User:Steven J. Koch/MTC/March 29 2011

Outline

 * 1) Review last HW
 * 2) Summary of Kramers' reaction rate theory (we'll discuss in detail following lectures, diffusion, etc.)
 * 3) Group work: Given prefactor of 10^-9 per second, Calculate bond lifetimes for energy barriers of: 1, 10, 20, and 40 kT
 * 4) Bond lifetime under force
 * 5) Why do we care?
 * 6) Evan Evans:  Everything about cells is kinetics, not equilibrium diffEQ
 * 7) Famous example: luekocyte rolling]
 * 8) RNA Polymerase II / nucleosome barriers
 * 9) Kinesin neck linker (see Larry's paper)
 * 10) Set-up the problem
 * 11) Group work: intuition
 * 12) Solve expected PDF for bond "strength" assuming constant force ramp rate, other assumptions
 * 13) Examples
 * 14) Preview next HW

Resources

 * Articles added to Mendeley
 * Easiest to follow: Evan Evans' Annual Review (2001): Evans, E. (2001). Probing the relation between force--lifetime--and chemistry in single molecular bonds. Annual review of biophysics and biomolecular structure, 30, 105-28. doi: 10.1146/annurev.biophys.30.1.105.
 * Thorough: Hänggi, P., Talkner, P., & Borkovec, M. (1990). Reaction-rate theory: fifty years after Kramers. Reviews of Modern Physics, 62(2), 251-341. doi: 10.1103/RevModPhys.62.251.
 * Bell, G. (1978). Models for the specific adhesion of cells to cells. Science, 200(4342), 618-627. doi: 10.1126/science.347575.
 * Wikipedia article on George Bell
 * Wikipedia article on Kramers (needs improvement!)