0.1688659	2	0.6287076	1.003991	231717.8	85642.8	146075	Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
YKL197C	PEX1	0.8698925	0.1100545	2	0.7468332	1.013229	84051	35130	48921	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
YKR083C	DAD2	0.9656163	0.1500151	2	0.7843507	1.188773	505115	213059	292056	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YLR105C	SEN2	0.8885354	0.002952958	2	0.8849064	0.8921793	367441	136841	230600	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5_prime splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YLR407W	YLR407W	0.9309728	0.05962406	2	0.8571349	1.011171	208870	86127	122743	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
YLR442C	SIR3	0.9196164	0.02971501	2	0.8825132	0.9582795	94012	37926	56086	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YML060W	OGG1	0.8281393	0.1793514	2	0.6458796	1.061831	130253	51619	78634	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
YML082W	YML082W	1.060435	0.2938581	2	0.7056846	1.593521	261884	121734	140150	Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YML115C	VAN1	4.877312	2.363477	2	0.1843319	129.0508	909427	783167	126260	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YMR154C	RIM13	0.9864066	0.08318408	2	0.8789969	1.106941	249036	92140	156896	Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
YMR179W	SPT21	0.9611113	0.1066992	2	0.8289938	1.114284	97472	40743	56729	Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance
YMR239C	RNT1	0.9328553	0.3207636	2	0.598062	1.455065	377262	170379	206883	RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3_prime end of U2 snRNA to ensure formation of the correct U2 3_prime end; involved in polyadenylation-independent transcription termination
YMR288W	HSH155	1.083567	0.2318685	2	0.7857669	1.494231	641920	322204	319716	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3_prime splice site-3_prime exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
YMR294W	JNM1	0.9437535	0.04763867	2	0.8834557	1.008167	226502	90753	135749	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
YMR313C	TGL3	0.7857402	0.1672903	2	0.6231415	0.9907664	91581	32496	59085	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
YNL129W	NRK1	0.9591957	0.00617209	2	0.9510257	0.967436	190086	66528	123558	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
YNL221C	POP1	0.9827107	0.1196063	2	0.8325963	1.15989	101165	43544	57621	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5_prime ends; binds to the RPR1 RNA subunit in RNase P
YNL222W	SSU72	0.9768438	0.19746	2	0.7429741	1.28433	260392	115759	144633	Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo
YNL293W	MSB3	0.9264976	0.02076696	2	0.9002116	0.9535511	441129	176804	264325	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth
YNL311C	YNL311C	0.6761627	0.3678622	2	0.4061014	1.125818	84187.9	31756.9	52431	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism
YNL320W	YNL320W	0.8809033	0.002366991	2	0.8780182	0.8837978	186739	76230	110509	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR011C	PRP2	0.993392	0.04812852	2	0.9292916	1.061914	158979	70793	88186	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing
YOL025W	LAG2	1.109618	0.004276165	2	1.103062	1.116214	413228	197089	216139	Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
YOR363C	PIP2	0.6463766	0.2252441	2	0.4730542	0.8832027	81919.6	40467.6	41452	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YOR373W	NUD1	1.051867	0.05246179	2	0.9781014	1.131195	1110005	476175	633830	Component of the spindle pole body outer plaque, required for exit from mitosis
YPL083C	SEN54	1.172005	0.281963	2	0.7928947	1.732381	546456	276226	270230	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YPL098C	MGR2	0.6702852	0.03464324	2	0.6388631	0.7032527	151397	50295	101102	Protein required for growth of cells lacking the mitochondrial genome
YPL120W	VPS30	0.9667909	0.0007519868	2	0.9657838	0.967799	322363	157104	165259	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1
YPL128C	TBF1	0.9562301	0.2430832	2	0.6827321	1.33929	1846746	765630	1081116	Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation
YPL135W	ISU1	1.358398	0.0269413	2	1.308612	1.410077	500646	199749	300897	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YPL255W	BBP1	1.079337	0.01674435	2	1.054577	1.104677	184248	77327	106921	Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YPR005C	HAL1	1.561167	0.6255328	2	0.6560548	3.714996	205366	99916	105450	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YPR019W	MCM4	0.6347883	0.5903734	2	0.2800801	1.438717	215400	56344	159056	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p
YPR155C	NCA2	0.8263013	0.1382548	2	0.6822172	1.000816	159162	60743	98419	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
YAR019C	CDC15	0.4511074	0.7480166	2	0.1599734	1.272074	119113	26030	93083	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II
YBL067C	UBP13	0.9483048	0.2666254	2	0.6553386	1.37224	93723	42435	51288	Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YBR125C	PTC4	0.9303436	0.144018	2	0.7620067	1.135868	161402	66396	95006	Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YBR158W	AMN1	0.7453331	0.2390799	2	0.5351159	1.038133	85384	31005	54379	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YBR233W	PBP2	1.195094	0.4960328	2	0.600951	2.376647	187225	77923	109302	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YDL042C	SIR2	0.9088021	0.001220978	2	0.9072655	0.9103413	109898	45589	64309	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
YDL197C	ASF2	0.9961558	0.04933945	2	0.9303145	1.066657	92322	46206	46116	Anti-silencing protein that causes derepression of silent loci when overexpressed
YDR118W	APC4	1.296646	0.4856221	2	0.6614924	2.541664	150365.8	73891	76474.8	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDR307W	YDR307W	1.033591	0.1057227	2	0.892718	1.196695	492941	261711	231230	Putative protein of unknown function
