Endy:Notebook/DNA Methyl Bit/Demethylation

Papers from Szyf's group claiming the existence of demethylase (MBD2)

 * Promoter-specific activation and demethylation by MBD2/demethylase.
 * Detich N, Theberge J, Szyf M.
 * J Biol Chem. 2002 Sep 27;277(39):35791-4. Epub 2002 Aug 12.
 * PMID: 12177048
 * Extracting DNA demethylase activity from mammalian cells.
 * Szyf M, Bhattacharya SK.
 * Methods Mol Biol. 2002;200:163-76.
 * PMID: 11951651
 * Extracting DNA demethylase activity from mammalian cells.
 * Szyf M, Bhattacharya SK.
 * Methods Mol Biol. 2002;200:155-61.
 * PMID: 11951650
 * Demethylase activity is directed by histone acetylation.
 * Cervoni N, Szyf M.
 * J Biol Chem. 2001 Nov 2;276(44):40778-87. Epub 2001 Aug 27.
 * PMID: 11524416
 * DNA methylation is a reversible biological signal.
 * Ramchandani S, Bhattacharya SK, Cervoni N, Szyf M.
 * Proc Natl Acad Sci U S A. 1999 May 25;96(11):6107-12.
 * PMID: 10339549
 * DNA demethylase is a processive enzyme.
 * 6: Cervoni N, Bhattacharya S, Szyf M.
 * J Biol Chem. 1999 Mar 26;274(13):8363-6.
 * PMID: 10085064
 * A mammalian protein with specific demethylase activity for mCpG DNA.
 * Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M.
 * Nature. 1999 Feb 18;397(6720):579-83.

Papers Arguing Against the Existence of a Demethylase

 * Ng, H. H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., and Bird, A. (1999) Nat. Genet. 23, 58-61
 * Boeke, J., Ammerpohl, O., Kegel, S., Moehren, U., and Renkawitz, R. (2000) J. Biol. Chem. 275, 34963-34967
 * Wade, P. A., Gegonne, A., Jones, P. L., Ballestar, E., Aubry, F., and Wolffe, A. P. (1999) Nat. Genet. 23, 62-66