User:Hikmet Geckil

Hikmet Geckil, Professor of Molecular Genetics  Department of Biology, School of Science and Letters, Inonu University 44280 Malatya, Turkey hgeckil[at]inonu.edu.tr                                              hikmet.geckil[at]fulbrightmail.org +90 422 377 3749

Education
* 1980-1984: B.S., Department of Biology at Firat University, Elazig, Turkey. * 1986-1988: M.S., Molecular Biology, Inonu University, Malatya, Turkey (Financial support: The Scientific and Technical Research Council of Turkey, (TUBITAK)) * 1988-1989 (5 months): English Language Education in Middle East Technical University (METU, ODTU), (FS: Turkish Ministry of Education). * 1989-1990 (7 months): American Language Academy, Baldwin-Wallace College, Berea, Ohio.(Financial support: The Turkish Ministry of Education) * 1991-1995: Ph.D., Molecular Biology-Biotechnology, Illinois   Institute of Technology, Chicago, Illinois. (Financial support: The Turkish Ministry of Education) * 1999-2000 (1 year): Postdoctoral Fellow, Department of Life Sciences, Ben Gurion University, Beer-Sheva, Israel. (Financial support: The Council for Higher Education of Israel) * 2009-2010 (6 months): Fulbright Postdoctoral Fellow, Center for Biomedical Engineering, Department of Health Sciences and Technology of Harvard University Medical School and Massachusetts Institute of Technology, Cambridge, MA (Financial support: Fulbright, US Department of State)

Teaching and Research Experience
* 1985-1988: Research Assistant at Inonu University, Biology Department, Malatya, Turkey * 1992:Instructor for "Women in Science and Engineering" summer program at Illinois Institute of Technology * 1992-1994: Teaching Assistant, Methods in Microbial Genetics and Genetic Engineering Laboratory (BIOL 523), at Illinois Institute of Technology (Practical aspects of recombinant DNA technology;                Growth, handling andmaintenance of cultures; Quantitative techniques; Use of mutagens; Isolation and genetic analysis of mutants inyeast, Saccharomyces cerevisiae; Cloning, transformation                 of Escherichia coli and restriction mapping ofDNA; Use of Southern blotting and amplification of DNA using PCR technology). * 1993-1994: Teaching Assistant, Advanced Biochemistry Laboratory (BIOL 519) at Illinois Institute of Technology (analytical methods for macromolecules; enzyme reactions; spectrophotometry;                purification of proteins; centrifugation; chromatography; electrophoresis; pHand ion specific electrode; radioisotope tracer methodology). * 1993-1994: Teaching Assistant, Molecular and Cell Biology Laboratory (BIOL 446/533) at Illinois Institute of Technology (Growth of Escherichia coli; Chromosomal DNA extraction from bacteria;                optical properties of DNA; Elements of genetic engineering: bacterial plasmid DNA extraction, restriction mapping and analysis; Cell fractionation: organelle isolationand markerenzyme assays;                 Protein fractionation; Estimation ofprotein molecular weight: polyacrylamide gel electrophoresis; Protein synthesis and detection in vitro: in vitro translation, electroblotting,                 chemiluminescence detection; Chromosome stability in yeast.    * 1994-1995: Teaching Assistant, Advanced Biochemistry Laboratory (BIOL 519) at Illinois Institute of Technology (analytical methods for macromolecules; enzyme reactions; spectrophotometry; purification of proteins; centrifugation; chromatography; electrophoresis; pH and ion specific electrode; radioisotope tracer methodology).   * 1996-1999: Assistant Professor, Department of Biology, Inonu University, Malatya, Turkey    * 1999-2000: Postdoctoral Fellow of The Council for Higher Education of Israel at Ben Gurion University (Israel)    * 2000-2005: Assistant Professor, Department of Biology, Inonu University, Malatya, Turkey    * 2005-2010: Associate Professor of Molecular Genetics, Department of Biology, Inonu University, Malatya, Turkey    * 2010-....: Professor of Molecular Genetics, Department of Biology, Inonu University, Malatya, Turkey    * 2009-2010: Fulbright Fellow, Center for Biomedical Engineering, Department of Health Sciences and Technology of Harvard University Medical School and Massachusetts Institute of Technology,                 Cambridge, MA

