Template:NcbiGeneAKT1

NCBI GeneID207Official SymbolAKT1 Full Namev-akt murine thymoma viral oncogene homolog 1Location14q32.32Related  HGNC:391 MIM:164730Other NamesAKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHAOrganismHomo sapiens<dt>Lineage<dd>Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dl> =AKT1= “The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]”

Interactions
AHNAK, AKT1, AKT1S1, AKT2, AKTIP, AKTIP, APLP2, APPL1, APPL1, AR, AR, AR, ARFIP2, ARHGAP29, ARHGAP32, ATXN1, Akt2, BAD, BAD, BCL10, BCL2L11, BRAF, BRAF, BRCA1, BRCA1, CAMKK1, CARHSP1, CASP3, CASP9, CCDC88A, CDKN1A, CDKN1B, CDKN1B, CHEK1, CHN2, CHUK, CHUK, CREB1, CSNK2A1, DLC1, EIF4EBP1, EP300, ESR1, ESR2, EZH2, FANCA, FANCA, FOXO1, FOXO3, FOXO4, FOXO4, GAB2, GAB2, GATA1, GATA2, GRB10, GSK3A, GSK3B, GSK3B, GSK3B, HIST2H2BE, HMOX1, HSP90AA1, HSP90AA1, HSP90AB1, HSP90AB1, HSPB1, HTT, HTT, IKBKB, ILK, ILK, ILK, IMPDH2, IMPDH2, IMPDH2, IRAK1, IRAK1, IRS1, IRS1, ITGB3, KRT10, KRT10, KTN1, MAP2K4, MAP2K4, MAP3K11, MAP3K11, MAP3K5, MAP3K8, MAP3K8, MAPK14, MAPK8IP1, MAPK8IP1, MAPKAP1, MAPKAPK2, MAPKAPK2, MARK2, MDM2, MDM2, MDM4, METTL1, METTL1, MS4A2, MST1R, MTCP1, MTCP1, MTOR, MTOR, NCF1, NCF1C, NF2, NOS3, NPM1, NR4A1, NR4A1, PAK1, PAK1, PAK6, PDE3B, PDK1, PDK2, PDPK1, PDPK1, PDPK1, PEA15, PEA15, PFKFB2, PHB2, PHLPP1, PIAS1, PIAS2, PIAS2, PIK3R1, PKN2, PKN2, PLXNA1, PLXNA1, PLXNB1, PPARGC1B, PPL, PPM1A, PPP2CA, PRG2, PRKCQ, PRKCQ, PRKCZ, PRKCZ, PRKDC, PRKDC, PTEN, PTPN1, RAB3D, RAC1, RAF1, RAF1, RHEBL1, RICTOR, RPS6KB1, RPS6KB1, S1PR1, SH2B2, SMAD2, SMAD2, SMAD3, SMAD3, SMAD4, SMAD4, SMAD7, SMAD7, SORBS2, SRC, STAT1, STUB1, TCL1A, TCL1A, TCL1A, TCL1B, TCL1B, TCL1B, TERT, TERT, THEM4, THEM4, TNFSF11, TOPBP1, TRIB3, TRIB3, TSC1, TSC1, TSC2, TSC2, TSC2, UBC, USP8, UXS1, VEGFA, WNK1, XIAP, YAP1, YBX1, YBX1, YWHAZ, YWHAZ, YWHAZ and YWHAZ This is a template for the NCBI gene AKT1 ID.207. To use this template insert :   : in body of the article. An article about AKT1 should be located at :AKT1