Gilbert:Available Projects

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Student Honours Project
Molecular Biology, Genetics, Biochemistry

Supervisors: Dr J. Allan and Dr N. Gilbert.

Title
The Purification and Characterisation of Heterochromatin

Description
The manner in which DNA is packaged into chromatin varies as a function of DNA sequence type and functional context. Some regions that adopt a more tightly folded form of the higher-order chromatin fibre (heterochromatic regions), can be fractionated from the bulk of the population by sucrose gradient sedimentation due to their distinctive sedimentation (hydrodynamic) properties. The aim of this project is to use this technology to purify condensed chromatin and subsequently to characterise both the histone and non-histone components of this material.