Research interests
The Genetic Engineering Laboratory (GEL) The main focus of the GEL involves isolation, cloning, and regulation of bacterial genes expressing products of high industrial importance. An anticancer enzyme, L-asparaginase, produced only by certain bacteria and L-dopa and dopamine, the drugs used in Alzheimer’s and Parkinson diseases are the main products under the investigation. The laboratory has also a long standing interest in Vitreoscilla hemoglobin, the first bacterial hemoglobin. As the production of formers are highly regulated by the availability of oxygen, the application of the latter in their production may have advantageous. In short, the basic philosophy of the GEL is to combine a state of the art knowledge in the life sciences with fundamental research and expertise in analytical chemistry as well as process engineering.

Publications
P-28: Gurkan UA, Moon S, Geckil H, Xu F, Wang S, Lu TJ and Demirci U.   Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing. Biotechnology Journal, 2011; 6(2): 138-149. P-27: Geckil H, Xu F, Xiaohui Z, Moon S-J, Demirci U.   Engineering hydrogels as extracellular matrix mimics. Nanomedicine, 2010; 5(3): 469-484. P-26: Kurt AG, Aytan E, Ozer U, Ates B and Geckil H   Production of L-DOPA and dopamine in bacteria bearing Vitreoscilla hemoglobin gene. Biotechnology Journal, 2009 4(7), 1077-1088. P-25: Aydin S, Karatas F and Geckil H.   Simultaneous Quantification of Acylated and Desacylated Ghrelin in Biological Fluids. Biomedical Chromatography, 20008; 22(12): 1354-1359. P-24: Aydin S, Geckil H, Kilic N, Erman F, Kilic SS and Yesilada O.   Is Ghrelin a Natural Anti-Microbial Agent? Turkish Journal of Medical Sciences, 2008; 38(2): 187-187. P-23: Aydin S*, Geckil H, Karatas F, Donder E, Kumru S, Kavak EC, Colak R, Ozkan Y, Sahin I.   Milk and blood ghrelin level in diabetics. Nutrition, 2007; 23(11-12): 807-811. P-22: Aydin S*, Ozercan IH, Geckil H, Dagli F, Aydin S, Kumru S, Kiliç N, Sahin I, Ozercan MR. Ghrelin is present in teeth. Journal of Biochemistry and Molecular Biology, (2007); 40(3):368-372. P-21: Aydin S*, Geckil H, Karaoglu A, Elkiran ET. Ghrelin: A novel peptide with therapeutic effect in certain cancers? Medical Hypotheses, (2007); 69(5): 1157-1158. P-20: Geckil H*, Gencer S, Ates B, Ozer U, Uckun M, Yilmaz I.   Effect of Vitreoscilla hemoglobin on production of a chemotherapeutic enzyme, L-asparaginase, by Pseudomonas aeruginosa. Biotechnology Journal, (2006); 1(2): 203-208. P-19: Aydin S*, Ozercan HI, Aydin S, Ozkan Y, Dagli F, Oguzoncul F, Geckil H.   Biological rhythm of saliva ghrelin in humans. Biological Rhythm Research, (2006); 37(2): 169-177. P-18: Aydin S*, Geckil H, Zengin F, Ozercan HI, Karatas F, Aydin S, Balik DT, Ozkan Y, Dagli F, Celik V.   Ghrelin in plants: What is the function of an appetite hormone in plants? Peptides, (2006); 27(7): 1597-1602. P-17: Ates B, Gencer S, Erenler SO, Uckun M, Ozer U, Yilmaz I, and Geckil H.   Production of L-asparaginase, a chemotherapeutic enzyme, in bacteria expressing Vitreoscilla haemoglobin. FEBS JOURNAL, (2006); 273: 139-139. P-16: Kahraman H, Gencer S, Geckil H.   Effect of Vitreoscillaon L-lysine alpha-oxidase, a chemotherapeutic enzyme, from Pseudomonas aeruginosa. FEBS JOURNAL, (2006); 273: 139-140. P-15: Kahraman H and Geckil H*. Degradation of benzene, toluene and xylene by Pseudomonas aeruginosa engineered with the Vitreoscilla hemoglobin gene. Engineering in Life Sciences, (2005); 5(4): 363-368. P-14: Geckil H*, Ates B, Durmaz G, Erdogan S, Yilmaz I.   