Hoatlin:Peter R.

1. Control of gene tx in Eukaryotes 2.	Regulation of mRNA processing 3.	Regulation of mRNA stability/turnover/XXX? 4.	The new world of RNA mediated gene regulation 5.	Regulation of protein biosynthesis
 * Genes and promoter
 * RNA polymerase/tx initiation complexes, etc
 * Tx factors and tx co-regulatory molecules
 * Co-activators (acetyl transferase)
 * Co-repressors (deacetylases, methylases, demethylases)
 * Basis of tx factors
 * Families
 * Functions
 * Mechanism of activation and inhibition
 * Choose key examples (CREB, NFkB, nuclear receptor)
 * Chromatin and transcription
 * Chromatin structure
 * Histones
 * Histone modification
 * Closed and open chromatin
 * Silencing, developmental changes, acute changes
 * Signal transduction pathways at the XX? of transcription
 * Splicing pathways and splicesome
 * Alternative RNA splicing, diversity of protein expression, etc
 * Short and long lived mRNA
 * Classic examples-RNA binding patterns
 * Non-coding RNAs
 * Slicing and dicing, shRNA, siRNA
 * siRNA and XX?

6.	Biodiversity of higher order chromatin structure and function

note potential overlap with CDB 622 Back to Main Page Hoatlin Lab