Lakkureddi Alagarsamy

Contact Info

 * Lakkureddi Alagarsamy (Reddi), PH.D.
 * Assistant Professor (Research)
 * Department of Medicine
 * Hematology/Oncology Division
 * 303 E. Superior Street
 * Lurie 5-250
 * Chicago IL 60611


 * Phone (312) 503-0987
 * FAX (312) 503-0189


 * e-mail: a-reddi@northwestern.edu

University website:

https://fsmweb.northwestern.edu/faculty/facultyProfile.cfm?xid=18711

http://www.medicine.northwestern.edu/scripts/bio.pl?pid=2595

Research interests

 * 1)  Mammary Gland Development and Cancer Onset
 * 2)  Cancer Metastasis
 * 3)  Signal transduction; RTK signaling

Publications
1: Raja SM, Clubb RJ, Ortega-Cava C, Williams SH, Bailey TA, Duan L, Zhao X, Reddi AL, Nyong AM, Natarajan A, Band V, Band H. Anticancer activity of celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. Cancer Biol Ther. 2011 Jan 16;11(2). [Epub ahead of print] PubMed PMID: 21088503.

2: Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H. Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGFR-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem. 2010 Oct 12. [Epub ahead of print] PubMed PMID: 20940296.

3: Tu C, Ortega-Cava CF, Winograd P, Stanton MJ, Reddi AL, Dodge I, Arya R, Dimri M, Clubb RJ, Naramura M, Wagner KU, Band V, Band H. Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16107-12. Epub 2010 Aug 30. PubMed PMID: 20805499; PubMed Central PMCID: PMC2941294.

4: Akbulut S*, Reddi AL*, Aggarwal P, Ambardekar C, Canciani B, Kim MK, Hix L, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Collins S, Quatela S, Phillips M, Licht JD. Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell. 2010 Oct;21(19):3487-96. Epub 2010 Aug 18. PubMed PMID: 20719962; PubMed Central PMCID: PMC2947483. (* Equal Contribution)

5: Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. J Biol Chem. 2010 Jan 8;285(2):1555-68. Epub 2009 Oct 13. PubMed PMID: 19826000; PubMed Central PMCID: PMC2801280.

6: Wen Q, Leung C, Huang Z, Small S, Reddi AL, Licht JD, Crispino JD. Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood. 2009 Jul 2;114(1):153-6. Epub 2009 Apr 1. PubMed PMID: 19339696; PubMed Central PMCID: PMC2710943.

7: Chung BM, Dimri M, George M, Reddi AL, Chen G, Band V, Band H. The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene. 2009 Apr 23;28(16):1821-32. Epub 2009 Mar 23. PubMed PMID: 19305428; PubMed Central PMCID: PMC2752420.

8: Raja SM, Clubb RJ, Bhattacharyya M, Dimri M, Cheng H, Pan W, Ortega-Cava C, Lakku-Reddi A, Naramura M, Band V, Band H. A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells. Cancer Biol Ther. 2008 Oct;7(10):1630-40. Epub 2008 Oct 9. PubMed PMID: 18769124; PubMed Central PMCID: PMC2727620.

9: Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR. Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. J Immunol. 2007 Oct 1;179(7):4435-43. PubMed PMID: 17878339.

10: Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P, Druker BJ, Naramura M, Band V, Band H. Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem. 2007 Oct 5;282(40):29336-47. Epub 2007 Jul 9. PubMed PMID: 17620338.

11: Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity. 2004 Jul;21(1):7-17. Review. PubMed PMID: 15345216.

12: Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H. Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20;279(34):36132-41. Epub 2004 Jun 18. PubMed PMID: 15208330.

13: Kannan S, Lakku RA, Niranjali D, Jayakumar K, Steven AH, Taralakshmi VV, Chandramohan S, Balakrishnan R, Schmidt C, Halagowder D. Expression of peanut agglutinin-binding mucin-type glycoprotein in human esophageal squamous cell carcinoma as a marker. Mol Cancer. 2003 Nov 5;2:38. PubMed PMID: 14613581; PubMed Central PMCID: PMC280694.

14: Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24. PubMed PMID: 12881521.

15: Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem. 2003 Aug 1;278(31):28950-60. Epub 2003 May 18. PubMed PMID: 12754251.

16: Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H. ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem. 2003 Apr 18;278(16):13829-37. Epub 2003 Feb 6. PubMed PMID: 12574167.

17: Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H. Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3794-9. PubMed PMID: 11904433; PubMed Central PMCID: PMC122603.

18: Rao N, Ghosh AK, Ota S, Zhou P, Reddi AL, Hakezi K, Druker BK, Wu J, Band H. The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation. EMBO J. 2001 Dec 17;20(24):7085-95. PubMed PMID: 11742985; PubMed Central PMCID: PMC125791.

19: Nath I, Vemuri N, Reddi AL, Bharadwaj M, Brooks P, Colston MJ, Misra RS, Ramesh V. Dysregulation of IL-4 expression in lepromatous leprosy patients with and without erythema nodosum leprosum. Lepr Rev. 2000 Dec;71 Suppl:S130-7. PubMed PMID: 11201870.

20: Nath I, Vemuri N, Reddi AL, Jain S, Brooks P, Colston MJ, Misra RS, Ramesh V. The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients. Immunol Lett. 2000 Dec 1;75(1):69-76. PubMed PMID: 11163869.

21: Reddi AL, Sankaranarayanan K, Arulraj HS, Devaraj N, Devaraj H. Serum alpha-N-acetylgalactosaminidase is associated with diagnosis/prognosis of patients with squamous cell carcinoma of the uterine cervix. Cancer Lett. 2000 Sep 29;158(1):61-4. PubMed PMID: 10940510.

22: Reddi AL, Sankaranarayanan K, Arulraj HS, Devaraj N, Devaraj H. Enzyme-linked PNA lectin-binding assay of serum T-antigen in patients with SCC of the uterine cervix. Cancer Lett. 2000 Feb 28;149(1-2):207-11. PubMed PMID: 10737726.