User:Jeffrey Kim/Notebook/Halogenated natural products from uncultured bacteria

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Novel Halometabolites from uncultured bacteria

 * Halogenations play a critical role in tuning the activity of small molecules. While halogenations are found in more than 4500 known natural products to date, the exquisite biosynthetic selectivity of this functionalization has only recently been elucidated for several mechanisms.  Here we aim to learn more about the role halogenating enzymes have played in natural product chemical evolution by uncovering novel biosynthetic pathways and natural products from the uncultured majority.