IGEM:IMPERIAL/2007/Ideas/Feasibility/PastIGEM

iGEM (2006) project ideas :

1. oscillator

2. Fluorescent biological photo paper Bio Photo Paper

3. Bio Computer based on Hin/Hix recombinase system (to solve Burnt Pancake problem) link

4. Self Assembling Photographs (using Chemotaxis) link

5. Bacterial Sensing Network Link

6. New Signalling Pathway : Chemotactic Receptors Up an Apartate gradient link

7. Cell to Cell Communication via Conjugation (passing plasmids from one cell to another) link
 * Berkely has done this for the past two years now

8. 'Water Colour' EColi (E.Coli expresses flourescent proteins in response to input signals) link

9. Light Directed Systems: link
 * light Controlled Chemotaxis
 * Edge Detector
 * Photofabrication

10. Tri-Metal Biosensor (Vanadium, Iron and Nickel) link

11. 'Quorumtaxis' system : link
 * Integrates the quorum-sensing and chemotaxis systems.
 * Bacteria engineered with this quorumtaxis system will be able to move towards high concentrations of quorum pheromone

12. unconventional computing as a means of building novel computing paradigms link

13. Hydrogen Sensor link

14. Microscopic Relay Race link

15. Iron Biosensor link

16. link
 * Bacterial Dynamo
 * Cancer StickyBot
 * X-Verter/Predator-Prey System
 * Human Encryption
 * Protein Cleaving Switch

17. Stem Cell Research link
 * PROGRAMMED DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS USING ARTIFICIAL SIGNALING PATHWAYS

18. Bacterial Version of Game Freeze Tag link

19. BioClock, DNA Box , Cell Surface Targeting link

20. Bacterial Night Light link

21. Bacteria that smell pleasant link

22. link


 * Repressilator coupled with quorum sensing system
 * Luciferase GFP part
 * yellow fluorescent protein part

23. Bacterial Thermometer link

24. Edinburgh


 * Developing a bacterial bio-sensor that responds to a range of arsenic concentrations and produces a change in pH that can be calibrated in relation with this concentration - maybe lead as suggested - application...

25. Valencia

Combination of Sensor & Actuator

Detection of some stimulus: concentration of some chemical/light intensity - Sensor Grading its "intensity" - pH output based upon colour grading - Actuator

(Similar to the "smoke detector" idea)



26. ETH Zurich

Implementation from the engineer's point of view Half Adder AND Gate: presence of chemical induces the production of an inactive protein, which is activated by a second protein (produced when light is present): the first protein is then activating GFP production XOR Gate: a light sensible promoter a chemical sensible promoter we would need to give a kind of first signal to the system (to don't have light reactions before a certain moment, otherwise we have to work in a dark room...), an activation signal after the bacterias have grown on the plate
 * Building logic circuitry : an AND and an XOR Gate

"their" Pro's & Con's Pro's:

meaningful from an engineering point of view valuable parts addition to synthetic biology stepwise proceeding applicable (→ intermediate and partial results!) experiments visually attractive probably simple enough

Con's:

cheap copy of “bio-film” project (iGEM 2004) sensational experiments, have little in common with half adder maybe that a big vision is lacking general/practical benefit? (counter-argument: is this required?) too simple?



Freiburg
 * Making a DNA strand fold into a pre-determined form
 * Biomaterial/Biofilm concept



27. Tokyo Alliance
 * Tic-Tac-Toe playing bacteria - logic processing