YDR362C	TFC6	1.113739	0.07259432	2	1.007137	1.231623	102239	39556	62683	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
YDR391C	YDR391C	0.849957	0.02734427	2	0.8183487	0.8827862	80096	29594	50502	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YDR411C	DFM1	0.855967	0.03364929	2	0.8169651	0.896831	168397	63974	104423	ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes
YFR008W	FAR7	0.9836367	0.1224699	2	0.8300799	1.1656	449518	171403	278115	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
YFR017C	YFR017C	0.870193	0.3073151	2	0.5683844	1.33226	200479	85782	114697	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YFR041C	ERJ5	0.6740495	0.1727281	2	0.5305502	0.8563613	1790499	672143	1118356	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YGL064C	MRH4	0.8566724	0.2766273	2	0.583865	1.256947	159944	71889	88055	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YGL201C	MCM6	0.9432672	0.08019599	2	0.8440432	1.054156	351518	140484	211034	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR195W	SKI6	1.191445	0.0801358	2	1.066203	1.331398	700500	304560	395940	Exosome non-catalytic core component; involved in 3_prime-5_prime RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
YHL010C	ETP1	0.9507704	0.05872232	2	0.876457	1.031385	314901	136542	178359	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
YHR066W	SSF1	1.119878	0.08386565	2	0.9969924	1.25791	148958	88612	60346	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YHR083W	SAM35	1.046391	0.2136274	2	0.778236	1.406943	997883	413924	583959	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YHR167W	THP2	1.053583	0.0241218	2	1.018943	1.089401	613337	192471	420866	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YIL002C	INP51	1.038794	0.2531993	2	0.7313552	1.47547	342872	159995	182877	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
YIL046W	MET30	1.117057	0.2720513	2	0.7661735	1.628633	130035	48299	81736	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
YIL068C	SEC6	0.8379406	0.1681734	2	0.6637269	1.057882	213189	86361	126828	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly
YIL147C	SLN1	5.061541	2.548872	2	0.1479494	173.1619	86687.4	61744	24943.4	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
YJR022W	LSM8	0.8487969	0.2307087	2	0.6165097	1.168605	360849	125911	234938	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YJR119C	JHD2	0.9623352	0.09265505	2	0.846364	1.094197	156531	76317	80214	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
YJR140C	HIR3	0.8655773	0.002448221	2	0.8626454	0.8685193	141033	55179	85854	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly
YJR147W	HMS2	1.155424	0.00314548	2	1.150398	1.160472	89265	39414	49851	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKR052C	MRS4	1.503858	0.2939266	2	1.000673	2.260069	108576	43516	65060	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations
YLR001C	YLR001C	0.7826331	0.06992192	2	0.7103495	0.8622721	65258.9	25329.9	39929	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
YLR032W	RAD5	0.9265038	0.1599837	2	0.7422544	1.156489	199924.7	75267.7	124657	DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p
YLR085C	ARP6	0.8744292	0.2017941	2	0.661096	1.156604	122214	51327	70887	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YLR241W	YLR241W	0.5400139	0.1515704	2	0.4376979	0.6662472	581890	161233	420657	Putative protein of unknown function, may be involved in detoxification
YLR425W	TUS1	0.9568255	0.2321854	2	0.6935536	1.320035	92440	36178	56262	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YMR005W	TAF4	1.138395	0.3850154	2	0.6676545	1.94104	343195	136411	206784	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
YMR036C	MIH1	0.9546179	0.1126559	2	0.8166234	1.115931	136785	57830	78955	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YMR160W	YMR160W	1.004179	0.1056724	2	0.8673745	1.16256	132552	54539	78013	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene
YNL022C	YNL022C	0.2583852	1.699824	2	0.02449861	2.725173	1281512	112605	1168907	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
YOL023W	IFM1	1.010536	0.1298027	2	0.8441573	1.209707	226493	99540	126953	Mitochondrial translation initiation factor 2
YOR078W	BUD21	0.8600075	0.2682058	2	0.5930193	1.247199	273491	82164	191327	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
YOR358W	HAP5	1.081678	0.160232	2	0.8662715	1.350647	278993	112808	166185	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
YPR079W	MRL1	0.8088543	0.0957279	2	0.708356	0.9236109	358437	141263	217174	Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
YPR116W	RRG8	1.236909	0.08013416	2	1.106891	1.382199	134278	57575	76703	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
YDR373W	FRQ1	0.7800921	0	1	0.7800921	0.7800921	124842	43632	81210	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
YOR194C	TOA1	1.215185	0	1	1.215185	1.215185	67065	26440	40625	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
YDR116C	MRPL1	1.010775	0	1	1.010775	1.010775	123398	48425	74973	Mitochondrial ribosomal protein of the large subunit
YDR405W	MRP20	0.9705911	0	1	0.9705911	0.9705911	548464	190584	357880	Mitochondrial ribosomal protein of the large subunit
YGL133W	ITC1	0.9089256	0	1	0.9089256	0.9089256	1876231	752917	1123314	Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YHR060W	VMA22	1.369357	0	1	1.369357	1.369357	191966	60206	131760	Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YLR287C-A	RPS30A	0.7100256	0	1	0.7100256	0.7100256	241186	95412	145774	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YLR178C	TFS1	0.7051689	0	1	0.7051689	0.7051689	419406	169498	249908	Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase
YPL055C	LGE1	0.99167	0	1	0.99167	0.99167	226427	58321	168106	Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
YDR381C-A	YDR381C-A	1.052931	0	1	1.052931	1.052931	2554223	1167430	1386793	Protein of unknown function, localized to the mitochondrial outer membrane
YHR057C	CPR2	0.8832362	0	1	0.8832362	0.8832362	410760	172140	238620	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
