User:Ronald Y. Kwon













Contact Info

 * Ronald Y. Kwon, Ph.D.
 * Senior Fellow
 * Department of Orthopaedics and Sports Medicine, University of Washington
 * Email me through OpenWetWare

Research Interests
The capacity for bone to adapt its structure to optimally suit its mechanical environment has been recognized for two hundred years. In general, mechanical loading (such as would occur during physical activities such as weight lifting or playing tennis) induces bone formation, while unloading (for example, due to prolonged bed rest or microgravity during spaceflight) induces bone loss. Given that mechanical loading is one of the primary natural factors in inducing bone formation, my broad research goal is to better understand the physical, cellular, and molecular mechanisms mediating skeletal adaptation to mechanical loading, and to exploit these mechanisms to develop novel pharmacological and biomechanical therapies for bone loss and/or skeletal regeneration.

Education and Postgraduate Training

 * Senior Fellow, Department of Orthopaedics and Sports Medicine, University of Washington, 01/10-current
 * Postdoctoral Fellow, La Jolla Bioengineering Institute, 09/08-12/10
 * Ph.D., Mechanical Engineering, Stanford University, 09/05-09/08
 * M.S., Mechanical Engineering, Stanford University, 09/03-09/05
 * B.S., Mechanical Engineering, University of California Berkeley, 08/97-05/02

Funding

 * National Institutes of Health Ruth L. Kirchstein National Research Service Award Postdoctoral Fellowship, 12/08-present
 * National Science Foundation Graduate Fellowship, 09/03-09/06

Honors

 * American Society for Bone and Mineral Research Young Investigator Award, 10/10
 * Young Investigator Award, International Bone Fluid Flow Workshop, 10/10
 * Pfizer Inc. Endowed Scholarship to attend Zebrafish Genetics and Development Course, Marine Biological Laboratory, 08/10
 * Plenary Poster Presentation, 31st Annual American Society for Bone and Mineral Research Meeting, 09/09
 * 2nd Place, PhD Student Paper Competition, 2008 ASME Summer Bioengineering Conference, 06/08
 * Best PhD Student Presentation, Society for Physical Regulation in Biology and Medicine 25th Annual Scientific Conference, 01/07
 * Best PhD Student Presentation, Society for Physical Regulation in Biology and Medicine 23rd Annual Scientific Conference, 01/05

Publications
Book Chapters


 * 1) Book1 Kwon RY, Hoey DA, and Jacobs CR. Mechanobiology of Primary Cilia. In Cellular and Biomolecular Mechanics and Mechanobiology, Springer. Accepted.

Journal Publications


 * 1) PMIDTBD Kwon RY and Frangos JA. Quantification of lacunar-canalicular interstitial fluid flow through computational modeling of fluorescence recovery after photobleaching. Cell Mol Bioeng 2010 Jul 13. doi:10.1007/s12195-010-0129-8
 * 2) PMID20371630 pmid=20371630
 * 3) PMID20200992 pmid=20200992
 * 4) PMID19417913 pmid=19417913
 * 5) PMID19174467 pmid=19174467
 * 6) PMID18568835 pmid=18568835
 * 7) PMID17997378 pmid=17997378
 * 8) PMID17673554 pmid=17673554
 * 9) PMID17559856 pmid=17559856
 * 10) PMID17251324 pmid=17251324
 * 11) PMID15796326 pmid=15796326

