User:Nancy Ouyang/Notebook/20.020(S10)/2010/03/17

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System-Level Design
2020(S10)_Lecture:week_7#Week_7_Studio Breaking down a complicated problem into simpler parts: System > Device > Part > DNA


 * Nutrient recycling
 * Main nutrients: P, N, K, Ca, Mg, S
 * Focus on metabolic engineering for just two


 * Codependence
 * Should not be too difficult, known art. endocrine signals.
 * Biomolecules as signals which diffuse, NOT proteins (which only work if cells right next to each other) b/c bacteria and algae are fairly far apart in tank
 * Term is (not sure) commensalism?


 * Decontamination
 * Against mold, insects, etc.
 * Goals: inexpensive, not environmentally harmful, not easy to evolve resistance to
 * Engineer bac and alg to tolerate cold? But probably decreased efficiency
 * Look at extremophiles


 * Worries
 * Algae output locked up in algae?
 * Bacteria growing out of control and crashing?


 * System Diagram image:


 * Components that need biological engineering:
 * Oil secretion
 * Nutrient recycling
 * Steady state (constitutively attempt recycle nutrients) or what?
 * If constitutively, will always have enough nutrients, but energy costs and possibly bacteria population crash
 * Worry about start state
 * Especially if know that going to be rebooting frequently, start state becomes important


 * Notes
 * Investigate prior arr: Commensalism, there's previous research. Yeast and tryptophan, also something about mammalian cells
 * Growth temperature syncing
 * Worry about Mutations in our algae / bacteria
 * Biology: not absolute, probabilities
 * Perhaps have an expected "shelf life"
 * Have the bacteria produce antibodies, and only system reboot when superbug comes along


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