YKL020C	SPT23	1.295135	0	1	1.295135	1.295135	117348	50467	66881	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YPL097W	MSY1	0.9456265	0	1	0.9456265	0.9456265	145468	57522	87946	Mitochondrial tyrosyl-tRNA synthetase
YAR008W	SEN34	1.007536	0	1	1.007536	1.007536	518166	226208	291958	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3_prime splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YDR404C	RPB7	0.8850341	0	1	0.8850341	0.8850341	30383	11539	18844	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved recruitment of 3_prime-end processing factors to transcribing RNA polymerase II complex and in export of
YER163C	YER163C	1.406015	0	1	1.406015	1.406015	40557	16456	24101	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein
YFR047C	BNA6	0.8640055	0	1	0.8640055	0.8640055	292530	100300	192230	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YHL038C	CBP2	0.06598047	0	1	0.06598047	0.06598047	550246	16666	533580	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YLL033W	IRC19	1.065666	0	1	1.065666	1.065666	110030	49426	60604	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
YMR060C	SAM37	1.211094	0	1	1.211094	1.211094	225923	115556	110367	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
YMR188C	MRPS17	0.8634833	0	1	0.8634833	0.8634833	100952	36327	64625	Mitochondrial ribosomal protein of the small subunit
YMR222C	FSH2	0.9857072	0	1	0.9857072	0.9857072	117891	42044	75847	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
YOR212W	STE4	1.01717	0	1	1.01717	1.01717	800230	329350	470880	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YAL044W-A	YAL044W-A	1.505616	0	1	1.505616	1.505616	66487	33054	33433	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
YBR195C	MSI1	1.148303	0	1	1.148303	1.148303	436070	200500	235570	Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
YCL036W	GFD2	1.093135	0	1	1.093135	1.093135	68662	28869	39793	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YDL188C	PPH22	1.068433	0	1	1.068433	1.068433	189464	96234	93230	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YDR175C	RSM24	1.032237	0	1	1.032237	1.032237	314210	132275	181935	Mitochondrial ribosomal protein of the small subunit
YDR439W	LRS4	1.070538	0	1	1.070538	1.070538	500283	203353	296930	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
YER047C	SAP1	0.9181893	0	1	0.9181893	0.9181893	28256	11202	17054	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YGL098W	USE1	0.8161933	0	1	0.8161933	0.8161933	134075	45146	88929	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YGL252C	RTG2	0.9778995	0	1	0.9778995	0.9778995	28583	11951	16632	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YGR075C	PRP38	1.007679	0	1	1.007679	1.007679	88036	34601	53435	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
YGR129W	SYF2	2.036867	0	1	2.036867	2.036867	240044	132978	107066	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
YHR053C	CUP1-1	1.023866	0	1	1.023866	1.023866	57970	31253	26717	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YIR023W	DAL81	1.0131	0	1	1.0131	1.0131	421388	188537	232851	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YJR111C	YJR111C	1.198681	0	1	1.198681	1.198681	312400	135510	176890	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YKL048C	ELM1	1.069919	0	1	1.069919	1.069919	454570	196030	258540	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
YKL093W	MBR1	1.651391	0	1	1.651391	1.651391	92328	47356	44972	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YKL159C	RCN1	0.9038322	0	1	0.9038322	0.9038322	106924	41849	65075	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
YKL218C	SRY1	0.9988014	0	1	0.9988014	0.9988014	164190	70012	94178	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
YLR321C	SFH1	1.22224	0	1	1.22224	1.22224	280433	124396	156037	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YML062C	MFT1	1.027654	0	1	1.027654	1.027654	75995	33474	42521	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
YMR209C	YMR209C	0.8941345	0	1	0.8941345	0.8941345	50229	21093	29136	Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
YNL214W	PEX17	0.7160246	0	1	0.7160246	0.7160246	197118	77644	119474	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
YNL263C	YIF1	0.9322271	0	1	0.9322271	0.9322271	301650	122390	179260	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles
YOR148C	SPP2	0.9390553	0	1	0.9390553	0.9390553	206961	90421	116540	Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YPL045W	VPS16	1.020971	0	1	1.020971	1.020971	275550	115440	160110	Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
YPR158W-B	YPR158W-B	1.181	0	1	1.181	1.181	1962530	901330	1061200	NA
YPR175W	DPB2	0.6705109	0	1	0.6705109	0.6705109	38520	12083	26437	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YAR018C	KIN3	0.9570294	0	1	0.9570294	0.9570294	109055	43751	65304	Nonessential protein kinase with unknown cellular role
YBR096W	YBR096W	0.9086779	0	1	0.9086779	0.9086779	259375	124165	135210	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YDL220C	CDC13	1.005642	0	1	1.005642	1.005642	54389	21398	32991	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
YDR108W	GSG1	0.9285051	0	1	0.9285051	0.9285051	29423	12085	17338	Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
YDR173C	ARG82	0.9336196	0	1	0.9336196	0.9336196	68986	27806	41180	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YDR425W	SNX41	0.8272667	0	1	0.8272667	0.8272667	257930	109730	148200	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
YER016W	BIM1	0.929973	0	1	0.929973	0.929973	205434	85544	119890	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YGL022W	STT3	0.8604371	0	1	0.8604371	0.8604371	107360	38565	68795	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
