Prince:Notebook/PPIX/Candidate Protein Pair

Properties

 * Solved PDB binding structure
 * There are ~10,000 structures with 2 chains on PDB, so plenty of candidates.
 * Available in purified state
 * Forms a complex in vivo
 * Ideally, this would be manipulatable
 * Available in affinity tag form for IP.

Potential Candidates

 * Gα/Gβ
 * Gβ/Gγ are only stable when together
 * Gβ/Gγ and their interactions with Phosducin or PhLP are potentially superior candidates
 * There is a directly manipulatible interaction (BMW Lab has an inhibitor of that interaction)
 * Phosducin-Gβ/Gγ structures are known
 * JAK/STAT
 * GRB2/SOS
 * SH2 domain??
 * Phos/Jun
 * ERK2/MKP1 or MKP3
 * R2-AKAP