Julius B. Lucks/Meetings and Notes/SMBE2007/methods population genetics

= Monty Slatkin : The conditional allele frequency spectrum = Wed Jun 27 09:56:11 EDT 2007
 * w/ Svante Pavo

Words to Look Up

 * allele frequency spectrum
 * Gegenbauer polynomials
 * Fesenstein's law - 'Everything that is true is obvious.'

Talk

 * summarize large amount polymorphic sequence data from species
 * sample N chromosomes - f_i density of sites i at which i chromosomes carry derived allele
 * consider allele freq spectrum in light of dna sequence of closely-related species
 * neanderthal and human
 * whether neanderthal carriers derived allele or ancestral allele
 * use chimpanzee as an outgroup to decide which is derived and which ancestral
 * use Kimura's diffusion equation on 2 branches - look at joint spectrum
 * assumes randomly mating population
 * in case where have derived allele in neanderthal
 * freq spectrum in species 1 is uniform - indep of pop size and history of pop sizes
 * separated for longer-longer periods - more independant distributions
 * when sample single chrom of neanderthal - as if sampled single chrom from humans