SynBERC:Tumors

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= Tumor Killing Bacterium Devices =

Contacts: J. Christopher Anderson, Adam Paul Arkin, Christopher Voigt

Environmental Sensors
Endogeneous promoters sensitive to the different environments may be discovered by microarray analysis, or RIVET-like analysis of cells grown in the appropriate environments. These will need spec sheets made for them. However, how one makes pluggable, dynamic range tunable, synthetic systems for sensing is still an open question.

Tumor

 * Tumor Antigen Touch Sensor

Immune Shielding

 * K-Capsule Engineering

Growth Control

 * Iron Uptake Engineering

Cell Attachment/Invasion

 * Modified pili
 * Invasin Engineering

Synthesis and Delivery of Therapeutics

 * Type III Secretion Engineering
 * Endocytic vacuole lysis

Metabolic Auxotrophies

 * DAP Engineering

Multi-input Genetic Logic Gates

 * Genetic Two-Input AND
 * A multi-input signal integrator
 * Inverters

Memory Systems

 * Invertible Switch Engineering

Signal Pathway Logic

 * Signaling Scaffold Engineering

Instrumentation

 * Expressible anoxic fluorophors
 * molecular beacons for transcript monitoring