User:Xiaosai Yao



Graduate Student Wittrup Lab Department of Biological Engineering Massachusetts Institute of Technology

Office: E19-563 Email: xyao@mit.edu Website

Education

 * 2008 - current, PhD, MIT
 * 2007, BS, Johns Hopkins

Research interests
I am interested in developing cancer therapeutics using protein engineering, in particular affinity maturation with yeast surface display developed by the Wittrup lab. I design and synthesize tumor-targeting antibodies. I am also interested in the mechanisms of cancer metastasis. My research involves the characterization of circulating tumor cells.

Previous research experience
Advisor: Dr. Andrew Wan Encapsulation of pancreatic islets with polyelectrolyte fibers for immunoisolation
 * Institute of Bioengineering and Nanotechnology Singapore, 2007-2008

Advisor: Dr. Elizabeth Jaffee Characterization of Foxp3+ CD8+ tumor infiltrating lymphocytes in FVB and neu-N transgenic mouse models
 * The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, 2005-2007

Advisor: Dr. Vincenzo Cerundolo Study of CD1e and gamma-delta TCR
 * Weatherall Institute of Molecular Medicine Oxford University, 2006

Advisor: Prof. Wanjin Hong Characterization of SIMPLE (Small Integral Membrane Protein of Lysosome/Late Endosome)
 * Institute of Molecular Cell Biology Singapore, 2004-2006