Antioxidant, free radical scavenginging and metal chelating characteristics of propolis. American Journal of Biochmemistry and Biotechnology, 2005; 1(1): 27-31. P-13: Geckil H* Ates B, Gencer S, Uckun M, and Yilmaz I.   Membrane permeabilization of Gram-negative bacteria with a potassium phosphate/hexane aqueous phase system for the release of L-asparaginase: an enzyme used in cancer therapy. Process Biochemistry, 2005; 40(2): 573-579. P-12: Geckil H*, Barak Z, Chipman DM, Erenler SO, Webster DA and Stark BC. Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene. Bioprocess and Biosystems Engineering, 2004; 26(5): 325-330. P-11: Geckil H*, Arman A, Gencer G, Ates B and Yilmaz HR. Vitreoscilla hemoglobin renders Enterobacter aerogenes highly susceptible to heavy metals. Biometals, 2004; 17(6): 715-723. P-10: Geckil H*, Gencer S and Uckun M.   Vitreoscilla hemoglobin expressing Enterobacter aerogenes and Pseudomonas aeruginosa respond differently to carbon catabolite and oxygen repression for production of L-asparaginase: an enzyme used in     cancer therapy. Enzyme and Microbial Technology, 2004; 35(2-3): 182-189. P-09: Ates B, Yilmaz I, Geckil H*, Iraz M, Birincioglu M, Fiskin K.   Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage. Journal of Pineal Research, 2004; 37(3): 149-152. P-08: Geckil H* and Gencer S.   Production of L-asparaginase in Enterobacter aerogenes expressing Vitreoscilla hemoglobin for efficient oxygen uptake. Applied Microbiology and Biotechnology, 2004; 63(6): 691-697. P-07: Erenler SO, Gencer S, Geckil H*, Stark BC, and Webster DA. Cloning and expression of the Vitreoscilla hemoglobin gene in Enterobacter aerogenes: effect on cell growth an oxygen uptake. Applied Biochemistry and Microbiology, 2004; 40(3): 288-295. P-06: Geckil H*, Gencer S, Kahraman H, and Erenler SO. Genetic engineering of Enterobacter aerogenes with Vitreoscilla hemoglobin gene: cell growth, survival, and antioxidant enzyme status under oxidative stress. Research in Microbiology, 2003; 154(6): 425-431. P-05: Munzuroglu O*, Karatas F, and Geckil H.   The vitamin and selenium contents of apricot fruit of different varieties cultivated in different geographical regions. Food Chemistry, 2003; 83(2): 205-212. P-04: Munzuroglu O*, Obek E and Geckil H.   Effects of simulated acid rain on the pollen germination and pollen tube growth of apple (Malus sylvestris Miller cv. Golden). Acta Biologica Hungarica, 2003; 54(1): 5-103. P-03: Yurekli F*, Geckil H, and Topcuoglu F.   The synthesis of indole-3-acetic acid by the industrially important white-rot fungus Lentinus sajor-caju under different culture conditions. Mycological Research, 2003; 107(3): 305-309. P-02: Munzuroglu O* and Geckil H.   Effects of metals on seed germination, root elongation, coleoptile and hypocotyl growth in Triticum aestivum and Cucumis sativus. Archives of Environmental Contamination and Toxicology, 2002; 43(2): 203-213. P-01: Geckil H*, Stark BC, and Webster DA. Cell growth and oxygen uptake of Escherichia coli and Pseudomonas aeruginosa are differently affected by the genetically engineered Vitreoscilla hemoglobin gene. Journal of Biotechnology, 2001; 85(1): 57-66.

Other articles
* A-01: Aydin S*, Geckil H, Caylak Eand Kilic N (2004). Mikroorganizmalarin kanser tedavisinde kullanimi. Firat Medical Journal, 9(2): 30-34.