YGL032C	AGA2	1.106244	0	1	1.106244	1.106244	252700	109530	143170	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YGL057C	GEP7	0.9770396	0	1	0.9770396	0.9770396	432160	160940	271220	Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL065C	ALG2	0.4822763	0	1	0.4822763	0.4822763	112780	35917	76863	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YGL205W	POX1	1.215362	0	1	1.215362	1.215362	65018	30368	34650	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YGR071C	YGR071C	0.8305648	0	1	0.8305648	0.8305648	47260	19080	28180	Putative protein of unknown function; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGR152C	RSR1	1.054107	0	1	1.054107	1.054107	1562970	642890	920080	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YGR212W	SLI1	0.8907892	0	1	0.8907892	0.8907892	73847	30030	43817	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
YHL013C	OTU2	1.0932	0	1	1.0932	1.0932	2932500	1363300	1569200	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YHR168W	MTG2	0.9176838	0	1	0.9176838	0.9176838	129212	47876	81336	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
YHR184W	SSP1	1.513798	0	1	1.513798	1.513798	67619	38777	28842	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
YHR198C	AIM18	0.8989572	0	1	0.8989572	0.8989572	296850	115520	181330	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YIL095W	PRK1	0.9078529	0	1	0.9078529	0.9078529	237638	88538	149100	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YJL023C	PET130	1.103217	0	1	1.103217	1.103217	40411	17782	22629	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL062W	LAS21	0.6838074	0	1	0.6838074	0.6838074	12174880	5532605	6642279	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
YJL126W	NIT2	1.528514	0	1	1.528514	1.528514	403420	205230	198190	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YJR066W	TOR1	0.8127438	0	1	0.8127438	0.8127438	117255	44678	72577	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
YKL170W	MRPL38	1.00056	0	1	1.00056	1.00056	144913	59283	85630	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
YLL006W	MMM1	0.8063216	0	1	0.8063216	0.8063216	70012	26934	43078	ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
YLL007C	YLL007C	0.9351912	0	1	0.9351912	0.9351912	43813	15811	28002	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene
YLL035W	GRC3	0.9512938	0	1	0.9512938	0.9512938	243450	107720	135730	Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated
YLR243W	YLR243W	1.243828	0	1	1.243828	1.243828	1532840	794490	738350	Putative protein of unknown function; YLR243W is an essential gene
YLR368W	MDM30	0.9751341	0	1	0.9751341	0.9751341	41650	17072	24578	F-box protein; associates with mitochondria and has a role in mitochondrial fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
YLR371W	ROM2	0.8413967	0	1	0.8413967	0.8413967	74094	29461	44633	GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP
YML081W	YML081W	0.8789663	0	1	0.8789663	0.8789663	65262	24426	40836	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YML102W	CAC2	1.050729	0	1	1.050729	1.050729	538883	244503	294380	Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YMR090W	YMR090W	0.8212203	0	1	0.8212203	0.8212203	47746	16832	30914	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
YNL090W	RHO2	0.8555784	0	1	0.8555784	0.8555784	3003700	1152900	1850800	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YNL151C	RPC31	0.8123477	0	1	0.8123477	0.8123477	439137	195017	244120	RNA polymerase III subunit C31
YNL191W	DUG3	1.053097	0	1	1.053097	1.053097	249650	110510	139140	Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YNR031C	SSK2	0.7837605	0	1	0.7837605	0.7837605	122775	41126	81649	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
YOL067C	RTG1	0.9896091	0	1	0.9896091	0.9896091	72890	31439	41451	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
YOL124C	TRM11	1.162426	0	1	1.162426	1.162426	134066	53617	80449	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YOR188W	MSB1	0.797321	0	1	0.797321	0.797321	32008	10023	21985	Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
YPL016W	SWI1	0.8250825	0	1	0.8250825	0.8250825	40108	14729	25379	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]
YPL046C	ELC1	0.9581297	0	1	0.9581297	0.9581297	195000	85530	109470	Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation
YPL233W	NSL1	1.126938	0	1	1.126938	1.126938	35714	17320	18394	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YAR003W	SWD1	0.9461633	0	1	0.9461633	0.9461633	263630	107430	156200	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YAR042W	SWH1	0.9826078	0	1	0.9826078	0.9826078	49240	21336	27904	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
YBL054W	TOD6	1.114417	0	1	1.114417	1.114417	138290	57757	80533	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne
YBR074W	YBR074W	1.093876	0	1	1.093876	1.093876	200211	91591	108620	Putative metalloprotease
YBR141C	YBR141C	0.6913717	0	1	0.6913717	0.6913717	70918	25879	45039	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene
YCL012C	YCL012C	0.9576709	0	1	0.9576709	0.9576709	89322	34349	54973	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YCR046C	IMG1	0.847745	0	1	0.847745	0.847745	57108	22073	35035	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YCR069W	CPR4	0.8012179	0	1	0.8012179	0.8012179	55736	13336	42400	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
YDL010W	GRX6	0.8719156	0	1	0.8719156	0.8719156	82634	33476	49158	Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7
YDL224C	WHI4	1.014302	0	1	1.014302	1.014302	196819	84279	112540	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YDR031W	MIC14	0.9276438	0	1	0.9276438	0.9276438	100318	38719	61599	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs
YDR055W	PST1	0.9231053	0	1	0.9231053	0.9231053	65794	20008	45786	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YDR147W	EKI1	0.9892175	0	1	0.9892175	0.9892175	726550	296680	429870	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YDR200C	VPS64	0.9598771	0	1	0.9598771	0.9598771	66547	27737	38810	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; localizes to the cytoplasm and endoplasmic reticulum membrane
