User:Sebastian Muller Dunelm

Contact Information



 * Sebastian Müller
 * Institut Curie
 * 26, Rue d'Ulm, 75248
 * Paris, France
 * Email me

Currently, I work in the G. Almouzni Lab at the Institut Curie as a postdoctoral researcher in epigenetics and chromatin dynamics. I am also the co-funder and executive editor of City Connect.

Education

 * 2010, Ph.D., University of Cambridge (England, U.K.)
 * 2006, M.Sci, Durham University (England, U.K.)
 * 2002, CPE, Lincoln College (England, U.K.)
 * 2001, German Abitur, Evangelisches Schulzentrum Leipzig (Germany)
 * 1999, GCSE, Lomond School (Scotland, U.K.)

Research Interests



 * Cancer research: molecular and cellular mechanisms of the aetiology of cancer
 * DNA structure and function
 * G-quadruplex DNA and RNA
 * Synthesis of nucleic acid interacting small molecules
 * Epigenetic roles of DNA and RNA structures
 * Centromeres and satellite DNA

Skills

 * Languages: German (fluent), English (fluent), French (conversational)


 * Cell Biology: Cell culture, Immunohistochemistry, fluorescence microscopy, fluorescent and luminescent cell assays (apoptosis, senescence, viability, cytotoxicity etc.), transfections
 * Molecular Biology: Vector cloning, q-PCR, colony PCR, agarose and PA gel electrophoresis, DNA extraction, radioactive labelling
 * Chemical Synthesis: Synthesis of small synthetic molecules, NMR, UV-vis, HRMS
 * Biophysics: FRET-melting, circular dichroism, nucleic acid NMR, fluorescent titration
 * I.T.: LaTeX, HTML, OriginLab, ChemDraw, Microsoft Office, Photoshop
 * Teaching: A-level teaching, teaching of undergrad students in supervisions and tutorials up to Masters level, supervision of 1st year Ph.D. students

Awards

 * 2006-2010: Cancer research UK, Scholarship, Cambridge, U.K.
 * 2005:     Full Colours in Rowing, Durham University, College of St. Hild & St. Bede, U.K.
 * 2001:     Buchpreis der Deutschen Physikalischen Gesellschaft, Germany

Personal Interests

 * Rowing
 * Classical Music
 * Gym and running
 * Piano
 * Ancient and modern history and archeology
 * Astronomy

Publications
S. Müller, D. Sanders, R. Rodriguez, M. Di Antonio, S. Matsis and S. Balasubramanian, ''J. Med. Chemistry, 2011, under submission'', “Small molecules that show selective growth inhibition for cancer cells, low cytotoxicity and induce telomere shortening”

M. Bejugam, M. Gunaratman, S. Müller, S. Sewitz, D. A. Sanders, S. Neidle and S. Balasubramanian, ''ACS Med. Chem. Lett.,'' 2010, 1, 306-310, “Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines”

S. Müller, S. Kumari, R. Rodriguez and S. Balasubramanian, Nature Chem., 2010, 2, 1095-1098, “Small molecule-mediated G-Quadruplex isolation from human cells”

S. Müller, G. D. Pantos, R. Rodriguez and S. Balasubramanian, Chem.Commun., 2009, 80-82, “Controlled-folding of a small molecule modulates DNA G-quadruplex recognition”

R. Rodriguez, S. Müller, J. A. Yeoman, C. Trentesaux, J.-F. Riou and S. Balasubramanian, ''J. Am. Chem. Soc.'', 2008, 130, 15758-15759, “A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres”

J. Jaiswal, G. Marlow, G. Summerill, I. Mahjneh, S. Müller, M. Hill, K. Miyake, H. Haase, L. Anderson, I. Richard, S. Kiuru-Enari, P. McNeil, S. Simon and R. Bashir, Traffic, 2006, 8, 77-88, “Patients with a non-dysferlin Myoshi Myopathy have a novel membrane repair defect”

J. Jaiswal, K. Miyake, G. Summerill, S. Müller, I. Mahjneh, F. Baas, M. de Visser, P. McNeil and R. Bashir, Neuromuscular Disorders, 2005, 15, 692, “Defective membrane repair in non-dysferlin Miyoshi Myopathy”

Groups
G. Almouzni Research Group

S. Balasubramanian Research Group

R. Bashir Research Group


 * Introductory tutorial
 * OpenWetWare help pages