* A-02: Kahraman H and Geckil H* (2005). Benzoik Asitin Vitreoscilla hemoglobin geni aktarılmış Pseudomonas aeruginosa tarafından yıkımı. Fen ve Muhendislik Bilimleri Dergisi, Firat Universitesi, 17(2); 342-348.   * A-03: Geckil H (2005). "Iki Emekli Bilim Adaminin Hikayesi: Genetige Karsi Biyokimya" Universite ve Toplum (University and Society), 5(3): 1-2.

* A-04: Geckil H (2006). "Molekuler Yasam Bilimlerinde Ph.D. Derecesi Icin Standartlar" (translated from "Standarts for the Ph.D. Degree in the Molecular Biosciences ", a study by the International Union           of Biochemistry and Molecular Biology, IUBMB). This copyright free study has been published or publicized in: o Inonu Universitesi Tip Fakultesi Dergisi (Journal of Inonu University Medical Faculty), 13(3): 203-219 o Inonu University, Faculty of Art and Sciences o Turkish Academy of Sciences o Turkish Biochemical Society o International Union of Biochemistry and Molecular Biology, IUBMB

* Geckil H. Genomlarla Eğlence: Mikoçiğner DNA Bulmacası, Science in School, 2007: 1(5); 28-31. A translation of the original article: "Fun with genomes: the Mycomuncher DNA Puzzle" * Geckil H. Gözler Ufukta, ayaklar yerde: Tim Hunt'la söyleşi, Science in School, 2007: 1(6); 9-13. A translation of the original article "Eyes on the horizon, feet on the ground: interview with Tim               Hunt", "Science in School". * Geckil H. Romalılara ait yollar, tren istasyonları ve kontrolörler: RNA araştırmalarında son buluşlar. Science in School, 2007: 1(6); 20-24. A translation of the original article "Of Roman roads, train               yards and inspectors: recent discoveries in RNA research" * Kurt AG and Geckil H. Proteini kristallere büyütme. Science in School, 2009: 11; 30-36. A translation of the original article "Growing crystals from proteins" * Aytan E and Geckil H. Folik asit: öğrenciler neden bu konuyu bilmeli? Science in School, 2009: 13; 59-64. A translation of the original article "Folic acid: why school students need to know about it" * Türkoğlu Z and Geckil H. Okulda nanoteknoloji. Science in School, 2008: 10; 70-75. A translation of the original article "Nanotechnology in school"

Books and Book Chapters
BROCK MİKROORGANİZMALARIN BİYOLOJİSİ  Translation Editor: Cumhur Çökmüş 2010, Palme Publishing, Ankara, Türkiye Translated Chapters: Bölüm 9- Virolojinin Esasları (Chapter 9- Principles of Virology) Bölüm 11- Ökaryotik Hücre Biyolojisi ve Ökaryotik Mikroorganizmalar (Chapter 11- Eukaryotic Cell Biology and Eukaryotic Microorganisms) ORIGINAL BOOK “Brock’s Biology of Microorganisms” Michael Madigan and John Martinko 11th Edition (2002), Pearson Prentice-Hall

BİYOKİMYA  Translation Editors: Yusuf Tutar, Hikmet Geçkil, Mehmet Karataş 2009, Nobel Publisihin, Ankara, Türkiye Translated Chapter: Bölüm K- Lipid Metabolizması (Chapter K- Lipid Metabolism) ORIGINAL BOOK “Instant Notes in Biochemistry” by David Hames and Nigel Hooper 2007, 3rd Edition, Taylor & Francis

MOLEKÜLER HÜCRE BİYOLOJİSİ  Translation Editors: Hikmet Geçkil, Murat Özmen, Özfer Yeşilada Palme Publishing, Ankara, Türkiye (In press) Translated Chapters: Bölüm 1- Yaşam Hücrelerle Başlar (Chapter 1- Life Starts with cells) Bölüm 2- Kimyasal Temeller (Chapter 2- Chemical Foundadtions) ORIGINAL BOOK “MOLECULAR CELL BILOGY” Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Matthew P. Scott, Anthony Bretscher, Hide Ploegh and Paul Matsudiara 2008, 6th edition, W.H. Freeman & Company, New York