YDR249C	YDR249C	0.9457159	0	1	0.9457159	0.9457159	57814	19340	38474	Putative protein of unknown function
YDR261C	EXG2	1.107457	0	1	1.107457	1.107457	418480	191170	227310	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDR262W	YDR262W	1.199515	0	1	1.199515	1.199515	125827	59710	66117	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YDR329C	PEX3	0.888573	0	1	0.888573	0.888573	50434	21314	29120	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
YDR357C	YDR357C	1.070859	0	1	1.070859	1.070859	150205	68368	81837	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR416W	SYF1	1.121479	0	1	1.121479	1.121479	62262	28710	33552	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
YDR484W	VPS52	0.9646923	0	1	0.9646923	0.9646923	47907	21627	26280	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
YER144C	UBP5	0.9063718	0	1	0.9063718	0.9063718	164021	75610	88411	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
YFL025C	BST1	0.6003122	0	1	0.6003122	0.6003122	42967	16097	26870	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YFL033C	RIM15	1.013264	0	1	1.013264	1.013264	86051	31492	54559	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YFR029W	PTR3	1.036796	0	1	1.036796	1.036796	47608	20644	26964	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YFR048W	RMD8	0.8349336	0	1	0.8349336	0.8349336	97490	37046	60444	Cytosolic protein required for sporulation
YGL028C	SCW11	1.016074	0	1	1.016074	1.016074	162088	69975	92113	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YGL144C	ROG1	0.925155	0	1	0.925155	0.925155	145251	57704	87547	Protein with putative serine active lipase domain
YGL175C	SAE2	1.007273	0	1	1.007273	1.007273	60984	25111	35873	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
YGL208W	SIP2	0.9780908	0	1	0.9780908	0.9780908	316560	119690	196870	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YGR248W	SOL4	0.8583691	0	1	0.8583691	0.8583691	41558	16315	25243	6-phosphogluconolactonase with similarity to Sol3p
YHR031C	RRM3	0.8596235	0	1	0.8596235	0.8596235	75085	28849	46236	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YHR111W	UBA4	7.268498	0	1	7.268498	7.268498	212330	110910	101420	Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response
YHR119W	SET1	0.9776127	0	1	0.9776127	0.9776127	35604	13972	21632	Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain
YHR129C	ARP1	1.683077	0	1	1.683077	1.683077	158646	74995	83651	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
YHR209W	CRG1	0.7567159	0	1	0.7567159	0.7567159	72918	26019	46899	Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance
YIL048W	NEO1	0.8912656	0	1	0.8912656	0.8912656	61240	21565	39675	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YIL077C	YIL077C	1.207103	0	1	1.207103	1.207103	33031	13178	19853	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YIL106W	MOB1	0.8292562	0	1	0.8292562	0.8292562	67409	25567	41842	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
YIL131C	FKH1	0.9683354	0	1	0.9683354	0.9683354	70728	27183	43545	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YIL156W	UBP7	0.8447373	0	1	0.8447373	0.8447373	204157	82187	121970	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YJL019W	MPS3	0.594601	0	1	0.594601	0.594601	48685	17007	31678	Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement
YJL133W	MRS3	0.9646923	0	1	0.9646923	0.9646923	47317	17481	29836	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations
YJR086W	STE18	0.8646031	0	1	0.8646031	0.8646031	203314	80684	122630	G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YJR149W	YJR149W	1.016477	0	1	1.016477	1.016477	141395	55973	85422	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL012W	PRP40	0.9230201	0	1	0.9230201	0.9230201	52881	22331	30550	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YKL055C	OAR1	0.9835743	0	1	0.9835743	0.9835743	70905	29754	41151	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
YKR010C	TOF2	0.9678668	0	1	0.9678668	0.9678668	199240	72580	126660	Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site
YKR096W	YKR096W	0.8785802	0	1	0.8785802	0.8785802	75883	28646	47237	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain
YKR100C	SKG1	1.015486	0	1	1.015486	1.015486	82389	36326	46063	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YLR024C	UBR2	1.005399	0	1	1.005399	1.005399	30381	13651	16730	Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
YLR082C	SRL2	0.9715341	0	1	0.9715341	0.9715341	124875	51545	73330	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YLR126C	YLR126C	1.018278	0	1	1.018278	1.018278	25079	10605	14474	Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein
YLR223C	IFH1	1.080147	0	1	1.080147	1.080147	85255	37166	48089	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
YLR278C	YLR278C	0.8392782	0	1	0.8392782	0.8392782	31259	10028	21231	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
YLR283W	YLR283W	0.9490367	0	1	0.9490367	0.9490367	150071	63998	86073	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
YLR383W	SMC6	0.9471491	0	1	0.9471491	0.9471491	44556	17937	26619	Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
YLR386W	VAC14	0.8616233	0	1	0.8616233	0.8616233	103792	36407	67385	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YLR423C	ATG17	0.8388558	0	1	0.8388558	0.8388558	950189	485995	464194	Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity
YLR433C	CNA1	0.8590327	0	1	0.8590327	0.8590327	94132	36458	57674	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YML011C	RAD33	0.9828976	0	1	0.9828976	0.9828976	304590	122580	182010	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YML061C	PIF1	0.8560178	0	1	0.8560178	0.8560178	118202	43699	74503	DNA helicase; exists in two forms; the nuclear form is involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; the mitochondrial form is involved in repair and recombination of mitochondrial DNA
YMR010W	YMR010W	0.8373106	0	1	0.8373106	0.8373106	75196.9	29745.9	45451	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YMR097C	MTG1	0.9894133	0	1	0.9894133	0.9894133	103530	44979	58551	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
YMR263W	SAP30	1.112941	0	1	1.112941	1.112941	200603	88633	111970	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YNL051W	COG5	1.012915	0	1	1.012915	1.012915	65351	26062	39289	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNR020C	ATP23	1.14833	0	1	1.14833	1.14833	84415	36849	47566	Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex
YNR024W	MPP6	1.068216	0	1	1.068216	1.068216	48929	20520	28409	Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes
YNR032W	PPG1	1.335666	0	1	1.335666	1.335666	777800	408680	369120	Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YOL008W	COQ10	3.097797	0	1	3.097797	3.097797	241740	130690	111050	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
YOL011W	PLB3	0.7804573	0	1	0.7804573	0.7804573	79776	26893	52883	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YOL017W	ESC8	0.7897023	0	1	0.7897023	0.7897023	57802	21620	36182	Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
YOL066C	RIB2	0.5321413	0	1	0.5321413	0.5321413	44909	20287	24622	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
YOL108C	INO4	1.132272	0	1	1.132272	1.132272	173903	77438	96465	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
YOR022C	YOR022C	1.057697	0	1	1.057697	1.057697	65565	26835	38730	Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR228C	YOR228C	0.8454515	0	1	0.8454515	0.8454515	76997	29520	47477	Protein of unknown function, localized to the mitochondrial outer membrane
YOR262W	YOR262W	1.029177	0	1	1.029177	1.029177	101118	43649	57469	Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B
YOR284W	HUA2	1.068741	0	1	1.068741	1.068741	57245	22523	34722	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YOR290C	SNF2	1.044899	0	1	1.044899	1.044899	82368	42282	40086	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YOR329C	SCD5	0.8050882	0	1	0.8050882	0.8050882	596050	277747	318303	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
YPL006W	NCR1	0.8022463	0	1	0.8022463	0.8022463	2086157	935717	1150440	Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YPL026C	SKS1	1.031385	0	1	1.031385	1.031385	92688	40155	52533	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YPL051W	ARL3	0.9090083	0	1	0.9090083	0.9090083	212862	81782	131080	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
YPL144W	POC4	0.9670245	0	1	0.9670245	0.9670245	587860	221090	366770	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YPL146C	NOP53	0.74744	0	1	0.74744	0.74744	97484	37595	59889	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YPL151C	PRP46	1.145174	0	1	1.145174	1.145174	37515	17027	20488	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
YPL166W	ATG29	1.034148	0	1	1.034148	1.034148	146428	62690	83738	Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved
YPL180W	TCO89	0.8583691	0	1	0.8583691	0.8583691	462860	181810	281050	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
YPR006C	ICL2	3.464883	0	1	3.464883	3.464883	119216	84370	34846	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YPR009W	SUT2	1.097165	0	1	1.097165	1.097165	49946	20079	29867	Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YPR081C	GRS2	0.8644537	0	1	0.8644537	0.8644537	59500	26219	33281	Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels
YBR003W	COQ1	0.8869966	0	1	0.8869966	0.8869966	428260	169760	258500	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YBR024W	SCO2	1.04988	0	1	1.04988	1.04988	52299	21471	30828	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YBR129C	OPY1	0.9836711	0	1	0.9836711	0.9836711	43854	18421	25433	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR214W	SDS24	0.9079354	0	1	0.9079354	0.9079354	175285	64565	110720	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis
YCR067C	SED4	0.8808245	0	1	0.8808245	0.8808245	62872	23721	39151	Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p
YDL242W	YDL242W	4.658313	0	1	4.658313	4.658313	35291	26450	8841	NA
YDR079C-A	TFB5	1.054708	0	1	1.054708	1.054708	464570	194570	270000	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
YDR103W	STE5	0.8979885	0	1	0.8979885	0.8979885	79989	32281	47708	Pheromone-response scaffold protein; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p that facilitates Ste7p-mediated activation
YDR229W	IVY1	2.357156	0	1	2.357156	2.357156	39240	14362	24878	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YDR240C	SNU56	1.105327	0	1	1.105327	1.105327	58896	23781	35115	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YDR475C	JIP4	0.9137427	0	1	0.9137427	0.9137427	206452	86852	119600	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
YDR492W	IZH1	0.9864852	0	1	0.9864852	0.9864852	50135	19572	30563	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YER053C	PIC2	0.9402031	0	1	0.9402031	0.9402031	32099	12496	19603	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YER182W	FMP10	0.7693491	0	1	0.7693491	0.7693491	21733.3	6732.3	15001	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL084C	GUP1	0.7202535	0	1	0.7202535	0.7202535	53532	19231	34301	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YGL139W	FLC3	0.8635579	0	1	0.8635579	0.8635579	149111	58099	91012	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YGL161C	YIP5	0.9880447	0	1	0.9880447	0.9880447	107629	47224	60405	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YGL181W	GTS1	0.8689607	0	1	0.8689607	0.8689607	94757	38373	56384	Arf3p GTPase Activating Protein (GAP) that localizes to endocytic patches; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms; localizes to nucleus and induces flocculation when overexpressed
YGL256W	ADH4	0.9057971	0	1	0.9057971	0.9057971	56462	20557	35905	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YGR044C	RME1	1.069381	0	1	1.069381	1.069381	113389	49337	64052	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation
YGR068C	ART5	0.8870753	0	1	0.8870753	0.8870753	44967	18566	26401	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
