User:Pakpoom Subsoontorn/Notebook/Genetically Encoded Memory/2008/10/08

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Science Questions/ To-do list
the end, the fraction of cells whose genome is actually rewritten will likely to be significantly less than a hundred percent.
 * In the abstract level, how could we live with imperfect efficiency? No matter writing mechanism we choose in
 * Directed evolution/ protein chimera could be used for constructing the library of enzymes and target site on DNA. Take a look at: engineering ZFN projects by Dana Carroll (Utah)/ David J Segal (UC Davis) and intergrase directed evolution by Michele Carlos (Stanford)
 * Are there DNA binding proteins in nature for any specific DNA sequence?...Bioinformatics/structural question question.
 * On in vivo directed evolution, we want to have the sequence to mark for highly mutation site to be out site the highly mutation site itself.


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