Editorship
•	Editor,Biotechnology Journal, Wiley-VCH Publications, Weinheim, Germany •	Technical Editor (2004-2006), American Journal of Biochemistry and Biotechnology, Science Publications, New York, USA •	Associate Editor (2006-present), American Journal of Biochemistry and Biotechnology, Science Publications, New York, USA •	Editor, Journal of Applied Biological Sciences, A journalby Nobel Publishing and Nobel Science Research Center, Ankara, Turkey •	Member of Editorial Board, FIRAT ÜNİVERSİTESİ Fen Bilimleri Dergisi, A Journal Published by the Institute of Science, Firat University, Elazig, Turkey •	Member of Editorial Board, Turkish Journal of Science and Technology, A Journal Published by the Institute of Science, Firat University, Elazig, Turkey

Scholarships, Degrees, Honors
•	1986-1987: Scholarship for master study (Molecular Biology) from "The Scientific and Technical Research Council of Turkey, (TUBITAK)" •	1987-1988: Honor member (A Graduate Student Recognition), TUBITAK •	1988: Secondplace in National Exam in Biological Sciences carried out by the "Turkish Ministry of Education" for postgraduate studies abroad. •	1988: Scholarship award from "Turkish Ministry of Education" for graduate (Ph.D.) study(Biotechnology/Genetic Engineering) in the United States of America. •	1995: Ph.D.degree from Illinois Institute of Technology (Chicago), USA (GPA: 3.625/4.0). •	1999-2000: Post-doctoral fellow of "The Council for Higher Education of Israel" (Ben-Gurion University, Israel) •	1996(November): Foreign Language Proficiency Examination for State Employees (KPDS)- (Level A, 90/100)-a gradual montly compansetion for thosewho score 70+ is paid for a 5 year period •	2006(November): Foreign Language Proficiency Examination for State Employees (KPDS)-(Level A, 94/100) •	2005- present: Serving regularly on proposal review panels for TUBITAK •	2008- present: Instructor for Biology Olympiads, organized by TUBITAK, to prepare secondary school students for tackling biological problems,inventiveness, and creativity in an international competition held yearlyin selected centers around the world (The International Biology Olympiad). •	2008-present: Refereeing in "Technology and Inovation Funding Programs- TEYDEB" of TUBITAK. TEYDEB encourages research and development activities of private companies settled in Turkey. •	2009:Chairing and organizing the Biology Section of Secondary Education Science Project Competitions Program sponsored by TUBITAK. The activity involved students from selected high schools from 11 major cities in the region (Esatern Anatolia) and around (South Eastern Anatolia) •	2009-2010 (6 months): Fulbright Fellow, Center for Biomedical Engineering, Department of Health Sciences and Technology of Harvard University Medical School and Massachusetts Institute of Technology, Cambridge, MA (Financial support: US Department of State) •	Listed in the 7th edition of "Who's Who in Science and Engineering", 2002 •	Listed in the "2000 Outstanding Scientists of the 21st Century" publishedby the International Biographical Centere (IBC), 2004. •	Listed in the Laureate of the "Living Science Award" given by theInternational Biographical Centere (IBC), 2004. •	Listed in the 9th edition of "Who's Who in Science and Engineering", 2007. •	Inclusion in Who's Who in Science and Engineering 2011-2012 (11th Edition)

Research, Project, Supervising
Genetic Engineering of Vitreoscilla Hemoglobin Gene * Cloning, expression and effect of Vitreoscilla hemoglobin gene in industrially important microorganisms * Oxidative stress and antioxidant properties of bacteria genetically engineered with Vitreoscilla hemoglobin gene© * Potential use of Vitreoscilla hemoglobin in bioremediation * Production of industrially important fermantative solvents through the use of Vitreoscilla hemoglobin© * Use of Vitreoscilla hemoglobin for the enhancement of production of L-asparaginase: an enzyme used in cancer therapy© * Metabolic engineering: secondary metabolite flux distribution in Erwinia herbicola expressing Vitreoscilla hemoglobin gene© Natural and Synthetic (artificial) Antioxidants and Oxidants * Effect of melatonin in bacteria and higher animals * Antioxidative and metal chelating characteristics of propolis and CAPE (caffeic acid phenethyl ester) * Ghrelin Bioprocess Engineering * Development of methods for bioprocessing of products with high therapeutic value * Bacterial synthesis of L-DOPA and DOPAMINE [(Cloning, isolation, expression of the genes (Tyrosine phenol lyase and dopaminedecarboxylase) for L-DOPA and DOPAMINE production in bacteria)].