YGR077C	PEX8	0.6674231	0	1	0.6674231	0.6674231	30234	10811	19423	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
YGR147C	NAT2	0.9541074	0	1	0.9541074	0.9541074	104743	36526	68217	Protein with an apparent role in acetylation of N-terminal methionine residues
YGR150C	CCM1	1.024737	0	1	1.024737	1.024737	159112	63577	95535	Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
YGR255C	COQ6	1.002315	0	1	1.002315	1.002315	223096	96366	126730	Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YHR016C	YSC84	0.8981498	0	1	0.8981498	0.8981498	105000	41156	63844	Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p
YHR036W	BRL1	0.9828976	0	1	0.9828976	0.9828976	728320	224050	504270	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YHR075C	PPE1	1.020127	0	1	1.020127	1.020127	39668	16118	23550	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YHR199C-A	NBL1	1.186465	0	1	1.186465	1.186465	32164	16311	15853	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p
YHR202W	YHR202W	0.8558713	0	1	0.8558713	0.8558713	125012	48523	76489	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YHR207C	SET5	0.9780908	0	1	0.9780908	0.9780908	349200	140990	208210	Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
YIR024C	YIR024C	0.7770008	0	1	0.7770008	0.7770008	276576	94676	181900	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
YJL091C	GWT1	0.5706134	0	1	0.5706134	0.5706134	212580	56920	155660	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YJL134W	LCB3	0.8130081	0	1	0.8130081	0.8130081	348870	134480	214390	Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
YJR005W	APL1	0.8614748	0	1	0.8614748	0.8614748	50834	20461	30373	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
YJR055W	HIT1	0.819941	0	1	0.819941	0.819941	46244	17916	28328	Protein of unknown function, required for growth at high temperature
YJR099W	YUH1	0.9520183	0	1	0.9520183	0.9520183	229654	78644	151010	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YKL011C	CCE1	1.219795	0	1	1.219795	1.219795	50007	20495	29512	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
YKL130C	SHE2	0.9175996	0	1	0.9175996	0.9175996	53953	20457	33496	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
YLL004W	ORC3	1.026568	0	1	1.026568	1.026568	87703	40717	46986	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YLL015W	BPT1	0.8462385	0	1	0.8462385	0.8462385	260854	98594	162260	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
YLL062C	MHT1	0.54609	0	1	0.54609	0.54609	66881	18886	47995	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YLR011W	LOT6	1.397194	0	1	1.397194	1.397194	67166	26940	40226	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
YLR211C	YLR211C	1.00059	0	1	1.00059	1.00059	49428	20908	28520	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
YLR324W	PEX30	0.8755801	0	1	0.8755801	0.8755801	115070	38501	76569	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YLR352W	YLR352W	1.127447	0	1	1.127447	1.127447	74992	27433	47559	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YML065W	ORC1	0.9057971	0	1	0.9057971	0.9057971	34422	13700	20722	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
YML076C	WAR1	0.7996162	0	1	0.7996162	0.7996162	159061	61559	97502	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YML117W	NAB6	0.9237875	0	1	0.9237875	0.9237875	98472	39734	58738	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
YMR045C	YMR045C	1.842639	0	1	1.842639	1.842639	167430	112220	55210	NA
YMR130W	YMR130W	1.017449	0	1	1.017449	1.017449	40700	16040	24660	Putative protein of unknown function; YMR130W is not an essential gene
YMR171C	EAR1	0.8667013	0	1	0.8667013	0.8667013	253165	95345	157820	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
YMR207C	HFA1	0.9179365	0	1	0.9179365	0.9179365	63860	23007	40853	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
YMR210W	YMR210W	0.8082768	0	1	0.8082768	0.8082768	75419	27565	47854	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YMR234W	RNH1	1.079016	0	1	1.079016	1.079016	174960	74040	100920	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
YNL062C	GCD10	1.08286	0	1	1.08286	1.08286	49045	19609	29436	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YNL066W	SUN4	0.69915	0	1	0.69915	0.69915	294830	126340	168490	Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YNL116W	DMA2	6.269199	0	1	6.269199	6.269199	346403	264510	81893	Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr
YNL323W	LEM3	0.8306338	0	1	0.8306338	0.8306338	416060	135200	280860	Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YNR039C	ZRG17	0.8912656	0	1	0.8912656	0.8912656	246684	88424	158260	Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc
YOL093W	TRM10	1.800699	0	1	1.800699	1.800699	47115	25943	21172	tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs
YOL103W-B	YOL103W-B	1.279296	0	1	1.279296	1.279296	79614	32695	46919	NA
YOR115C	TRS33	0.9646923	0	1	0.9646923	0.9646923	78356	32394	45962	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YOR144C	ELG1	0.9893154	0	1	0.9893154	0.9893154	271040	110860	160180	Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
YOR172W	YRM1	0.6742634	0	1	0.6742634	0.6742634	42921	17950	24971	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
YOR316C	COT1	1.061842	0	1	1.061842	1.061842	106272	46000	60272	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
YOR321W	PMT3	0.5777675	0	1	0.5777675	0.5777675	20162.7	5079.7	15083	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YPL008W	CHL1	1.011562	0	1	1.011562	1.011562	43067	17106	25961	Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p
YPL069C	BTS1	1.234446	0	1	1.234446	1.234446	60672	20646	40026	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YPL072W	UBP16	0.8218953	0	1	0.8218953	0.8218953	43073	17983	25090	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
