Paul Jaschke

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Bio
I am currently a post-doc in Drew Endy's lab at Stanford University. The focus of my project is to redesign phage using both rational and combinatorial methods in order to finish the genetics of a simple system.

I started off my science career at the University of Alberta (Canada), working in the Casey and Michalak labs. Summer student work in the Casey Lab on the human sodium-bicarbonate co-transporter protein resulted in an authorship in a peer-reviewed publication. My honors project in the Michalak Lab had me determining the role of calcium signalling and calreticulin on murine embryonic stem cell differentiation. After achieving a B.Sc. (Honors) in Biochemistry in 2003 I went to the Beatty Lab at the University of British Columbia to start my Ph.D. While at UBC I discovered that a photosynthetic organism called Rhodobacter sphaeroides was capable of re-routing its chlorophyll biosynthetic machinery around a blockage to generate a new type of chlorophyll. November 2010 I was conferred a Ph.D in Microbiology and Immunology from UBC.

Contact Info
I work in the Endy Lab in the Department of Bioengineering
 * Paul R Jaschke
 * Stanford University
 * Stanford, California, USA
 * pjaschke 'AT' stanford.edu
 * Email me through OpenWetWare
 * [[Media:Paul_Jaschke,_PhD.vcf|v-card]]

Education
2010 Ph.D. Microbiology and Immunology, University of British Columbia, Canada

2003 B.Sc. Honors Biochemistry, University of Alberta, Canada

Publications
Jaschke PR, Hardjasa A, Digby E, Hunter CN, Beatty JT. (2011). A bchD (Mg-chelatase) mutant of Rhodobacter sphaeroides synthesizes zinc-bacteriochlorophyll through a novel zinc-containing intermediates. ''J. Biol. Chem. Jun 10;286(23):20313-22. ''. Abstract [[Media:J. Biol. Chem.-2011-Jaschke-20313-22.pdf|PDF]]



Jaschke PR, Saer RG, Noll S, Beatty JT. (2011). Modification of the genome of Rhodobacter sphaeroides and construction of synthetic operons. Methods in Enzymol. 497:519-38. Abstract pdf



Jaschke PR, Drake I, Beatty JT. (2009). Modification of a French pressure cell to improve microbial cell disruption. Photosynth Res. 102(1): 95-7. Abstract [[Media:Jaschke-2009-Photosynth Res.pdf|PDF]] Jaschke PR. (2010). Discovery and characterization of a new zinc-bacteriochlorophyll biosynthetic pathway and photosystem in a magnesium-chelatase mutant. PhD Thesis. University of British Columbia. Abstract [[Media:ubc_2010_fall_jaschke_paul.pdf|PDF]]

Lin S,Jaschke PR, Wang H, Paddock M, Tufts A, Allen JP, Rosell FI, Mauk GA, Woodbury NW, Beatty JT. (2009). Electron transfer in the Rhodobacter sphaeroides reaction center assembled with zinc bacteriochlorophyll. Proc Natl Acad Sci USA.106(21): 8537-42. Abstract [[Media:Lin-2009-PNAS.pdf|PDF]]

Jaschke PR, LeBlanc HN, Lang AS, Beatty JT. (2008). The PucC protein of Rhodobacter capsulatus mitigates an inhibitory effect of light-harvesting 2 alpha and beta proteins on light-harvesting complex 1. Photosynth Res. 95(2-3): 279-84. Abstract [[Media:Jaschke-2008-Photosynth Res.pdf|PDF]]

Jaschke PR, Beatty JT. (2007). The photosystem of Rhodobacter sphaeroides assembles with zinc bacteriochlorophyll in a bchD (magnesium chelatase) mutant. Biochemistry. 46(43): 12491-500. Abstract [[Media:Jaschke-2007-Biochemistry.pdf|PDF]]

Loiselle FB, Jaschke P, Casey JR. (2003). Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain. Mol Membr Biol. 20(4): 307-17. Abstract [[Media:Loiselle-2003-Mol Mem Biol.pdf|PDF]]

Presentations
Jaschke PR and Beatty JT. (2010). Out of the Blue. In a mutant lacking the magnesium-chelatase complex, we find zinc-bacteriochlorophyll incorporated into the photosystem and a new way to make bacteriochlorophyll. [[Media:Out_of_the_Blue-ICTPPO_2009.pdf|PDF]]

Jaschke PR and Beatty JT. (2007). Discovery of zinc-bacteriochlorophyll in Rhodobacter sphaeroides. [[Media:ASM-Seattle_March_2007.pdf|PDF]]

Professional Activities
Graduate Student Advisor to University of British Columbia iGEM Team. Press: [[Media:UBC Reports iGEM Story.pdf|Students build tiny E.coli ‘trafﬁc light’ (see pg.9)]]

Useful links
Mendeley Profile

LinkedIn Profile

Rhodobacter sphaeroides on Wikipedia

Hobbies
Beer Making

Snowboarding

Hiking & Camping