Kristoffer Chin: Week 5

Question
The question we are asking for week 5 is if there are specific differences nucleotide sequences that cause an increase in the rate of CD4 T cells decline in rapid progressors compared to non-progressors.

Hypothesis
We believe that there will be a difference in the nucleotide sequences found in the nucleotide sequences in rapid progressors and non-progressors

Subjects

 * For the group of rapid progressors, we have chosen 4-V2, 4-V3, 4-V4, 10-V4, 10-V5, 10-V6, 11-V2, 11-V3, 11-V4. These subjects were chosen because they had the highest frequencies of visit which allowed a better variable of CD4 T cells to choose from.  These specific visits were chosen because they had the highest rate of CD4 T Cell decline
 * For the group of non-progressors, we have chosen 2-V1, 2-V3, 2-V4, 12-V3, 12-V4, 12-V5, 13-V2, 13-V3, 13-V5. These subjects were chosen because they were the only recorded nonprogressors in the experiment.  These visits were chosen because they had the highest CD4 T cell count among all visits.
 * All clones will also be analyzed for each visit to find a difference in the nucleotide sequence.

Journal articles

 * 1) Paper1 pmid=18778482
 * 2) Paper2 pmid=16385396
 * 3) Paper3 pmid=15342497
 * 4) Paper4 pmid=19164593
 * 5) Paper5 pmid=19164593