Image:SIRT2.jpg

Fig. 1 shows an example of gene conservative clustering. Chromosome loci (50kb) from different vertebrate genomes are ‘pinned through’ SIRT2 homologs. Arrows correspond to open reading frames: red-SIRT2 homologs, green-NF-kappaB inhibitor beta To the left: Proposed model of the interaction between SIRT proteins and and NF-kappaB regulatory network. Dashed lines-putative links derived from gene positional clustering.