User:Dr. Om V. Singh

Contact Info



 * Dr. Om V. Singh
 * Assistant Professor
 * University of Pittsburgh
 * 300 Campus Drive
 * Bradford, PA-16701, USA
 * Email me through OpenWetWare

Education
Post-doctoral Fellow– The Johns Hopkins Univ. Sch. Med., Baltimore, MD

M.S.- (Regulatory Affairs in Life Sciences), The Johns Hopkins Univ., Baltimore, MD.

Ph.D.- (Microbial Biotechnology), Indian Institute of Technology (IIT), Roorkee.

M.Sc.- (Zoology, sp.- Entomology), C.C.S. University, Meerut.

B.Sc.- (Biol. Sci.), Merrut University, Merrut.

Research interests
HIGH-DIMENSIONAL BIOLOGY OF RADIATIONS RESISTANCE MICROBES (EXTREMOPHILES) AND THERAPEUTIC IMPLICATIONS USING VALUE ADDED PRODUCTS OF COMMERCIAL INTEREST

DIVERSITY AND HIGH-DIMENSIONAL BIOLOGY OF ANTIBIOTICS RESISTANCE MICROBES

DEVELOPMENT OF BIOMASS INTO ALTERNATIVE FUEL EXPLORING GUT MICROORGANISMS OF MODEL INVERTEBRATES

PHARMACOPROTEOMICS OF PROTEIN MISFOLDING (IN COLLABORATION)

Publications
1. Singh O.V. and Gabani P. (2011) Therapeutic implications of Radiation-resistant Extremophiles. J Applied Microbiology (In press) doi: 10.1111/j.1365-2672.2011.04971.x.

2. Chandel A.K., and Singh O.V. (2011) Weedy lignocellulosic feedstock and Metabolic Engineering: Advancing the generation of ‘Biofuel’. Applied Microbiology Biotechnology. 89(5), 1289-1303.

3. Chandel A.K., Singh O.V., Rao L.V., Chandrasekhar G, Narasu M.L. (2011) Bioconversion of novel substrate Saccharum spontaneum, a weedy material, into ethanol by Pichia stipitis NCIM3498. Bioresource Technology 102(2) 1709-1714.

4. Chandel A.K., Singh O.V., Narasu M.L., Rao L.V. (2011) Bioconversion of Saccharum spontaneum (wild sugarcane) hemicellulosic hydrolysate into ethanol by mono and co-cultures of Pichia stipitis NCIM3498 and thermotolerant Saccharomyces cerevisiae-VS3. New Biotechnol. DOI: 10.1016/j.nbt.2010.12.002.

5. Singh O.V. and Colonna T.E. (2011) Prescription drug reimportation in the United States: Friend or foe. Pharmaceutical Technol. 35(2) 97-88.

6. Singh O.V. and Colonna T.E. (2011) The impasse over US drug reimportation may be a blessing in disguise. Regulatory Affairs Pharma, 6 January 2011.

7. Nagaraj N.S. and Singh, O.V.* (2010) Using genomics to develop novel antibacterial therapeutics. Critical Review Microbiology, 36(4) 340-348.

8. Singh O.V.* (2010) Protein misfolding diseases and paradigm of proteomics based therapeutic targets. Expert Review of Proteomics. Editorial comment 7(4), 463-4.

9. Handerson, M., Singh O.V., Zeitlin P.L. (2010) Applications of proteomic technology to premature proteolysis of CFTR in cystic fibrosis. Expert Review of Proteomics 7(4), 473-86.

10. Nagaraj, N.S. and Singh O.V. (2010) Proteomics: A strategies to understand the novel targets in protein misfolding and cancer therapy. Expert Review of Proteomics 7(4), 613-23.

11. Vivekanandan P. and Singh, O.V. (2010) Molecular methods in the diagnosis and management of chronic hepatitis B. Expert Review of Molecular Diagnostics, 10(7) 921-935.

12. Nagaraj N.S., Anilakumar K.R., Singh O.V. (2010) Diallyl disulfide cause caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway. J Nutritional Biochemistry, 21(5): 405-412.

13. Chandel A.K., Singh O.V., Chandrasekhar G., Rao L.V., Narasu M.L. (2010) Key-drivers influencing the commercialization of ethanol-based biorefineries. J. of Commercial Biotechnology, 16, 239-257. DOI:10.1057/jcb.2010.5

14. Singh, O.V. and Chandel A.K. (2010) Two dimensional gel electrophoresis: Discovering biomolecules for environmental bioremediation. Methods Molecular Biology, 599: 141-56.

