Building blocks

Inventory of different kind of building blocks required.

=Adaptors=

If we want our system to be as modular as possible we'll have to use very efficient adaptor domains. For example, we can couple a unique "writer domain" to multiple targeting domains.

Proteins:


 * Leucine zippers


 * PDZ domains

(note: check for Kd etc...)

=Targeting domains=

We will probably have to target enzymes to specific DNA sites for example or proteins to specific localizations.

zinc-finger other DNA binding domains
 * DNA targetting domain

Nuclear localization signals
 * Localization domains

Nuclear export sequences

Membrane targeting

mitochondrial targeting

Endoplasmic reticulum

Secretion

Nuclear membrane