BioControl:Reading

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Recommendations
Papers that at least one of us has read and enjoyed, with a short summary and explanation of relevance.


 * Important mathematical background that underlies transcriptional regulation, the most prevalent feedback system in biology. I find it interesting that biology separates (to some degree) the amount of protein expressed from a protein's function, and this separation allows for control over the number of proteins in the cell. -Kelsic Phillips1


 * Modular functional modeling of feedback mechanisms in the heat shock response. An example of how protein numbers can be controlled via feedback vs. parameter tuning. Doyle


 * Experiment and modelling that demonstrate how negative transcriptional regulation can change the time-response of a genetic circuit. Elowitz


 * Engineeging implementation of negative transcriptional feedback for control over the variance of protein distributions. An example of how transcriptional feedback can be used for precise gene control. Becskei


 * Theoretical paper discussing the minimum number of molecules required to perform stable switching. It's article #74 on his publications page -Milo


 * A quorum sensing system regulates a gene that causes cell death. The result is a population control circuit. They're able to generate step-response-like plots of cell growth vs. time and show that with control the cells grow to a lower steady state value. You_Nature2004 --Mary 17:52, 14 November 2006 (EST)


 * This paper uses the population control circuit from the paper above, but runs the reactions in a microfluidic bioreactor. Since they're feeding in fresh media and they can take measurements for ~8 days straight. Under the microfluidic conditions they observe oscillatory behavior from genetic circuits that maintained a constant steady state under the bulk growing conditions. Balagadde_Science2005 --Mary 18:11, 14 November 2006 (EST)

Possibilities
papers that no one has read, but that might be interesting.
 * Nature: Systems Biology User's Guide