PROJECTS (as PI)

* October 1 2007-October 1 2009: Hikmet Geckil, Burhan Ates, Sule Bulut, Aslı Giray Kurt. Production of L-DOPA and dopamine in bacteria expressing Vitreoscilla hemoglobin, A project supported by The Scientific andTechnical Research Council of Turkey, TUBITAK (No: 107T478), Project budget: 100,000 USD plus 1000 USD/monthPhD scholarship for two years. * 2006-2008: Birol Mutlu, Hikmet Geckil and Sukru Karakus. Some taxonomical studies on genus Erysimum in Turkey. A project supported by The Scientific and Technical Research Council ofTurkey (TBAG                105T126), Project budget: 100,000 USD. * 2005-2006: Hikmet Geckil, Burhan Ates, Sebnem O Erenler, Salih Gencer, Suleyman Aydin. Cloning, isolation and expression of L-asparaginase, an antileukemic enzyme, gene (ansB) gene in various Gram-negative bacteria, The State Planning Organization of Turkish Prime Ministry, DPT 2003/K120610, Project budget: 50,000 USD. * 2004-2005: The production, chemical characterization and clinical aspects of L-asparaginase of bacterial origin. A graduate research project with a 6,000 USD budget supported by the Research Fund Unit of Inonu University, APYB 2004/93. * 2005-2006: Cloning, expression and isolation of L-asparaginase, an enzyme used in cancer therapy, gene (ansB) in various gram-negative bacteria. A graduate research project with a 6,000 USD budget supported by the Research Fund Unit of Inonu University, APYB 2005/25. * 2003-2004: The use of Vitreoscilla hemoglobin in Enterobacter aerogenes : some industrial applications. A project supported by The Scientific and Technical Research Council of Turkey, TUBITAK (TBAG2267(102T197)), Project budget: 40,000 USD. * 2003-2004: The degradation/removal of textile dyes from industrial effluents through the use of biotechnological methods. A collectiveproject supported by The State Planning Organization of                Turkish Prime Ministry, (DPT:2003K120610), Project budget: 175,000 USD. * 2002-2003: The industrial use of Pseudomonas aeruginosa engineered with the Vitreoscilla hemoglobin gene. A project supported by the Research Fund Unit of Inonu University, APYB 2002/05, Project budget: 12,000 USD. * 2001: Effect of organic solvents on metabolic and physiological activities of Enterobacter aerogenes engineered with Vitreoscilla hemoglobin gene. A project supported by the Research Fund Unit of Inonu University, APYB 2001/16, Project budget: 5000 USD.

RESEARCH PROJECTS REVIEW PANELS

Since 2005 serving regularly on either one of the below TUBITAK review panels:

* The Basic Sciences Research Group (TBAG) * Health Sciences Research Group (SBAG) * Public Research Grant Committee (KAMAG) * Social Sciences and Humanities Research Group (SOBAG) * TECHNOLOGY AND INOVATION FUNDING PROGRAMS DIRECTORATE (TEYDEB) * Research and Application Center for Gifted and Talented * Since 2008 Instructure for TÜBİTAK Biology Olympiads

