Cfrench:multidomhem

Analysis of multi-domain proteins with putative hemerythrin-like domains
Our analysis showed a variety of large multi-domain proteins with a hemerythrin-like domain, usually at the C-terminus or N-terminus. Other domains present were generally identified by sequence comparison as being involved in signalling: mainly methyl-accepting chemotaxis proteins (MCPs), diguanylate cyclases (GGDEF domains), histidine kinase domains, CheY-like response receiver domains, and cAMP-binding domains, and in one case an apparent phosphatase domain. The most obvious interpretation is that the hemerythrin domains act as oxygen sensors, and the auxiliary domains function in signal transduction to alter the cell's state. Sequence comparisons allowed the majority of the putative multi-domain hemerythrins to be assigned to a few well defined families.

Multi-Domain Hemerythrins
MCP = methyl-accepting chemotaxis receptor CNBP = cyclic nucleotide binding protein GGDEF = cyclic di-GMP synthase HK = histidine kinase RR = CheY-like receiver domain phos = phosphatase X = unknown

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