BioControl:Week2/Notes

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 * I like to briefly notate every paper I read, and it made sense to put it here. feel free to add anything more -Kelsic

Summary

 * Eukaryotic Chemotaxis is locally dependent rather than globally polarized.
 * Stochastic processes result in a biased-random-walk in the direction of chemical gradients:
 * Membrane receptor binding events trigger local lamellipod extensions.
 * Direction of chemical gradient determines an angular probability distribution for membrane extension.
 * a single "compass-parameter" is sufficient to specify the probability distribution of the cell's biased random walk.
 * dependent upon gradient strength and angular change per extension
 * Experimental - Tracking cells during migration and chemotaxis: measured PI3-kinase activation in:
 * primary DCs (I think this is Dendritic Cells) w/ C5a as a G protein coupled chemoattractant
 * fibroblasts w/ platelet-derived growth factor (PDGF)as a tyrosine coupled chemoattractant

Background
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 * Wikipedia:Chemotaxis
 * Wikipedia:Dendritic Cells
 * Wikipedia:Fibroblasts
 * Nature-Cell motility: Sharks' teeth and dunes - molecular lamellipod extension
 * Purcell-Life at Low Reynolds Number - how cells move