User:Blent/Seminar 07 fall

Title

 * Toward Personalized Medicine in BMI-based Methodology: A case study of Carbamazepine and challenges in the future

What is personalized medicine

 * personalized biomedical data collection and analysis
 * easy-to-use personalized diagnosis kit
 * personalized biomedical date-driven medicine usage
 * which medicine should one take? (decision of medicine)
 * how much medicine should one take? (dosage of medicine)
 * references
 * personalized medicine coalition
 * Personalized Medicine in Cancer: Matching Patients and Drugs (Genome News Network, Oct 28th, 2004)
 * Gefitinib, a cancer drug
 * Personalized medicine: A new approach to staying well (Boston Globe News, July 17th, 2005)
 * Genomics and Personalized Medicine (FDA Consumer magazine, Nov-Dec 2005 issue)
 * Genomics at FDA

case study: CBZ-SJS

 * Medical genetics: a marker for Stevens-Johnson syndrome, 2004 April Nature
 * HLA-B 1520 is an universal marker for Han Chinese in Taiwan
 * MS蛋白質序列分析
 * MALDI-TOF mass spectrometry-based SNP genotyping, 2002 Pharmacogenomics
 * High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry: practice, problems and promise, 2001 Hum Mutat.
 * A marker for Stevens-Johnson syndrome ...: ethnicity matters, 2006 The Pharmacogenomics Journal
 * HLA-B 1502 may NOT be an universal marker for CBZ-SJS
 * Genetic aspects of immune-mediated adverse drug effects, 2005 Nature
 * Nitric Oxide Synthase in Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome, 2000 Journal of Investigative Dermatology
 * 嚴重藥物過敏，可以預防 (科學人 2004 May)
 * 公視 探索未知世界 第二集: 解毒生命密碼-基因與藥物過敏
 * 基因型鑑定 預防藥物過敏邁向個人化醫療 (中廣新聞網 3/8, 2007)
 * 我國個人化醫療跨出一大步，讓藥害救濟由事後救濟邁向事前預防 (行政院衛生署藥物資訊網 9/17, 2007)
 * 預防抗癲癇藥害 明年起先測基因 - 首見研究成果當警語 (自由時報生活新聞 9/18, 2007)
 * 台灣獨步全球 預防抗癲癇藥害 - 明年起先測基因 首見研究成果當警語 (大紀元電子報 9/18, 2007)
 * Carbamazepine is an long half-live drug

case study: Warfarin (抗凝血劑) and dosage estimation

 * Warfarin Therapy: Evolving Strategies in Anticoagulation, Feb 1999, American Family Physician
 * Genetic variation (VKORC1) alters response to warfarin, 2/6/05. By NIH/National Institute of General Medical Sciences
 * Genetic Factors for Warfarin Dose Prediction, 2007 Clinical Chemistry

case study: The First race-specific drug BiDil

 * 活力藥師網番外篇-藥瓶裡的種族問題
 * Race in a Bottle, Jonathan Kahn. (Sci Am 2007 Aug)
 * 藥瓶裡的種族問題 科學人 2007 Sep
 * author: Jonathan Kahn
 * Are race-specific drugs unethical? With BiDil on the market, experts weigh the moral implications, Nov 2005
 * BiDil: Isosorbide dinitrate and hydralazine
 * Hydralazine price
 * Isosorbide Dinitrate price
 * BiDil price

Movies

 * Gattaca: 千鈞一髮 1997

Outlines (Sep 20, 2007)

 * BMI = BI + MI
 * what BMI can do
 * Neuroinformatics (NI)
 * Cancer research (CR)
 * Personalized Medicine (PM)
 * Motivation and case study
 * Stevens-Johnson syndrome and HLA-B 1502
 * Methodology
 * MI
 * BI
 * Products
 * Problems remained

Background

 * intersection between Bioinformatics and Medical Informatics
 * total search results
 * Bioinformatics and Medical Informatics: Collaborations on the Road to Genomic Medicine? 2003 JAMIA
 * The Interactions Between Clinical Informatics and Bioinformatics, 2000 JAMIA
 * Opportunities at the Intersection of Bioinformatics and Health Informatics, 2000 JAMIA
 * Training the Next Generation of Informaticians: The Impact of "BISTI" and Bioinformatics—A Report from the American College of Medical Informatics, 2004 JAMIA
 * Military Research Needs in Biomedical Informatics, 2000 JAMIA
 * Synergies in Medical Informatics and Bioinformatics

Materials

 * Scientific American (English)
 * Scientific American (Taiwan)
 * BioIT
 * Genetic Engineering & biotechnology News
 * 華文生技網
 * 科學人知識庫