User:Mark Blenner

Mark Blenner


Immune Disease Institute Harvard Medical School Timothy Springer's Lab 3 Blackfan Circle Boston, MA 02115 blenner@idi.harvard.edu

Previously, I worked in the Banta Lab at Columbia University.

Currently, I am a Research Fellow in the Springer Lab at the Immune Disease Institute affiliated with Harvard Medical School and Children's Hospital.

Education

 * Current, Postdoctoral Fellow, Harvard Medical School (Immune Disease Institute)
 * 2009, PhD, Columbia University (Chemical Engineering)
 * 2007, MS, Columbia University (Chemical Engineering)
 * 2004, BS, Manhattan College (Chemical Engineering)

Research interests
My research interests involve studying protein conformational change. Using a combination of biochemical, biophysical and single-molecule techniques, we can begin to understand the complex ways in which proteins are able to regulate their properties. Using protein engineering tools, such as directed evolution and other high throughput technologies, we can better understand protein conformational changes, as well as conformational dynamics. This work sheds new light on biological function and pathological dysfunction. This knowledge and these tools are used to design advanced biotechnologies addressing problems in medicine, biosensing and nanotechnology.


 * 1) Protein Engineering
 * 2) Conformational Control of Protein Activity
 * 3) Biological Conformational Switches
 * 4) Directed Evolution & High Throughput Technologies
 * 5) Single-molecule Biophysics
 * 6) Structural Biology

Awards & Honors

 * American Heart Association Postdoctoral Fellowship (2010-2012)
 * Draddy Medal for Excellence in Engineerin (2004)

Publications

 * 1) Paper1 pmid=20438736
 * 2) Paper2 pmid=20420519
 * 3) Paper3 pmid=19860484
 * 4) Paper4 pmid=18218715
 * 5) Paper5 pmid=17376876

Useful links

 * Introductory tutorial
 * OpenWetWare help pages