Saeij lab:Reprints

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Publications
Updated January 2009 // In this paper we used quantitate genetics to identify Toxoplasma genes that are expressed in a strain-specific manner. For one of these genes, the rhoptry kinase ROP18, it is known that it is the difference in expression level between strains that causes differences in virulence. The biological consequences of expression level differences of the other genes is currently unknown. // Here we removed for the first time four adjacent genes using double homologous recombination. These are surface antigens that are expressed in bradyzoites but not in tachyzoites. Interestingly, parasites without these surface antigens are less able to persist in the brain of mice. We also show that using a bradyzoite specific promoter driving luciferase expression can show stage conversion in real time in life mice in vivo (using an IVIS imaging system).
 * 1) paper1 pmid=18552283
 * 1) paper2 pmid=18347037

// These authors contributed equally // These authors contributed equally // These authors contributed equally
 * 1) paper3 pmid=17335814
 * 2) paper4 pmid=17183270
 * 1) paper5 pmid=17170306
 * 1) paper6 pmid=16801557
 * 2) paper7 pmid=16697685
 * 3) paper8 pmid=16406121
 * 4) paper9 pmid=16098810
 * 5) paper10 pmid=15664907
 * 1) paper11 pmid=15446445
 * 2) paper12 pmid=14735923
 * 3) paper13 pmid=12946102
 * 4) paper14 pmid=12880636
 * 5) paper15 pmid=12697312
 * 6) paper16 pmid=12590974
 * 7) paper17 pmid=12477499
 * 8) paper18 pmid=11817378
 * 9) paper19 pmid=10803847
 * 10) paper20 pmid=10541807
 * 11) paper21 pmid=9914921
 * 12) paper22 pmid=9438833

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