Template:NcbiGeneACCN1

 NCBI GeneID40Official SymbolACCN1 Full Nameamiloride-sensitive cation channel 1, neuronal Location17q12 See relatedHGNC:99 Ensembl:ENSG00000108684 HPRD:03471 MIM:601784 Other Names ACCN ; BNC1 ; MDEG ; ASIC2 ; BNaC1 ; ASIC2a ; hBNaC1 ; OrganismHomo sapiens<dt>Lineage<dd>Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dl> =ACCN1= "This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified"