User:Yiannis Kaznessis

Contact Info



 * Yiannis Kaznessis
 * Department of Chemical Engineering and Materials Science
 * University of Minnesota
 * 421 Washington Ave SE
 * Minneapolis, MN 55455, USA
 * Email me through OpenWetWare

In my group we are interested in computational synthetic biology. We are developing the Synthetic Biology Software Suite, a publicly available software suite that assists in rationally designing synthetic gene regulatory networks. We combine components from BioBricks to generate networks of biomolecular reactions. We combine stochastic-discrete, stochastic-continuous and continuous-deterministic models to simulate these reaction networks. Version 1.0.2 is available on Sourceforge.net. We are now incorporating the connection with BioBricks.

In recent work (Ramalingam, KI, Tomshine, JR, Maynard, JA, Kaznessis YN. " Forward engineering of synthetic bio-logical AND gates" Biochemical Engineering Journal, 2009, 47(1-3):38-47), we used multiscale models of gene regulatory networks to design, build and test bio-logical AND gates.

We are also participating in the iGEM competition. We were awarded a Gold Medal in 2009 for SynBioSS work.

Education

 * 1999, PhD, University of Notre Dame
 * 1994, BS, Aristotle University in Thessaloniki

Research interests

 * 1) Statistical mechanics (yes, it can be fun!)
 * 2) Synthetic biology
 * 3) Computer simulations

Computational Synthetic Biology Publications

 * 1) Paper10 pmid=19830714
 * 2) Paper11 pmid=19644174
 * 3) Paper12 pmid=18757873
 * 4) Paper1 pmid=17986347
 * 5) Paper2 pmid=18190181
 * 6) Paper3 pmid=17408514
 * 7) Paper4 pmid=17200605
 * 8) Paper5 pmid=16920827
 * 9) Paper6 pmid=16504125
 * 10) Paper7 pmid=16356038
 * 11) Paper8 pmid=15740306
 * 12) Paper9 pmid=16183880

Useful links

 * Introductory tutorial
 * OpenWetWare help pages