ACADEMIC SUPERVISING

* M.S., Şebnem O. Erenler(2002); Effect of the bacterial hemoglobin gene on physiological and metabolic activities of Enterobacter aerogenes; Department of Biology, Inonu University. * M.S., Nafia C. Ateş (2003); Production of fermentative products and solvent tolerance by Enterobacter aerogenes carrying the Vitreoscilla hemoglobin gene; Department of Biology, Inonu University. * Ph.D., Hüseyin Kahraman (2004); Potential use of Pseudomonas aeruginosa in bioremediation using a genetically engineered Vitreoscilla hemoglobin gene; Department of Biology, Inonu University. * M.S., Salih Gencer(2004); Vitreoscilla hemoglobin geni klonlanmış bakterilerde L-asparaginaz enziminin sentezi: önemeli bir kanser kemoterapi ajanı; Department of Biology, Inonu University * M.S., Mirac Uckun(2006); Screening of random mutagenised Gram-negative bacterial strains for high level L-asparaginase production; Department of Biology, Inonu University. * M.S., Ufuk Özer (2006); Dopamine synthesis in bacteria; Department of Biology, Inonu University * Ph.D., Burhan Ateş (2007);(Co-advisor) Production, chemical characterization and some clinical applications of anticancerogenic L-asparaginase from various Gram-negative bacteria; Department of                               Chemistry, Inonu University. * Ph.D., Şebnem O. Erenler (2007); Cloning, isolation and expression of L-asparaginase gen (ansB) in Gram-negative bacteria. Department of Biology; Inonu University. * M.S., Emel Aytan (2009); Production of L-DOPA in Erwinia herbicola bearing the Vitreoscilla hemoglobin gene; Department of Biology, Inonu University * M.S., Salih Gencer (2009);The Effect of Oxidative Stress and RNA interferance on Expression of Matrix metalloproteinase genes (MMPs) in Gastric Cancer; Department of Molecular Biology and Genetics, Fatih University, Istanbul

ACADEMIC SUPERVISING (ongoing...)

* Ph.D., Veyis Selen (2008 -); Simultaneous synthesis of L-DOPA and dopamine using recombinant microorganisms, Department of Chemical Engineering, Firat University * Ph.D., Aslı Giray Kurt (2010 -); Effect of Vitreoscilla Hemoglobin on secondary metabolite flux distribution in Erwinia herbicola; Department of Biology, Inonu University * Ph.D., Emel Aytan; Ph.D. thesis subject not assigned yet * Ph.D., Züleyha Türkoğlu; Ph.D. thesis subject not assigned yet; (my student through a collaboration between UNIP memeber universities)

RECENT CONFERENCES GIVEN

* Human Genome: are we all clones? (04/2003), Inonu University-Faculty of Science and Letters * The importance of microbial biotechnology (05/2009), 1st National Student Biotechnology Congress, Fatih University, Istanbul * Pharmocogenomics in the post-genomic era (05/2005), Inonu University-Faculty of Pharmacy * RNAi: new functions and horizons for RNA (03/2005), Inonu University-Faculty of Science and Letters * Human Genome Project: are we haunted by our genes? (11/2003), Inonu University-Faculty of Science and Letters

SEMINARS SUPERVISED

* L-asparaginase: a bacterial enzyme used in cancer therapy, by Mr. Salih Gencer (Jan28 2004) * Metabolic engineering and its applications, by Mrs. Sebnem O Erenler (June 25 2003) * Bacterial hemoglobins and their application s, by Mrs. Nafia C Ates (June 19 2003) * Hemoglobins: from bacteria to man, by Mrs. Sebnem O Erenler (June 11 2003) * A method for production of enzymes with high industrial importance: random mutagenesis and screening, by Mirac Uckun (Feb 2 2005) * Bacterial biosynthesis of L-DOPA and dopamine: two important neurotransmitters, by Mr. Ufuk Ozer (Jan 27 2006) * A technology for gene silencing : RNA inteference, by Mr. Salih Gencer (Jan 25 2006) * Individulas with identical genes but highly different characters: the hidden power of epigenetics, by Mr. Salih Gencer (July 12, 2006) * Bacterial pigmentation. Emel Aytan (Feb 3 2009) * Phage typing as an cloning vehicle, Asli Giray Kurt (Feb 3 2009) * Metagenomics: study and applications of unculturable organisms, Emel Aytan (June 18 2010) * Ten Years On: The Clinical Translation of Human Genome Project, Emel Aytan (Jan 14 2011) * How the metabolism of cancer cells differs, Zuleyha Turkoglu (Jan 25 1011)

ALUMNI

* Şebnem Özalp Erenler, Assist. Prof., Department of Biology, Inonu University * Burhan Ateş, Assoc. Prof., Department of Chemistry, Inonu University * Hüseyin Kahraman, Assist. Prof., Department of Biology, Inonu University * Salih Gencer, Reserach Assoc. Dr., Department of Bioengineering, Fatih University * Ufuk Özer, Ph.D. student, Department of Biology, Universty of South Carolina