Chandra:SE 302

2006 Meetings
The meetings will be in SERC Room 102 on Tuesdays and Thursdays at 4-00 pm.

Lecture Notes

 * 7th March 2006. Classification of Protein Structure.

Syllabus

 * Introduction to the process of drug and vaccine discovery,
 * Principles of drug action,
 * Drug and target structures,
 * Brief introduction to systems biology, pharmacology and chemoinformatics,
 * Use of genomics and proteomics for understanding diseases at the molecular level,
 * Sequence-structure-function relationship in proteins,
 * Strategies for target identification and validation,
 * Protein structure prediction,
 * Molecular modeling protein-ligand interactions,
 * Structure-based ligand design,
 * Lead identification, design and lead optimization,
 * Challenges in drug and vaccine discovery,
 * Relevant algorithms and topics from current literature.

Reading

 * Mount DW, Bioinformatics - Sequence and Genome Analysis, 2nd Edition, Cold Spring Harbor Laboratory Press, 2004. ISBN: 0879697121
 * Mannhold R, Kubinyi H, Timmerman H (Editors), Bioinformatics - From Genomes to Drugs Vol.I & II, Wiley - VCH, 2002 ISBN: 3527299882
 * Flower, D R (Editor), Drug Design - cutting edges approaches, Royal Society of Chemistry, 2002. ISBN: 0854048162