User:Yanan Du

Yanan Du Ph.D
Principle Investigator/Professor Department of Biomedical Engineering, School of Medicine, Tsinghua University, China, 100084

Email: [mailto:duyanan@tsinghua.edu duyanan@tsinghua.edu.cn]

Department website: BME@Tsinghua

Lab Website: http://openwetware.org/wiki/Du-Lab

Education

 * Postdoc, Harvard-MIT Science and Technology, MIT; Brigham & Woman's hospital, Harvard Medical School
 * PhD, Bioengineering, National University of Singapore
 * BEng, Chemical Engineering, Tsinghua University

Professional experiences

 * 2009.5-2010-8 Research affiliate, Wyss Institute for Biologically Inspired Engineering, Harvard University, USA
 * 2004.5-2007.7 Research affiliate, Institute of Bioengineering and Nanotechnology, A-STAR, Singapore

Research interests

 * 1) Cell/Tissue Engineering, Biomaterials;
 * 2) Nano/microscale technologies for bio-sensing, diagnostic and drug screening;
 * 3) Bio-mimetic in vitro physio/pathological model;

Professional activities

 * Editorial Board member of "Biomaterials and Biodevices",VBRI Press
 * Editorial Board member/Associate editor of "Journal of Medical Imaging and Health Informatics"
 * IEEE-Engineering in Medicine and Biology Society (IEEE-EMBS) Technical committee on “Bionanotechnology”.
 * Guest editor of Journal of Nanomaterials
 * Guest editor of Journal of Mechanics in Medicine and Biology
 * Reviewer of the following journals: 'Integrative biology’; 'Biomedical Devices’; ‘Biofabrication’; ‘Journal of Mechanics in Medicine and Biology’, ‘Biomicrofluidics’, ‘Composite Part B: Engineering’; ‘Society For Biomaterials 2011 Annual Meeting’ et al
 * Member of the Biomedical Engineering Society since 2008

Publications
Journal Articles
 * 1)   Y. Du, M. Ghodousi, H. Qi, N. Haas, W. Xiao, A. Khademhosseini ‘Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels’  Biotechnology and Bioengineering  "in press" (2011)
 * 2)    H. Qi, Y. Du, L. Wang, H. Bae, H. Kaji, Ali Khademhosseini ‘Patterning Single mouse embryonic bodies with defined polarities in 3D hybrid microgel’, Advanced materials (2011) 22(46):5276-81  (co-first author) (cover, reported by Technology review, Material review) 
 * 3)    J. He, Y. Du, Y. Guo, M. Hancock, B. Wang, H. Shin, J. Wu, D. Li, A. Khademhosseini ‘Microfluidic synthesis of composite cross-gradient materials for Investigating cell-biomaterial interactions’ Biotechnology and Bioengineering 2010 108:175-85  (co-first author)
 * 4)    J. Wu, I. Wheeldon, Y. Guo, T. Lu, Y. Du, B. Wang, J. He, Y. Hu, A. Khademhosseini ‘Nanoliter-Scale Chamber array for High Throughput Screening of Drug Cytotoxicity and Drug-Drug Interactions, Biomaterials, 32:841-8 (2011)
 * 5) 	Y. Du, M. Hancock, J. He, J. Villa-Uribe, B. Wang, D. Cropek, A. Khademhosseini ‘Convection driven generation of long-range material gradients’ Biomaterials 31:2686-2694 (2010)
 * 6) 	Y. Du, M. Ghodoosi, E. Lo, M. Vidula, O. Emir, A. Khademhosseini ‘Surface-directed assembly of cell-laden microgels as 3D tissue constructs’ Biotechnology and Bioengineering 105(3): 655-662 (2010)
 * 7)    J. He, Y. Du, J. Villa-Uribe, A. Khademhosseini ‘Rapid generation of hydrogel chemical/mechanical gradient in a simple microfluidic device for biological applications’ Advanced Functional Materials 20(1): 131-137 (2010) (co-first author)
 * 8) 	N. Kachouie, Y. Du, H. Bae, M. Khabiry, A.F. Ahari, B. Zamanian, J. Fukuda, A. Khademhosseini ‘Directed assembly of cell-laden hydrogels for engineering functional tissues’ Organogenesis in press
 * 9) 	Z. Shi, N. Chen, Y. Du, A. Khademhosseini, M. Alber ‘Stochastic model of self-assembly of cell-laden hydrogels’ Physical Review E 80: 061901 (2010)
 * 10) 	Y. Du, J. Shim, M. Vidula, Matthew J. Hancock, E. Lo, B. Chung, M. Khabiry, J. Borenstein, D. Cropek, A. Khademhosseini ‘Rapid generation of spatially and temporally controllable centimeter-length concentration gradients in a microfluidic device’ Lab on a Chip 9(6): 741-848 (2009) (cover)
 * 11) 	M. Khabiry, B. Chung, M. Hancock, H. Soundararajan, Y. Du, D. Cropek, A. Khademhosseini ‘Cell Docking within Double Grooved Substrates in a Microfluidic Device’ Small 5(10): 1186-1194 (2009)
 * 12) 	Y. Du, E. Lo, S. Ali, A. Khademhosseini, ‘Directed assembly of cell-laden microgels for fabrication of 3D tissue engineering constructs’ Proceedings of the National Academy of Sciences 105(28): 9522-7 (2008) (Reported by Nature, Technology Review, Focus, Scientific America and as spotlight at MIT website homepage)
 * 13) 	Y. Du, E. Lo, M. Vidula, M. Khabiry, A. Khademhosseini “Method of Bottom-up Directed Assembly of Cell-Laden Microgels’ Cellular and Molecular Bioengineering (2008) 1: 157-162 (Outstanding paper award in Biomedical Engineering Society 2008)
 * 14) 	Y. Du, R. Han, S. Ng, F. Wen, T. Wohland, H. Yu ‘A Novel Synthetic Sandwich Culture of 3D Hepatocyte Monolayer’ Biomaterials 29: 290-301 (2008)
 * 15) 	Y. Toh, J. Zhang, Y. Khong, Y. Du, W. Sun, H. Yu ‘Capillary electrophoresis with laser induced fluorescence detection (CE-LIF) as a common analytical platform for sensitive quantification of hepatic metabolic functions’ Analyst 133(3): 326-30 (2008)
 * 16) 	Y. Du, R. Han, S. Ng, J. Ni, W. Sun, T. Wohland, S. Ong, H. Yu ‘Identification and characterization of a novel pre-spheroid 3D hepatocyte monolayer on galactosylated substratum’ Tissue Engineering 13(7): 1455-1468 (2007)
 * 17) 	X. Pan, C. Aw, Y. Du, H. Yu, T. Wohland ‘Characterization of poly(acrylic acid) diffusion dynamics on the grafted surface of poly(ethylene terephthalate) films by fluorescence correlation spectroscopy’ Biophysical Reviews and Letters 1 (4): 1-9 (2006)
 * 18) 	Y. Du, S. Chia, R. Han, S. Chang, H. Yu, "3D hepatocyte monolayer on hybrid RGD/galactose substratum” Biomaterials 27: 5669-5680 (2006)

