User:EdipAkpinar

This page is under construction, please come back later to check the most recent information.

=Transplant Tolerance Induction for Solid Organ Transplantation=

News: 1/20/06 -- Transplant Tolerance Is being constructed.

Experimental models

 * 1) Studies in small rodents (mice, rats)
 * 2) Studies in nonhuman primates

Immunosuppressor agens used

 * 1) Antilymphocyte antisera: Antilymphocyte globulin, thymoglobulin, rituximab.
 * 2) Immunosupressor drugs: Sirolimus, Tacrolimus

Adjuvant donor bone marrow (BM) infusion

 * 1) Whole unfractionated BM infusion.
 * 2) Fractionated BM infusion
 * 3) Enriched BM progenitor cell infusion

"Laws of transplantation"

 * 1) Transplants between inbred strains will succeed.
 * 2) Transplants between inbred strains will fail,
 * 3) Transplants from a member of an inbred parental strain to an F-1 offspring will succeed, but those in the reverse direction will fail.
 * 4) Transplant from F2 and all subsequentt generations to F1 animals will succeed.
 * 5) Transplants from inbred parental strains to the F2 generation will usually, but not always fail.

NOTE: This website is a place where you could find some introductory recent information on transplantation tolerance. It is currently prepared by one individual, therefore it is restricted in terms of rigorous verification and "recentness". A mirror of this page is also beign built at TransplantWiki. If you would like to contact me for anything please feel free to do so:[mailto:edipakpinar@morphomes.org e-mail_1]or [mailto:ea82@georgetown.edu e-mail_2].