YPL089C	RLM1	1.015156	0	1	1.015156	1.015156	29389	10300	19089	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YPL137C	GIP3	0.963484	0	1	0.963484	0.963484	62792	23407	39385	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YPR017C	DSS4	0.9637625	0	1	0.9637625	0.9637625	38259	14960	23299	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YPR058W	YMC1	0.9533797	0	1	0.9533797	0.9533797	58345	23720	34625	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YPR066W	UBA3	0.8707767	0	1	0.8707767	0.8707767	30388	11339	19049	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YPR158C-D	YPR158C-D	1.31827	0	1	1.31827	1.31827	63543	28229	35314	NA
YPR178W	PRP4	0.980873	0	1	0.980873	0.980873	27103	10817	16286	Splicing factor, component of the U4/U6-U5 snRNP complex
YPR182W	SMX3	0.8935752	0	1	0.8935752	0.8935752	44423	19126	25297	Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
YAR010C	YAR010C	1	NA	0	NA	NA	0	0	0	NA
YCL009C	ILV6	1	NA	0	NA	NA	0	0	0	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
YDR365W-A	YDR365W-A	1	NA	0	NA	NA	0	0	0	NA
YLR333C	RPS25B	1	NA	0	NA	NA	0	0	0	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YPR052C	NHP6A	1	NA	0	NA	NA	0	0	0	High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2
YBR189W	RPS9B	1	NA	0	NA	NA	0	0	0	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YKL096W-A	CWP2	1	NA	0	NA	NA	0	0	0	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YMR002W	MIC17	1	NA	0	NA	NA	0	0	0	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs
YBL080C	PET112	1	NA	0	NA	NA	0	0	0	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
YOR111W	YOR111W	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function
YBR185C	MBA1	1	NA	0	NA	NA	0	0	0	Membrane-associated mitochondrial ribosome receptor; involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
YGR256W	GND2	1	NA	0	NA	NA	260920	105200	155720	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDR406W	PDR15	1	NA	0	NA	NA	1131470	540490	590980	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YER027C	GAL83	1	NA	0	NA	NA	0	0	0	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
YGR126W	YGR126W	1	NA	0	NA	NA	76156	44132	32024	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YLR064W	PER33	1	NA	0	NA	NA	181452	53792	127660	Putative protein of unknown function; localizes to the endoplasmic reticulum with some nuclear pore complex association; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; YLR064W is not an essential gene
YLR189C	ATG26	1	NA	0	NA	NA	0	0	0	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YMR080C	NAM7	1	NA	0	NA	NA	71164	30872	40292	ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance
YNR071C	YNR071C	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function
YPL222W	FMP40	1	NA	0	NA	NA	160798	47688	113110	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL056W	GPB2	1	NA	0	NA	NA	0	0	0	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p
YCL008C	STP22	1	NA	0	NA	NA	99319	39284	60035	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
YDL044C	MTF2	1	NA	0	NA	NA	0	0	0	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
YDL161W	ENT1	1	NA	0	NA	NA	194343	59993	134350	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YDL193W	NUS1	1	NA	0	NA	NA	0	0	0	Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
YDR045C	RPC11	1	NA	0	NA	NA	119836	47916	71920	RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YER044C	ERG28	1	NA	0	NA	NA	0	0	0	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
YER143W	DDI1	1	NA	0	NA	NA	0	0	0	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control
YGR014W	MSB2	1	NA	0	NA	NA	0	0	0	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YJL102W	MEF2	1	NA	0	NA	NA	0	0	0	Mitochondrial elongation factor involved in translational elongation
YNL006W	LST8	1	NA	0	NA	NA	0	0	0	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YPR137C-B	YPR137C-B	1	NA	0	NA	NA	0	0	0	NA
YDL189W	RBS1	1	NA	0	NA	NA	147338	78549	68789	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YDR119W	VBA4	1	NA	0	NA	NA	175189	45719	129470	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
YDR259C	YAP6	1	NA	0	NA	NA	50554	21411	29143	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism
YER030W	CHZ1	1	NA	0	NA	NA	0	0	0	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif
YGL134W	PCL10	1	NA	0	NA	NA	0	0	0	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YGR004W	PEX31	1	NA	0	NA	NA	0	0	0	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YGR017W	YGR017W	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YHR040W	BCD1	1	NA	0	NA	NA	0	0	0	Essential protein required for the accumulation of box C/D snoRNA
YHR149C	SKG6	1	NA	0	NA	NA	0	0	0	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YHR159W	YHR159W	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YIL056W	VHR1	1	NA	0	NA	NA	0	0	0	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YLR188W	MDL1	1	NA	0	NA	NA	0	0	0	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
YLR207W	HRD3	1	NA	0	NA	NA	0	0	0	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
YLR332W	MID2	1	NA	0	NA	NA	0	0	0	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YMR144W	YMR144W	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YNL014W	HEF3	1	NA	0	NA	NA	3407200	1267200	2140000	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YNL196C	SLZ1	1	NA	0	NA	NA	0	0	0	Sporulation-specific protein with a leucine zipper motif
YNL249C	MPA43	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR029C	YNR029C	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function, deletion confers reduced fitness in saline
YOL062C	APM4	1	NA	0	NA	NA	0	0	0	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
YOR004W	UTP23	1	NA	0	NA	NA	0	0	0	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YOR070C	GYP1	1	NA	0	NA	NA	0	0	0	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YOR074C	CDC21	1	NA	0	NA	NA	0	0	0	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YPL064C	CWC27	1	NA	0	NA	NA	0	0	0	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p
YPL096W	PNG1	1	NA	0	NA	NA	0	0	0	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
YPL229W	YPL229W	1	NA	0	NA	NA	0	0	0	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene