IGEM:Harvard/2006/DNA nanostructures

 Project Overview Designs Notebook Protocols Presentations Literature  

Project Overview

 * Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
 * The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
 * As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
 * We expect that molecular containers could have several interesting scientific and clinical applications, such as
 * Drug and gene delivery
 * Bio-marker scavenging (early detection of biomarkers)
 * Directed evolution (compartmentalized selections)
 * Using multiplexing for combinatorial chemical synthesis
 * Capture and stabilization of multiprotein complexes
 * Protein folding (chaperones)
 * Cell sorting

Working Team Members

 * Tiffany Chan (talk, edits)
 * Katherine Fifer (talk, edits)
 * Valerie Lau (talk, edits)
 * Matthew Meisel (talk, edits)
 * Lewis Hahn (talk, edits)
 * TA: Shawn Douglas (talk, edits)