User:Wei Pan



Welcome to the Wei Pan homepage, hosted by OpenWetWare.

Curriculum Vitae

Email: weipan@mail.ustc.edu.cn

Phone: (+86)551-3601800; (+86)13965063991

Address:

Biomedical Engineering Institute

Department of Electronic Science and Technology

University of Science and Technology of China (USTC)

Hefei, Anhui, P. R. China. 230027

Education

 * Sep. 2008 - present,     M.S., Biomedical Engineering, University of Science and Technology of China
 * Sep. 2004 - Jun. 2008,   B.S., Automatic Control,      Harbin Institute of Technology

Research interests
Applying contorl theory to Systems Biology and Synthetic Biology.

Project
Current Project (USTC):

1. Inferring genetic regulatory networks topology and function via closed-loop subspace system identification and robust filter

2. iGEM project: Develop software to automatically design synthetic genetic regulatory networks with desired functions


 * Develop system identification algorithm for linear and nonlinear genetic regulatory networks.


 * Construct a database of Biobricks with specific functions, DNA sequences and structures to facilitate the design procedure.


 * Sensitivity and reliability analysis of designed genetic regulatory networks.


 * Develop friendly interface using Qt platform.


 * Embed SBML compiler to make model input and output in a standard form.


 * Extend to Eclipse plug-in in Java for cross platforms.


 * Construct website for the product and provide service on line.


 * Help USTC wet team to perform simulation and modeling.

Past Project (HIT):

Undergraduate independent research

1. Multistability of Genetic Regulatory Networks 2. Robust Stability of Stochastic Genetic Regulatory Networks 3. H∞ Feedback Control for Genetic Regulatory Networks
 * Apply switched system theory and multiple Lyapunov function to investigate multistability of genetic regulatory networks [1].
 * Genetic Regulatory Networks are modeled as nonlinear differential equations with time delay. Both monostability and multistability are analyzed in a uniform framework [2].
 * Multivariable regulation functions which different variables multiply together are considered in genetic regulatory networks. Apply Linear Matrix Inequality and Lyapunov-Krasovskii functional theory to investigate multistability of genetic regulatory networks [3].
 * Noise is ubiquitous in gene expression and genetic regulatory networks are formulated as nonlinear stochastic differential equations with time delays. Both intrinsic and extrinsic noises are considered in this formulation to model the uncertainty and fluctuation of kinetic parameters and time delays. A novel Lyapunov - Krasovskii functional has been proposed using the stochastic analysis approach. The theorem is formulated in the form of Linear Matrix Inequality [4].
 * Robust synthetic gene circuits have been designed to attenuate the noise in genetic regulatory networks with time delays using H∞ control theory [5].

Professional & teaching experience

 * Sep 2008 – present: Master graduate student and research assistant in Prof. Huanqing Feng Group, Department of Electronic Science and Technology, USTC.


 * Feb 2009 – present: Captain for the international Genetically Engineered Machine competition (iGEM) USTC software team, Department of Biology, USTC.
 * Mar 2009 – Jul 2009: Teaching assistant for Biochemistry, Department of Biology, USTC.


 * Jan 2007 – Jul 2008: Research undergraduate student in Prof. Huijun Gao Group, Space Control and Inertial Technology Research Center, HIT.

Professional activities
Reviewer for the following journals:


 * Journal of Computational Biology
 * IEEE Transactions on Systems, Man, and Cybernetics--Part B: Cybernetics
 * International Journal of Systems Science
 * Neurocomputing.

Publications
[1]. W. Pan*, Z. Zhang and H. Liu, “Multistability of Genetic Regulatory Networks”, International Journal of Systems Science. (to appear) * - Corresponding author [pdf file] [2] W. Pan, Z. Wang and H. Gao, “Monostability and Multistability of Genetic Regulatory Networks with Different Types of Regulation Functions”. Nonlinear Analysis: Real World Applications. (to appear) [pdf file]

[3] W. Pan, Z. Wang and H. Gao, “On Multistability of Delayed Genetic Regulatory Networks with Multivariable Regulation Functions”. Journal of Mathematical Biology. (Revised) [pdf file]

[4] W. Pan, Z. Wang and H. Gao, “Robust Stability of Genetic Regulatory Networks with Stochastic Time Delays Under Intrinsic and Extrinsic Noise”. Neurocomputing. (Submitted) [pdf file]

[5] W. Pan, Z. Wang and H. Gao, “Robust H∞ Feedback Control for Uncertain Stochastic Delayed Genetic Regulatory Networks with Additive and Multiplicative Noise”, International Journal of Robust and Nonlinear Control. (Submitted) [pdf file]

Useful links

 * Professor Huijun Gao
 * Professor Zidong Wang