Conference Presentations, Proceedings, and Abstracts
Podium Presentations
 * 1) Kwon RY, Meays DR, and Frangos JA. Microfluidic enhancement of skeletal fluid flow inhibits hindlimb unloading-induced bone loss in mice. Biomedical Engineeering Society Annual Meeting 2009. Invited Talk
 * 2) Kwon RY, Meays DR, and Frangos JA. Microfluidic enhancement of skeletal fluid flow inhibits hindlimb unloading-induced bone loss in mice. Society for Physical Regulation in Biology and Medicine 2009.
 * 3) Kwon RY, Temiyasathit S, Tummala P, Quah CC, and Jacobs CR. Adenylyl cyclase 6 and cAMP mediate primary cilia dependent mechanosensing in bone cells. Society for Physical Regulation in Biology and Medicine 2009.
 * 4) Kwon RY, Temiyasathit S, Tummala P, Quah CC, and Jacobs CR. Adenylyl cyclase 6 mediates primary cilia-regulated decreases in cAMP in bone cells exposed to dynamic fluid flow. 30th ASBMR Annual Meeting 2008, JBMR 23:S13.
 * 5) Kwon RY, Temiyasathit S, Tummala P, Quah CC, and Jacobs CR. Investigating the role of primary cilia in oscillatory fluid flow-induced increases in intracellular cAMP levels in MC3T3-E1 osteoblastic cells. Trans Orthopaedic Research Society 2008, 68.
 * 6) Kwon RY, Jacobs CR, and Lew AJ. A microstructurally informed model for the three-dimensional mechanical response of actin networks. US National Congress on Computational Mechanics 2007.
 * 7) Kwon RY and Jacobs CR. ''Viscoelasticity of bone cells exposed to fluid flow in vitro. Trans. Orthopaedic Research Society 2007, 150.
 * 8) Johnston TR, Kwon RY, and Jacobs CR. Side view characterization of bone cells and their primary cilia using adapted fluid flow chamber. Trans. Orthopaedic Research Society 2007, 147.
 * 9) Clowes EJ, Kwon RY, Tummala P, Carter DR, and Jacobs CR. Role of cytoskeletal tension in osteogenesis due to loading induced fluid flow. Trans. Orthopaedic Research Society 2007, 150.
 * 10) Kwon RY and Jacobs CR. Viscoelasticity of bone cells exposed to fluid flow in vitro. Society for Physical Regulation in Biology and Medicine 2007. Best PhD Student Presentation
 * 11) Kwon RY, Jacobs CR, and Lew AJ. Homogenization of the actin cytoskeleton: An approach based on finite element analysis, microstructure characterization and weighted principal component analysis. Trans. Orthopaedic Research Society 2006, 363.
 * 12) Kwon RY, Ayeni, OA, and Jacobs CR. Investigation of the mechanics of bone cells exposed to fluid flow. Trans Orthopaedic Research Society 2006, 129.
 * 13) Kwon RY, Ayeni, OA, and Jacobs CR. Mechanics of deformation of osteoblastic cells exposed to steady and oscillatory fluid flow. Society for Physical Regulation in Biology and Medicine 2006.
 * 14) Kwon RY, Abad-Manterola P, Lew A, and Jacobs CR. Computational modeling of actin networks and the cytoskeleton. Society for Physical Regulation in Biology and Medicine 2005. Best PhD Student Presentation
 * 15) Kwon RY, Abad-Manterola P, Jacobs CR, and Lew A. Computational modeling of actin networks and the cytoskeleton. California Tissue Engineering Annual Meeting 2004.
 * 16) Bayraktar HH, Gupta A, Kwon RY, and Keaveny TM. Multiaxial failure behavior of human femoral trabecular bone. Trans. Orthopaedic Research Society 2003, 202.
 * 17) Keaveny TM, Bayraktar HH, and Kwon RY. Shear loading is the weakest link for femoral neck trabecular bone. Trans. Orthopaedic Research Society 2002, 555.

Poster Presentations
 * 1) Kwon RY, Meays DR, and Frangos JA. Microfluidic enhancement of skeletal fluid flow inhibits hindlimb unloading-induced bone loss in mice. 31st ASBMR Annual Meeting 2009. Plenary Poster
 * 2) Kwon RY, Meays DR, and Frangos JA. Microfluidic enhancement of skeletal fluid flow inhibits hindlimb unloading-induced bone loss in mice. New York Skeletal Biology and Medicine Conference 2009.
 * 3) Kwon RY, Temiyasathit S, Tummala P, Quah CC, and Jacobs CR. Primary cilia mediate intracellular cAMP responses in bone cells exposed to dynamic fluid flow. ASME Summer Bioengineering Conference 2008, 192511. 2nd Place, PhD Student Paper Competition
 * 4) Kwon RY, Quah, CC, and Jacobs CR. Computational models of fluid flow through the osteocyte pericellular space show substantial loading on their cell bodies due to pressure gradients. Trans Orthopaedic Research Society 2008, 1179.
 * 5) Doll JC, Harjee N, Klejwa N, Kwon RY, Coulthard S, and Pruitt BL. Biological measurements of C. Elegans touch sensitivity with microfabricated force sensors. MicroTAS 2007, 0896.
 * 6) Klejwa N, Harjee N, Kwon RY, Coulthard S, and Pruitt BL. Transparent SU-8 three-axis micro strain gauge force sensing pillar arrays with biological applications. Transducers 2007, AM0261.
 * 7) Kwon RY, Jacobs CR, and Lew AJ. A novel approach to image based modeling of the actin cytoskeleton. ASME Summer Bioengineering Conference 2006.
 * 8) Kwon RY, Jacobs CR, and Lew AJ. Computational modeling of actin networks. ASME Summer Bioengineering Conference 2005.
 * 9) Kwon RY, Ayeni, OA, and Jacobs CR. Mechanics of deformation of bone cells. Biomedical Computation at Stanford 2005.

Teaching Experience

 * Co-instructor, Mechanics of the Cell, Stanford University, 09/07-12/07
 * Guest Lecturer, Orthopaedic Bioengineering, Stanford University, 10/04
 * Teaching Assistant, Mechanics of the Cell, Stanford University, 03/05-06/05
 * Teaching Assistant, Orthopaedic Bioengineering, Stanford University, 09/04-12/04
 * Tutor, Stanford University Upward Bound, 09/03-05/04
 * Tutor, University of California Berkeley Upward Bound, 01/01-05/02
 * Tutor, East Bay Asian Youth Center, 01/00-01/01

Academic Links

 * La Jolla Bioengineering Institute
 * Cell and Molecular Biomechanics Laboratory

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