MIBLab:Notebook/Systems and Synthetic Biology.

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Project Description/Abstract
This lab book and associated page were created as a method of documenting my progress towards an eventual IGEM entry. The majority of the work on the page was done by myself in association with my research mentors Chang Quo and May D. Wang Ph.D.

The aims of the project were:-

1.To identify a few standout IGEM entries of differing levels of complexity and mechanisms of action

2.Document and catalog the parts used in these synthetic constructs.

3.Attempt to locate literature sources describing and characterizing these parts.

4.Identify possible issues and any applications of motifs and parts used in these shortlisted systems.

5.Model these systems based on biologically validated characteristics of these parts derived from the sources located in "3." using a single or  a combination of in silico tools.

6.Locate in silico software tools to aid in the design & modeling of novel synthetic systems. (can be considered a subsection of "5.")

7.Compare these tools using one of the chosen IGEM entries as a test bed. The ability of the tools to suit this purpose is the major criteria for consideration. (Add link to paper manuscript?)

Future Goals: Document and understand the reasons for the limitations on the size of synthetic constructs in their current implementation in terms of the numbers of biological parts and associated control points, i.e. promoters.

Design and construct a novel synthetic system with the aim of future, physical implementation of such a system.

A timeline of progress made with this project can be found here:-

http://openwetware.org/wiki/MIBLab:Notebook/Systems_and_Synthetic_Biology./Entry_Base