User:Carsten C. Mahrenholz

Contact Info



 * Carsten C. Mahrenholz


 * Molecular Libraries and Recognition Group
 * Charité Medical School


 * Berlin, Germany
 * Email me through OpenWetWare

I work in the Institute of Medical Immunology at Charité Medical School. I've joined because Hopefully I can find some people to share information about my phd-topics (coiled-coils and SPOT-synthesis) and add some related methodical and input value.

Education
Institute of Medical Immunology, Charité Medical School, Berlin and Freie University, Berlin
 * 2006-2010  PhD (Boichemistry)

Humboldt University, Berlin and Gutenberg University, Mainz
 * 2001-2005 Dipl. Biol. (Molecular Biology, Biophysics, Immunology)

Berlin School of Economics, Berlin and Ashcroft International Business School, Cambridge, UK
 * 2006-2008 MBA (General Management - Dual Award)

Research interests

 * 1) Coiled-Coil interaction, stoichometry and peptide design (We use biochemical high-throughput(SPOT- and Peptide-Synthesis) methods, biophysics (ITC, AUZ, Biacore) and informatics (SVM) to define the rules of association on the amino-acid level.)
 * 2) association landscapes for coiled-coil protein interaction
 * 3) evolution theory
 * 4) bionic economics

Publications

 * Ay, B., Streitz, M., Boisguerin, P., Mahrenholz, C.C., Schuck, S.D., Kern, F., Volkmer, R., Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. Biopolymers 88 (1): 64-75 (2007)
 * 1) Portwich, M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., A Network of Coiled Coil Associations Derived from Synthetic GCN4 Leucine Zipper Arrays. Angew Chem Int Ed 46 (10): 1654-1657 (2007)
 * 2) and Portwich, M., Keller, S., Strauss, H.M., Mahrenholz, C.C., Kretzschmar, I., Kramer, A., Volkmer, R., Ein mithilfe synthetischer GCN4-Leucinzipperarrays aufgedecktes Coiled-Coil-Assoziationsnetzwerk. Angew Chem 119 (10): 1682-1686 (2007)
 * 3) Mahrenholz, C.C.*, Fidan, Z.*, Portwich, M., Volkmer, R., Analysis of coiled coil associations by SPOT technology. Chem Today 26 (2): 22-25 (2008)
 * 4) Mahrenholz, C.C., Tapia, V., Stigler, R., Volkmer, R., A study to assess the crossreactivity of cellulose membrane-bound peptides with detection systems: an analysis at the amino acid level. J Pept Sci 16: 297–302 (2010)
 * 5) Mahrenholz, C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: Predicting and profiling by means of a machine learning approach. Mol Cell Proteomics 10(5): M110.004994 (2011)
 * 6) Czarna, A., Riffkin, H., Mahrenholz, C.C., Arens, J., Strauss, H.,Wolf, E., Quantitative analyses of mouse Cryptochrome - Bmal1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock. J Biol Chem Apr 25. [Epub ahead of print] (2011)
 * 7) Patent1 Mahrenholz CC and Portwich M. Peptides interacting with alpha-helical coiled-coil streuctures and/or coiled-coil sequences, substances derived therefrom, and use thereof (WO/2007/068240)

Communications and Talks

 * 1) Mahrenholz CC, Schuck S, Kretzschmar I, Ay B, Volkmer R. An optimized SPOT synthesis protocol: High-throughput synthesis of peptides with authentic and free C-termini. Chem Bio Net (2005)
 * 2) Volkmer R, Portwich M, Strauss HM, Mahrenholz CC, Kretzschmar I, Keller, S. Analysis of coiled-coil associations by SPOT technology and biophysics. 8th German Peptide Symposium (2007)
 * 3) Mahrenholz CC, Promiscuous coiled-coils and their pharmacological potential. 6th Bionnale (2008)
 * 4) Abfalter IG*, Mahrenholz CC*, Bodenhofer U, Hochreiter S. Analyzing Coiled Coil Proteins With Support Vector Machines to Design New Anti-Viral Drugs. Intelligent Systems for Molecular Biology (2008)
 * 5) Mahrenholz CC, Tapia V, Stigler R, Volkmer R. Peptides crossreacting with detection systems – Analysis at the amino acid level. 9th Peptide Symposium (2009)
 * 6) Mahrenholz CC*, Abfalter IG*, Bodenhofer U, Volkmer R, Hochreiter S. Defining distinctive rules for stoichiometry and recognition of coiled coil proteins using bioinformatical methods. 9th Peptide Symposium (2009)
 * 7) Abfalter, I.G.*, Mahrenholz, C.C.*, Bodenhofer, U., Hochreiter, S., New insights into coiled coil formation by means of support vector machines. European Conference on Computational Biology and ISMB (2009)
 * 8) Mahrenholz, C.C., Portwich, M., Abfalter, I.G., Volkmer, R., Coiled coil formation: a multi-method approach to solve a glass bead game. Protein Modules and Networks in Health and Desease (2009)
 * 9) Volkmer, R., Mahrenholz, C.C., Otte, L., Landgraf, C., Investigation of coiled coil domain based associations with synthetic peptide arrays: advantages and limitations. Protein Modules and Networks in Health and Desease (2009)
 * 10) Mahrenholz, C.C., Tapia, V., Stigler, R., Volkmer, R., Detection systems cross reacting with peptides – Analysis at the amino acid level. Available from Nature Precedings  (2010)
 * 11) Mahrenholz, C.C., Tapia, V., Stigler, R.D., Volkmer, R., A study to assess the crossreactivity of cellulose membrane bound peptides with detection systems: An analysis at the amino acid level. 31th European Peptide Symposium (2010)
 * 12) Mahrenholz, C.C., Abfalter, I.G., Bodenhofer, U., Volkmer, R., Hochreiter, S., Complex networks govern coiled coil oligomerization: A multi-method approach. 31st European Peptide Symposium (2010)
 * 13) Bodenhofer, U., Kothmeier, A., Abfalter, I.G., Mahrenholz, C.C., Hochreiter, S., Decoding Sequence Classification Models for Acquiring New Biological Insights. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings  (2010)
 * 14) Mahrenholz, C.C.*, Abfalter, I.G.*, Bodenhofer, U., Volkmer, R., Hochreiter, S., PrOCoil - Advances in predicting two- and three-stranded coiled coils. 18th International Conference on Intelligent Systems for Molecular Biology. Available from Nature Precedings  (2010)

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