Rabinow lab

Goals
We see developments in synthetic biology as an opportunity to invent new forms of collaborative practice. Standard approaches have sought to anticipate how new scientific developments will impact “society,” positioning themselves external to, and “downstream” of, the scientific work per se. This positioning, for example, was mandated by the Human Genome Initiative and the so-called ELSI project (ethical, legal, and social implications). By contrast, we are committed to an approach that fosters a co-production among disciplines and perspectives from the outset. The value of collaboration is that its goal is to build a synergistic and recursive structure within which significant challenges, problems, and achievements are more likely to be clearly formulated and successfully evaluated. Synthetic biology already represents a highly innovative assemblage of multiple scientific sub-disciplines, diverse forms of funding, complex institutional collaborations, serious forward-looking reflection, intensive work with governmental and non-governmental agencies, focused legal innovation, imaginative use of media, and the like. We begin with the assumption that from the outset, Thrust IV must be an integral, if distinctive, part of this overall effort. It is a principle goal of Thrust IV to invent and sustain this form of collaboration.

Thrust IV takes as its goal the articulation of a different model. If the scientific aims of synthetic biology can be summarized as the effort to make living things better and to make better living things, then the principle question that orients the four modules of Thrust IV is: How should complex assemblages bringing together a broad range of diverse actors be ordered so as to make it more rather than less likely that their near-future goals will be realized? This question and the challenge it poses to standard arrangements involves a number of key principles; Uncertainty, Adaptation and Recursivity

learn more about Thrust 4: [[Media:Thrust_4_alpha.doc‎ ]]

excerpts from the SynBERC Official Strategic Plan [[Media:Human_Practices_excerpts.doc]]

Ethics
Rethink the relationship of ethics and science in view of the highly innovative assemblage of objectives and practices in synthetic biology; analysis of the limitations and advantages of recent bio-ethics projects, including Belmont, Asilomar, ELSI, and Presidential Commissions; empirical research on evolving ethical practices in synthetic biology (including IP and security), monitoring differences in context and practical experience; design and develop collaborative ethical practices that reconfigure science and ethics for synthetic biology; stabilization and transfer of these collaborative practices.

Berkeley Human Practices Lab: [[Media:Ethics_Module_Paragraphs.doc]]

Ontology
Reflect on the form and essence of the parts, devices, chassis, and systems being created by synthetic biology; analyze the differences between the objects created in older recombinant technologies and those projected in synthetic biology; empirical research tracking how these parts, devices, chassis, systems, and test beds are designed and the ways that evolution and contemporary synthetic approaches differ from and enforce each other; observe and design new institutional arrangements and interventions appropriate to the new objects being brought into the world; stabilization and transfer of new modes of productively assembling scientific, technological, economic, cultural, ethical, and security components.

Berkeley Human Practices Lab: [[Media:Ontology_Module_Paragraphs.doc]]

Security
Here is BHPL Response to the Draft Sloan Report: Synthetic Genomics, Options for Governance [[Media:Response to Draft Governance Report.pdf]]

Energy
DOE Working Narrative for Biofuels ELSI Grant [[Media:Working_Narrative_Final.doc‎]]

NSF Site Visit Reaction
The Berkeley Human Practices Lab power point presentation is here:[[Media:Sitevisit.ppt]]

Reaction to site visit here: [[Media:BHPL_site_visit_reaction.doc‎]]

GLOSSARY
Collaboration:

Results from co-laboring. Cooperation is people with the same skills, working on something together. Whereas collaboration is people with different skills, practices, etc working on something together.

ELSI:

Ethical, Legal, Social Implications model of regulating science. It was designed for specific ends - to limit scientific excess through audit and regulation. It makes sure that wider human practices are considered outside of and “downstream” from scientific practices. Insensitive to: mutually formative relations; real time identification of emergent problems

Emergence:

That which can only be partially explained or comprehended by previous modes of analysis or existing practices. The emergent stylizes old and new elements and practices

Equipment:

practices linking truth claims, affects, ethical orientations

Ethics:

inquiry into contemporary forms of flourishing. We understand ethics to be what the Greeks thought ethics to be, the question of the practices around the “good life” and what the good life means today. What does it mean to be a scientist today? In a public university or national lab? To work on the projects of security, health, energy, environment that you are working on? And how does that fit together in more than careerism and stock options?

Flourishing (eudaemonia):

a way of thinking about the “good” which does not presuppose moral limits nor operate solely on a logic of cost/benefit.

Ontology:

inquiry into objects, techniques, logics, relationships; their significance

Practices:

Problematization:

Problematization designates a dynamic process whereby difficulties, blockages, or uncertainties are formulated as problems to which diverse solutions can be proposed. Problematization as a process is closely related to remediation as a practice. In light of problematization, remediation can be thought of as a set of practices whereby a set of difficulties and blockages are identified, rendered in the form of problems (a change of medium from tacit blockage to explicit problem), and thereby made available to remedy.

Problem Space:

recognition that all involved in SynBERC are contributing to critical domains of human life: energy, health, security, environment.

Remediation:

Involves remedy - which is not a solution but an inflection toward the goal of the good and mediation - both change of medium and attention to how hoped for future actualities are mediated relative to the present.

COURSES
Fall '07

Undergraduate Class 112B "Synthetic Biology"

The class is a collaborative human practices approach to topic areas in synthetic biology such as IP, health, security and the environment.

Course Syllabus [[Media:Synthetic_Biology_Syllabus.pdf]]

Student Presentations:

Malaria

Slides [[Media:Malaria_pwrptsFINAL-1-.pdf‎]] Paper [[Media:MALARIA.doc]]

Tumor Killing Bacteria

Slides[[Media:TKB_actualFINAL.pdf]] Paper[[Media:TKB.doc]]

Safety, Security, Preparedness

Slides[[Media:Safety,_Security,_and_Preparedness_team_slides-1-.pdf‎]] Paper[[Media:Securityessay.doc‎]]

IP

Slides[[Media:Intellectual_Property.pdf]] Paper[[Media:IntellectualProperty.doc]]

Biofuels

Slides[[Media:Biofuels.pdf]] Paper[[Media:Biofuels.doc]]

WORK SCHEDULE
BHPL-Potter St Meeting Schedule

ARC Work

name=Calendar:Rabinow Lab view=threemonths format=%name/%year-%month-%day weekstart=7