15. Singh O.V. (2010) Perspectives of patent infringement and pharmaceutical drug development. Regulatory Affairs Pharma, 20 July, 415-416.

16. Singh O.V. (2010) Regulatory and safety assessments of genetically engineered food. Studies in Ethics, Law, and Technology 4(1), Article 2. DOI: 10.2202/1941-6008.1100.

17. Singh O.V., Yaster M., Guan Y., Dharmarajan A.M., Raja S.N., Zeitlin P.L. and Tao Y-X (2009) Peripheral nerve injury modulated proteome of synaptosome-associated proteins in spinal cord dorsal horn. Proteomics 9(5): 1241-1253.

18. Nagaraj N.S., Singh, O.V.* (2009) Integrating Omics oriented Biomarkers to comprehend lung cancer. Expert Opinion on Medical Diagnostics 3(2): 167-180.

19. Singh O.V., Harvey S.P. (2008) Integrating biological processes to facilitate the generation of ‘Biofuel’. J Industrial Microbiology and Biotechnology (Editorial comment) 35(5): 291-2. PMID: 18347827.

20. Singh, O.V. (2008) Modulated gluconic acid production from immobilized cells of Aspergillus niger ORS-4.410 utilizing grape must. J. Chemical Tech. Biotechnol. 83(6): 780-787.

21. Kumar R., Singh S and Singh O.V. (2008) Bioconversion of lignocellulosic biomass: Biochemical and molecular perspectives. J Industrial Microbiology and Biotechnology. 35(5): 377-91. PMID: 18338189

22. Chandel, A.K., Rao, L.V., Rudravaram, R. and Singh, O.V.* (2008) The realm of Penicillin G Acylase in -lactam antibiotics. Enzyme Microbial Technology 42(3): 199-207.

23. Singh, O.V., Pollard, H.B. and Zeitlin, P.L. (2008) Chemical rescue of ∆F508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells. Molecular Cellular Proteomics 7(6): 1099-110. PMID: 18285607

24. Perumal V. and Singh O.V. (2008) High-Dimensional Biology to comprehend Hepatocellular carcinoma. Expert Review of Proteomics 5(1):45-60. PMID: 18282123

25. Nagaraj N.S. and Singh O.V. (2007) Proteomic and Genomic Analysis of Human Tumor Cells Treated with Diallyl Disulfide. J. Nutr. 137, 278S-295S.

26. Singh O.V. and Kumar R. (2007) Biotechnological production of gluconic acid: Future Implications. Appl. Microbiol. Biotechnol. 75(4), 713-722. PMID: 17525864

27. Singh O.V. (2007) Integrating “-omics” into biological processes and modeling for bioremediation. OMICS: A Journal of Integrative Biology (Editorial Comment) 11(3), 231-232. PMID: 17883336

28. Kumar, R., Singh, S and Singh, O.V. (2007) Bioremediation of toxic Radionuclides: Emerging technologies. OMICS: A Journal of Integrative Biology, 11(3) 295-304. PMID: 17883340

29. Singh O.V., Vij N., Mogayzel P., Jozwik C., Pollard H.B and Zeitlin P.L (2006) Pharmacoproteomics of 4-Phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells. J Proteome Research, 5 (3), 562-571. PMID: 16512671

30. Singh O.V (2006) Proteomics and Metabolomics: The Molecular make up of toxic aromatic pollutant bioremediation. Proteomics, 6 (20), 5481-5492. PMID: 16972298

31. Singh O.V and Nagaraj N.S (2006) Transcriptomics, Proteomics and Interectomics: Unique approaches to track the insights of Bioremediation. Brief. Functional Genomics Proteomics, 4 (4), 355-365. PMID: 17202126

32. Singh O.V. (2006) Mutagenesis and analysis of mold Aspergillus niger for extracellular glucose oxidase production using sugarcane molasses. Appl. Biochem. Biotechnol., 135(1), 43-58. PMID: 17057255

33. Singh O.V and Singh R.P (2006) Bioconversion of grape must into modulated gluconic acid production by Aspergillus niger ORS-4.410. J. Appl. Microbiol., 100 (5), 1114- 1122. PMID: 16630012

34. Singh O.V., Ghai, S., Paul, D and Jain R.K. (2006). Genetically Modified Crops: Success, Safety assessment and public concern. Appl. Microbiol. Biotechnol., 71 (5), 598-607. PMID: 16639559

35. Labana S., Singh O.V., Basu A., Pandey G and Jain R.K (2005) A microcosm study on bioremediation of p-nitrophenol contaminated soil using Arthrobacter protophormiae RKJ100. Appl. Microbiol. Biotechnol., 68 (3), 417-424. PMID: 15806356

36. Singh O. V, Kapur N and Singh R.P (2005) Evaluation of agro-food byproducts for gluconic acid fermentation by Aspergillus niger ORS-4.410. World J Microbiol. Biotechnol., 21 (4), 519-524.

