BioControl:Week5

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Next meeting

 * Friday, 1/19 at 9am in 110 Steele

Topics

 * Bacterial Chemotaxis
 * Perfect adaptation
 * Amplification

Reading

 * 1) Barkai pmid=9202124
 * 2) Keymer pmid=16446460

Discussion

 * The cells are selecting for noisy function Korobdova, but too much noise (particularly with extreme amplification) would seem to be a problem. If you could specify everything in this system, where would you want noise?
 * Drunken random walks seem to be a common solution to this kind of problem - why?
 * It looks to me (Jkm) like a good way to deal with noisy inputs. Is there more to it? Are there better (engineering?) ways of solving the same problem?
 * Going from experiments to models (particularly in biology) - are assumptions (CheB only demethylates active receptors) good, since they give us testable hypotheses? Or bad, since they're just artificial constraints in order to get the 'right' answer?