User:Kim S. Bell-Anderson/Notebook/Metabolic Profile of Kruppel-like factor 3 (KLF3) knockout mice

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Background

 * KLF3 is an evolutionary conserved zinc finger containing transcription factor belonging to the SP/KLF family. It is widely expressed and functions primarily as a transcriptional repressor by directly recruiting the co-repressor C-terminal binding protein (Ctbp).  Ctbp is a putative metabolic sensor as it responds to fluctuations in cellular NADH levels. Thus KLF3 is a potential mediator of Ctbp downstream effects in response to energy fluxes within the cell. We have previously reported that Klf3-/- mice are lean, partly as a result of reduced adipose tissue mass and adipocyte size.