37. Singh, O.V and Jain R.K (2003). Phytoremediation of toxic aromatic pollutants from soil. Appl. Microbiol. Biotechnol., 63(2), 128-35. PMID: 12925865.

38. Singh, O.V., Gunjan P., Budhiraja R. and Jain R.K. (2003). Phytoremediation: An overview on metallic ions decontamination from soil. Appl. Microbiol. Biotechnol., 61, (5-6), 405-412. PMID: 12764555

39. Singh, O.V., Jain R.K. and Singh R.P. (2003). Gluconic acid production under varying fermentation conditions by Aspergillus niger. J Chemical Technol. Biotechnol., 78, (2-3), 208-212.

40. Singh, O.V. and Singh R.P. (2003). Utilization of grape must for gluconic acid production using polyurethane sponge and calcium alginate immobilized cells of Aspergillus niger ORS-4.410. Commun Agric Appl Biol Sci., 68 (2 Pt A): 253. PMID: 15296173

41. Samanta, S.K., Singh, O.V and Jain, R.K. (2002). Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation. Trends in Biotechnology, 20 (6), 243-248. PMID: 12007492

42. Singh, O.V. and Singh, R.P (2002). Utilization of agro-food by-products for gluconic acid production by Aspergillus niger ORS-4 under surface culture cultivation. J Sci. Ind. Res., 61, 356-360.

43. Singh, O.V. and Singh, R.P. (2002). Microbial production of glucose oxidase by Aspergillus niger. Proc. 5th Asia Pacific Cong. Med. Biol. Eng. & 11th Int. Cong. Biomed. Eng. Singapore.

44. Singh, O.V., Gunjan, P and Jain, R.K. (2001). Bioremediation of p-nitrophenol using soil microcosm. Proc. Int. Conf. Remediation of Contaminated Sediments. Venice, Italy. (on CD)

45. Singh, O.V., Sharma, A and Singh, R.P (2001). Optimisation of fermentation conditions for gluconic acid production by mutant Aspergillus niger. Indian J Exp. Biol., 39, 1136-1143. PMID: 11906107

46. Singh, O.V., Sharma, A and Singh, R.P (2001). Gluconic acid production by Aspergillus niger mutant ORS-4.410 in submerged and solid state surface cultivation. Indian J Exp. Biol., 39, 691-696. PMID: 12019764

47. Singh, O.V., Pereira, B.M.J and Singh, R.P (1999). Isolation and characterization of a potent fungal strain Aspergillus niger ORS-4 for gluconic acid production. J Sci. Ind. Res., 58, 594-600.

48. Singh, O.V and Verma, S.R (1997). Factors affecting citric acid production by Aspergillus niger in submerged culture. J Natcon, 9 (1); 1-7.

Book Chapters:

1. Singh, O.V.*, Nagaraj N.S. and Gabani, P (2011) System Biology: Integrating ‘-omics” oriented approaches to determine microbial toxins. System Toxicology: From Omics Technology to Nanotechnology”, Eds. Sahu SC and Casciano DA., The John Wiley and Sons Ltd. Publisher. Pp469-488.

2. Chandel A.K., da Silva SS., Singh OV* (2011) Detoxification of lignocellulosic hydrolysates for improved bioconversion of bioethanol. Biofuel, Ed. P. Zobic InTech Publisher. ISBN 978-953-307-178-7. (In press).

4. Singh O.V.* and Harvey S.P. (2010) Applications of Biotechnology for the Utilization of Renewable Energy Resources. Sustainable Biotechnology: Sources of Renewable Energy. (Editorial comment) Eds. Singh, O.V. and Harvey S.P., Springer press UK, pp. xiii-xvii.

5. Chandel, A.K., Singh O.V and Rao L.V. (2010) Biotechnological applications of Hemicellulosic derived sugars: State-of-the art. Biotechnology and Sustainable source of energy. Eds. Singh, O.V. and Harvey S.P., Springer press UK, pp. 63-81.

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