Kafatos:Meister, Stephan



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Education

 * 2007-present Postdoctoral Fellow at the Scripps Research Institute, San Diego, USA
 * 2005-2006     working at Imperial College, London, UK.
 * 2001-2006     PhD student, EMBL, Heidelberg, Germany.
 * 1999-2000     visiting graduate student at Duke University, NC, USA.
 * 1996-2001     Diplom Biol., University of Wuerzburg, Germany.
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The role of PGRP proteins in innate immunity pathways in the malaria vector Anopheles gambiae.
The Anopheles gambiae peptidoglycan recognition protein (PGRP) gene family consists of 7 genes with 13 PGRP domains. We analyze the role of these genes in the mosquito immune defense to bacteria and the malaria parasite Plasmodium berghei. We have previously shown that the NF-κB transcription factor REL2 is involved in defense against both types of bacteria and malaria parasites meister2005. IMD is only responsible for the reaction against Gram-positive bacteria and Plasmodium. Our data suggests significant divergence as well as many similarities of immune signaling between Anopheles gambiae and the fruit fly Drosophila melanogaster. The differences most likely reflect the different lifestyles of the two insects and, consequently, different infectious agents that the two insects encounter during their lifetimes. In mosquitoes, one of these agents is the malaria parasite Plasmodium.
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Conference posters

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Publications

 * 1) phd2006 Meister S, PhD Thesis, EMBL/University of Heidelberg, 2006.
 * 2) meister2005 pmid=16076953
 * 3) meister2004 pmid=15582524
 * 4) kumar2003 pmid=14623973
 * 5) christoph2002 pmid=12364793
 * 6) holt2002 pmid=12364791
 * 7) dimopoulos2002 pmid=12077297
 * 8) dunipace2001 pmid=11516643
 * 9) Diplom Meister S, Diploma Thesis, University of Wuerzburg, 2001.
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