User:Ilya/Yeast/Mating pheromone response pathway

Components

 * List of pathway components at yeastpheromonemodel.org
 * GPCR
 * Ras
 * Pheromone
 * Cdc28

Miscellaneous

 * Crosstalk in the pathways is eliminated by formation of pathway-specific complexes (Ste5:Ste11:Ste7:Fus3, Pbs2:Ste11:Hog1)
 * In S. cerevisiae, meiosis is initiated only by diploid cells deprived of glucose and nitrogen and grown in the presence of a nonfermentable carbon source 5

Pheromone processing genes

 * STE14
 * carries out C-terminal methylation of prenylated proteins including a-factor, Ras1p, and Ras2p
 * encodes the prenylcysteine-dependent carboxyl methyltransferase that mediates methylation, the final step in modification of CAAX proteins; Ste14p is also membrane associated 4
 * STE13
 * Dipeptidyl aminopeptidase A involved in maturation of a-factor
 * AXL1
 * Protease involved in proteolytic step of a-factor N-terminal processing
 * STE23
 * RAM1, RAM2
 * Required for a-factor prenylation
 * STE24
 * RCE1
 * KEX2
 * KEX1
 * STE23

Other genes
These genes are part of the mating machinery in yeast but not necessary part of the mating pheromone response pathway.
 * Swe1 - protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity
 * Ras1 - pombe homolog interacts with MAPKKK
 * SAG1 (α-agglutinin) - provides tight cell-cell adhesion during mating in S. cerevisiae.
 * FUS1 - protein with SH3 domain required for cell fusion during mating, located at the tip of the mating projection
 * BNI1/YNL271C (Saccharomyces cerevisiae)
 * Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1