User:J. C. Martinez-Garcia/Notebook/HMS Activities/2008/11/03

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 * style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]] Coming back to the raw data
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 * style="background-color: #F2F2F2" align="center"|  |Main project page


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Working from the scratch
I decided to work in the modeling task concerning the modified AKT signaling following a raw data approach. I asked to David to give the original data that he obtained from the experiments that he performed. He send me a message with the requested data, which are given in the next figure:



Then, I decided to follow three different approaches:
 * 1) Design a neural network just to match the data.
 * 2) Model the modified AKT signaling pathway using the SimBiology toolbox of MatLab.
 * 3) Directly obtain a model using the nonlinear differential equations formalism.

I think that a perceptron based network will be good for the first purpose. I suppose that a network can be configured in order to have two different inputs (the Zstk drug concentration and the mTOR raptor inhibitor). The idea is to have a black-box model which display the two different given behaviors (with or without mTOR raptor inhibitor). For the second approach the advantage would be to have a model easily available for anybody working with the Matlab framework.

Meeting with Pilpel
Tomorrow I will read again the Pilpel papers. I asked him to have a meeting next Wednesday.


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