20.109(F09):TR Purple

= Engineering an Adenovirus Selectively Targeting Pancreatic Cancer Cells = Rachael Holmes & Sylvie Polsky

Research Problem and Goals
Engineer a non-replicating adenovirus vector that uses phage display to selectively infect cancerous pancreatic cells. The virus will encode an immunotoxin or a protein that will inhibit proliferation and cause apoptosis in cancer cells. The virus will also encode a reporter gene such as EGFP to enable visualization of cells that the virus is infecting, and determine if the virus is successfully targeting pancreatic cancer cells.