Sriram Kosuri

Bio
I am curently a postdoc in George Church's lab in the Department of Genetics at Harvard Medical School and the Wyss Institute. From September 2007 to February 2009, I worked at a small Cambridge-area startup called Joule Unlimited. I am also on the Board of Directors for OpenWetWare. I previously did a short postdoctoral stint in Mike Laub's lab working on cell cycle in Caulobacter crescentus. Prior to the Laub lab, I was a graduate student in Drew Endy's lab and worked on understanding the development of a simple virus (T7) that infects E. coli. As an undergraduate at UC Berkeley, I worked with Adam Arkin, Dale Kaiser, and Roy Welch on modeling traveling wave formation in M. xanthus.

Publications
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription Feng Zhang, Le Cong, Simona Lodato, Sriram Kosuri, George Church & Paola Arlotta ''Nature Biotechnology (2011) doi:10.1038/nbt.1775

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips Sriram Kosuri, Nikolai Eroshenko, Emily LeProust, Michael Super, Jeffrey Way, Jin Billy Li & George Church Nature Biotechnology (2010) 28:1295  doi:10.1038/nbt.1716 News & Views, Cover Art

TABASCO: A single molecule, base-pair resolved gene expression simulator Sriram Kosuri, Jason Kelly and Drew Endy BMC Bioinformatics 2007, 8:480    doi:10.1186/1471-2105-8-480 URL

Refactoring bacteriophage T7 Leon Y. Chan, Sriram Kosuri and Drew Endy Molecular Systems Biology 13 September 2005 DOI:10.1038/msb4100025 URL PDF reprint News & Views October 2004 version

Interests

 * Developing technologies on making biology easier to engineer.


 * Enabling the design, construction, and use of biological organisms for the purposes of further scientific understanding; keeping extremely aware of the use of engineered biological organisms for other purposes.


 * Understanding those aspects of biological design that allow for certain robust features of development in the face of large intrinsic and extrinsic variation specifically on non-evolutionary time-scales (I am currently giving up on the past. That may change in the future.).


 * Property rights as related to biological information and organisms; understanding and reforming current and future frameworks; I really like these people


 * OpenWetWare of course!

Past Projects
Rebuilding T7

TABASCO -- A single molecule base-pair resolved gene expression simulator

Measure and Models of T7 Infection

How does T7 deal with Uncertainty

T7.2 Tests

Interesting Stuff
The beginnings of a blog.

See my interesting stuff page

Post-doctoral Fellowships

[[Media:CGR Research Plan.pdf|A failed Research Plan for a job at Harvard's CGR]]

My Thesis!

My contributions to OWW

Sriram Kosuri/temp

Contact
Phone: still waiting OWW users: Post a message on my talk page, or send me an email. Email: Postal: Harvard Medical School Genetics Department New Research Building (NRB) Rooms 232 77 Ave. Louis Pasteur Boston, MA 02115 USA

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