Image:DSBa.JPG

Fig.1. The kinetics of DSBs generation and repair process under IR=8Gy. (a) The stochastic trace of DSBs generation induced by continuous IR; (b) The dynamic relationships among intact DSBs, DSBCs and resulting DSBs.

Fig.2. The dynamics of ATM activation versus continuous IR time. ATM* increase against the decreasing of ATM dimer and ATM monomer under the cooperation of DSBCs and positvive self-feedback of ATM*, reaching the maximal after about 20 minutes and keep saturation.