Book chapters
 * 1) 	Ali Khademhosseini, Yanan Du, Bimal Rajalingam, Joseph P. Vacanti, Robert Langer, ‘Microscale Technologies for Tissue Engineering’; In “Advanced in tissue engineering ”; Edited by Julia Polak, Sakis Mantalaris and Sian E Harding; Imperial College Press (2008), P349-369, (co-first author)
 * 2) 	Yanan Du, Donald Cropek, Mohammad R. Kaazempur Mofrad, Eli J. Weinberg, Ali Khademhosseini, Jeffrey Borenstein, ‘Microfluidic systems for engineering vascularized tissue constructs’; In “Microfluidics for Biological Applications”; Edited by Wei-Cheng Tian and Erin Finehout; Springer (2009)
 * 3) 	Pilnam Kim, Yanan Du, Ali Khademhosseini, Robert Langer, Kahp Y. Suh, ‘Unconventional patterning methods for BioNEMS’; In “Nanopatterning and Applications”; Edited by John A. Rogers and Hong H. Lee; Wiley (2009) (co-first author)
 * 4) Yanan Du '3D HEPATOCYTE MONOLAYER FOR HEPATOCYTE BASED APPLICATIONS' LAP LAMBERT Academic Publishing (2010)
 * 5) 	Adam Hacking, Yanan Du, Ali Khademhosseini, ‘Polymer patterning for biological application’; In “Comprehensive Polymer Science, 2nd edition”; Edited by Martin Moeller and Krzysztof Matyjaszewski; Elsevier (expected 2011)

Patents 


 * 1) 	Yanan Du, Rongbin Han, Hanry Yu ‘Stabilizing a novel 3D hepatocyte monolayer culture by a hybrid bioactive substratum for hepatocyte-based applications’ PCT/SG2007/000147 (2008), EP Application No./Patent No.: 07748592.6 – 1222 (2009)
 * 2) 	Ali Khademhosseini, Yanan Du, ‘Method and system for generating spatially and temporally controllable concentration gradients’ PCT/US2009/064555 (2009)
 * 3) 	Ali Khademhosseini, Jeffrey Borenstein, Hojae Bae, Yanan Du, Jane Wang, Jason Nichol, Robert Langer, ‘Microfluidic construction of vascularized tissues’, Invention disclosure submitted (2010)
 * 4)     Ali Khademhosseini, Masoud Khabiry, Bong Geun Chung, Matthew Hancock, and Yanan Du, ‘Double-groove cell docking’ Invention disclosure submitted (BWH, NP-043214-066771) (2010)

Useful links

 * Tsinghua University: http://www.tsinghua.edu.cn/eng/index.jsp
 * School of Medicine, Tsinghua University: http://www.tsinghua.edu.cn/docsn/yxy/English/index_eng.html
 * Biomedical Engineering, Tsinghua University: http://bme.med.tsinghua.edu.cn/
 * Prof. Ali Khademhossieni's lab: http://www.tissueeng.net/lab/
 * Prof.Hanry Yu's lab: http://hanrylab.med.nus.edu.sg/
 * Wyss Institute: http://wyss.harvard.edu/